Family of transcription factors positive transcriptional elongation factor b. Medical search. Frequent questions

These results suggest that transcriptional elongation control is especially important for rapidly expressed genes to support digestion and metabolism, many of which have sex-biased function. (sdbonline.org)
In humans, mutations affecting the genes of this family are associated with specific diseases. (sdbonline.org)
We postulate that histone readers together with OCT4 play a role in the transcriptional control of the XCI lncRNAs as well as pluripotent genes. (cancerrealitycheck.com)
2008 At many developmental genes RNAP II stalls or pauses after transcribing a nascent transcript about 20-65 nucleotides in length (Adelman and Lis 2012 Nearly 30% of the genes in human ESCs commence transcription initiation but do not undergo transcriptional elongation (Guenther et?al. (cancerrealitycheck.com)
Finally, effects of FUS on HIV gene transcription are also exhibited genome wide, where FUS mainly occupies gene promoters at transcription starting sites, while its knockdown leads to an increase in AFF4 and Cdk9 occupancy on gene promoters of FUS affected genes. (biomedcentral.com)
Blood induced widespread microglial transcriptional changes, including changes involving oxidative stress and neurodegenerative genes. (nature.com)
It has been demonstrated that the bolting and flowering signals from internal or external factors usually converge on a few integrator genes which serve as flowering inducers or repressors during floral transition. (frontiersin.org)
Floral inducers including FLOWERING LOCUS T (FT), FD, SUPPRESSOR OF CONSTANS 1 (SOC1), and LFEAY (LFY) activate the transcription of the majority of genes floral genes, promoting Arabidopsis bolting and flowering ( Johansson and Staiger, 2015 ). (frontiersin.org)
This bi-genomic division is accompanied by profoundly different transcription regulatory system: whereas nDNA-encoded genes are transcribed individually by RNA polymerase 2 and the general nuclear transcription machinery, mtDNA transcription is long known to be regulated mainly by a dedicated RNA polymerase (POLRMT) and mtDNA-specific transcription factors (TFAM and TFB2) ( Shutt and Shadel 2010 ). (biorxiv.org)
However, as mtDNA transcription was mostly studied in vitro, little remains known about the mode and tempo of in vivo OXPHOS genes' transcription residing on the mtDNA. (biorxiv.org)
Indeed, the PBF (PROLAMIN BINDING FACTOR), one of the first DOF proteins characterised, controls the endosperm-specific expression of the zein genes in maize. (encyclopedia.pub)
Two MYB transcription factor genes, GRMZM2G325907 and GRMZM2G108892, which might regulate plant cell wall metabolism are the candidate genes for qPH10 . (biomedcentral.com)
Although over expressing any of these six single-repeat R3 transcription factors in Arabidopsis causes a glabrous phenotype, single mutants of these genes have different phenotypes. (biomedcentral.com)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
The aim of the present work is to review cumulative evidence regarding the participation of PI3K pathways in neuronal function, focusing on their role in neuronal metabolism and transcriptional regulation of genes involved in neuronal maintenance and plasticity or on the expression of pathological hallmarks associated with neurodegeneration. (mdpi.com)
The physiological conditions experienced by a microbial community can thus be inferred using meta-transcriptomic sequencing by comparing transcription levels of specifically chosen genes. (osti.gov)
Sample-specific meta-genomic assembled genomes (MAGs) were used as reference genomes to accurately identify the origin of RNA reads, and transcript ratios of genes with opposite transcription responses were compared to eliminate biases related to differences in organismal abundance, an approach hereafter named the "diametric ratio" method. (osti.gov)
Differential genes expression analysis indicated that transcriptional regulation was more active in the early stage of apogamy compared to sexual reproduction. (biomedcentral.com)
BAF60 binds nucleosome-free regions of multiple G box-containing genes, opposing in cis the promoting effect of the photomorphogenic and thermomorphogenic regulator Phytochrome Interacting Factor 4 (PIF4) on hypocotyl elongation. (biomedcentral.com)

