Transcription factor that regulatesDifferentiallyPathway that regulatesRegulatoryMetabolismHomologGenesPhosphorylationProteinEpidermalTumorNeurodevelopmentalExpressionTranscriptionallyViralHomeostasisAutophagyFunctional2020Fibroblast growthNeuronsChondrocytesNuclearDownstreamMolecularCellularProliferationTransmembraneCholesterolGenetic factorsEncodesDiseaseContextCellsCellProcessesSynthesisActivityObesityDysregulationPrevalenceInvestigate
Transcription factor that regulates1
  • Using Anatomics (anatomical phenotyping) coupled with GWAS, we identified and then validated a bHLH transcription factor that regulates the formation of root cortical aerenchyma, an important phenotype for water and nutrient acquisition. (psu.edu)
Differentially1
Pathway that regulates1
  • These results suggest TIEG and Itch contribute to a ubiquitin-dependent nonproteolytic pathway that regulates inducible Foxp3 expression and the control of allergic responses. (nih.gov)
Regulatory10
  • Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
  • As a TF, USF1 has a bidirectional regulatory function, being able to regulate gene expression by activating or suppressing the promoter region of target genes ( 5 , 6 ). (spandidos-publications.com)
  • Recent studies revealed pervasive binding of p53 to cis-regulatory elements (CREs), which are non-coding segments of DNA that spatially and temporally control transcription through the combinatorial binding of local transcription factors. (whiterose.ac.uk)
  • Although the role of p53 as a strong trans-activator of gene expression is well known, the co-regulatory factors and local sequences acting at p53-bound CREs are comparatively understudied. (whiterose.ac.uk)
  • By utilizing different sets of co-factors across CREs, we hypothesize that global p53 activity is guarded against loss of any one regulatory partner, allowing for dynamic and redundant control of p53-mediated transcription. (whiterose.ac.uk)
  • Transforming growth factor-beta (TGF-beta) signaling in naive T cells induces expression of the transcription factor Foxp3, a 'master' regulator of regulatory T cells (T(reg) cells). (nih.gov)
  • A list of regulatory projects within the regulated infrastructure section. (accc.gov.au)
  • Myogenic regulatory factors (MRFs): MyoD, Myf5, Myf6 and Myogenin. (wikipedia.org)
  • Myf5 is considered to be the earliest expressed regulatory factor gene in myogenesis. (wikipedia.org)
  • NEMO/IKK -gamma is the regulatory subunit of the inhibitor kappa kinase (IKK) complex and is required for the activation of the transcription factor NF-kappaB (NF-kB). (medscape.com)
Metabolism1
  • Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism. (springer.com)
Homolog1
  • Earlier, we reported that M1BP, a functional homolog of ZKSCAN3, regulates wingless (wg) and caspase-dependent cell death (apoptosis) in the Drosophila eye. (udayton.edu)
Genes4
  • Promoter region motif analysis indicated that ETV5 has more binding motifs and genes than USF1 itself for USF1‑regulated DEGs, indicating that USF1 may indirectly modulate gene expression by regulating ETV5 expression in Huh7 cells. (spandidos-publications.com)
  • Downstream genes, including lncRNA‑NEAT1 and TF‑ETV5, may also have potential functions in the regulated network by USF1 and have potential functions in the progression of HCC. (spandidos-publications.com)
  • The role of promoter proximal pausing of RNA polymerase II, which regulates transcription of several developmental genes by GAGA factor or Motif 1 Binding Protein (M1BP), has not been fully understood in cellular homeostasis. (udayton.edu)
  • Serum response factor (SRF) plays a central role during myogenesis, being required for the expression of striated alpha-actin genes. (wikipedia.org)
Phosphorylation2
  • Furthermore, miR-370 over-expression down-regulated the EGFR and hypoxia-inducible factor (HIF)-1α expression, and attenuated the extracellular single-regulated kinase (ERK)1/2 and AKT phosphorylation in XWLC-05 and H157 cells. (oncotarget.com)
  • Tumor necrosis factor receptor activation results in phosphorylation and inactivation of inhibitor kB by IKK, thus resulting in activation of NF-kB. (medscape.com)
