• Excitatory amino acid transporter 1 (EAAT1) is a protein that, in humans, is encoded by the SLC1A3 gene. (wikipedia.org)
  • EAAT1 is also often called the GLutamate ASpartate Transporter 1 (GLAST-1). (wikipedia.org)
  • Many of the well studied efflux transporters, such as P-glycoprotein (P-gp), MRP2, and BCRP are members of the ATP-binding cassette transporter superfamily. (aspetjournals.org)
  • Cross-species target mining identified two genes, interleukin-8 ( IL-8 ) and solute carrier family 1 (glial high affinity glutamate transporter), member 3 ( SLC1A3 ), which were uniformly expressed in dog but not in all pediatric osteosarcoma patient samples. (biomedcentral.com)
  • The key factor determining transmembrane lactate transport is the monocarboxylate transporter 1 protein coded for by the SLC16A1 gene. (biomedcentral.com)
  • In French-Canadian HMSN/ACC patients, a mutation was identified in a gene, which encodes a potassium/chloride cotransporter (KCC3), solute carrier family 12 member 6 (termed SLC12A6 ) located on chromosome 15q13-q14. (nature.com)
  • We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. (stowers.org)
  • Expression of each cluster's gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq. (stowers.org)
  • Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is defined by a cytosine, adenine, guanine (CAG) repeat expansion in exon 1 of the huntingtin gene leading to the production of mutant huntingtin (mHtt). (bmj.com)
  • Solute Carrier Family 6 Member 1 (SLC6A1) has been identified as a cancer-promoting gene in various human cancers, such as clear cell renal cell carcinoma and ovarian cancer. (biomedcentral.com)
  • Risperidone-induced weight gain is associated with a number of factors, including gene polymorphisms ( 12 - 14 ), exercise ( 15 - 17 ), peripheral molecules ( 18 ), and hyperphagia caused by regulating the expression of melanocortin-4 receptor (MC4R), neuropeptide Y (NPY), and agouti-related peptide (AgRP) ( 19 - 21 ). (frontiersin.org)
  • Members of both the SLC4 and SLC26 mammalian gene families encode Na + -independent Cl - -HCO3 - exchangers. (tcdb.org)
  • Hypoxia was found to induce A498 cell invasion, migration, and the release of inflammatory cytokines, while repressing human solute carrier family 14 member 1 gene expression. (biomedcentral.com)
  • Overexpression of the solute carrier family 14 member 1 gene could abolish hypoxia-induced invasion, reduce the migration of A498 cells, inhibit the hypoxia-induced release of inflammatory cytokines, and arrest the cell cycle at the G1/S checkpoint. (biomedcentral.com)
  • The results elucidate a mechanism wherein the solute carrier family 14 member 1 gene participates in the occurrence and development of hypoxia-induced renal cell carcinoma in a mitochondria-dependent manner. (biomedcentral.com)
  • Therefore comparative genomic analysis of T . equi was undertaken to: 1) identify genes contributing to immune evasion and persistence in equid hosts, 2) identify genes involved in PBMC infection biology and 3) define the phylogenetic position of T . equi relative to sequenced apicomplexan parasites. (biomedcentral.com)
  • Rifampin (an organic anion-transporting peptide 2 inhibitor) or GG918 [GF120918 ( N -(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide)] (a potent P-glycoprotein inhibitor) were used to estimate effects of uptake or efflux transporters on digoxin metabolism. (aspetjournals.org)
  • Specific point mutations in human anion exchanger 1 (AE1) convert this electroneutral anion exchanger into a monovalent cation conductance. (tcdb.org)
  • AEs 1-3), Na + -coupled anion exchange (e.g. (tcdb.org)
  • The goal of this study is to investigate whether these dicationic drugs are substrates for human organic cation transporters (hOCTs, solute carrier family 22A1-3) and whether hOCTs play a role in their tissue distribution, elimination, and toxicity. (aspetjournals.org)
  • Membrane trafficking defects caused by mutation in OCRL may explain renal tubular defects observed in Lowe syndrome, including the inability of proximal tubular cells (PTC) to reabsorb low-molecular weight (LMW) proteins and other solutes such as phosphorus and bicarbonate from the glomerular filtrate. (medscape.com)
  • Elevated levels of solute carrier family 14 member 1 expression induced mitochondrial reactive oxygen species accumulation, diminished the intracellular adenosine triphosphate level, and destroyed both mitochondrial membrane potential integrity and mitochondrial morphology. (biomedcentral.com)
