Family cdc2 protein kinase. Medical search. Frequent questions

Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. (molcells.org)
One such important family of regulatory RBPs is the Serine-Arginine (SR) family of proteins. (molcells.org)
STP, serine/threonine protein phosphatase. (rupress.org)
The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
Also called p56 or KKIAMRE [28 29 CDKL2 (cyclin-dependent kinase-like 2) is among the most distant people from the cdc2-related serine/threonine proteins kinase and mitogen-activated proteins kinase (MAPK) family members [29]. (healthcarecoremeasures.com)
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes-like. (umbc.edu)
Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase 1 (CDK1) subfamily, catalytic (c) domain. (umbc.edu)
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (umbc.edu)
Launch Glycogen synthase kinase 3 (GSK3) is certainly a serine/threonine kinase portrayed as two equivalent isoforms, and [1], [2]. (globaltechbiz.com)
Cyclins and CDKs assemble into complexes with one another as cells progress through G1 phase, cyclins being required to activate the serine-threonine kinase activity of their catalytic partners. (biomedcentral.com)
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3. (umbc.edu)
ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC family of serine-threonine kinases and takes part in regulating the shape and movement of cells by acting on the cytoskeleton. (glpbio.cn)

Cyclin-dependent kinase 10 has been shown to interact with ETS2. (wikipedia.org)
Cyclin-dependent kinase (CDK) 10, is reported to play an essential role in the progression from the G2 to M phase of the cell cycle. (jcancer.org)
Endogenous regulation of the cell cycle depends on phosphorylation and dephosphorylation of the cyclin- cyclin-dependent kinase (CDK)-cyclin-dependent kinase inhibitor (CDKI) pathway. (jcancer.org)
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (novusbio.com)
This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. (novusbio.com)
This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. (novusbio.com)
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. (ayassbioscience.com)
PFTK1 acts as a cyclin-dependent kinase that regulates cell cycle progression and cell proliferation. (signalchem.com)
Cyclin-dependent kinases and tumor suppressor proteins are stimulators and modulators of cell division. (ptgcn.com)
2015) Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts. (guidetopharmacology.org)
CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression. (umbc.edu)
Cdc2 (cyclin-dependent kinase-1) is one of several kinase proteins controlling cell division and is frequently de-regulated in cancer cells. (erimos.com)
The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. (fcgportal.org)
The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer. (antikoerper-online.de)
The cyclin-dependent kinase activator, Spy1A, is targeted for degradation by the ubiquitin ligase NEDD4. (antikoerper-online.de)
The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes. (wikidata.org)
Cyclins regulate the cell cycle in association with cyclin dependent kinases (CDKs). (biomedcentral.com)
CDKs are under inhibitory control of cyclin dependent kinase inhibitors (CDKIs). (biomedcentral.com)
PCNA is a co-factor of cyclin-D and it makes a complex with cyclin-D, a cyclin dependent kinase (CDK), and a cyclin dependent kinase inhibitor (CDKI). (biomedcentral.com)
The progression of cells through the cell cycle is regulated by a family of protein kinases known as the cyclin-dependent kinases (CDKs). (biomedcentral.com)
Furthermore, CDK-activating kinase (CAK) phosphorylates cyclin-bound CDKs on a single threonine residue, a modification that is essential for their activity [ 6 - 9 ]. (biomedcentral.com)
Cyclin-dependent kinase inhibitors (CDKIs) are proteins that bind to and inhibit the activity of CDKs. (biomedcentral.com)
The p21 family (p21, p27, p28 and p57) can bind to broad range of CDK-cyclin complexes and inhibit their activities. (biomedcentral.com)
CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. (umbc.edu)
This may be due to compensation provided by CDK1 (also called Cdc2), which can also bind cyclin E and drive the G1 to S phase transition. (umbc.edu)
After vascular complex pathway is caused on a Electrical snRNP, MAML( other) radicals direct in brain with cyclin C, including protein of followed high-affinity ligands in TAD and PEST cilia of NICD1 by CDK8. (evakoch.com)
The identity of this protein has not been determined, but may represent an alternative splice product of the cyclin C gene, as has been identified in other species. (bdbiosciences.com)
Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. (bdbiosciences.com)
Cyclin C associates with Cdk8, forming a complex which can induce gene transcription of Cdc2 (Cdk1). (bdbiosciences.com)
Because Cdc2 kinase is important for cell entry into mitosis, cyclin C's ability to regulate cell cycle progression may be attributed, in part, to modulation of Cdc2 protein expression.6 Cyclin C has a predicted molecular weight of 36 kD. (bdbiosciences.com)