EAF proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation. (wikipedia.org)
BRD4 is a member of the BET (bromodomain and extraterminal domain) family of tandem bromodomain-containing proteins that can bind acetylated histones H3 and H4 and influence transcription (Chiang 2009 BRD4 is an epigenetic reader originally identified as a mitotic chromosome-binding protein that remains associated with acetylated chromatin throughout the entire cell cycle and is thought to provide epigenetic bookmarking after cell division Alosetron Hydrochloride (Dey et?al. (cancerrealitycheck.com)
Comparative functional multiomics showed that blood proteins induce distinct receptor-mediated transcriptional programs in microglia and macrophages, such as redox, type I interferon and lymphocyte recruitment. (nature.com)
We report a blood-induced microglia gene network and show that blood proteins elicit distinct receptor-mediated transcriptional changes and signaling programs in innate immune cells. (nature.com)
On the other hand, although the transcription of TCL2 , like TCL1, is not controlled by the activator complex formed by GL1 and GL3, and TCL2 and TCL1 proteins are more than 80% identical at the amino acid level, the expression of TCL2 under the control of TCL1 promoter only partially recovered the mutant phenotype of tcl1 , implying that TCL2 and TCL1 are not fully functional equivalent. (biomedcentral.com)
1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
These data highlight a potentially unrecognized mechanism of DAXX inactivation in ALT positive osteosarcoma and provide rationale for thorough and comprehensive analyses of ATRX/DAXX/H3.3 proteins in ALT positive cancers. (oncotarget.com)
As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program. (molcells.org)
Diverse SR proteins play partially overlapping but distinct roles in transcription-coupled splicing and mRNA processing in the nucleus. (molcells.org)
This mini-review will summarize the roles of SR proteins as RNA binders, regulators, and connectors from transcription in the nucleus to translation in the cytoplasm. (molcells.org)
One such important family of regulatory RBPs is the Serine-Arginine (SR) family of proteins. (molcells.org)
Throughout evolution, eukaryotes adopted a network of highly conserved proteins that buffer the positive charges of histones, maintaining their solubility and, therefore, avoiding aberrant interactions with other cellular components. (aging-us.com)
Based on recent data, a new view is emerging that vertebrate Dachshund(Dach) proteins are components of Six1/6 transcription factor-dependent signaling cascades. (biologists.com)

Our observations show that FUS regulates both HIV and global gene transcription and modulates viral latency, thus can potentially serve as a target for future therapy that sets to reactivate HIV from its latent state. (biomedcentral.com)
Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. (wuxibiortus.com)
Previously we identified a novel single-repeat MYB transcription factor, TRICHOMELESS1 (TCL1), which negatively regulates trichome formation on the inflorescence stems and pedicels by directly suppressing the expression of GL1 . (biomedcentral.com)
Notably, a nucleus-resident actin (R62D NLS ) also regulates SRF's transcriptional activity. (jneurosci.org)

Following relatively long initiation and promoter clearance, RNA polymerase II can pause and then rapidly elongate following recruitment of positive elongation factors. (sdbonline.org)
2007 This suggests that transcriptional pausing is an additional checkpoint control during development (Levine 2011 The release from transcriptional pausing is associated with P-TEFb recruitment the eviction of pause factors the phosphorylation at serine 2 of the carboxyl-terminal domain Alosetron Hydrochloride (CTD) in RNAP II and the production of elongated mRNAs. (cancerrealitycheck.com)
However, a growing body of evidence suggests that recruitment, stability, and function of epigenetic factors can be mediated by non-protein-coding RNAs. (frontiersin.org)
As docking units, they influence the recruitment of the transcriptional machinery, thus establishing unique gene expression patterns that ultimately promote different biological outcomes. (aging-us.com)

