• In this review, we summarize the current understanding of the molecular mechanisms by which SUMOylation pathways regulate skeletal cells in physiological and disease contexts. (mdpi.com)
  • Natriuretic peptide signaling has been implicated in a broad range of physiological processes, regulating blood volume and pressure, ventricular hypertrophy, fat metabolism, and long bone growth. (elifesciences.org)
  • Among the components of this signaling pathway, we show that natriuretic peptide receptor 3 (Npr3) plays a pivotal role by differentially regulating two developmental programs through its dual function as clearance and signaling receptor. (elifesciences.org)
  • Using a combination of MO-based knockdowns, pharmacological inhibitors and rescue assays we demonstrate that Npr3 cooperate with guanylate cyclase natriuretic peptide receptor 1 (Npr1) and natriuretic peptides (Nppa/Nppc) to regulate NC and CP formation, pointing at a broad requirement of this signaling pathway in early embryogenesis. (elifesciences.org)
  • We propose that Npr3 acts as a clearance receptor to regulate local concentrations of natriuretic peptides for optimal cGMP production through Npr1 activation, and as a signaling receptor to control cAMP levels through inhibition of adenylyl cyclase. (elifesciences.org)
  • Fas antigen, also termed APO-1 or CD95, is a transmembrane protein and a member of the tumor necrosis factor receptor/nerve growth factor receptor superfamily which mediates apoptosis upon oligomerization. (nih.gov)
  • Moreover, supplement of osteogenesis chemical compounds is commonly applied to improve the differentiation efficiency. (researchsquare.com)
  • Moreover, peptide addition could apparently up-regulate the expression of marker gene/protein in hESCs, especially the differentiation efficiency was improved by determining the optimal treatment periods. (researchsquare.com)
  • Our work has a great value in improving the in vitro osteogenic differentiation efficiency of hPSCs by adding functional osteogenesis compounds at specific stages and promoting the fundamental and clinical applications of osteoblast like cells. (researchsquare.com)
  • The modification of proteins by s mall u biquitin-related mo difier (SUMO) molecules, SUMOylation, is a key post-translational modification involved in a variety of biological processes, such as chromosome organization, DNA replication and repair, transcription, nuclear transport, and cell signaling transduction. (mdpi.com)
  • In this study, we investigated whether the 5 known tooth-agenesis-causing MSX1 missense mutations disrupt this Pax9-potentiation effect, or if they lead to deficiencies in protein stability, protein-protein interactions, nuclear translocation, and DNA-binding. (versila.com)
  • The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. (nih.gov)
  • However, how to obtain enough functional seed cells of osteoblasts is still needed to be solved. (researchsquare.com)
  • In this regard, many kinds of growth factors have been applied to establish robust and efficient induction methods for the derivation of osteoblast like cells from hPSCs 8 , 9 . (researchsquare.com)
  • In tooth bud mesenchyme of mice, both proteins are required for the expression of Bmp4, which is the key signaling factor for progression to the next step of tooth development. (versila.com)
  • Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)