It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
CDC2 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF) , which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. (caslab.com)
CRKs (cdc2-related kinases), Cyclins and CKSs (cdc2-kinase subunit) are involved in the progression through the cell cycle. (lancs.ac.uk)

His Virology study combines topics in areas such as Receptor tyrosine kinase, Endocytosis and Intracellular. (research.com)
The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
The cdc25 gene product is a tyrosine phosphatase that acts as an initiator of M-phase in eukaryotic cell cycles by activating p34 cdc2 . (biologists.com)
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. (wikidata.org)
Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2. (wikidata.org)
A striking feature observed only in Lck- deficient T cells was the presence of a constitutively tyrosine- phosphorylated 32-kDa protein. (uaeu.ac.ae)
Lck-deficient transfectants expressed high levels of cdc2 protein and its regulatory units, cyclins A and B. The majority of cdc2, however, was tyrosine-phosphorylated and therefore enzymatically inactive. (uaeu.ac.ae)
These findings provide evidence that, in mature T lymphocytes, cell-cycle progression through the G 2 -M check point requires expression of the Src-family protein tyrosine kinase, Lck. (uaeu.ac.ae)
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. (affbiotech.cn)

The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). (thermofisher.com)
Apoptosis is regulated by the inhibitor of apoptosis protein (IAP) family of proteins, through their inhibition of caspase-induced cell death. (erimos.com)
The apoptosis rate was 34.63 ± 2.57% (vs 19.69 ± 1.63%, P = 0.002) in JAK kinase inhibitor AG490 plus bufalin treatment group. (biomedcentral.com)
The biological download of SMAD2 and SMAD3 is known by SMURF type membranes, which consist acids for I. In turbine, Apaf-1 R-SMAD: ligand Hepatocyte is leader of extracellular humans( projections), including a applicable kinase-inhibitor turnover. (erik-mill.de)
GC25482 GSK269962A HCl GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. (glpbio.cn)
GC66338 ROCK1-IN-1 WAY-624704 is a novel Rho kinases (ROCK) inhibitor with an Ki of 17 nM. (glpbio.cn)
GC36208 H-1152 dihydrochloride H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). (glpbio.cn)

CDK1, also named as CDC2, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2/CDKX subfamily.CDC2 plays a key role in the control of the eukaryotic cell cycle. (caslab.com)

CDKs belong to a large family of STKs that are regulated by their cognate cyclins. (umbc.edu)

Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene. (wikipedia.org)
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. (wikipedia.org)
The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. (wikipedia.org)
This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. (thermofisher.com)
This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). (thermofisher.com)
Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. (technuc.com)
As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program. (molcells.org)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
Transforming the gene sequence on DNA to an RNA message (a process called transcription) that can then be converted to protein is essential to the regulation of protein production. (erimos.com)
Next, protein-protein interaction (PPI) networks were used to further explore the biomarkers with the most interactions in gene modules. (biomedcentral.com)
You can find six phosphorylation sites in RSK1 that are crucial for its activation and its own subsequent part in substrate phosphorylation (21 22 Of the phosphorylation of Ser-380 can be very important to RSK1 activation traveling functions such as for example rules of gene manifestation and protein synthesis and cell cycle regulation as a downstream Nisoxetine hydrochloride kinase in the Mos-MAPK pathway (23). (biospraysehatalami.com)
approximately half of these DNMs disrupt gene function and the remainder result in altered protein function. (cam.ac.uk)

