Family anion exchange protein 1 erythrocyte. Medical search. Frequent questions

Human being anion exchanger 2 (AE2) is definitely a plasma membrane protein that regulates intracellular pH and cell volume. (techuniq.com)
Keywords: anion exchanger 2 tumor suppressor P16 ERK gastrin Launch Colon cancer is normally a significant global public medical condition with rapidly increasing incidence. (techuniq.com)
The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. (antibodypedia.com)
The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. (antibodypedia.com)
Specific point mutations in human anion exchanger 1 (AE1) convert this electroneutral anion exchanger into a monovalent cation conductance. (tcdb.org)
To test the pathophysiology, we produced mice that lack the erythroid anion exchanger (AE1), the principal Ank1 ligand. (dana-farber.org)

Members of both the SLC4 and SLC26 mammalian gene families encode Na + -independent Cl - -HCO3 - exchangers. (tcdb.org)
A comparable volume-pH(i) link may also be important in other cell types expressing anion exchangers. (ox.ac.uk)

Twenty alpha-amino acids are the subunits which are polymerized to form proteins. (lookformedical.com)
All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)

Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene. (wikipedia.org)
Of family members in this research who presented with epilepsy, 70-80% had large deletions in the NA gene, now known as VPS13A , on chromosome 9. (medscape.com)
Wiethoff S, Xiromerisiou G, Bettencourt C, Kioumi A, Tsiptsios I, Tychalas A. Novel single base-pair deletion in exon 1 of XK gene leading to McLeod syndrome with chorea, muscle wasting, peripheral neuropathy, acanthocytosis and haemolysis. (medscape.com)
This was mediated via membrane Cl(-)/HCO(3)(-) exchange (the AE1 gene product), irrespective of whether recovery was from an intracellular acid or base load, and with no evident contribution from other transporters such as Na(+)/H(+) exchange. (ox.ac.uk)
14) strand proteins in gene-internal of FGFR3 and capable sunshine amyloid or proteotoxic cell increasing( Otsuki, 1999). (evakoch.com)
It binds and inactivates the 140 kDa subunit of RNA polymerase II, blocking all gene expression leading to proteins. (helmberg.at)

As noted above, the AE or solute carrier 4 (SLC4) family includes 10 members (SLC4A1-5, SLC4A7-11), which are expressed in multiple tissues in the human body. (tcdb.org)

Although mammalian SLC4/AE polypeptides mediate only electroneutral Cl - -anion exchange, trout erythroid AE1 also promotes osmolyte transport and increased anion conductance. (tcdb.org)

33, inorganic extractions re- placed ion exchange at the beginning of jutawan trader forex nuclear fuel cycle for separating uranium from other leach liquors. (qrforex.com)
Several important physiological and physio-pathological functions are played by many CA isozymes, which are strongly inhibited by aromatic and heterocyclic sulfonamides as well as inorganic, metal complexing anions. (rhea-db.org)

These hereditary adjustments disrupt or alter multiple signaling pathways such as for example Wnt/β-catenin Notch Hedgehog epidermal development aspect receptor (EGFR) Ras and PI3K/Akt [1]. (techuniq.com)
BACKGROUND: Acid retention associated with reduced GFR exacerbates nephropathy progression in partial nephrectomy models of CKD and might be reflected in CKD patients with reduced eGFR by increased anion gap (AG). (cdc.gov)

Search proteins in UniProtKB for this molecule. (rhea-db.org)
We identify serum- and glucocorticoid-inducible kinase-1 (SGK-1) as the key molecule responsible for the glucocorticoid-enhanced release of ATP from astrocytes. (nature.com)

They are ANTIPORTERS that exchange vesicular PROTONS for cytoplasmic NEUROTRANSMITTER and play an essential role in regulating neurotransmission. (uams.edu)

Longobardi L, Torello M, Buckway C, O'Rear L, Horton WA, Hwa V, Roberts CT, Chiarelli F, Rosenfeld RG, Spagnoli A. A novel insulin-like growth factor (IGF)-independent role for IGF binding protein-3 in mesenchymal chondroprogenitor cell apoptosis. (rush.edu)

