Family of proteins caenorhabditis elegans proteins. Medical search. Frequent questions

This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. (nih.gov)
So far, serial sections electron microscopy (ssEM) of tissues and organs has been successfully used to, for example, reconstruct the 3D ultrastructure of the nervous system from higher organisms such as Caenorhabditis elegans , Drosophila and mammals 7 . (nature.com)
Experiments in human cell lines, mice, Drosophila, and Caenorhabditis elegans have shown that endonuclease G (ENDOG) plays a protective role against the development of TSC. (medscape.com)
Originalmente fueron identificadas como una clase de proteínas relacionadas con la proteína mothers against decapentaplegic, Drosophila y proteínas sma de CAENORHABDITIS ELEGANS. (bvsalud.org)
They were originally identified as a class of proteins that are related to the mothers against decapentaplegic protein, Drosophila and sma proteins from CAENORHABDITIS ELEGANS. (bvsalud.org)

In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). (embl-heidelberg.de)

As the genomes of different organisms are sequenced and annotated it is becoming apparent that the complexity of an organism does not depend on the total number of protein-coding genes. (biologists.com)
The roundworm Caenorhabditis elegans is a simple model organism whose genes are highly conserved during evolution. (ehu.eus)

The primary focus of this project is to analyse the in vivo fu nction in C. elegans of the metallopeptidase, cysteine proteinase and activation associated secreted protein families and to identify the key genes in each family. (europa.eu)
Alternative splicing is the primary mechanism by which a limited number of protein-coding genes can generate proteome diversity. (biologists.com)
While most genes are members of larger gene families, qua-1 is a single copy gene. (diva-portal.org)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
The three mammalian genes encoding members of the caveolin family are similar in sequence (Table 1 ). (biomedcentral.com)
Additionally, hpl-2 mutant animals also exhibited upregulation of autophagic genes, suggesting that SynMuv/DRM proteins participate in this process. (ehu.eus)

This C2 domain is about 116 amino-acid residues and is located between the two copies of the C1 domain in Protein Kinase C (that bind phorbol esters and diacylglycerol) (see PDOC00379) and the protein kinase catalytic domain (see PDOC00100). (bionity.com)
Predicted to enable protein kinase regulator activity. (wormbase.org)
Peli1 regulates the activation of a metabolic kinase, mTORC1, through its interaction with mTORC1 inhibitory proteins TSC1 and TSC2. (medscape.com)
They bind to structural components (emerin, nesprin), chromatin components (histone), signal transduction molecules (protein kinase C), and several gene regulatory molecules. (medscape.com)

Mammalian Lin28 and C. elegans LIN-28 have been shown to inhibit biogenesis of the conserved cellular differentiation-promoting microRNA let-7 by directly binding to unprocessed let-7 transcripts. (stanford.edu)
SLO-1 is the nematode ortholog of the mammalian potassium channel known as the BK channel, and the researchers say their findings in the C. elegans model could open up new avenues of research into aging in higher organisms. (genengnews.com)
Mammalian microfibrillar-associated protein 2 (MFAP2 or MAGP1), a matrix protein. (expasy.org)

U11/U12-35K is highly conserved among bilateria and plants, but lacks in some organisms, such as Saccharomyces cerevisiae and Caenorhabditis elegans. (nih.gov)

The derived amino acid sequence of Ov-phy-1 encoded a peptide that was most similar to the two Caenorhabditis elegans prolyl 4-hydroxylase homologues and to the isoform II enzymes of vertebrates. (embl.de)

Moreover, U11/U12-35K shows significant sequence homology to U1 snRNP-specific 70 kDa protein (U1-70K or snRNP70). (nih.gov)
Sequence homologies between four cytoskeleton-associated proteins. (embl.de)
Caveolin-3 (Cav-3) has greater protein-sequence similarity to Cav-1 than to Cav-2, but it is expressed mainly in muscle cells, including smooth, skeletal, and cardiac myocytes. (biomedcentral.com)
A phylogenetic tree of all known caveolins shows that the C. elegans Cav-1 sequence is only distantly related to all the others (Figure 1 ). (biomedcentral.com)
A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)
1] "Genome sequence of the nematode C. elegans: a platform for investigating biology. (tcdb.org)

Proteins that activated immunity are potential antigens for immunization and the multi-omics phylum-spanning prioritization database that was created is a valuable resource for identifying target proteins in a wide array of different parasitic nematodes. (frontiersin.org)
Here we show that orthologs of qua-1 exist in many nematodes, including Brugia malayi, which shared a common ancestor with C. elegans about 300 million years ago. (diva-portal.org)
We study the molecular events that give rise to the sensation of touch and temperature using C. elegans nematodes as a model system. (stanford.edu)
Similarly, pharmacological blockade of SLO-1 using the BK channel blocker paxilline effectively slowed motor aging and extended lifespan in aged, but not young C. elegans nematodes. (genengnews.com)

