Loading...
  • endocrine tumors
  • BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant hereditary disorder associated with the development of endocrine tumors due to reduced expression of the tumor suppressor protein menin. (springer.com)
  • Recent studies indicate a general role of menin in carcinogenesis, affecting the prevalence and clinical course of common non-endocrine tumors such as breast cancer, hepatocellular carcinoma and melanoma. (springer.com)
  • CONCLUSION: The results and clinical course of disease in this case indicate the potential role of menin in the development of non-endocrine or atypical-endocrine tumors in MEN1 patients. (springer.com)
  • Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited tumor syndrome characterized by the development of multiple endocrine tumors. (lu.se)
  • genes
  • Scientists have found that altering members of the p53 gene family, known as tumor suppressor genes, causes rapid regression of tumors that are deficient in or totally missing p53. (healthcanal.com)
  • The study, led by Elsa R. Flores, Ph.D. , associate professor of molecular and cellular oncology , centered on p63 and p73 because of the genes' ability to cause tumor regression or spur its growth due to their unique genetic makeup. (healthcanal.com)
  • Fang M, Xia F, Mahalingam M, Virbasius CM, Wajapeyee N, Green MR, 2013 MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair. (springer.com)
  • apoptosis
  • It is widely appreciated that the program of apoptosis is retained in many types of leukemias and solid tumors and that apoptosis contributes to the tumor response to anticancer agents. (aacrjournals.org)
  • Two major pathways for apoptosis have been identified, involving either mitochondria ( intrinsic ) or tumor necrosis factor (TNF)-family death receptors ( extrinsic ) as initiators of caspase protease activation and cell death. (aacrjournals.org)
  • These eight compounds did not increase Fas surface levels and also sensitized PPC-1 cells to apoptosis induced by TNF-family member TNF-related apoptosis-inducing ligand, consistent with a post-receptor mechanism. (aacrjournals.org)
  • Altogether, these findings show the feasibility of identifying compounds that selectively enhance apoptosis via the extrinsic pathway, thus providing research tools for uncovering resistance mechanisms and a starting point for novel therapeutics aimed at restoring sensitivity of tumor cells to immune effector mechanisms. (aacrjournals.org)
  • TNF-family death receptors trigger apoptosis through a mechanism involving recruitment of certain caspase-family proteases to their cytosolic domains (e.g., caspases 8 and 10 in humans), resulting in formation of a death-inducing signaling complex. (aacrjournals.org)
  • cancer
  • The family of Keira Dixon, from Swan Street in Sible Hedingham, hope to raise thousands of pounds for children's cancer charity Clic Sargent as part of the campaign. (suffolkfreepress.co.uk)
  • Thus, a clear understanding of this interplay in cancer is needed to treat tumors with p53 alterations. (healthcanal.com)
  • Flores' team found that by deleting the p63 and p73 versions that lacked transactivation domains, they were able to metabolically reprogram cells so that the cancer progression was stopped and reversed in p53-deficient tumors. (healthcanal.com)
  • Members of the family demonstrated many different atypical tumors, such as renal cell carcinoma, papillary thyroid cancer and prostate cancer. (springer.com)
  • DNA sequencing of two of the atypical tumors (prostate cancer, papillary thyroid cancer) did not reveal a loss of heterozygosity, indicating an impact on menin expression and function in the heterozygous state, in line with results in +/− Men1 mutant mice developing prostate cancer. (springer.com)
  • The Rao lab also found that another family of proteins called NFAT turned on Nr4a in T cells that entered tumors, suggesting that both proteins were somehow involved in wearing out cancer-fighting T cells. (fiercebiotech.com)
  • In tumor-bearing mouse models, the experimental CAR-T cells promoted tumor regression and kept most of the mice alive over the 90-day study period, while the rodents that got normal CAR-Ts died of cancer by day 35, according to the team. (fiercebiotech.com)
  • In mice, knocking out Sirt2 led to high rates of breast tumors in females, while about a quarter of male mice (but only one out of 26 female mice) lacing the gene developed liver cancer. (bioworld.com)
  • For 99 percent of the time, cancer care is provided at home by the family," said Betty Ferrell , Ph.D., R.N., director of Nursing Research and Education at City of Hope. (cityofhope.org)
  • Ferrell has led City of Hope in a five-year National Cancer Institute-funded study to provide comprehensive services for lung cancer patients and their families, focused on quality-of-life issues from the start of treatment. (cityofhope.org)
  • These answers provide a fuller picture of patients and how their lives might be affected by cancer - revealing, for example, what other illnesses they may be facing, who cares for them, what family members they usually care for, and any major recent life changes. (cityofhope.org)
  • This summer, Ferrell started a program to replicate the family-caregiver portion of the lung cancer program in low-income families. (cityofhope.org)
  • regression
  • We found that IAPP is involved in tumor regression and that amylin, the protein encoded by the IAPP gene, stops a cell's ability to metabolize glucose, leading to programmed cell death," said Flores. (healthcanal.com)
  • Pramlintide, a synthetic type of amylin that is currently used to treat type 1 and type 2 diabetes, caused rapid tumor regression in p53-deficient lymphomas of the thymus. (healthcanal.com)
  • necrosis
  • After receiving treatment for a brain tumor, PET scans can also be used to differentiate new tumor growth from scar tissue or necrosis (cells killed by radiation). (caregiver.org)
  • commonly
  • A limitation of such therapies, however, is acquired or intrinsic resistance to TNF-family death ligands and death receptors, which commonly occurs in advanced malignancies ( 6 ). (aacrjournals.org)
  • treatment
  • The tissue is studied to confirm the type of tumor, and to help the healthcare team outline a treatment plan. (caregiver.org)
  • Novocure's tumor-treating electric field system scored an FDA nod in mesothelioma, making it the first new treatment in more than 15 years. (fiercebiotech.com)
  • primary
  • CASE PRESENTATION: A German family with a history of primary hyperparathyroidism presented to our Hospital for further evaluation. (springer.com)
  • Cell
  • Yang YQ, Qi J, Xu JQ, Hao P, 2014 MicroRNA-142-3p, a novel target of tumor suppressor menin, inhibits osteosarcoma cell proliferation by down-regulation of FASN. (springer.com)
  • The exact molecular mechanism of T cell exhaustion has been a mystery, but scientists believe it partially explains why CAR-Ts can't act on solid tumors. (fiercebiotech.com)
  • Characterization of the effects of the eight compounds on a panel of 10 solid tumor cell lines revealed two structurally distinct compounds that frequently sensitize to extrinsic pathway agonists. (aacrjournals.org)
  • syndrome
  • Nevertheless, in families with uncommon manifestations of the syndrome early diagnostic adjustments should be considered. (springer.com)
  • types
  • Researchers from the National Institutes of Health have shown that Sirt2, a member of the anti-aging sirtuin family, functions as a tumor suppressor and that it does so for different tumor types for males and females. (bioworld.com)