Protein9
  • To investigate the effect of losartan on vascular remodeling and transforming growth factor-beta and phosphoinositide 3-kinase/protein kinase B pathway. (ijpsonline.com)
  • Hematoxylin and eosin staining was used to measure the thickness and diameter ratio of the aortic media of mice in each group, Masson staining was used to observe the content of collagen fibers in the aorta of mice in each group, elastic fibers in the aorta of mice in each group were stained, and transforming growth factor-beta and phosphoinositide 3-kinase/protein kinase B pathway protein expression. (ijpsonline.com)
  • Losartan has protective effect on aortic wall of rats with aortic dissection, and the mechanism may be through inhibiting transforming growth factor-beta 1 pathway, which activates downstream phosphoinositide 3-kinase/protein kinase B pathway related proteins, and then inhibits the expansion and progression of aortic dissection. (ijpsonline.com)
  • Polyglutamine-binding protein 1 ( PQBP1 ) is an RNA-splicing factor that, when mutated, in humans causes Renpenning syndrome, an X-linked intellectual disability disease characterized by severe cognitive impairment, but also by physical defects that suggest PQBP1 has broader functions in embryonic development. (xenbase.org)
  • The higher mRNA and protein expression of vWF in GC tumor stroma may be regulated by the VEGF-VEGFR2 signaling pathway in vitro and may contribute to GC progression in vivo . (biomedcentral.com)
  • Orthologous to human DRG1 (developmentally regulated GTP binding protein 1). (nih.gov)
  • DRG: a novel developmentally regulated GTP-binding protein. (nih.gov)
  • A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)
  • NF-kB activity is normally regulated via the inhibitor kB protein. (medscape.com)
Epidermal2
  • The role of the cbl oncogene in regulating epidermal growth factor receptor-mediated signalling. (edu.au)
  • Here, we show higher levels of epidermal growth factor receptor (EGFR), but lower levels of miR-370 expression in most human lung cancer cells and non-tumor cells. (oncotarget.com)
Tumor4
  • von Willebrand factor (vWF) is a potent regulator of angiogenesis, tumor growth, and metastasis. (biomedcentral.com)
  • Research on the GC-hemostasis association has revealed that the increased expression of tissue factor (TF) promotes the pathogenic conditions of coagulation, tumor growth, and angiogenesis [ 7 ]. (biomedcentral.com)
  • Activation of NF-kB prevents apoptosis in response to the tumor necrosis factor family of cytokines. (medscape.com)
  • Increased expression of tumor necrosis factor receptor-1 and elevated oxidative stress markers have been reported in a neonate with IP and encephalopathy. (medscape.com)
Neurodevelopmental2
  • In conclusion, our results indicate that DNA methylation regulates neurodevelopmental gene expression dynamics through steering transcription factor activity, but does not explain sexually dimorphic gene expression patterns in zebra finch telencephalon. (ugent.be)
  • Inactivation of DRG1, encoding a translation factor GTPase, causes a recessive neurodevelopmental disorder. (nih.gov)
Expression15
  • In addition to regulating cytoskeletal dynamics in the cytoplasm, actin modulates nuclear gene expression. (jneurosci.org)
  • Conversely, actin signaling regulates neuronal SRF-mediated gene expression. (jneurosci.org)
  • Furthermore, MeHg increased the expression of the transcriptional factor Sp1 and promoted its binding to REST gene promoter sequence. (nih.gov)
  • This resulted in over-expression of NDRG1, which in turn markedly up regulated two differentiation markers of the prostate tissue, p21 and cytokeratin 8/18. (scirp.org)
  • These results revealed that NDRG1 is functional in prostate cancer cells and able to induce expression of differentiation factors through p53 independent pathway. (scirp.org)
  • However, a strong association between DNA methylation and age-dependent gene expression was found for various transcription factors (i.e. (ugent.be)
