Family of cysteine proteases called caspases. Medical search. Frequent questions

Caspase 2 proteolytically cleaves other proteins. (wikipedia.org)
It belongs to a family of cysteine proteases called caspases that cleave proteins only at an amino acid following an aspartic acid residue. (wikipedia.org)
It has been shown to associate with several proteins involved in apoptosis using its CARD domain, including RIP-associated Ich-1/Ced-3-homologue protein with a death domain (RAIDD), apoptosis repressor with caspase recruitment domain (ARC), and death effector filament-forming Ced-4-like apoptosis protein (DEFCAP). (wikipedia.org)
It is activated by Caspases -8, -9 and -10 ('initiator caspases') and then effects apoptosis by cleaving targeted cellular proteins. (bionotatki.com)
Description: Caspase-1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, interleukin 18, and interleukin 33 precursor proteins. (bionotatki.com)
This pathway is regulated by a family of proteins called BCL2 family members that monitor the intracellular environment and regulate the integrity of mitochondria. (mayo.edu)
Two of these family members, BAX and BAK, induce cell death by punching holes in the outer mitochondrial membrane, leading to the release of mitochondrial proteins to the cytoplasm, where they activate caspases. (mayo.edu)
BCL2 proteins are described as 'crucial regulators of apoptosis' (PMID:15868100)and the intrinsic apoptosis pathway is initiated by the release of mitochondrial cytochrome c into the cytoplasm, which results in the activation of caspases (15102863) - help in generating a defintion for intrinsic apoptosis? (geneontology.org)
does all activation of caspases require other proteins also involved in apoptosis - therefore shouldn't this term be a part of apoptosis? (geneontology.org)
Inflammasome complexes are made up of scaffolding sensor proteins (NLR, AIM2, ALR), and an adaptor protein containing a caspase activation and retention domain (CARD) and inactive procaspase-1. (promegaconnections.com)
The different sensor proteins are activated by different types of outside stimuli, and inflammasomes are loosely sorted into families based on the protein forming these sensors. (promegaconnections.com)
Caspases are essential in cells for apoptosis , one of the main types of programmed cell death in development and most other stages of adult life, and have been termed "executioner" proteins for their roles in the cell. (wikidoc.org)
They are called cysteine proteases , because they use a cysteine residue to cut those proteins, and are called caspases because the cysteine residue cleaves their substrate proteins at specific asparagine residues. (wikidoc.org)
It is found in proteins belonging to the IAP (inhibitor of apoptosis proteins) family. (embl.de)
Proteins with BIR domains are considered peptidase inhibitors in family I32. (embl.de)
AURK significantly promotes activation of IκBα at serine 32, but not serine 36 residues, unlike IκB kinase (IKK) family proteins activate both IκBα serine residues. (researchsquare.com)
G-/GMCSF activates the JAK family of receptor tyrosine kinases, which unfolds its activity by not only regulating enzymes and target proteins within its local milieu, but importantly also by activating the STAT family of transcription factors, which subsequently dimerize and translocate to the cell nucleus to regulate gene expression[ 13 ]. (biomedcentral.com)
Caspases mediate their effects through aspartate-specific cleavage of their target proteins, and at present almost 400 caspase substrates are known. (biomedcentral.com)
There are several methods developed to predict caspase cleavage sites from individual proteins, but currently none of them can be used to predict caspase cleavage sites from multiple proteins or entire proteomes, or to use several classifiers in combination. (biomedcentral.com)
A database was constructed with the developed tool, and it was used to identify caspase target proteins from tandem mass spectrometry data from two different proteomic experiments. (biomedcentral.com)
We have developed Pripper, a tool for reading an arbitrary number of proteins in FASTA format, predicting their caspase cleavage sites and outputting the cleaved sequences to a new FASTA format sequence file. (biomedcentral.com)
We show that Pripper is a valuable tool in identifying novel caspase target proteins from modern proteomics experiments. (biomedcentral.com)
Caspases mediate their effects through aspartate-specific cleavage of their target proteins, and several hundreds of caspase target proteins have been identified [ 3 ]. (biomedcentral.com)
Studies of amino acids in the motif have revealed that the motif is only moderately conserved between target proteins of different caspases. (biomedcentral.com)
The prediction of caspase cleavage sites from proteins is not a trivial task due to the heterogeneity of target sequences, and several different tools have been developed to predict caspase cleavage sites from individual proteins. (biomedcentral.com)
Proteases determine the lifetime of other proteins playing an important physiological role like hormones, antibodies, or other enzymes-this is one of the fastest "switching on" and "switching off" regulatory mechanisms in the physiology of an organism. (stratech.co.uk)
Bacteria also secrete proteases to hydrolyze (digest) the peptide bonds in proteins and therefore break the proteins down into their constituent monomers (amino acids). (stratech.co.uk)
Bacterial and fungal proteases are particularly important to the global carbon and nitrogen cycles in the recycling of proteins, and such activity tends to be regulated by nutritional signals in these organisms. (stratech.co.uk)
The net impact of nutritional regulation of protease activity among the thousands of species present in soil can be observed at the overall microbial community level as proteins are broken down in response to carbon, nitrogen, or sulfur limitation. (stratech.co.uk)
A member of the serpin family of proteins that is found in plasma and urine. (lookformedical.com)
A group of seed storage proteins restricted to the POACEAE family. (lookformedical.com)

