• A family of structurally-related angiogenic proteins of approximately 70 kDa in size. (rush.edu)
  • A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A . They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells. (nih.gov)
  • Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS. (bvsalud.org)
  • A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE. (lookformedical.com)
  • VEGF therapy biomarker neuropilin receptor tyrosine kinase (RTK) vascular endothelial growth factor ( VEGF ) The mammalian VEGF (vascular endothelial growth factor) family consists of five homodimeric polypeptides of 40 kDa: VEGF-A, -B, -C and -D and PlGF (placental growth factor). (silverchair.com)
  • Here, we demonstrated that CNP activates the cAMP/protein kinase A (PKA) pathway and that this activation contributed to the elongation of the hypertrophic zone in the growth plate. (tokushima-u.ac.jp)
  • Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). (bvsalud.org)
  • To measure intravitreal low-density lipoprotein receptor-related protein 6 (LRP6) and vascular endothelial growth factor (VEGF) levels in the eyes of patients with proliferative diabetic retinopathy (PDR) and to observe their correlation with PDR activity. (molvis.org)
  • Both genetic and drug targeting experiments have demonstrated the requirement for the vascular endothelial growth factor ( VEGF ) system, the Delta-like-Notch system and the transforming growth factor β (TGFβ)/bone morphogenetic protein (BMP. (silverchair.com)
  • A polypeptide substance comprising about one third of the total protein in mammalian organisms. (lookformedical.com)
  • They have high specificity for members of the TIE RECEPTOR FAMILY. (rush.edu)
  • Members of the human GH family are closely related structural variants, whereas members of the rat, mouse, and bovine PRL families exhibit considerable sequence diversity. (biomedcentral.com)
  • Adding chemical groups to the DNA backbone and modifying histone proteins impart distinct characteristics on chromatin architecture. (frontiersin.org)
  • In this minireview we examine the structure, expression patterns, and biological actions of the PRL and GH families from rodents (primarily rat and mouse), ruminants (primarily ovine and bovine), and primates (primarily human). (biomedcentral.com)
  • PRL gene families of rodents and ruminants and the GH gene family of primates represent excellent examples of species-specific gene expansion. (biomedcentral.com)
  • These inhibit proteins which contribute to abnormal blood vessel growth. (laderavision.com)
  • For example, angiostatic treatments, which combat blood vessel growth with steroid injections. (laderavision.com)
  • As a transcription factor alone or interacting with other transcription factors, it regulates the expression of many genes such as the c-jun family members that are associated with c-Fos within the AP-1 transcription complex. (arvojournals.org)
  • While the mouse and rat PRL families are largely orthologous, the expanded bovine PRL family is not orthologous with rodent PRL families, which suggests the independent utilization of the ancestral PRL template [ 12 ]. (biomedcentral.com)
  • Paul, who is able to get his immediate family to the hotel which is still largely seen as a place of sanctuary, will have to use the considerable skills he has used to run the hotel as well as he has instead to keep himself, his family and any others taking refuge at the hotel alive, whether bunny hop halo infinite be Hutu or Tutsi. (watanianews.net)
  • An overriding theme characteristic of the PRL and GH families is their association with pregnancy and regulatory mechanisms controlling viviparity. (biomedcentral.com)
  • In this review we examine the structure, expression patterns, and biological actions of the pregnancy-specific PRL and GH families. (biomedcentral.com)
  • Lists of PRL and GH family members from the mouse and rat, bovine and ovine, and human and rhesus monkey are provided in Tables 1 , 2 and 3 . (biomedcentral.com)
  • To date at least 26 separate mouse genes encoding members of the PRL family have been localized within a one-megabase segment [ 4 ]. (biomedcentral.com)
  • Research has shown there are many other factors such as family history, smoking, hypertension, obesity, and/or a high cholesterol, high fat diet that may contribute towards the development of macular degeneration. (laderavision.com)
  • To examine the involvement of c-Fos protein in light-induced photoreceptor cell death in rats. (arvojournals.org)
  • There was an acute accumulation of c-Fos protein in photoreceptors associated with cell death. (arvojournals.org)
  • A family of structurally related angiogenic proteins of approximately 70 kDa in size. (nih.gov)
  • Angiogenic Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS. (umassmed.edu)
  • This graph shows the total number of publications written about "Angiogenic Proteins" by people in this website by year, and whether "Angiogenic Proteins" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Angiogenic Proteins" by people in Profiles. (umassmed.edu)
  • CXCL10 is involved in chemotaxis, induction of apoptosis, regulation of cell growth and mediation of angiostatic effects. (spandidos-publications.com)
  • Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. (cusabio.com)
  • The chemokine interferon-γ inducible protein 10 kDa (CXCL10) is a member of the CXC chemokine family which binds to the CXCR3 receptor to exert its biological effects. (spandidos-publications.com)
  • CXCL10 specifically activates a receptor, CXCR3, which is a seven trans-membrane-spanning G protein-coupled receptor ( 6 ) predominantly expressed on activated T lymphocytes (Th1) ( 7 ), natural killer (NK) cells, inflammatory dentritic cells, macrophages and B cells ( 8 , 9 ). (spandidos-publications.com)
  • Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. (cusabio.com)
  • A major role of chemokines is to mediate leukocyte migration through interaction with G-protein-coupled receptors. (medscape.com)
  • Chemokines are a superfamily of 8- to 10-kDa soluble chemotactic cytokines that bind to their connate G protein-coupled receptors to cause a cellular response, such as migration, adhesion, or chemotaxis. (molvis.org)
  • The chemokine family contains many regulators of inflammation, cellular function and cellular migration-all critical factors in understanding the potential potency of a novel cellular therapeutic. (biomedcentral.com)
  • 17. Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion. (nih.gov)
  • The interferon-induced angiostatic CXC chemokines, monokine induced by interferon (Mig/CXCL9) and interferon-inducible T-cell chemoattractant (I-TAC/CXCL11), also activate CXCR3. (spandidos-publications.com)
  • 11. The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis. (nih.gov)
  • 8. Inadequate activation of the GTPase RhoA contributes to the lack of fibronectin matrix assembly in von Hippel-Lindau protein-defective renal cancer cells. (nih.gov)
  • Matrix metalloproteinases (MMPs) are a tightly regulated family of proteolytic enzymes that break down extracellular matrix (ECM) and basement membrane components. (bvsalud.org)