Alzheimer DiseaseAmyloid beta-Peptidestau ProteinsAmyloid beta-Protein PrecursorAge of OnsetBrainNeurofibrillary TanglesPlaque, AmyloidApolipoprotein E4Presenilin-1Amyloid Precursor Protein SecretasesDementiaCognition DisordersAtrophyNeuropsychological TestsAmyloidDementia, VascularPresenilin-2Apolipoproteins ENeurofibrilsMild Cognitive ImpairmentMagnetic Resonance ImagingPeptide FragmentsAgingHippocampusMental Status ScheduleMice, TransgenicNeuronsGenetic Predisposition to DiseaseCognitionMutationLewy Body DiseaseMemantinePresenilinsAspartic Acid EndopeptidasesDisease Models, AnimalAniline CompoundsLongitudinal StudiesDisease ProgressionCholinesterase InhibitorsGenotypePedigreeCerebral CortexNational Institute on Aging (U.S.)Memory DisordersSubstantia InnominataCase-Control StudiesCerebral Amyloid AngiopathyNerve DegenerationNeurodegenerative DiseasesAutopsyAmyloidogenic ProteinsRisk FactorsDown SyndromeTime FactorsCohort StudiesBiological MarkersBrain ChemistryProdromal SymptomsPositron-Emission TomographyParkinson DiseaseAge FactorsProtease NexinsPhenylcarbamatesTauopathiesFamily HealthAllelesNootropic AgentsNerve Tissue ProteinsIndansSeverity of Illness IndexGenetic TestingLewy BodiesClioquinolThiazolesFrontotemporal DementiaDNA Mutational AnalysisAmnesiaMolecular Sequence DataTemporal LobePolymorphism, Single NucleotidePsychomotor AgitationReference ValuesNeuropil ThreadsGene FrequencyMembrane ProteinsHeterozygoteImmunohistochemistryApolipoprotein E3InsulysinPhosphorylationAmino Acid SequenceMemoryTacrineModels, BiologicalPhenotypeFollow-Up StudiesChromosomes, Human, Pair 21Monomeric Clathrin Assembly ProteinsPsychiatric Status Rating Scales