In addition, shuttling SR proteins act as adaptors for mRNA export and as regulators for translation in the cytoplasm. (molcells.org)
This mini-review will summarize the roles of SR proteins as RNA binders, regulators, and connectors from transcription in the nucleus to translation in the cytoplasm. (molcells.org)
Most SR proteins are located exclusively in the nucleus, but some SR proteins (mainly SRSF1, SRSF3, and SRSF7) can shuttle between the nucleus and the cytoplasm. (molcells.org)
The study incorporates disciplines such as Cytoplasm, Mutation, Sterile alpha motif, Wild type and Fusion protein in addition to Molecular biology. (research.com)
The passage of a cell through the cell cycle is controlled by proteins in the cytoplasm. (ptgcn.com)
DAZ family proteins are located in the nucleus and/or in the cytoplasm of male and female germ cells at different developmental stages throughout the gametogenesis. (ijbs.com)
The localization of DAZ family proteins suggests that they can regulate mRNA translation occurring in the cytoplasm. (ijbs.com)
Immune system Nevertheless, nuclear launch of Bora isn't the only system by which its service of Aurora A is controlled since the bora mutant phenotype can be rescued by Bora fused to a signal, which keeps the protein in the cytoplasm, or fused to a localization signal, which maintains the protein in the nucleus until nuclear envelope breakdown. (others-signal.com)

Mitotic cyclins stably associate with CDC2 and function as regulatory subunits. (caslab.com)

The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. (wikidata.org)
Aurora A is involved with centrosome readiness, spindle assembly, and uneven protein localization throughout mitosis. (others-signal.com)

The role of cell cycle checkpoint proteins is to integrate internal and external factors to determine whether the cell is prepared for progression of the cell cycle. (ptgcn.com)
The sequential activation of the members of this family and their phosphorylation of certain substrates promotes the progression through the cell cycle. (biomedcentral.com)
In the present study, we provide evidence that this aberrantly hyperphosphorylated protein is p34(cat2) (cdc2) a key regulator of cell-cycle progression. (uaeu.ac.ae)

These genes, encoding for RNA binding proteins, contain a highly conserved RNA recognition motif and at least one DAZ repeat encoding for a 24 amino acids sequence able to bind other mRNA binding proteins. (ijbs.com)
DAZ family genes are highly conserved. (ijbs.com)
These proteins have a highly conserved RNA recognition motif (RRM) for binding target mRNAs and at least one characteristic sequence of 24 amino acids, which are termed as DAZ repeats [ 1 ]. (ijbs.com)

This domain occurred 376 times on human genes ( 869 proteins). (umbc.edu)
It selectively reduces transcription of genes that have promoters controlled by the Sp1 factor, such as survivin, cdc2 and VEGF. (erimos.com)
The family includes Boule (or Boll ), Dazl (or Dazla ) and DAZ genes. (ijbs.com)
Here we discuss DAZ family genes in a phylogenic perspective, focusing on the common and distinct features of these genes, and their pivotal roles during gametogenesis evolved during evolution. (ijbs.com)
DAZ (Deleted in Azoospermia) family genes are important fertility factors in many animals including humans. (ijbs.com)
Briefly, miRNAs are expected to account for 1-5% of the human genome and to interfere with at least 30% of the protein-coding genes ( 4 , 5 ). (frontiersin.org)
first patterns( progeny, class, protein lifetime, and complex anion) be depending genes: NF-kappaB is silenced via list catabolism C octanoyl, RAS has required via RasGRP cells, NF-AT creates coupled via Tumor, and AKT( PKB) methylates achieved via PDK1( involved in Shinohara and Kurosaki 2009, Stone 2006). (erik-mill.de)
This domain occurred 379 times on human genes ( 874 proteins). (umbc.edu)

It is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. (caslab.com)

The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. (wikidata.org)
Familia de cinasas dependientes del ciclo celular que se relacionan estructuralmente con la PROTEÍNA CINASA CDC28 DE SACCHAROMYCES CEREVISIAE y con la PROTEÍNA CINASA CDC2 que se encuentra en mamíferos. (bvsalud.org)
A family of cell cycle-dependent kinases that are related in structure to CDC28 PROTEIN KINASE, S CEREVISIAE and the CDC2 PROTEIN KINASE found in mammalian species. (bvsalud.org)

The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). (novusbio.com)

Adding further complexity to this picture is the fact that both kinases and phosphatases can function in signaling networks where multiple kinases and phosphatases contribute to the outcome of a pathway. (rupress.org)
Western Blot was used to determine the protein expression of the apoptosis inhibitors livin and caspase-3, the apoptosis-related proteins Bax and Bcl-2, as well as the key protein kinases in the Jak-stat3 signaling pathway, stat3 and p-stat3. (biomedcentral.com)
high bacteria are as proteins of pathway ATM rise, either as acids for greenhouse initiation or for the dehydrogenase of binding eIF2 disorders. (evakoch.com)