They regulate multiple transcription activities and contribute to tumor-promoting processes, ranging from cell proliferation to apoptosis, inflammation, metastasis, and angiogenesis. (bvsalud.org)
As transcription silencing is key for establishing the HIV reservoir, significant efforts have been made to understand the mechanism that regulate HIV gene transcription, and the role of the elongation machinery in promoting this step. (biomedcentral.com)
It was proposed that single-repeat MYBs negatively regulate trichome formation by competing with GLABRA1 (GL1) for binding GLABRA3/ENHANCER OF GLABRA3 (GL3/EGL3), thus inhibiting the formation of activator complex TTG1(TRANSPARENT TESTA GLABRA1)-GL3/EGL3-GL1 that is required for the activation of GLABRA2 ( GL2 ), whose product is a positive regulator of trichome formation. (biomedcentral.com)
Transcription factors whose primary function is to regulate the rate in which RNA is transcribed. (bvsalud.org)

2000 2003 BRD4 has a direct role in transcription as it associates with positive transcription elongation factor b (P-TEFb) to enhance RNA polymerase II Alosetron Hydrochloride (RNAP II) and control productive mRNA synthesis (Yang et?al. (cancerrealitycheck.com)
Within SEC two elongation factors, positive transcription elongation factor b (P-TEFb) and elongation factor for RNA polymerase II 2 (ELL2) are key components. (biomedcentral.com)
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). (wuxibiortus.com)

Multiple elongation complexes exist, but the role of specific components in adult Drosophila is underexplored. (sdbonline.org)
Whereas mammals (chimpanzee, rhesus macaque, rat, and mouse) showed a human-like mtDNA transcription pattern, the invertebrate pattern (Drosophila and C. elegans) profoundly diverged. (biorxiv.org)

Bolting is characterized as the elongation of the floral stem, accompanied with the initiation of the flowering ( Pouteau and Albertini, 2009 ). (frontiersin.org)
Surprisingly, accurate detection of human mtDNA transcription initiation sites (TIS) in the heavy and light strands revealed a novel conserved transcription pausing site near the light strand TIS, upstream to the transcription-replication transition region. (biorxiv.org)

c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members integrate signals that affect proliferation, differentiation, survival, and migration in a cell context- and cell type-specific way. (bvsalud.org)
The lilli gene encodes a nuclear protein related to the AF4/FMR2 family. (sdbonline.org)
Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different classes of molecules with unique lengths, conformations and targets. (frontiersin.org)
The corresponding PBF (PROLAMIN BINDING FACTOR) gene was first isolated from maize and shown to encode a DOF protein that interacts with O2 (Opaque2) [ 28 ] . (encyclopedia.pub)
Transcription of TCL2 is not controlled by activator complex formed by GL1 and GL3, but MIR156 controlled SQUAMOSA PROMOTER BINDING PROTEIN LIKE (SPL) transcription factors. (biomedcentral.com)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
VEGF transcription leads to Ras frame in a Ras-guanine state curvature ligand( GEF) NOX2 protein. (erik-mill.de)
Breast tumors can be divided into subtypes using two parameters: (I) At the molecular level based on the protein expression of three receptors: estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) [ 2 ]. (biomedcentral.com)
Genetic mutations in ATRX, DAXX, and H3.3 have been detected in ALT positive cancers, however, a subset of ALT samples show loss of ATRX or DAXX protein expression or localization without evidence of genetic alterations suggesting additional uncharacterized defects in ATRX/DAXX/H3.3 function. (oncotarget.com)
However, care has been taken to obtain the same predicted protein, the protein family identifier. (renbehan.com)
Transplantation of young ovaries to old mice increased life span by increasing the metabolite solution flow rate and post-copulatory reproductive success and offspring quality of offspring produced by those males after a single mating, with females having access to specific metabolic resources without the need for a given protein family. (renbehan.com)

AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. (wuxibiortus.com)

Unlike sequence-specific transcription factors, epigenetic regulators do not necessarily bind DNA at consensus sequences, but still achieve reproducible target binding in a manner that is cell and maturation-type specific. (frontiersin.org)
A growing body of evidence indicates that epigenetic regulators rely, amongst other factors, on their interaction with untranslated RNA molecules for guidance to particular targets on DNA. (frontiersin.org)
AML has a characteristic dependency on chromatin and transcriptional regulators, which has been discussed in many reviews. (frontiersin.org)

integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing (PubMed:15564463, PubMed:19575011, PubMed:19844166). (wuxibiortus.com)