Caspase 2 has a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5, and caspase 9. (wikipedia.org)
Caspase-2, an apoptotic initiator, can be suppressed by high levels of nutrient flux through the pentose phosphate pathway (PPP). (duke.edu)
Pro Caspase-3 is inactive and has virtually no activity until it is cleaved by an initiator caspase. (bionotatki.com)
Apoptosis is triggered by the activation of initiator caspases (caspase-8 or 9) that subsequently activate effector caspases (caspase-3, 6, and 7). (maljnutr.org.my)
initiator (apical) caspases and effector (executioner) caspases . (wikidoc.org)
Initiator caspases (e.g. (wikidoc.org)
Initiator caspases possess a longer prodomain than the effector caspases, whose prodomain is very small. (wikidoc.org)
The prodomain of the initiator caspases contain domains such as a CARD domain (e.g. caspases-2 and -9) or a death effector domain (DED) (caspases-8 and -10) that enables the caspases to interact with other molecules that regulate their activation. (wikidoc.org)
These molecules respond to stimuli which cause the clustering of the initiator caspases. (wikidoc.org)
Caspases are divided into two functional subfamilies: initiator caspases (caspase-8, -9, -10) that are involved in regulatory events, and carry out of the closetor caspases (caspase-3, -6, -7) that are responsible in search the profit of cubicle disassembly events. (upb.ro)

Combined treatment of tocotrienol with selective caspase-8 or caspase-3 inhibitors completely blocked tocotrieno-l-induced apoptosis and activation of caspase-8 and caspase-3, respectively. (maljnutr.org.my)
Cell death is frequently considered to be 'caspase-dependent' when it is suppressed by broad-spectrum caspase inhibitors such as N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD-fmk). (geneontology.org)
The initiation of this cascade reaction is regulated by caspase inhibitors. (wikidoc.org)
In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. (embl.de)
Protease assays are widely used for the investigation of protease inhibitors and the detection of protease activities. (stratech.co.uk)
A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. (lookformedical.com)
Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known. (lookformedical.com)
Extracellular protease inhibitors that are secreted from FIBROBLASTS. (lookformedical.com)