  • Transfection of a miR-181b inhibitor could increase the expression levels of the ferroptosis-related proteins solute carrier family 7 members 11 (SLC7A11) and glutathione peroxidase 4 (GPX4), thereby inhibiting the occurrence of ferroptosis in chondrocytes. (biomedcentral.com)
  • In humans, the AE family (also called the SLC4 family) is composed of 10 paralogous members, among which are the proteins that perform Na + -independent Cl-HCO 3 - exchange (e.g. (tcdb.org)
  • As noted above, the AE or solute carrier 4 (SLC4) family includes 10 members (SLC4A1-5, SLC4A7-11), which are expressed in multiple tissues in the human body. (tcdb.org)
  • As a member of ICT,SLC6A1 encodes sodium- and chloride-dependent gamma amino-butyric acid (GABA) carrier (GAT-1), and restores it to presynaptic terminals by eliminating GABA with synaptic cleft [ 11 ]. (biomedcentral.com)
  • Description: A sandwich ELISA kit for detection of Solute Carrier Family 1, Member 5 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (glideruniversity.org)
  • Gallus gallus solute carrier family 17 member 8 (SLC17A8), mRNA. (genomes.nl)
  • Risperidone upregulates fatty acid synthase (FASN) and sterol regulatory element-binding protein 1 (SREBP1) expression in hepatocyte cultures and mouse liver by targeting the hepatic SREBP-1c/FASN couple, which is also one of the mechanisms by which risperidone induces weight gain ( 24 ). (frontiersin.org)
  • Interestingly, ZNFX1 antisense RNA 1 (ZFAS1) could abolish its tumor suppressor effect by binding microRNA (miR)-150, while miR-150 could inhibit the invasion of hepatic carcinoma cells by inhibiting zinc finger E-box binding homeobox 1 (ZEB1) and matrix metalloproteinases (MMP)14 and MMP16 ( 10 ). (spandidos-publications.com)
  • During exercise, one of the most important factor in muscle tissue is oxygen availability, which determinates carbohydrate and lactate metabolism [ 1 ]. (biomedcentral.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Solute Carrier Family 1, Member 5 (SLC1A5) in Tissue homogenates, cell lysates and other biological fluids. (glideruniversity.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Solute Carrier Family 1, Member 5 (SLC1A5) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (glideruniversity.org)
  • By developing novel tools and harnessing the power of metabolomics, proteomics and functional genomics, our lab will define 1) how the lysosome communicates with other cellular compartments to fulfill the metabolic demands of the cell under various metabolic states, 2) and how its dysfunction leads to rare and common human diseases. (stanford.edu)
  • Additional members of the phylum Apicomplexa, important to global human and animal health include the organisms in the genus Plasmodium as well as T . parva and T . annulata , and Babesia bovis causes of malaria, bovine theileriosis and babesiosis, respectively. (biomedcentral.com)
  • For a more thorough review of the role of phosphatidylinositol and the cellular and physiological functions of OCRL1 please refer to the following 2 reviews: (1) McCrea HJ, De Camilli P. Mutations in phosphoinositide metabolizing enzymes and human disease. (medscape.com)
  • Runt-related transcription factor 2 (RUNX2) belongs to the RUNX family (including RUNX1-3) and has been recognized as a key modulator and master transcription factor for osteogenesis, as well as prostate and skeletal development ( 4 - 7 ). (spandidos-publications.com)
  • The intercellular level of glutathione (GSH) is mainly affected by solute carrier family 7 member 11 (SLC7A11), which is an essential constituent of the amino acid antiporter system xc- [ 11 ]. (biomedcentral.com)
  • branched chain amino acid transaminase 1. (gsea-msigdb.org)
  • Three metabolites - pipecolate (metabolomic biomarker of B6 and folate intakes), pyridoxate (marker of B6 and folate) and docosahexaenoate (DHA, marker of B6) - were associated with 10, 3 and 1 differentially methylated positions (DMPs), respectively. (bvsalud.org)
  • doi:10.1302/0301-620X.93BSUPP_I.0930069b (inactive 1 August 2023). (wikipedia.org)
  • 15(1): 166, 2023 Oct 19. (bvsalud.org)
  • APOE associated to the LVP allows the initial virus attachment to cell surface receptors such as the heparan sulfate proteoglycans (HSPGs), syndecan-1 (SDC1), syndecan-1 (SDC2), the low-density lipoprotein receptor (LDLR) and scavenger receptor class B type I (SCARB1) (PubMed:12970454, PubMed:12356718, PubMed:12913001, PubMed:28404852, PubMed:22767607). (proteopedia.org)
  • BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
  • cornichon family AMPA receptor auxilia. (gsea-msigdb.org)