CDC2/CDKX subfamily. (abcam.cn)

To fully understand this complex and essential regulatory process, the kinases and phosphatases mediating the changes in cellular phosphorylation must be identified and characterized. (rupress.org)
In some invertebrate species, BOULE protein play a pivotal role in germline specification and a conserved regulatory role in meiosis. (ijbs.com)
The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. (fcgportal.org)

Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)

Diverse SR proteins play partially overlapping but distinct roles in transcription-coupled splicing and mRNA processing in the nucleus. (molcells.org)
His work carried out in the field of Cytosol brings together such families of science as Nucleus and Virology. (research.com)
Bora is really a nuclear protein that is excluded from the nucleus throughout prophase in a Cdc2 dependent manner. (others-signal.com)

Antibody reactivity against cell lysate and recombinant protein for WB. (novusbio.com)
His research in SAMHD1 intersects with topics in Cell culture, Viral replication, Origin recognition complex and Kinase. (research.com)
Felipe Diaz-Griffero interconnects Jurkat cells, Mutant and TRIM Family in the investigation of issues within Cell biology. (research.com)
The scientist's investigation covers issues in Cell biology, Capsid, Cell cycle, Transmembrane protein and Phosphorylation. (research.com)
The key role of checkpoint proteins is to detect DNA damage and send a signal to delay cell cycle advance until the damaged chromosomes are repaired (Figure 1). (ptgcn.com)
Besides changes in EMT marker expression HMLE cells expressing some kinases such as CDKL2 ZAK FYN and MET lost cell-cell contact Mubritinib and acquired a spindle fibroblast-like mesenchymal morphology (Fig. (healthcarecoremeasures.com)
The CKS proteins were first described as components of the cell cycle machinery in yeast and their action has been implicated in the regulation of CDK function. (lancs.ac.uk)
The functional complementation between the CKS proteins of two evolutionary distant organisms supports the role of Tcp12CKS1 as a key regulator in T. cruzi cell cycle. (lancs.ac.uk)
Caspases are essential for apoptosis and are deemed the "executioner" proteins for their roles in the cell. (erimos.com)
Key proteins as mentioned above are involved in the regulation of the signaling pathways that control cell growth, division and death. (erimos.com)
By blocking production of survivin, cdc2 and VEGF, terameprocol can attack the tumors by inducing tumor cell death, preventing further growth, and starving the tumors by restricting growth of their blood supply. (erimos.com)
GSK3 inhibitors decrease the proliferation of Kinase Assay MCF7 cells had been lysed with Cell Lysis Buffer (Cell Signaling Technology, 9803). (globaltechbiz.com)
Cell department is controlled through cooperation of different kinases. (biospraysehatalami.com)
however a 45 kD protein may also be observed in some cell types using the antiserum. (bdbiosciences.com)

More over, TPX2 is only necessary for a part of Aurora A dependent processes: TPX2 inactivation by RNAi causes spindle problems and reduction of Aurora A from the mitotic spindle, but centrosome maturation is normal, and the centrosome pool of the kinase is unchanged. (others-signal.com)

Consistent with the mRNA level, the protein level of Ntn-4 was also found to be decreased in NSCLC cells. (bvsalud.org)
Notably, RNA-binding protein quaking 5 (Qki-5) was found to exhibit antitumor activity in lung cancer, not only by enhancing the level of Ntn-4 by binding to Ntn-4 mRNA, but also by suppressing the proliferation, invasion and migration of NSCLC cells. (bvsalud.org)
Basically, Daz family proteins function as adaptors for target mRNA transport and activators of their translation. (ijbs.com)
Basically, DAZ family proteins have been proposed to function as adaptors for mRNA transport and activators of their translation. (ijbs.com)

remaining of IGF1( IGF-I) or IGF2( IGF-II) to the vesicular flow factors of the peptide 1 intestinal amino adenosine heterogeneity( IGF1R) is the DNA of two antimicrobial lacking kinases: the SOS-RAS-RAF-MAPK( ERK) ligand and the PI3K-PKB( AKT) phosphate( generally polyubiquitinated in Pavelic et al. (erik-mill.de)

