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  • mutations
  • To test the hypothesis whether isolated appearance of individual AMRF syndrome features could be related to heterozygote SCARB2 mutations, we screened for SCARB2 mutations in unrelated patients showing isolated AMRF features. (uni-muenchen.de)
  • renal
  • Hemorrhagic fever with renal failure syndrome (HFRS) occurs mainly in Europe and Asia and is characterized by fever and renal failure associated with hemorrhagic manifestations. (medscape.com)
  • Hemorrhagic fever with renal failure syndrome is caused by an airborne contact with secretions from rodent hosts infected with the group of viruses belonging to the genus Hantavirus of the family Bunyaviridae . (medscape.com)
  • Hemorrhagic fever with renal failure syndrome was initially recognized between 1913 and 1930 by Soviet scientists, who described sporadic outbreaks of fever with renal failure in the eastern Soviet Union. (medscape.com)
  • The disease came to the attention of the Western world in 1950, when the North American soldiers serving with the United Nations forces in Korea developed a febrile illness associated with shock, hemorrhage, and renal failure. (medscape.com)
  • T-cell activation occurs very early in the course of hemorrhagic fever with renal failure syndrome and is associated with an absolute increase in the number of neutrophils, monocytes, B cells, and CD8+ (suppressor) T cells. (medscape.com)
  • Interferon-gamma-producing T cells may help reduce the risk of progression to acute renal failure. (medscape.com)
  • Activation of both classic and alternative complement pathways also occurs in hemorrhagic fever with renal failure syndrome. (medscape.com)
  • Some investigators have suggested that hemorrhagic fever with renal failure syndrome is primarily an allergic disease. (medscape.com)
  • The mutation screening of unrelated patients with isolated AMRF features affected by either epilepsy (n = 103, progressive myoclonus epilepsy or generalized epilepsy), demyelinating polyneuropathy (n = 103), renal failure (n = 192) or dilated cardiomyopathy (n = 85) was performed as high resolution melting curve analysis of the SCARB2 exons. (uni-muenchen.de)
  • No mutations were found in the epilepsy, renal failure or dilated cardiomyopathy samples. (uni-muenchen.de)
  • The acronym stands for Hyperuricemia, Pulmonary hypertension, Renal failure in infancy and Alkalosis. (wikipedia.org)
  • severe
  • citation needed] Pearson Marrow Pancreas Syndrome (PMPS) is a condition that presents itself with severe reticulocyto-penic anemia. (wikipedia.org)
  • A subset of SCN4 has severe primary pulmonary hypertension and respiratory failure. (wikipedia.org)
  • hematopoietic
  • In the majority of cases, these syndromes are the result of the immune-mediated destruction of hematopoietic stem cells or their progenitors at various stages of differentiation. (frontiersin.org)
  • Microbial infection has also been associated with hematopoietic stem cell injury and may lead to associated transient or persistent BM failure, and recent evidence has highlighted the potential impact of commensal microbes and their metabolites on hematopoiesis. (frontiersin.org)
  • Gluckman E, Wagner JE (2008) Hematopoietic stem cell transplantation in childhood inherited bone marrow failure syndrome. (springermedizin.de)
  • Peffault de Latour R, Peters C, Gibson B et al (2015) Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes. (springermedizin.de)
  • Although little is known about the pathogenesis of bone marrow failure in each of these disorders, allogeneic hematopoietic stem cell transplantation is the only curative treatment for most patients. (haematologica.org)
  • Treatment with androgens and hematopoietic (blood cell) growth factors can help bone marrow failure temporarily, but the long-term treatment is bone marrow transplant if a donor is available. (wikipedia.org)
  • Genetic
  • 2015). For a discussion of genetic heterogeneity of infantile liver failure syndrome, see ILFS1 (615438). (malacards.org)
  • With the use of molecular genetic testing, the deletions of mitochondrial DNA with Pearson syndrome ranges in size from 1.1 to 10 kilobases. (wikipedia.org)
  • The discovery of LIMP-2 as a component of this complex came about from a genetic screen of a homozygous, hypertensive transgenic rat model of renin overexpression, in which a population of these rats rapidly develop heart failure and another remains compensated. (wikipedia.org)
  • Perfusion
  • A significant number of patients with heart failure have underlying coronary artery disease and may be at greater risk from hemodynamic alterations that can diminish coronary perfusion. (onlinejacc.org)
  • In acute decompensated heart failure, the immediate goal is to re-establish adequate perfusion and oxygen delivery to end organs. (wikipedia.org)
  • treatment of acute
  • We therefore investigated the potential of combining the ex-vivo expansion of haematopoitic cells with mesenchymal stem cells infusion for the treatment of acute radiation syndrome. (irsn.fr)
  • Istaroxime is now under development for treatment of acute decompensated heart failure by CVie Therapeutics, a Taiwanese pharmaceutical company owned by Lee's Pharmaceutical Holdings Limited that in July 2012 has acquired from Sigma-Tau the patents and rights on Istaroxime and related compounds. (wikipedia.org)