Loading...
  • Cdk5
  • The researchers found potential evidence linking cyclin E to Alzheimer's disease, because it binds to an enzyme called Cdk5 that is involved in memory. (healthcanal.com)
  • The scientists didn't test cyclin E in Alzheimer's mice, but they did show that when cyclin E binds to Cdk5 molecules, it locks them away in an unusable form. (healthcanal.com)
  • In the current Developmental Cell paper, Junko Odajima, PhD, a postdoctoral fellow in the Sicinski laboratory and the paper's co-lead author (with Zachary P. Wills, PhD, from Harvard Medical School), showed that cyclin E in the brain attaches itself to the Cdk5 enzyme. (healthcanal.com)
  • When cyclin E molecules bind to an inactive Cdk5, synapses formation is increased, and, presumably, memory function improves. (healthcanal.com)
  • Other studies have shown that cocaine increases the activity of an enzyme, cyclin-dependent kinase 5 (Cdk5), that inhibits MEF2 activity. (drugabuse.gov)
  • The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. (uniprot.org)
  • This accumulation correlates with an increase in CDK5 kinase activity. (uniprot.org)
  • Furthermore
  • Furthermore, Cla4 undergoes a dramatic hyperphosphorylation in response to the combined activity of Nap1, the Clb2-Cdc28 kinase complex, and the GTP-bound form of Cdc42. (nih.gov)
  • Ink4d
  • Antisense morpholino oligonucleotides directed against Xl-Ink4d were used to knock down the protein level of Xl -Ink4d during development. (diva-portal.org)
  • dendritic spines
  • RNA interference sequences that reduce production of MEF2 proteins result in more dendritic spines (the knoblike projections in the micrographs) along neurons of the nucleus accumbens. (drugabuse.gov)
  • Interestingly, our results indicated that NGL-1 and CDKL5 directly interact and in primary neurons both proteins co-localized at the dendritic spines. (mpg.de)
  • contrast
  • As their hypothesis had suggested, mice deficient in cyclin E performed worse than rodents who had a normal amount of cyclin E. This contrast highlighted the importance of cyclin E for learning and memory. (healthcanal.com)
  • homologous
  • Arath;CycB1;3 is most homologous to the plant CycB1group cyclins and contains a conserved motif that is typical of this group. (deepdyve.com)
  • MEF2
  • The Texas team's investigations centered on a small family of proteins, myocyte enhancer factor 2 (MEF2), whose many functions include regulating the number of excitatory synaptic connections in the brain. (drugabuse.gov)
  • MEF2 family transcription factors can also promote myogenic differentiation. (bionity.com)
  • amyloid
  • Insoluble fibrillar plaques of amyloid β-proteins (Aβ) and neurofibrillary deposits of hyperphosphorylated tau proteins are the diagnostic lesions of AD, but their temporal mechanistic relationship has long been debated. (pnas.org)
  • Intensive research over almost 30 y has led to the hypothesis that progressive cerebral accumulation of the 42-residue amyloid β-protein (Aβ) may precipitate the synaptic dysfunction and cytoskeletal changes that underlie the symptoms of AD ( 1 ). (pnas.org)
  • Although insoluble amyloid plaques are one of the two neuropathological hallmarks of AD, recent studies suggest that these are in equilibrium with small, diffusible oligomers of Aβ that may serve as the principal synaptotoxic form of the protein ( 2 ). (pnas.org)
  • targets
  • The in silico study suggested that among all the molecular targets identified by our target fishing approach, Protein Kinase 3 (PK5) and Glycogen Synthase Kinase 3β (GSK-3β) are the most likely molecular targets for the synthesised compounds. (scielo.br)
  • Soluble
  • It is shown that in the postoperative period, besides antigens similar to those of the normal muscles, other antigens which may belong to stage-specific ones viagra appears in the fraction of soluble proteins. (apicstoledo.org)
  • inactivation
  • Inactivation of CDKL3, also called NKIAMRE (NKIATRE in rat), by translocation is associated with mild mental retardation. (umbc.edu)
  • form
  • Many types of cancer cells, including breast, ovarian, colon, and blood cancers, are driven by the overexpression of cyclin E, which acts like a car's accelerator pressed to the floor, speeding the cells through their growth-and-division cycle and allowing tumors to form and spread. (healthcanal.com)
  • Cyclins are able to bind to cyclin-dependent kinases in order to form a stable protein complex between the two. (apologeticspress.org)
  • Since our first description of PQBP1 mutations in families with a syndromic form of X-linked intellectual disability (XLID) PQBP1 has been linked to several XLID disorders. (mpg.de)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • pathway
  • We have used a simple genetic screen to identify additional proteins that function in this pathway. (nih.gov)
  • molecules
  • Tim Hunt was awarded the 2001 Nobel Prize in Physiology or Medicine with Paul Nurse and Leland H. Hartwell for their discoveries of protein molecules that control the division (duplication) of cells. (fampeople.com)
  • metabolism
  • In primary neurons, PQBP1 co-localized with its interaction partners in specific cytoplasmic granules, which stained positive for RNA, suggesting that PQBP1 plays a role in cytoplasmic mRNA metabolism, which is further supported by the partial co-localization and interaction of PQBP1 with the fragile X mental retardation protein (FMRP), one of the best-studied proteins found in RNA granules. (mpg.de)