OxidoreductaseNADHKinaseNADPNicotinamide adenine dinuPyruvateGlyceraldehyde 3-phosphaBiosyntheticGeneSynthaseEnzymeProteinCytosolicSaccharomycesGlucoseInorganic phosphateSodium azideAcyltransferaseEnzymesOxidativePathwayTransporterInositolDependentTriglyceridesSubunitEthanolAlcoholFatty acidsCarbon sourceMoleculesLociAcidCytochromeTranscriptional regulatorEukaryotesInterproscanComplex
Oxidoreductase2
- The systematic name of this enzyme class is sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase. (wikipedia.org)
- Other names in common use include L-glycerol-3-phosphate:NAD(P)+ oxidoreductase, glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide, (phosphate)), glycerol 3-phosphate dehydrogenase (NADP+), and glycerol-3-phosphate dehydrogenase [NAD(P)+]. This enzyme participates in glycerophospholipid metabolism. (wikipedia.org)
NADH4
- In enzymology, a glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) is an enzyme that catalyzes the chemical reaction sn-glycerol 3-phosphate + NAD(P)+ ⇌ {\displaystyle \rightleftharpoons } glycerone phosphate + NAD(P)H + H+ The 3 substrates of this enzyme are sn-glycerol 3-phosphate, NAD+, and NADP+, whereas its 4 products are glycerone phosphate, NADH, NADPH, and H+. (wikipedia.org)
- The glycerol-3-phosphate shuttle (G3PS) is a major NADH shuttle that regenerates reducing equivalents in the cytosol and produces energy in the mitochondria. (bvsalud.org)
- In the sixth step of the glycolytic pathway, the first step of the second phase, the payoff phase, glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) catalyses the oxidation of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate (1,3-BPG), with the concomitant reduction of NAD + to NADH. (imingo.net)
- Increased hepatic levels of glycerol 3-phosphate (3-GP) after ethanol ingestion are related to an increase in the ratio of the oxidized form of nicotinamide adenine dinucleotide (NAD + ) to the reduced form (NADH) in the liver. (medscape.com)
Kinase3
- Amino acid kinase family [Interproscan]. (ntu.edu.sg)
- Single deletions of the genes encoding for the glycerol/H + symporter ( STL1 ), the glycerol kinase ( GUT1 ), and the mitochondrial FAD + -dependent glycerol 3-phosphate dehydrogenase ( GUT2 ) abolished glycerol growth in this strain, implying that it uses the same glycerol utilization pathway as previously identified in auxotrophic laboratory strains. (biomedcentral.com)
- glycerol kinase [Source:HGNC Symbol;Acc. (gsea-msigdb.org)
NADP2
- a) They are linked as coenzymes either to NAD (Nicotinamide adenine dinucleotide) or to NADP (Nicotinamide adenine dinucleotide phosphate). (biologydiscussion.com)
- In Escherichia coli , besides the PEPCK reaction, there is another pathway to form PEP from C 4 -dicarboxylic acid which involves the NAD- and NADP-dependent malic enzymes (MAEA and MAEB) and phosphoenolpyruvate synthase (PPS). (asm.org)
Nicotinamide adenine dinu1
- The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). (aipunuobio.com)
Pyruvate1
- protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
Glyceraldehyde 3-phospha3
- Glyceraldehyde 3-phosphate dehydrogenase [Interproscan]. (ntu.edu.sg)
- Finally the PPP can also be used to produce glyceraldehyde-3-phosphate which can then be fed into the TCA and ETC cycles allowing for the harvest of energy. (imingo.net)
- This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. (aipunuobio.com)
Biosynthetic1
- Pyridoxal phosphate biosynthetic protein PdxA [Interproscan]. (ntu.edu.sg)
Gene4
- OBJECTIVES: Transient infantile hypertriglyceridemia (HTGTI) is caused by mutations in the glycerol-3-phosphate dehydrogenase 1 (GPD1) gene. (bvsalud.org)
- The d-2-hydroxyacid dehydrogenase (2HADH) family illustrates a complex evolutionary history with multiple lateral gene transfers and gene duplications and losses. (rcsb.org)
- Sirtuins or "silent information regulators" of gene transcription, are a family of enzymes which are expressed throughout all phyla of life. (frontiersin.org)