The p16 family (p15, p16, p18 and p19) binds to and inhibits the activities of CDK4 and CDK6. (biomedcentral.com)

The antibody is specific to the 2 isoforms of CDC2. (caslab.com)
Quality control test: Antibody Reactive Against Recombinant Protein. (novusbio.com)

This feature probably contributes to the relatively wide kinase specificity profile of AP24534, including VEGFR and FGFR family kinases, receptors perhaps not restricted by the three currently authorized BCR ABL drugs. (others-signal.com)

mobile assays [1 20 21 using human being mammary gland epithelial cells (HMLE) a vintage EMT experimental model [13 14 22 In keeping with outcomes from the luciferase reporter assay inside our cDNA displays many under-studied kinase applicants and positive settings (FYN and MET) significantly up-regulated the manifestation of mesenchymal markers including vimentin fibronectin and N-cadherin in HMLE cells (Fig. (healthcarecoremeasures.com)
A comprehensive kinase interaction map for dasatinib was recently described, though assay differences preclude direct comparison of the kinase users of AP24534 and dasatinib. (others-signal.com)

Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. (affbiotech.cn)

Elevation of the Bax/Bcl-2 ratio and a decrease in IAP family proteins XIAP and survivin were also observed following terpinen-4-ol treatment. (hindawi.com)
One of the IAP family members, survivin, is over-expressed in pre-cancerous and cancerous cells, and rarely found in healthy adult cells. (erimos.com)
Cdc2 is also involved in the activation of survivin. (erimos.com)

CDK4 is a member of the Ser/Thr protein kinase family. (thermofisher.com)

Four polo family members are present in mammalian cells: Plk1 Plk2/Snk Plk3/Fnk/Prk and Plk4/Sak. (biospraysehatalami.com)

In this mini-review, the essential functions of SR proteins in splicing regulation, with a focus on their roles as RNA binders in the ribonucleoprotein complex (RNP) will be summarized. (molcells.org)
Some kinases are essential scientific objectives of imatinib, nilotinib, and/or dasatinib, although only dasatinib has been reported to inhibit all SRC family kinases. (others-signal.com)

Belongs to the protein kinase superfamily. (abcam.cn)

2015) Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex. (guidetopharmacology.org)
0.01), further up-regulated Bax protein expression, down-regulated livin and Bcl-2 protein expression and enhanced caspase-3 activation. (biomedcentral.com)
Dazl can regulate the expression, transport and localization of target mRNAs of proteins which control the differentiation, growth and maturation of germ cells. (ijbs.com)
The release of mouse from the conversion in kinase shows STIM1 to confer with ORAI and TRPC1 levels in the hydrolase binding, depending in an Expression of due complex antagonists( Muik et al. (erik-mill.de)

Kinase selectivity studiesshowed that AP24534 does not inhibit Aurora kinases, clearly distinguishing it from other T315I inhibitors in development. (others-signal.com)

Although the importance of kinases in this process has long been recognized, an appreciation for the complex and fundamental role of phosphatases is more recent. (rupress.org)

All of these members contain a conserved C-terminal amino acid sequence termed the polo box domain which provides a docking site for certain proteins (1) and a kinase domain which is predicted to activate many protein kinases including Aurora A/B PKA ERK1/2 RSK1/2 Akt/PKB and MEK1 (2). (biospraysehatalami.com)

By using anti-Tcp12CKS1 antiserum, protein kinase (PK) activities were immunoprecipitated. (lancs.ac.uk)

Anatomy16

Organisms9

Chemicals and Drugs173

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes40

Information Science3

Serine12

Cyclin30

Subunit3

Tyrosine9

Inhibitor7

Cdk11

CDKs1

Gene13

Cytoplasm8

Function as regulatory subunits1

Mitosis2

Progression3

Highly conserved3

Genes8

Phosphorylates1

Cerevisiae3

Phosphorylate1

Pathway3

Subfamily1

Regulatory3

SUBCELLULAR LOCALIZATION1

Nucleus3

Cell14

Mitotic1

MRNA4

MAPK1

Cdk61

Antibody2

Specificity1

Assay2

Oncogene1

Survivin3

CDK41

Mammalian1

Essential2

Superfamily1

Expression4

Inhibitors1

Complex1

Predicted to activate1

Antiserum1