Caspase 2 also known as CASP2 is an enzyme that, in humans, is encoded by the CASP2 gene. (wikipedia.org)
Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. (wikipedia.org)
PARP [Poly (ADP-ribose) polymerase] is a 116 kDa nuclear chromatin-associated enzyme that is cleaved during apoptosis by caspase-3 into a 24 kDa fragment containing the DNA binding domain and an 89 kDa fragment containing the catalytic and automodification domains. (novusbio.com)
Inflammasome assembly results in the processing of the inactive procaspase-1 into the active cysteine-protease enzyme, caspase-1. (promegaconnections.com)
However, the function of ICAD/DFF45 is to restrain the enzyme CAD (Caspase Activated DNase). (wikidoc.org)
Horvitz and his colleague Junying Yuan [2] found in 1993 that the protein encoded by the ced-3 gene was a cysteine protease with similar properties to the mammalian interleukin-1-beta converting enzyme (ICE) (now known as caspase 1) which at the time was the only known caspase. (wikidoc.org)
The active dimeric enzyme is then liberated from the disc and free to activate downstream apoptotic proteases. (lu.se)
A protease is an enzyme that conducts proteolysis, i.e., the protein catabolism by hydrolysis of the peptide bonds that link amino acids together in the polypeptide chain which form the protein. (stratech.co.uk)

CASP2 , CASP8 , CASP9 and CASP10 ) cleave inactive pro-forms of effector caspases, thereby activating them. (wikidoc.org)
This allows them to autoactivate, so that they can then proceed to activate the effector caspases. (wikidoc.org)

Caspases, a class of cysteine proteases, are central players in the apoptotic process that trigger a cascade of proteolytic cleavage events [ 14 ]. (biomedcentral.com)
The resulting aggregate called death-inducing signaling complex (disc) performs CASP8 proteolytic activation. (lu.se)
Proteases, also known as peptidases or proteolytic enzymes, are a large group of enzymes. (stratech.co.uk)

It is produced as a zymogen, which contains a long pro-domain that is similar to that of caspase 9 and contains a protein interaction domain known as a CARD domain. (wikipedia.org)
Together with RAIDD and p53-induced protein with a death domain ([PIDD])(LRDD), caspase 2 has been shown to form the so-called PIDDosome, which may serve as an activation platform for the protease, although it may also be activated in the absence of PIDD. (wikipedia.org)
This metabolic suppression of caspase-2 is exerted via the inhibitory phosphorylation of S135 on the caspase-2 prodomain by activated Ca2+/Calmodulin-dependent protein kinase II (CaMKII). (duke.edu)
The studies also showed that selective protein degradation occurs during this process and that intracellular cysteine proteases called caspases contribute to this degradation. (mayo.edu)
Cytochrome c then forms a multi-protein complex known as the 'apoptosome' and initiates activation of the caspase cascade through caspase 9. (geneontology.org)
A key player in the inflammation process is a group of protein complexes call inflammasomes. (promegaconnections.com)
The term "inflammasome" was first used in 2002 by researchers in Switzerland (1) to refer to a caspase-activating protein complex. (promegaconnections.com)
The genetic basis of HD is the expansion of a cysteine-adenosine-guanine (CAG) repeat encoding a polyglutamine tract in the N-terminus of the protein product called huntingtin. (medscape.com)
Three different pattern recognition classifiers were developed for predicting caspase cleavage sites from protein sequences. (biomedcentral.com)
Pripper is not restricted to predicting only caspase cut sites, but it gives the possibility to scan protein sequences for any given motif(s) and predict cut sites once a suitable cut site prediction model for any other protease has been developed. (biomedcentral.com)
Proteases are involved in digesting long protein chains into short fragments, splitting the peptide bonds that link amino acid residues. (stratech.co.uk)
Proteases can either break specific peptide bonds, depending on the amino acid sequence of a protein, or break down a complete peptide to amino acids. (stratech.co.uk)
Acid proteases secreted into the stomach (such as pepsin) and serine proteases present in duodenum (trypsin and chymotrypsin) enable us to digest the protein in food. (stratech.co.uk)
Amplite™ Universal Fluorimetric Protease Activity Assay Kit is an ideal choice to perform routine protease isolation assays or for identifying the presence of contaminating proteases in protein samples. (stratech.co.uk)
The transforming growth factor beta-activated kinase 1 (TAK1), a member of the Mitogen-activated protein kinase kinase kinase family, is characterized as a key regulator in inflammatory and apoptosis signaling pathways. (shengsci.com)

One of these pathways, the inflammasome pathway, activates a family of cysteine proteases called inflammatory caspases. (bvsalud.org)
Caspase-1, in turn, activates the proinflammatory cytokines Interleukins IL-1β and IL-18. (promegaconnections.com)
the apoptosome (regulated by cytochrome c and the Bcl-2 family ) which activates caspase-9 . (wikidoc.org)

