• HED embraces a genetically heterogeneous group of diseases and is due to mutations of several genes that encode components of the tumor necrosis factor α (TNFα)-related signaling pathway (Cluzeau et al. (springer.com)
  • [ 4 ] The Hox genes, well described as the master regulators of development, encode a set of transcription factors that specify the identity of particular segments during embryogenesis. (medscape.com)
  • A remarkable proportion of the new neural crest genes encode soluble ligands that control neural crest precursor specification into each cell lineage, including pigmented, neural, glial, and skeletal derivatives. (biomedcentral.com)
  • Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
  • Since a missense mutation in the homeobox gene, MSX1, was previously linked to tooth agenesis in a single family lacking second premolars and third molars, we performed a mutational analysis of MSX1 by PCR. (nih.gov)
  • The rostral division of the neural tube into its 3 main sections falls under the control of homeobox (Hox) family of genes. (medscape.com)
  • In vitro, Mage-D1 not only binds to p75 neurotrophin receptor (p75NTR) but also to distal-less homeobox 1(Dlx1) and msh homeobox 1 (Msx1). (researchsquare.com)
  • Further studies confirmed that p75NTR participates in the regulation of tooth development maybe by changing the activity of the key factor distal-less homeobox/msh homeobox (Dlx/Msx), and melanoma-associated antigen D1 (Mage-D1) seems to be play a role in the differentiation and mineralization of EMSCs 5 , 6 . (researchsquare.com)
  • Polycomb group (PcG) proteins are key regulators of gene expression and developmental programs via covalent modification of histones, but the factors that interpret histone modification marks to regulate embryogenesis are less studied. (bvsalud.org)
  • Signaling mechanisms mediated by the Transforming Growth Factor-β (TGF-β) superfamily regulate a variety of developmental processes. (biomedcentral.com)
  • Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. (biomedcentral.com)
  • Differentiated somatic cells can be reprogrammed into a pluripotent-like state through four defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc (OSKM) [ 1 , 2 ]. (biomedcentral.com)
  • data indicate that linc00598 plays an important role in cell cycle regulation and proliferation through its ability to regulate the transcription of CCND2. (cusabio.cn)
  • The first regulator has effects on the second regulator such that the two regulators jointly regulate a target gene. (biomedcentral.com)
  • Nonetheless, the precise co-factors which help pSmad1/5 going into the particular nucleus to regulate Msx1 in dental mesenchymal cells remain unknown. (microtubule-signal.com)
  • In this review, we centered on some immune linked genes and analyzed their expressions while in the different developmental phases and sexes. (chk1inhibitor.com)
  • Review - Time for Radical Changes in Brain Stem Nomenclature - Applying the Lessons From Developmental Gene Patterns [1] "The traditional subdivision of the brain stem into midbrain , pons , and medulla oblongata is based purely on the external appearance of the human brain stem. (edu.au)
  • This essay recommends a new brain stem nomenclature based on developmental gene expression, progeny analysis, and fate mapping. (edu.au)
  • These proteins are transcription factors that control developmental pathways. (nih.gov)
  • Homeodomain proteins play key roles in development and gene regulation in eukaryotes. (embl.de)
  • Underlying the development of neural crest is a gene regulatory network, described as a set of interacting signals, transcription factors, and downstream effector genes that confer cell characteristics such as multipotency and migratory capabilities. (wikipedia.org)
  • A number of immune re sponsive effector genes exhibited distinctive expression patterns. (chk1inhibitor.com)
  • The absence of a mutation in exons 1 and 2 of MSX1 suggested that allelic mutations in the coding region of MSX1 are not associated with this phenotypically distinct form of oligodontia. (nih.gov)
  • Recent advances in understanding the molecular events underlying hypohidrotic ectodermal dysplasia (HED) caused by mutations of the genes encoding proteins of the tumor necrosis factor α (TNFα)-related signaling pathway have been presented. (springer.com)