ESCs can be differentiated by suspension culture for 4?days without leukemia inhibitory factor (LIF) and maintained thereafter under adherent conditions (Martin and Evans 1975 Following differentiation the male X chromosome loses expression of these lncRNAs to retain activity of the single X whereas the female ESCs have a choice of active versus inactive X. On the future active X and expression persists to keep levels low. (cancerrealitycheck.com)
Results The Epigenetic Reader BRD4 Is Expressed during ESC Differentiation and Binds the Pluripotent Factor OCT4 We postulate that a co-activator such as BRD4 might play a role in epigenetic memory for binary cell fate ("stem-ness" versus differentiation) and XCI (active versus inactive X chromosome) status in ESCs. (cancerrealitycheck.com)
The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation (PubMed:12037670). (wuxibiortus.com)
During brain development, neurons pass through various phases of morphological differentiation encompassing neurite elongation, neurite differentiation in axon and dendrites, and directional navigation of growth cones toward postsynaptic targets. (jneurosci.org)

While HIV recruits SEC via Tat, cells use other mechanisms to bring the elongation machinery to their promoter. (biomedcentral.com)

Concordantly, depletion of FUS elevates the occupancy of AFF4 and Cdk9 on the viral promoter and activates HIV gene transcription. (biomedcentral.com)

I will also discuss their emerging regulatory roles in mediating and connecting post-transcriptional processes from the nucleus to the cytoplasm. (molcells.org)
Advances in molecular biology and genome analysis now also allow for detailed descriptions of DNA-binding transcription factors and transcriptional regulatory networks. (medscape.com)

DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect (PubMed:9857195, PubMed:10912001, PubMed:11112772). (wuxibiortus.com)

The Alternative Lengthening of Telomeres (ALT) pathway stimulates telomere elongation and prevents cellular senescence in approximately 60% of osteosarcoma. (oncotarget.com)

Cardiac missense and histone of NOTCH1 have on linearly kept PEST family roles in NOTCH1( Fryer et al. (evakoch.com)

For this step to be efficiently executed, the viral Trans-Activator of Transcription, Tat, acts as a master regulator of transcription elongation by tethering SEC to the HIV trans-activator response (TAR) stem-loop RNA on the viral short transcripts, and synergistically enhancing RNAPII pause-release and elongation. (biomedcentral.com)
The bZIP ELONGATED HYPOCOTYL 5 (HY5) transcription factor is another major regulator of thermo- and photomorphogenesis. (biomedcentral.com)

Early studies on the regulation of gene transcription of the proviral human immunodeficiency virus (HIV) have laid the foundations to our current understanding of how metazoan transcription elongation is regulated [ 1 ]. (biomedcentral.com)

3, 3'- (3, 5-DCPBC) inhibits cell survival, migration, and proliferation of different metastatic and non-metastatic melanoma cell lines through profound suppression of the phosphorylation of Epidermal Growth Factor receptor (EGFR) and proto-oncogene cellular sarcoma (c-SRC) related downstream pathways. (bvsalud.org)
FUS inhibits the activation of HIV transcription by AFF4 and ELL2, and silences overall HIV gene transcription. (biomedcentral.com)
In fact, it was recently proved that HY5 inhibits PIF4-directed hypocotyl elongation by competitive chromatin binding to common targets. (biomedcentral.com)
Binding of ferrous iron to the DtxR molecule forms a complex that binds to the tox gene operator and inhibits transcription. (medscape.com)

Single-repeat R3 MYB transcription factors (single-repeat MYBs) play important roles in controlling trichome patterning in Arabidopsis . (biomedcentral.com)
We analyzed here the role of TRICHOMELESS2 (TCL2), a previously-uncharacterized single-repeat MYB transcription factor in trichome patterning in Arabidopsis . (biomedcentral.com)
Trichome patterning in Arabidopsis is controlled by several different types of transcription factors. (biomedcentral.com)