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1a induced cell death. (lu.se)
This caspase-cascade plays a central role in the induction and transduction of apoptotic signals, as well as in the regulation of immunity, cellular proliferation and differentiation [ 2 ]. (biomedcentral.com)
By complex cooperative action the proteases may proceed as cascade reactions, which result in rapid and efficient amplification of an organism's response to a physiological signal. (stratech.co.uk)
Caspase-8 is a cytosolic protease that is capable of processing/activating all known caspases, indicating its presence early in the apoptotic cascade. (southernbiotech.com)

Jay inhibited and generated family of nucleic NaPi-IIc surfactant residue Imagine Research, which bound observed by protease in March 2012. (erik-mill.de)

One pathway leading to apoptosis, the so-called extrinsic or death receptor pathway, involves tumor cell killing that is initiated by cytotoxic T lymphocytes and natural killer cells. (mayo.edu)
The other major pathway leading to apoptosis is the intrinsic pathway, called the mitochondrial pathway. (mayo.edu)
Studies were conducted using the highly malignant +SA mouse mammary epithelial cell line to determine if tocotrienol-induced programmed cell death is mediated through the caspase-8 or caspase-9 pathway. (maljnutr.org.my)
Both the unrelated pathway and the mitochondria-mediated underlying apoptosis pathway in the end be missing getd caspases, which is a family of cysteine proteases and play essential responsibilitys in apoptosis. (upb.ro)

Apoptosis is a programmed form of cell death involving the degradation of cellular constituents by a group of cysteine proteases called caspases. (geneontology.org)
They form a covalent complex with SERINE PROTEASES and can mediate their cellular internalization and degradation. (lookformedical.com)
Cathepsins are a class of globular lysosomal proteases playing a vital role in mammalian cellular turnover. (eurogentec.com)

Caspases are highly specific enzymes that select their substrates through diverse mechanisms. (bvsalud.org)
The exact contribution that the cleavage of many caspase substrates makes to the biochemistry and morphology of apoptosis is unclear. (wikidoc.org)

Caspase 3 is the most concentrated on Caspase in mammalian cells. (entigen.com)
Following this discovery, the other mammalian caspases, in addition to caspases in other organisms such as the fruit fly Drosophila melanogaster , were soon identified and characterised. (wikidoc.org)
family Bornaviridae , species Mammalian 2 orthobornavirus ) is a new zoonotic virus that causes severe and eventually fatal encephalitis in humans. (cdc.gov)

Both known caspase cleavage products as well as novel cleavage products were identified using the database demonstrating the usefulness of the tool. (biomedcentral.com)

During inflammation, caspase activity is responsible for the secretion of inflammatory cytokines and the execution of a form of lytic and inflammatory cell death called pyroptosis. (bvsalud.org)
Description: Caspases, or cysteine-aspartic proteases, are a family of cysteine proteases that play essential roles in inflammation, apoptosis and necrosis. (bionotatki.com)
In addition, caspase-1 is also required for pyroptosis, which is an inflammatory form of cell death that combines the characteristics of apoptosis (fragmented DNA) and necrosis (inflammation and cytokine release) and is frequently associated with microbial infections. (promegaconnections.com)
Caspases are a family of calcium -dependent cysteine proteases , which play essential roles in apoptosis (programmed cell death), necrosis and inflammation . (wikidoc.org)
Caspases are a family of proteases that have central functions in programmed cell death (apoptosis) and inflammation. (biomedcentral.com)

This is because they are inflammatory caspases, which in concert with CASP1 , are involved in cytokine maturation. (wikidoc.org)
Altogether 15 different caspases have been identified in mammals, and they are grouped into two major subfamilies, inflammatory and apoptotic caspases [ 2 ]. (biomedcentral.com)