- Gene silencing by this family of enzymes has been correlated directly with longer lifespan in yeast and worms ( Yang and Sauve, 2005 ). (frontiersin.org)
Synthase2
- 18874) imidazoleglycerol phosphate synthase%2C cyclase subunit CP001857 CDS Arcpr_0021 19046. (go.jp)
- 3-hydroxy-3-methylglutaryl-CoA synthase. (gsea-msigdb.org)
Enzyme3
- This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. (wikipedia.org)
- Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering eLife, 9, pp. e54639. (unipv.it)
- In Rhizobium species, a PEPCK-deficient mutant fails to grow on minimal medium with succinate or other citric acid cycle intermediates but can grow on glucose and glycerol as a sole carbon source, suggesting that PEPCK functions here as a key gluconeogenic enzyme ( 30 ). (asm.org)
Protein10
- protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC73290","lpxD","Escherichia coli","UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase [Ensembl]. (ntu.edu.sg)
- 1251 orc1%2Fcdc6 family replication initiation protein CP001857 CDS Arcpr_0002 1251. (go.jp)
- 9195) PhoH family protein CP001857 CDS Arcpr_0008 9278. (go.jp)
- 41666) ExsB family protein CP001857 CDS Arcpr_0048 41748. (go.jp)
- 45756) PEBP family protein CP001857 CDS Arcpr_0056 45795. (go.jp)
- 47904) TATA-box binding family protein CP001857 CDS Arcpr_0059 47991. (go.jp)
- Y-box binding protein 3 [Source:HGNC Sym. (gsea-msigdb.org)
- G protein nucleolar 3 [Source:HGNC Symb. (gsea-msigdb.org)
- heat shock protein family A (Hsp70) mem. (gsea-msigdb.org)
Cytosolic2
- The high flux through cytosolic glycerol-3-phosphate dehydrogenase (GPD) is required to maintain redox balance and support lipid synthesis. (bvsalud.org)
- Instead, loss of GPD2 upregulates cytosolic GPD on a transcriptional level and promotes cancer cell proliferation by increasing glycerol-3-phosphate supply. (bvsalud.org)
Saccharomyces2
- Plasmid pSR3 carrying gpd1 and gpp2 encoding two isoforms of glycerol-3-phosphate dehydrogenase from Saccharomyces cerevisiae and plasmid pLB2 carrying aldO encoding alditol oxidase from Streptomyces violaceoruber were introduced into E. coli to enable the production of glycerate from glucose via glycerol. (bvsalud.org)
- The current knowledge about the genetics and physiology of glycerol uptake and catabolism in the versatile industrial biotechnology production host Saccharomyces cerevisiae has been mainly based on auxotrophic laboratory strains, and carried out in the presence of growth-supporting supplements such as amino acids and nucleic bases. (biomedcentral.com)
Glucose1
- From the Rancho Bernardo Research, the identical SNP also showed significant connection to the attached traits homeostasis design evaluation regarding insulin opposition (R Equates to 3.3 times 10(-4)), fasting carbs and glucose (P = 1.1 by Ten(-3)), and sort Two diabetes (G Equates to Nine. (vegfr-3inhibitor.com)
Inorganic phosphate1
- Which of the following enzymes incorporates inorganic phosphate into the substrate? (medquizzes.net)
Sodium azide1
- Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. (aipunuobio.com)
Acyltransferase2
- Hexapeptide repeat of succinyl-transferase, Bacterial transferase hexapeptide (six repeats), UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Interproscan]. (ntu.edu.sg)
- CGI-58, at least in vitro, also acts as an acyl-CoA-dependent acylglycerol-3-phosphate acyltransferase. (imingo.net)
Enzymes1
- PEPCKs have been generally classified according to their nucleotide specificities: enzymes from bacteria, yeast, and plants mainly use adenosine nucleotides, but enzymes from a variety of eukaryotes and mammals use guanosine or inosine phosphates ( 24 ). (asm.org)
Oxidative1
- Previous studies shed light on the important role that Aspergillus nidulans gfdB, putatively encoding a NAD+-dependent glycerol-3-phosphate dehydrogenase, plays in the oxidative and cell wall integrity stress tolerance of this filamentous fungus model organism. (bvsalud.org)
Pathway1
- Lipolysis /lɪˈpɒlɪsɪs/ is the metabolic pathway through which lipid triglycerides are hydrolyzed into a glycerol and three fatty acids. (imingo.net)