Moreover these actin mutants affect neurite elongation, an actin function which by pharmacological actin interference was ambiguous. (jneurosci.org)

Thus, transcriptional profiles suggest that Lilliputian and Suppressor of Triplolethal are obligatory cofactors in the adult and that they can also function with Cyclin-dependent kinase 9 at a subset of loci. (sdbonline.org)

The expression and activity of PIF4 are also regulated by the circadian clock, possibly influencing time-dependent transcriptional responses to environmental cues [ 13 ]. (biomedcentral.com)

Transcriptional elongation is a generic function, but is also regulated to allow rapid transcription responses. (sdbonline.org)

We report that chick Dach1 interacts with the Smad complex and the corepressor mouse Sin3a, thereby acting as a repressor of BMP-mediated transcriptional control. (biologists.com)

Our studies show that Brd4 interacts with the pluripotent factor OCT4 and is important for maintaining stem cell fate and the expression of the lncRNAs controlling XCI. (cancerrealitycheck.com)

Thus, 3, 3'- (3, 5-DCPBC) endowed with the unique property to simultaneously suppress phosphorylation of multiple downstream kinases, such as EGFR/JAK/STAT and EGFR/SRC and their corresponding transcription factors. (bvsalud.org)
RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription (PubMed:21127351). (wuxibiortus.com)

Loss of FMR2 gene transcription causes mental retardation. (sdbonline.org)
SRF controls gene transcription of various actin isoforms (e.g. (jneurosci.org)
Thus, herein we provide first evidence that neuronal motility not only depends on cytoplasmic actin dynamics but also on the availability of actin to modulate nuclear functions such as gene transcription. (jneurosci.org)

Since download manual of structural kinesiology 2011 death repels an oligomerization expression, and presenile organelles have retrograde, one of the congenital steps activates catalyzed as in the response of site family. (erik-mill.de)

Here we identify recurrent mutations within Wilms tumours that involve the highly conserved YEATS domain of MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development. (nature.com)

Cellular factors which play role in host defense mechanisms against HIV were identified and their role in HIV induced inflammation was established. (europa.eu)
Telomere elongation is a requisite for cellular immortality and a hallmark of cancer cells. (oncotarget.com)

BPBF has also been shown to interact with GAMYB, a barley transcription factor belonging to the R2R3 MYB family [ 31 ] , and to cooperatively induce expression of the Hor2 ( Hordein2) prolamin gene [ 31 ] . (encyclopedia.pub)

The telomerase holoenzyme promotes telomere elongation by using the RNA component TERC as a template for reverse transcription at telomere ends. (oncotarget.com)
ALT, however, promotes telomere elongation using homology directed DNA damage repair via break induced replication [ 1 - 4 ]. (oncotarget.com)

The dynamic nature of chromatin establishes the access to the genetic material and, as a consequence, influences a large number of biological processes, such as DNA replication, repair and transcription [ 1 , 2 ]. (aging-us.com)

These study results should be treated with caution, due to the presence of confounding factors that might also distinguish between NEC and control infants. (osti.gov)

Finally, mtDNA transcription termination sites have been either mapped in-vitro, or were associated with MTERF binding sites ( Christianson and Clayton 1986 ), thus, again, limiting the capability to in-vivo map transcription terminations sites in diverse organisms. (biorxiv.org)
Through in-vitro pharmacological super-enhancer disruption assays, we confirmed that super-enhancers upregulate NSMCE2 and MAL2 transcriptionally, and, through bioinformatics, we found that high levels of NSMCE2 strongly associate with patients' poor response to chemotherapy, especially for patients diagnosed with aggressive triple negative and HER2 positive tumor types. (biomedcentral.com)

However, while the role of the super elongation complex (SEC) in enhancing transcription activation of HIV is well established, the function of SEC in modulating viral latency is less defined and its cell partners are yet to be identified. (biomedcentral.com)
Hormones and growth factors play a role in these different stages of mammary development and are also implicated in breast cancer. (biologists.com)
The human ortholog of MEF2 is the Elongation Factor Gene (EF-G) 2, which has previously been shown to play a specific role in mitochondrial ribosome recycling. (prolekarniky.cz)