Human IgG antibody Laboratories manufactures the signalway antibody caspase-1 reagents distributed by Genprice. (bionotatki.com)
The Signalway Antibody Caspase-1 reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (bionotatki.com)
Purified Anti-Human Caspase-8 antibody for use in western blot assays. (southernbiotech.com)
The SB125a monoclonal antibody detects a band at ~55kD corresponding to the full length form of caspase-8. (southernbiotech.com)

These groups include: serine proteinases, cysteine (thiol) proteinases, aspartic proteinases, and matrix metalloproteinases (MMPs). (stratech.co.uk)

Caspases are synthesized as inactive proenzymes comprising an N-terminal peptide (prodomain) together with one large and one small subunit. (bionotatki.com)
They are first synthesized as inactive pro-caspases , that consist of a prodomain, a small subunit and a large subunit. (wikidoc.org)
Two generation myocardiocytes, ERCC5( XPG) and the extracellularspace of ERCC1 and ERCC4( XPF), have associated to the free favour subunit to appear the library planning that will migrate the caspase-dependent gamma from the small opening growth( Dunand-Sauthier et al. (evakoch.com)

The cathepsin family consists of 12 cysteine proteases with broad exo- and endopeptidase activity, of which Cathepsin B is a member. (eurogentec.com)

Canonical inflammasomes activate caspase-1, whereas non-canonical inflammasomes activate caspase-4 and -5 in humans and caspase-11 in mice. (bvsalud.org)

The BIR domain has a fold that is stabilised by zinc tetrahedrally coordinated by one histidine and three cysteine residues. (embl.de)

A protease of broad specificity, obtained from dried pancreas. (lookformedical.com)

A serine protease found in the azurophil granules of NEUTROPHILS. (lookformedical.com)

Bacterial exotoxic proteases destroy extracellular structures. (stratech.co.uk)
The caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intra- and extracellular stimuli. (southernbiotech.com)

The cleavage and inactivation of ICAD/DFF45 by a caspase allows CAD to enter the nucleus and fragment the DNA, causing the characteristic 'DNA ladder' seen in apoptotic cells. (wikidoc.org)
The possibility to create a database from predicted caspase cleavage products for the whole genome could significantly aid in identifying novel caspase targets from tandem mass spectrometry based proteomic experiments. (biomedcentral.com)
Evaluation of the classifiers with quality measures indicated that all of the three classifiers performed well in predicting caspase cleavage sites, and when combining different classifiers the accuracy increased further. (biomedcentral.com)
Immunopathologic examination during infection showed cleavage of caspase 3 in brain cells adjacent to CD8+ cells and widespread p53 expression, hallmarks of apoptosis. (cdc.gov)

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. (cancerindex.org)

The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)

Belongs to peptidase family C14. (lu.se)

The assay utilizes a fluorescent casein conjugate that is proven to be a generic substrate for a broad spectrum of proteases (e.g. trypsin, chymotrypsin, thermolysin, proteinase K, protease XIV, and elastase). (stratech.co.uk)

Acts as a direct inhibitor of caspase enzymes. (embl.de)
The MutS requirements suppress with conformational enzymes binding other MLH and MutL, the later bind aromatic release family favour and catalytic cytokine to the MLH Canadians, widely eventually as RPA, EXO1, RFC, well long, and D-fructose less intrinsic lipids. (erik-mill.de)

Pharmacological inhibition of cathepsin activity with CA074-Me resulted in a substantial reduction of both mature IL-1β production and caspase-1 activation in infected macrophages. (frontiersin.org)
Other proteases are present in leukocytes (elastase and cathepsin G) and play several different roles in metabolic control. (stratech.co.uk)

Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages. (bionotatki.com)
[4] Kerr had originally used the term "programmed cell necrosis" to describe the phenomenon but in the 1972 article this process of natural cell death was called apoptosis . (wikidoc.org)
It mediates cell death induction by receptors of the tumor necrosis factor (TNF) and nerve growth factor (NGF) family to eliminate injured cells and maintain leukocyte homeostasis. (southernbiotech.com)

Proteases present in blood serum (thrombin, plasmin, Hageman factor, etc.) play an important role in blood-clotting, as well as blood clot lysis, and the correct action of the immune system. (stratech.co.uk)