Mitogen-activated proteins kinases (MAPK) transmit cell-proliferation indicators from plasma membrane to nucleus. (techuniq.com)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)

Our goal is to elucidate the functional networks that coordinate protein synthesis and quality control in the early secretory pathway. (stanford.edu)
The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
The extracellular transport of molecules 1, 4A and 103( synthesis) for regulation cell membranes and upstream DCs triggers reduced through modfiying to the functional midwifery CCR6 and not another extracellular different melanin( Yang et al. (erik-mill.de)

The cryo electron microsopic studies revealed that human AE2 protein forms a homodimer and stays in resting state of inward-facing conformation at physiological pH. (wikipedia.org)
Further conformational changes then turn the AE2 protein into an outward-facing conformation, releasing HCO3- into the extracellular environment and capturing Cl- into the binding pocket. (wikipedia.org)
Finally, the AE2 protein returns to its inward-facing conformation and releases Cl- into the cytosol. (wikipedia.org)
It is of fundamental importance in determining PROTEIN CONFORMATION. (lookformedical.com)
Jens simultaneously was for Statoil as a conformation Exploration Geologist, and he found act erythrocyte survival with Professor Virginia Toy at the University of Otago in New Zealand as expression of a Fulbright Fellowship. (erik-mill.de)

Although the C-terminal domain comprises a small percentage of the total protein, this domain in some cases (i) has PSD-95/Discs Large/ZO-1-binding motifs that may be important for protein-protein interactions (e.g. (tcdb.org)
Van Veen, H. W. (2016) Bacterial ABC multidrug exporters: from shared proteins motifs and features to diversity in molecular mechanisms. (cam.ac.uk)

Serum- and glucocorticoid-inducible kinase-1 (SGK-1) mediates the glucocorticoid-enhanced release of ATP from astrocytes by opening the pannexin-1 hemichannels. (nature.com)

Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. (antibodypedia.com)
Background: A vaccine targeting the erythrocyte stages of Plasmodium falciparum could play a role in preventing clinical disease. (bvsalud.org)
Differential Protein Expression Profiles Between Plasmodium falciparum Parasites Isolated From Subjects Presenting With Pregnancy-Associated Malaria and Uncomplicated Malaria in Benin. (labex-grex.com)

In humans, the AE family (also called the SLC4 family) is composed of 10 paralogous members, among which are the proteins that perform Na + -independent Cl-HCO 3 - exchange (e.g. (tcdb.org)
In this chapter, electrophilic agents nogenicity from studies of exposed (benzene, 1,3-butadiene, and eth- include direct-acting electrophilic humans. (who.int)
All of the chemicals discussed of this chemical was raised to carci- lung and the nasal cavity were iden- here are IARC Group 1 agents and nogenic to humans (Group 1) based tified as target organs in humans as such can be characterized as on strong mechanistic evidence and rats, respectively. (who.int)
Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)
or each of these agents, carcinogenicity in rats and/or mice, els, differences in exposure con- there was sufficient evidence of car- for example for the liver (aflatoxins, ditions between studies in animals cinogenicity from studies in rats and/ trichloroethylene [TCE], and vinyl and in humans, or limitations in Part 1 · Chapter 1. (who.int)

To achieve this, we prepared adrenalectomized (ADX) and sham-operated (sham) male ICR mice ( Fig. 1 ). (nature.com)

FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
Being typically a minor component of the cell membrane, they are of utmost importance for biological functions that rely on lipid-lipid and lipid-protein interactions (Schnaar and Kinoshita 2015 ). (springer.com)
Common among these 10 interactions of organic compounds, their power to detect excess cancer agents is the electrophilic nature of or their metabolites, with DNA and R 1 risk at particular sites. (who.int)
Title: Protein interactions with nanosized hydrotalcites of different composition. (aablocks.com)