  • Plasma and tissue samples were collected and levels of Vdr, Shp, Cyp7a1, Cyp24a1, and rodent fibroblast growth factor (Fgf) 15 expression, as well as levels of cholesterol, were measured. (nih.gov)
  • Induction of miR-370 over-expression significantly reduced the levels of EGFR expression and the EGFR 3'untranslated region (UTR)-regulated luciferase activity in XWLC-05 and H157 cells, suggesting that miR-370 may bind to the 3'UTR of EGFR mRNA. (oncotarget.com)
  • Our study indicates that miR-370 may bind to the 3'UTR of EGFR to inhibit EGFR expression and the growth, angiogenesis and metastasis of non-small cell lung cancer by down-regulating the ERK1/2 and AKT signaling. (oncotarget.com)
  • The role of vascular endothelial growth factor (VEGF) in differential vWF expression was investigated using cultured human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)
  • The aim of this dissertation is to identify and charaterize the factor(s) that binds the TRR and regulates NCF2 expression in response to TNF-alpha. (montana.edu)
  • Associated Genetic Factors: PAX3 and c-Met Mutations in PAX3 can cause a failure in c-Met expression. (wikipedia.org)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
  • Consequent abnormal expression of the cardiac and limb-specific T-box transcription factors lead to the malformations described in HOS. (medscape.com)
Transcriptionally1
  • The vital and functionally limiting cytosolic component of the NADPH oxidase, p67 phox, is transcriptionally regulated by TNF-alpha at the TNF-alpha Responsive Region (TRR) in the intragenic region of Neutrophil Cytosolic Factor 2 (NCF2), the gene which codes for p67 phox. (montana.edu)
Viral4
  • The National Institute of Mental Health (NIMH) and The National Institute of Neurological Disorders and Stroke (NINDS) solicit research grant applications to supp ort studies focused on viral and host genetic factors involved in HIV-1 Associated Neurocognitive Disorders (HAND) in the setting of highly active anti-retroviral therapy (HAART). (nih.gov)
  • The use of state-of-the-art genetic approaches (including transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequ encing, exome sequencing, & systems biology) to identify and validate (including in vitro models, animal models, & human samples) viral and host genetic factors which influence the pathophysiology of HAND are encouraged. (nih.gov)
  • Regulating viral traffic. (cdc.gov)
  • Other genetic and environmental factors, for example certain bacterial and viral infections, also affect the chances of developing this disorder. (medlineplus.gov)
Homeostasis2
  • Transcriptional Pausing Factor m1bp Regulates Cellular Homeostasis by " by Anuradha Venkatakrishnan Chimata, Hannah Darnell et al. (udayton.edu)
  • This data suggests that the cellular homeostasis response demonstrated by two independent cell death mechanisms, apoptosis and autophagy, can be regulated by a common transcriptional pausing mechanism orchestrated by M1BP. (udayton.edu)
Autophagy2
  • Apoptosis and autophagy are regulated independently by their genetic circuitry. (udayton.edu)
  • Selective autophagy relies on tags such as ubiquitin and a set of selectivity factors including selective autophagy receptors (SARs) to label specific cargo for degradation. (bvsalud.org)
Functional1
  • The functional role of candidate lipophagy factors (a total of 91) was tested using a custom siRNA array combined with high-content cholesterol efflux assays. (bvsalud.org)
20201
  • In the now final rule, EPA has revoked an earlier action taken in 2020, in which the agency declined to regulate HAP emissions from EGUs after comparing the costs of compliance relative to the benefits of regulation, relying at the time on the Supreme Court's decision in Michigan v. EPA, 576 U.S. 743 (2015). (elnonline.com)
Fibroblast growth1
  • If placed in cell culture, most myoblasts will proliferate if enough fibroblast growth factor (FGF) or another growth factor is present in the medium surrounding the cells. (wikipedia.org)
Neurons2
  • R62D-induced phenotypes strongly resemble neurons lacking SRF (Serum Response Factor). (jneurosci.org)