Here, we used a genomics/proteomics approach (including immunoblot experiments from pigs infected with T. suis ) to prioritize putative immunogenic excretory/secretory (E/S) proteins conserved across and specific to several gastrointestinal (GI) parasitic nematode species. (frontiersin.org)

p class=\'abstract\'>Lin28/LIN-28 is a conserved RNA-binding protein that promotes proliferation and pluripotency and can be oncogenic in mammals. (stanford.edu)

The Caenorhabditis elegans genome encodes ten proteins that share similarity with Hedgehog through the C-terminal Hint/Hog domain. (diva-portal.org)

So far, most caveolin-related research has been conducted in mammals, but the proteins have also been found in other animals, including Xenopus laevis, Fugu rubripes , and Caenorhabditis elegans . (biomedcentral.com)
Together, these proteins form the DRM complex, which is also known as the DREAM complex in mammals. (ehu.eus)

Family T2 was first recognised in MEROPS in 2000. (ebi.ac.uk)

There is a large superfamily of proteins that contains domains (referred to as ShKT domains) ressembling these two toxins. (expasy.org)

A cocktail of five recombinant proteins optimized for conserved GI nematode targets was used immunize pigs and test for active antibody responses in both the serum and intestinal ileal fluid of immunized pigs. (frontiersin.org)

Here, we report that C. elegans LIN-28 represses the expression of LIN-46, a downstream protein in the heterochronic pathway. (stanford.edu)

Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)
This work highlights both structural and mechanistic similarities with the small and trimeric G proteins and restricts the types of mechanisms responsible for the considerable enhancement of ATP hydrolysis associated with actin polymerization. (rcsb.org)
The conservation of functionalities involved in nucleotide binding and catalysis also provide insights into the mechanistic features of members of the family of actin-related proteins. (rcsb.org)
Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)

An antibody-protein array of putative immunogenic proteins was developed from a combined bioinformatic, experimental, and literature-based prioritization of homologous parasite proteins. (frontiersin.org)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)

E-values are based on searching the Pfam-A family against UniProtKB 2021_03 using hmmsearch. (xfam.org)
Pfam is a large collection of protein families. (deathbase.org)

RME-2 contains a typical NPXY internalization motif in its intracellular domain that is known to direct other members of the LDL-receptor family into clathrin-coated pits. (wormbook.org)
The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling. (expasy.org)

Intriguingly, helical localization patterns were reported for many other fluorescently tagged bacterial proteins (e.g. chemoreceptors, secretion proteins, RNase E, and the chromosome partitioning protein SetB) but often the questions remains how well these observations reflect the true situation 6 . (nature.com)

Is an ortholog of human KIFAP3 (kinesin associated protein 3). (wormbase.org)
Is an ortholog of human KIF3A (kinesin family member 3A). (wormbase.org)
Is an ortholog of human KIF17 (kinesin family member 17). (wormbase.org)

Synaptic release from motor neurons at NMJs is known to undergo a progressive functional decline beginning in early life, which contributes to age-dependent motor activity decline in C. elegans ," the authors wrote. (genengnews.com)

Taxonomic distribution of proteins containing CAP_GLY domain. (embl.de)
Fluorescence-tags, commonly used to visualize the spatial distribution of proteins within cells, can influence the localization of the tagged proteins by affecting their stability, interaction with other proteins or the induction of oligomerization artifacts. (nature.com)

It would be of great value to know the in vivo function of these proteins. (europa.eu)
Two compounds, Compound 1 (1,4-dihydrophenanthrolin-4-one-3-carboxylic acid) and Compound 5 [8-(N-butyl-N-ethylcarbamoyl)-1,4-dihydrophenathrolin-4-one-3-carboxylic acid], with comparable potencies in vivo, were chosen to investigate the effect of the inhibition of the hydroxylation of newly synthesized uterine collagen on the turnover of this protein in vivo. (embl.de)

Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. (rupress.org)

The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
It was isolated as one of several proteins that became phosphorylated on tyrosine residues in chicken embryo fibroblasts transformed with the v-Src oncogene [ 4 ]. (biomedcentral.com)

The tertiary structure of the enzymes of the glycosylasparaginase precursor family is typical of the "N-terminal nucleophile" hydrolases in clan PB. (ebi.ac.uk)