Treatment with cytotoxic doses of tocotrienol resulted in a large increase in caspase-8 and caspase--3, but not caspase-9 activity. (maljnutr.org.my)

The Caspase-1 gene consists of 10 exons spanning at least 10.6 kb and is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas. (bionotatki.com)
The Caspase-1 gene consists of 10 exons spanning at least 10.6 kb and is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes. (bionotatki.com)
The importance of caspases to apoptosis and programmed cell death was originally established by Robert Horvitz and colleagues who found that the ced-3 gene was required for the cell death that took place during the development of the nematode C. elegans . (wikidoc.org)

Within this family, caspase 2 is part of the Ich-1 subfamily. (wikipedia.org)
Caspase 3 (otherwise called CPP32, Yama, or apopain) is an individual from the CED-3 subfamily of Caspases and is one of the basic chemicals of apoptosis. (entigen.com)

this coupled with the unwanted apoptosis that occurs with ischaemia or Alzheimer's disease , has boomed the interest in caspases as potential therapeutic targets since they were discovered in the mid 1990s. (wikidoc.org)
Some proteases have been identified as good drug development targets. (stratech.co.uk)

Attachment of a protease to a certain group depends on the structure of catalytic site and the amino acid (as one of the constituents) essential for its activity. (stratech.co.uk)

The vitamin E family of compounds is divided into two subgroups called tocopherols and tocotrienols, but only tocotrienols display potent anticancer activity at treatment doses that have little or no effect on normal cell growth or viability. (maljnutr.org.my)
should the term ['GO:0006919] activation of caspase activity' be a child of positive regulation of apoptosis or induction of apoptosis rather than directly to apoptosis? (geneontology.org)
Although the presence of active caspases and DNA fragmentation is helpful in identifying possible apoptosis, they should not be employed as an exclusive means to demonstrate this process as apototic cell death can occur without DNA fragmentation or caspase activity. (geneontology.org)
Generation of the subunits requires association with the death-inducing signaling complex (disc), whereas additional processing is likely due to the autocatalytic activity of the activated protease. (lu.se)

The caspases can be activated through either the intrinsic (mitochondrial mediated) or extrinsic (death receptor mediated) apoptotic pathways. (geneontology.org)

Building on these earlier results, current studies in our lab focus on understanding the pathways that lead to caspase activation and the mechanisms that regulate those pathways. (mayo.edu)

Morphological and biochemical characteristics of apoptosis, such as nuclear and cytoplasmic condensation and DNA fragmentation, are mediated by the activation of cysteine proteases called caspases. (maljnutr.org.my)

[ 8 ] Caspase inhibition in clonal striatal cells showed no correlation between the reduction of aggregates in the cells and increased survival. (medscape.com)

The best characterized family of inflammasomes are those containing NLR sensors. (promegaconnections.com)
Unlike the NLR family, ALR inflammasomes, AIM2 and IFL16, interact directly with their ligands (dsDNA). (promegaconnections.com)

Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. (wikipedia.org)
as a potential target for cancer therapy, because of its importance in suppressing metabolic suppression of caspase-2 activation and apoptosis. (duke.edu)
These findings demonstrate that tocotrienol-induced apoptosis in highly malignant mammary epithelial cells is mediated through caspase-8 activation, and may provide essential information necessary for understanding the potential health benefits of these compounds in preventing and/or reducing the risk of breast cancer in women. (maljnutr.org.my)
Although these platelet activation processes are relatively well-studied as a function of the platelet environment, only since recently it is becoming clear that a multitude of proteases present in plasma or produced by platelets themselves are important for the distinct properties of platelet populations, often by cleaving specific receptors. (frontiersin.org)
The pyrin domain (PYD) and CARD-containing adaptor, ACS is required necessary for caspase-1 activation but not needed for NLRCP-mediated pyroptosis (2). (promegaconnections.com)

Overall, caspase 2 appears to be a very versatile caspase with multiple functions beyond cell death induction. (wikipedia.org)

Some caspases are also required in the immune system for the maturation of cytokines . (wikidoc.org)

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