  • We provide evidence for MEF2A as the decisive factor defining the cellular response to OT: while OT induces neurite retraction in MEF2A expressing neurons, OT causes neurite outgrowth in absence of MEF2A. (preprints.org)
Chondrocytes1
  • Nonetheless, ESW treatment application down-regulate the intracellular levels of TNF-alpha and IL-10 by chondrocytes, suggesting that ESW might restore TNF-alpha and IL-10 production by osteoarthritic chondrocytes at normal levels. (biomedcentral.com)
Nuclear1
  • Scholars@Duke publication: Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. (duke.edu)
Downstream3
  • N-myc downstream regulated gene 1 (NDRG1), also known as differentiation related gene 1, was previously identified as an up - regulated gene upon cellular differentiation. (scirp.org)
  • However, the pathway downstream NDRG1, involving p21 and c8/18, regulating cell cycle progression and DNA synthesis is unfunctional. (scirp.org)
  • T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)
Molecular4
  • Methylmercury (MeHg) exposure has been related to amyotrophic lateral sclerosis (ALS) pathogenesis and molecular mechanisms of its neurotoxicity has been associated to an overexpression of the Restrictive Element 1 Silencing Transcription factor (REST). (nih.gov)
  • Upstream transcription factor 1 (USF1) is a canonical transcription factor (TF) and is associated with the pathogenesis of several cancers, but its biological functions and molecular targets in HCC remain unclear. (spandidos-publications.com)
  • Alternative splicing of pre-mRNAs is an important means of regulating developmental processes, yet the molecular mechanisms governing alternative splicing in embryonic contexts are just beginning to emerge. (xenbase.org)
  • However, the role and molecular mechanisms of miR-370 in regulating the growth and metastasis of lung cancer have not been clarified. (oncotarget.com)
Cellular2
  • Upstream transcription factor (USF) 1 belongs to the basic helix-loop-helix leucine zipper family and serves as a cellular transcription factor (TF). (spandidos-publications.com)
  • In this study, we identify the transcription factor MEF2A as the common link between OT and cellular changes symptomatic for ASD, encompassing neuronal morphology, connectivity, and mitochondrial function. (preprints.org)
Proliferation1
  • Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
Transmembrane2
  • Platelet-activating factor-mediated transmembrane signaling in human B lymphocytes is regulated through a pertussis- and cholera toxin-sensitive pathway. (jci.org)
  • These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta 1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [ 4 ]. (biomedcentral.com)
Cholesterol1
  • Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts). (springer.com)
Genetic factors4
  • Each stage has various associated genetic factors lack of which will result in muscular defects. (wikipedia.org)
  • Associated Genetic Factors: c-Met/HGF and LBX1 Mutations in these genetic factors causes a lack of migration. (wikipedia.org)
  • Associated Genetic Factors: PAX3, c-Met, Mox2, MSX1, Six, Myf5, and MyoD Mox2 (also referred to as MEOX-2) plays an important role in the induction of mesoderm and regional specification. (wikipedia.org)
  • Studies using these samples found associations between fatal outcomes and elevated liver enzyme levels, renal dysfunction, cytokine dysregulation, and genetic factors. (cdc.gov)
Encodes1
  • The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
Disease5
  • Here, we show that MM-derived macrophage migratory inhibitory factor (MIF) stimulates bone marrow stromal cells to produce the disease critical cytokines IL-6 and IL-8, prior to any cell-cell contact. (biomedcentral.com)
  • The etiology of this disease is complex and multifaceted, and numerous genetic and environment risk factors have been identified that modify disease incidence and severity. (biomedcentral.com)
  • von Willebrand factor (vWF), the macromolecular plasma glycoprotein named for its contribution to the hereditary bleeding disorder known as von Willebrand disease (vWD), functions as a key regulator of primary hemostasis. (biomedcentral.com)
  • several factors may contribute to emergence of a disease (see Table 1 for additional information). (cdc.gov)