The DOF TF family is characterised by a highly conserved DNA binding domain (DOF domain), consisting of a CX2C-X21-CX2C motif, which is able to form a zinc finger structure. (encyclopedia.pub)

This pausing site correlated with the presence of a bacterial pausing sequence motif, yet the transcription pausing index varied quantitatively among the cell lines. (biorxiv.org)
Analysis of non-human organisms enabled de novo mtDNA sequence assembly, as well as detection of previously unknown mtDNA TIS, pausing, and transcription termination sites with unprecedented accuracy. (biorxiv.org)
Our approach paves the path towards in vivo, quantitative, reference sequence-free analysis of mtDNA transcription in all eukaryotes. (biorxiv.org)
These obstacles interfered with comparative in-vivo investigation of mtDNA transcription in diverse conditions, and hampered expanding the study of mtDNA nascent transcripts to organisms lacking an mtDNA reference sequence. (biorxiv.org)

vi GR can interact with p53, which alters NF κB pro inflammatory transcriptional activity. (soidglobal.com)

Overexpressing these mutant actins in mouse hippocampal neurons not only modulated growth-cone function but also neurite elongation, which was ambiguous by traditional pharmacological interference. (jneurosci.org)

The 8p11 inhibiting of download Dopamine in the Pathophysiology and Treatment of Schizophrenia: New Findings by interest via this response catalyses a transcriptional momentum-correlation in the consensus of Saturated association( Schnetkamp 2013). (evakoch.com)

The development of new tools and culture techniques has also enabled the factors that influence branching morphogenesis in the embryonic and pubertal gland to be identified. (biologists.com)
After birth, mammary development is arrested until puberty, when extensive elongation of the ducts, accompanied by secondary branching, takes place, thus providing a readily accessible system in which to study branching morphogenesis. (biologists.com)
Whilst much is known on the signaling components mediating diurnal, light, and temperature controls on plant development, their influence on chromatin-based transcriptional controls remains poorly explored. (biomedcentral.com)

Here, we identified a Lettuce auxin response factor 3 ( LsARF3 ), the expression of which was enhanced by heat and auxin treatments. (frontiersin.org)
R62D-induced phenotypes strongly resemble neurons lacking SRF (Serum Response Factor). (jneurosci.org)
A-site was others to specific response absorption will skip transported in unknown factors of Reactome. (erik-mill.de)

Expression profiles following lilliputian and Suppressor of Triplolethal RNAi were nearly identical raising the possibility that they are obligatory co-factors. (sdbonline.org)
Growth-cone collapse induced by ephrin-As, a family of repulsive axon guidance molecules, is impaired upon R62D expression, resulting in perseverance of ring-shaped F-actin filaments. (jneurosci.org)
neighboring Expression represses to underlie identified by the oxidoreductase of Rev with importin-beta and B23 and signaling at the Syndecan transcription through proteases between acts and hours. (evakoch.com)

Members of this subgroup share a conserved motif of 19 amino acids in the putative transcription activation domain at the C-terminal end. (gao-lab.org)

Anatomy6

Organisms3

Diseases2

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes22

Information Science3

Genes19

Proteins15

Regulates4

Recruitment4

Regulate4

Polymerase II3

Drosophila2

Initiation2

Protein11

Modulates1

Regulators3

MRNA1

Differentiation4

Machinery1

Promoter1

Regulatory2

NELF1

Stimulates1

Histone1

Regulator2

Metazoan1

Inhibits4

Arabidopsis3

Mutants1

Subset1

Cues1

Responses1

Repressor1

Stem1

Phosphorylation2

Gene transcription3

Activates1

Mutations1

Cellular2

Induce1

Promotes2

Replication1

Control1

Vitro2

Role3

Highly conserved1

Sequence4

Interact1

Function1

Consensus1

Development3

Response3

Expression3

Amino acids1