Transporter1
- Further disruption of glpF, encoding a glycerol transporter, increased the glycerate production to 0.80 ± 0.00 g/L. MR2 medium improved the glycerate production titers and specific productivities of E. coli EG_4, EG_5, and EG_6. (bvsalud.org)
Inositol1
- Lipid molecules have these properties because they consist largely of long hydrocarbon tails which are lipophilic in nature as well as polar headgroups (e.g. phosphate-based functionality, and/or inositol based functionality). (medmuv.com)
Dependent1
- 42329 iron %28metal%29 dependent repressor%2C DtxR family CP001857 CDS Arcpr_0049 complement(42326. (go.jp)
Triglycerides1
- To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. (imingo.net)
Subunit1
- Funciton: Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4. (lbl.gov)
Ethanol1
- In the present study, we obtained by rare mating (non-GMO strategy), and a subsequent sporulation, an interspecific S. cerevisiae × S. uvarum spore-derivative hybrid that improves or maintains a combination of parental traits of interest for the wine industry, such as good fermentation performance, increased ethanol tolerance, and high glycerol and aroma productions. (frontiersin.org)
Alcohol2
- Aldehyde dehydrogenase family, Iron-containing alcohol dehydrogenase [Interproscan]. (ntu.edu.sg)
- In fact, biodiesel production, that is, the transesterification of fats and oils with an alcohol, results in 10 lbs of crude glycerol for every 100 lbs of biodiesel produced [ 1 ]. (biomedcentral.com)
Fatty acids3
- Lipolysis is the metabolic process through which triacylglycerols (TAGs) break down via hydrolysis into their constituent molecules: glycerol and free fatty acids (FFAs). (imingo.net)
- SCIRP: Food and Nutrition Sciences, Vol. In this process, both in vivoand in cultur… This binding will likewise lead to the cAMP/PKA-led phosphorylation of hormone sensitive lipase, that will ultimately drive the release of free fatty acids and glycerol. (imingo.net)
- A higher concentration of 3-GP results in enhanced esterification of fatty acids. (medscape.com)
Carbon source2
- Glycerol has attracted attention as a carbon source for microbial production processes due to the large amounts of crude glycerol waste resulting from biodiesel production. (biomedcentral.com)
- This knowledge can be applied for further rational strain improvement with the goal of using glycerol as a carbon source in industrial biotechnology processes based on S. cerevisiae as a production organism. (biomedcentral.com)
Molecules1
- e) Cytochrome aa 3 contains 2 molecules of heme A, each having one Fe atom. (biologydiscussion.com)
Loci1
- Genetic linkage and reciprocal hemizygosity analysis demonstrated that GUT1 CBS 6412-13A is one of the multiple genetic loci contributing to the glycerol growth phenotype. (biomedcentral.com)
Acid1
- S. uvarum is a cryotolerant yeast that produces more glycerol, less acetic acid and exhibits a better aroma profile. (frontiersin.org)
Cytochrome2
- NapC/NirT cytochrome c family [Interproscan]. (ntu.edu.sg)
- f) The terminal cytochrome aa 3 is responsi-ble for the final combination of reducing equivalents with molecular oxygen. (biologydiscussion.com)
Transcriptional regulator1
- 14733) putative transcriptional regulator%2C AsnC family CP001857 CDS Arcpr_0015 complement(14711. (go.jp)
Eukaryotes1
- Other Eukaryotes - 3 (source: NCBI BLink). (ntu.edu.sg)
Interproscan7
- Tubulin/FtsZ family [Interproscan]. (ntu.edu.sg)
- OmpA family [Interproscan]. (ntu.edu.sg)
- MoaC family [Interproscan]. (ntu.edu.sg)
- Peptidase family M20/M25/M40, Peptidase dimerisation domain [Interproscan]. (ntu.edu.sg)
- short chain dehydrogenase [Interproscan]. (ntu.edu.sg)
- Mur ligase family, Mur ligase middle domain [Interproscan]. (ntu.edu.sg)
- Metallopeptidase family M24 [Interproscan]. (ntu.edu.sg)
Complex2
- d) More recent studies show that 2 cyto-chromes are combined with the same pro-tein and the complex is known as cyto-chrome aa 3 . (biologydiscussion.com)
- Funciton: Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex (EC 2.3.1. (lbl.gov)