One important model for mechanistic studies of endocytosis in C. elegans focuses on oocytes, which internalize huge quantities of yolk proteins and their associated lipids by clathrin-mediated endocytosis ( Grant and Hirsh, 1999 ). (wormbook.org)

Co-expression of Ov-phy-1 with the O. volvulus homologue of protein disulfide isomerase in a baculovirus system resulted in the production of enzymatically active O. volvulus prolyl 4-hydroxylase. (embl.de)
Taken with the present results, this suggests that the potential use of inhibitors of prolyl 4-hydroxylase to control excessive collagen deposition in pathological fibrosis may be limited by the need to maintain continuous inhibition of collagen hydroxylation so as to facilitate intracellular degradation of the accumulated protein. (embl.de)
This control is propagated through the alpha-subunit of prolyl 4-hydroxylase where protein levels were previously shown to rise fivefold with increasing cell density. (embl.de)

C2 domains are also found in clostridial alpha toxins , where they are used to bring the catalytic phospholipase domain into contact with the plasma membrane , conferring the toxic activity on the protein. (bionity.com)
Regions with significant homology [1] to the C2-domain have been found in many proteins. (bionity.com)
Nearly all known histone-acetyltransferase (HAT)-associated transcriptional co-activators contain bromodomains, which are approximately 110-amino-acid modules found in many chromatin-associated proteins. (embl-heidelberg.de)
New mutations have been found in the synaptic nuclear envelope protein 1 ( SYNE1 ) gene and in the synaptic nuclear envelope protein 2 ( SYNE2 ) gene in a few families, also termed Nesprin-1 and Nesprin-2, respectively. (medscape.com)
A European collaborative study found LMNA mutations in 18 families and 39 sporadic cases with an EMD2 phenotype. (medscape.com)

this family of proteins is hereafter called EBF) are a group of DNA-binding transcription factors with the basic helix-loop-helix (bHLH) domain. (aacrjournals.org)
Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
Acetylases are now known to modify a variety of proteins, including transcription factors, nuclear import factors and alpha-tubulin. (embl-heidelberg.de)

Using a fluorescent sulfhydryl probe as well as a sulfhydryl inhibitor, one observes a strong cell density response, supporting the hypothesis that cellular redox potential could alter protein stability. (embl.de)
Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
Acetylation regulates many diverse functions, including DNA recognition, protein-protein interaction and protein stability. (embl-heidelberg.de)

Many receptors and their associated ligands cluster into clathrin-coated pits by association with clathrin adaptor proteins such as the four-subunit complex AP2. (wormbook.org)

However, biochemical analysis of the fractions have shown that they contain multiple members of nematode protein families, such as metallopeptidases, cysteine proteinases and activation associated secreted proteins. (europa.eu)

Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
Applying this method, we show a cellular distribution of the staphylococcal alkaline shock protein 23 (Asp23), which is compatible with filament formation, a property of Asp23 that we also demonstrate in vitro . (nature.com)
However, fluorescently labeled proteins can exhibit altered or destroyed cellular functionalities, as previously reported, for instance, for the rod-shape determining protein MreB. (nature.com)
MS membrane proteins are essential for tissue development, cellular motion, osmotic homeostasis, and sensing external and self-generated mechanical cues like those responsible for touch and proprioception. (stanford.edu)
Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
The pocket protein family controls several cellular functions such as cell cycle, differentiation, and apoptosis, among others. (ehu.eus)
Cold temperatures activate a cellular cleansing mechanism called proteasome that breaks down defective protein aggregations and helps prevent proteins from clumping together. (medscape.com)

Endocytosis is the vesicle-mediated process used by all cells to internalize extracellular macromolecules, plasma membrane lipids, and plasma membrane proteins ( Figure 1 ). (wormbook.org)