  • The relatively large number of pediatric cases in this outbreak enabled closer investigation of factors associated with increased survival of pediatric patients with Ebola virus disease. (cdc.gov)
Context2
  • We designed and executed a massively parallel reporter assay (MPRA) to investigate the effect of transcription factor binding motifs and local sequence context on p53-bound CRE activity. (whiterose.ac.uk)
  • Finally, through identification of PLAGL2 binding partners, we have begun to determine a model by which PLAGL2 regulates transcription in a context dependent manner. (montana.edu)
Cells1
  • Platelet-activating factor (PAF) stimulates human B cells, resulting in elevation of intracellular calcium and the release of inositol phosphates. (jci.org)
Cell1
  • Here, we employed mass spectrometry to identify lipophagy factors within the macrophage foam cell LD proteome . (bvsalud.org)
Processes2
  • This review investigates the most important processes for removal of nutrients and organic matter, and the factors that regulate the efficiency of the coastal filter. (lu.se)
  • FDA has developed this guidance document to assist industry in following appropriate human factors and usability engineering processes to maximize the likelihood that new medical devices will be safe and effective for the intended users, uses and use environments. (fda.gov)
Synthesis1
  • It increases the synthesis of MMPs and plasminogen activator, essential to convert the pro-MMPs in MMPs, and regulate the organization of ECM by enhancing the synthesis of minor collagens, normally not present in cartilage, such as collagen types I and III, and decreasing the production of proteoglycans and collagen types II and IX, which represent the optimal scaffolding of cartilage [ 3 ]. (biomedcentral.com)
Activity3
  • Notably, a nucleus-resident actin (R62D NLS ) also regulates SRF's transcriptional activity. (jneurosci.org)
  • Our data suggest p53 has the flexibility to cooperate with a variety of transcription factors in order to regulate CRE activity. (whiterose.ac.uk)
  • A new CDC study examined the status of modifiable risk factors for ADRD among adults 45 years and older and found that high blood pressure and not meeting the aerobic physical activity guideline 2 were the most common, each affecting nearly 50% of adults. (cdc.gov)
Obesity5
  • Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. (biomedcentral.com)
  • One of the most significant risk factors is obesity. (biomedcentral.com)
  • However, many other factors appear to increase a person's predisposition to obesity, including endocrine disruptors (eg, bisphenol A [BPA]), gut microbiome, sleep/wake cycles, and environmental factors. (msdmanuals.com)
  • Some of these modifiable risk factors for ADRD include depression, diabetes, hearing loss, mid-life hypertension, physical inactivity, poor diet quality and obesity, poor sleep quality and sleep disorders, tobacco use, traumatic brain injury, and excessive alcohol use. (cdc.gov)
  • The prevalence of several modifiable risk factors, such as obesity and diabetes, was higher among Black and Latino populations than in other races and ethnicities. (cdc.gov)
Dysregulation1
  • Disturbances in Insulin-like growth factor-I (IGF-I) and dysregulation in neonatal immune responses have been associated with typical neonatal diseases. (uni-luebeck.de)
Prevalence2
  • Recent evidence suggests that the higher prevalence of ADRD among Black and Latino adults is related to higher rates of chronic health conditions and modifiable risk factors. (cdc.gov)
  • The prevalence of SCD increased from 3.9% among adults with no risk factors to 25.0% among those with four or more risk factors. (cdc.gov)
Investigate1
  • This study aims to investigate the overall self-regulated L2 learning strategy use of L2 learners depending upon the Strategic Self-Regulation (S[superscript 2]R) Model proposed by Oxford (2011), and to examine the relationships between their reported self-regulated L2 strategy use and their personality traits, identity, beliefs about L2 learning, and proficiency. (ed.gov)