AE1 and NBCe1), and (iii) may provide sites for regulation of transporter function via protein kinase A phosphorylation (e.g. (tcdb.org)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
De Franceschi L, Tomelleri C, Matte A, Brunati AM, Bovee-Geurts PH, Bertoldi M. Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity. (medscape.com)
receptors of Kv 1-4 dysplasia both residues and stones, not, molecules of Kv 5-12 3-kinase morphological effects. (erik-mill.de)

It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (lookformedical.com)

These molecules enabled us to address the question, where the Gb 3 sphingolipids are localized prior protein binding by means of fluorescence microscopy on giant unilamellar vesicles. (springer.com)
The present work shows that carboxy-SNARF-1, a pH fluorophore, when used with confocal imaging or flow cytometry, reliably reports pH(i) in individual, human RBCs, provided intracellular fluorescence is calibrated using a 'null-point' procedure. (ox.ac.uk)

2007). These proteins are important for the regulation of intracellular pH (pH i ) and play crucial roles in the epithelial absorption of HCO 3 - (e.g., in the renal proximal tubule) and secretion of HCO 3 - (e.g., in the pancreatic duct). (tcdb.org)

The animal AE proteins consist of homodimeric complexes of integral membrane proteins that vary in size from about 900 amino acyl residues to about 1250 residues. (tcdb.org)

A family of neurotransmitter transporter proteins that are INTEGRAL MEMBRANE PROTEINS of the LIPID BILAYER of SECRETORY VESICLES. (uams.edu)

Whereas the trisaccharidic head group of Gb 3 defines the specificity of Shiga toxin binding, the lipophilic part composed of sphingosine and different fatty acids is suggested to determine its localization within membranes impacting membrane organisation and protein binding eventually leading to protein internalisation. (springer.com)
This matrix is the carnitine of the fatty proteins activating in the 4-phosphate of duplex acid and chromatin conditions. (erik-mill.de)

The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. (antibodypedia.com)
SLC4 family members differ in their substrate dependence, charge transport stoichiometry, and tissue expression. (tcdb.org)
Vesicular Neurotransmitter Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
This graph shows the total number of publications written about "Vesicular Neurotransmitter Transport Proteins" by people in UAMS Profiles by year, and whether "Vesicular Neurotransmitter Transport Proteins" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Vesicular Neurotransmitter Transport Proteins" by people in Profiles over the past ten years. (uams.edu)
In this slow-flow compartment, blood plasma comes into direct contact with the hepatocytes' microvilli, which are packed with transport proteins. (helmberg.at)

This highly complex 'protein biogenesis' process is assisted by a diverse network of folding catalysts and protein-modifying enzymes and is scrutinized by molecular chaperones and other 'quality control' factors which ensure that only correctly folded and assembled proteins exit the ER and proceed to distal compartments of the secretory pathway. (stanford.edu)
The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)
In complexes, the other enzymes affect cleaved CBF1( or RBPJkappa), while in channels they are required Lag-1, immediately that the m ' CSL ' demonstrates separated been to this produced feature experience breast. (evakoch.com)
RNA enzymes may observe from also translocated proteins, they may phosphorylate suggested in proteins with delayed strategies, or they may outline known in membranes of factor factors. (evakoch.com)

release species with building protein of the translocation, with more inactive events clubbing with larger enzyme untranslated components in cleavage process( Bohling et al. (erik-mill.de)

Title: Compelling advantages of negative ion mode detection in high-mass MALDI-MS for homomeric protein complexes. (aablocks.com)

In 2005, based upon research involving several large French-Canadian families that presented with temporal lobe epilepsy, an expanded conceptualization of the molecular genetics of the autosomal recessive form NA was attained. (medscape.com)

Ankyrins link integral membrane proteins to the spectrin-based membrane skeleton. (dana-farber.org)
This indicates that AE1 and probably other integral membrane proteins have a 'lipid-anchoring' function. (dana-farber.org)

This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. (antibodypedia.com)

Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)
Membrane proteins must be threaded co-translocationally into the lipid bilayer to become membrane-integrated, often with complex topologies and typically form hetero- or homo- oligomers. (stanford.edu)

DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
However, despite growing biological and clinical significance, little is known about the structural arrangement of this receptor or any of its family members. (uci.edu)
The dysplasia receptor connect formed left into 12 processes, 1-12 with orange proteins from each ssDNA. (erik-mill.de)

Their N-terminal hydrophilic domains may interact with cytoskeletal proteins and therefore play a cell structural role. (tcdb.org)
All AE proteins are hypothesized to share a similar topology in the cell membrane. (tcdb.org)
The ER is the 'port of entry' for proteins destined for the cell surface and beyond. (stanford.edu)
Other cell types derived from hematopoietic stem cells include platelets and erythrocytes. (justia.com)

However, the amount of energy that can be stored in this way is limited: for their hydroxyl groups, glucose units are very hydrophilic: 1 g of glycogen binds 2.7 g of water. (helmberg.at)

Instrument effect on the activated protein C resistance plasma assay performed by a commercial kit. (ntu.ac.uk)

AE2 is functionally similar to the Band 3 Cl−/HCO3− exchange protein. (wikipedia.org)

Defects in such disparate systems (ie, basal ganglia and erythrocytes) have led to the suggestion that a common neurohematological membrane defect is involved. (medscape.com)
Hereditary defects in membrane skeleton proteins. (dana-farber.org)

Recent studies have shown that ferroptosis plays an important regulatory role in the occurrence and development of many diseases and has become the focus and hotspot of research on the treatment and prognosis improvement of related diseases (Fig. 1 ). (nature.com)

It is known that GSLs interact with both intracellular as well as exogenous proteins and are critical for membrane organisation, signalling, and recognition events. (springer.com)

Urine chloride was 95 mmol/L, pH 7.0, and urine protein-creatinine ratio 400 mg/g. (abdominalkey.com)

The protein comprises two domains that are structurally and functionally distinct. (antibodypedia.com)

Chakravarty A, Bhattacharya P, Banerjee D, Mukherjee S. Mcleod syndrome: Report of an Indian family with phenotypic heterogeneity. (medscape.com)

The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins. (lookformedical.com)

RNA data sourced from Human Protein Atlas . (antibodypedia.com)

Failure of the PN is associated with broad range of diseases including cancer, neurodegeneration, and immunological and metabolic disorders [ 1 ]. (hindawi.com)

Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
All Cbl cells bind a psychomotor CourseExplore that fails sterile entry buildings on linked proteins. (erik-mill.de)
The exchange of huge amounts of molecules between hepatocytes and blood is facilitated by fenestration of the endothelial cells lining wide sinusoids, allowing plasma to enter the perisinusoidal space, also known as space of Disse. (helmberg.at)

Neurobiol Dis 5:417431 Burley SK, Petsko GA (1985) Aromatic-aromatic interaction: a mechanism of protein struc- ture stabilization. (qrforex.com)

apolipoprotein C-I( APOC1, respectively 20 family) and apolipoprotein C4( APOC4, nervous ubiquitin)( Gibbons et al. (erik-mill.de)

A greenish-yellow, diatomic gas that is a member of the halogen family of elements. (uams.edu)

The vast majority of proteins entering the secretory pathway are synthesized on ribosomes docked at ER translocons and are co-transationally translocated into the ER lumen. (stanford.edu)

Fucan represents a family of water soluble, SP rich in sulfated l -fucose, extracted from extracellular matrix of these weeds (Li et al. (springer.com)

During the last decade, numerous bioactive polysaccharides with interesting functional properties have been discovered from seaweeds (Fig. 1 ). (springer.com)

For anticoagulation potency, the formation of the SP/protease protein complex and the associated non-specific polar interaction between the negatively and positively charged groups in the polysaccharide and protein is responsible for anticoagulant activity. (springer.com)
A type of ion exchange chromatography using diethylaminoethyl cellulose (DEAE-CELLULOSE) as a positively charged resin. (lookformedical.com)

Anatomy6

Organisms4

Diseases1

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes36

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