δ-Catenin belongs to the p120 catenin (p120ctn) family of catenins and binds to the cytoplasmic domains of type 1 and 2 cadherins at a membrane proximal region that is not involved in binding of either β-catenin or plakoglobin. (jneurosci.org)
Using yellow fluorescence protein (YFP) tagged MreB, it was initially suggested that MreB forms a continuous, cell-spanning helical filament running along the inner membrane of the cell 4 . (nature.com)
Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction. (stanford.edu)
This Viewpoint, which accompanies a Special Issue focusing on membrane mechanosensors, discusses unifying and unique features of both established and emerging mechanosensitive (MS) membrane proteins, their distribution across protein families and phyla, and current and future challenges in the study of these important proteins and their partners. (stanford.edu)
As the field continues to grow, so too will the list of proteins suspected to function as mechanosensors and the diversity of known MS membrane proteins. (stanford.edu)
Caveolins can serve as protein markers of caveolae ('little caves'), invaginations in the plasma membrane 50-100 nanometers in diameter. (biomedcentral.com)
Interestingly, VIP21 was isolated as an integral membrane protein component of transport vesicles derived from the trans-Golgi network in Madin-Darby canine kidney (MDCK) cells, suggesting that Cav-1/VTP21 may have a role in molecular trafficking as well as oncogenesis. (biomedcentral.com)
This complex includes nuclear membrane integral and associated proteins including emerin, lamin A/C, SUN1, SUN2, nesprin-1, and nesprin-2 that are proposed to form a mechanical link between the nucleoskeleton and cytoskeleton. (medscape.com)
Whatever the true mechanism, the discovery of mutations in several different nuclear membrane proteins that cause similar diseases will likely eventually lead to a better understanding of nuclear membrane physiology and the pathophysiology of diseases caused by mutations in these proteins. (medscape.com)

EDMD1 is caused by mutations in the EMD gene on the X chromosome that codes for the nuclear envelope protein emerin. (medscape.com)

Asp23 is the eponym of the poorly investigated Asp23 protein family (also termed DUF322, PF03780 or Gls24 family). (nature.com)

In a second step we will apply this technology to investigate the function of an additional nematode specific gene family, i.e. transthyretin-like protein family. (europa.eu)

A family of secreted mucins from the parasitic nematode Toxocara canis bears diverse mucin domains but shares similar flanking six-cysteine repeat motifs. (expasy.org)
a retinoblastoma protein (pRB)-related protein similar to p130. (ehu.eus)

For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. (nih.gov)
However, at present no ssEM protocol was available to investigate protein localization in entire bacterial cells. (nature.com)
A very small proportion of families exist whose genetic localization has not been determined. (medscape.com)

This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. (nih.gov)
This subfamily corresponds to the RRM of U11/U12-35K, also termed protein HM-1, or U1 snRNP-binding protein homolog, and is one of the components of the U11/U12 snRNP, which is a subunit of the minor (U12-dependent) spliceosome required for splicing U12-type nuclear pre-mRNA introns. (nih.gov)

In molecular biology, the crustacean neurohormone family of proteins is a family of neuropeptides expressed by arthropods. (wikipedia.org)
The QUA-1 proteins contain an N-terminal domain, the Qua domain, that is highly conserved, but whose molecular function is not known. (diva-portal.org)

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. (embl-heidelberg.de)

YP170-GFP, like endogenous yolk, is a cholesterol binding/transport protein related to human ApoB-100, the major protein component of serum low-density lipoprotein (LDL). (wormbook.org)

Therefore, to challenge the feasibility of this approach, we used the Staphylococcus aureus alkaline shock protein 23 (Asp23) as a model to gain a deeper insight into the spatial organization of Asp23 within the cell. (nature.com)

Roles have been identified for peptidases of this family (and in subclan PB(T) generally) in metabolism. (ebi.ac.uk)

The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and δ-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-mediated interaction, but have incompletely characterized neuronal functions. (jneurosci.org)

Green fluorescent protein promoter experiments also revealed SHL-1 expression in a subset of neurons as well as in C. elegans body wall muscle and in male-specific diagonal muscles. (wikigenes.org)

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. (embl.de)
Crystal structure of the cytoskeleton-associated protein glycine-rich(CAP-Gly) domain. (embl.de)
In 5 of 6 gene mutations that have been shown to cause EDMD, the affected protein is present in the LINC (linker of nucleoskeleton and cytoskeleton) complex. (medscape.com)

Anatomy8

Organisms6

Diseases1

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Psychiatry and Psychology1

Phenomena and Processes28

Information Science4

Drosophila5

Hypothetical protein1

Organism2

Genes7

Kinase4

Mammalian3

Saccharomyces1

Homologues1

Sequence6

Nematodes4

Species1

Abstract1

Genome1

Mammals2

20001

Superfamily1

Recombinant proteins1

Pathway1

Actin4

Putative2

Pfam2

Receptor2

Secretion1

Ortholog3

Contributes1

Distribution of proteins2

Vivo2

Kinesin1

Tyrosine residues2

Tertiary1

Oocytes1

Prolyl 4-hydroxyla3

Found5

Transcription3

Stability3

Adaptor1

Metallopeptidases1

Cellular7

Macromolecules1

Membrane9

Chromosome1

Poorly1

Nematode-specific1

Similar2

Localization3

Nuclear2

Molecular2

Genomic1

Human1

Model1

Metabolism1

Interaction1

Experiments1

Cytoskeleton3