  • Novel data were reviewed and discussed on the structure and functions of the components of TNFα-related signaling pathway, the consequences of mutations of the genes encoding these proteins, and the prospect for further investigations, which might elucidate the origin of HED. (springer.com)
  • The purpose of this report is to review current literature on the structure and function of components of the TNFα-related signaling pathway, to present a novel approach to their contribution in the differentiation of skin appendages and to discuss the role of mutations of genes encoding components of this pathway in the origin of HED. (springer.com)
  • Mutations of these genes are responsible for systemic tooth agenesis, in addition to the defects of other ectodermal structures, and this review is limited to description of the function of their protein products. (springer.com)
  • The molecular basis of non-syndromic tooth agenesis, which is caused by mutations of other genes mainly WNT10A , (Arte et al. (springer.com)
  • nonpolyposis CRC syndrome (Lynch syndrome), involve mutations Somatic mutations in the AXIN-complex proteins associated with in germline or in repair genes. (sagepub.com)
  • Mutations in this gene have been found in somatic sebaceous tumors. (cancer-genetics.org)
  • X linked Alport syndrome (ATS, OMIM 301050) is a hereditary glomerulonephritis resulting from either point mutations or intragenic deletions of the COL4A5 gene encoding the α5 chain of type IV collagen. (bmj.com)
  • With the exception of EDA1 and NEMO , both localized on the X chromosome, all other genes encoding components of the TNFα-related signaling pathway involved in differentiation of skin appendages, are localized on the autosomes (Table 1 ). (springer.com)
  • showed that knocking out Mage-D1 can induce the expression of autophagy-related genes by enhancing the activity and differentiation of osteoclasts, thereby accelerating the process of periodontitis 23 . (researchsquare.com)
  • 25 The downstream target genes of MAPK signaling cascades comprise of the differentiation related transcription aspects Jun ATF2/AP1, C/EBPB and Egr one, which are known to get necessary for myeloid differentiation. (chk1inhibitor.com)
  • 26 29 Yet, in spite of a lot of reviews for the function of important MAPK cascade kinases and their target genes in hematopoiesis,thirty it is not clear what reg ulates the MAPK cascades in VDD induced cell differentiation. (chk1inhibitor.com)
  • Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-β/activin/Nodal branches of TGF-β superfamily signaling are expressed in the developing subpallium. (biomedcentral.com)
  • Furthermore, Smad proteins, transcriptional effectors of TGF-β signaling, are co-expressed and physically interact in the basal ganglia with Dlx homeodomain transcription factors, which are critical regulators of the differentiation, migration and survival of telencephalic GABAergic neurons. (biomedcentral.com)
  • Lately, in vitro differentiation of human being embryonic stem cells proven that Wnt/-catenin signaling takes on an important part in releasing early genes that are necessary for NC advancement [22]. (globaltechbiz.com)
  • To check this hypothesis, we overexpressed inducible types of HES-1 and MSX-1 proteins in mouse ESCs and examined differentiation into Azlocillin sodium salt NC derivatives, including neural, soft muscle tissue, and chondrocyte-like cells, after activation of the transcription elements. (globaltechbiz.com)
  • Manifestation of Hes1 and Msx1 in Wild-type Sera Cells in Pluripotent Circumstances and after NC Differentiation To investigate the part of and in the differentiation of mESCs into neural crest cells, we utilized the stromal cell-inducing activity of Pre-adipose 6 (PA6) cells for 5 times [17], accompanied by the addition of BMP4, which commits cells to differentiate into NC derivatives [6]. (globaltechbiz.com)
  • This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. (cancer-genetics.org)
  • ED1 , encoding a ligand-ectodysplasinA-A1 (EDA-A1), EDAR , coding for ectodysplasinA-A1 receptor, EDARADD , programming the structure of EDAR-associated death domain protein and NEMO whose protein product, NFκB essential modulator (NEMO), is necessary for an indirect activation of nuclear factor κB (NFκB). (springer.com)
  • Furthermore, ectopic deposition of H2AK119ub on the Smad2 target gene gsc using a ring1a-smad2 fusion protein led to ectopic recruitment of RSF1. (bvsalud.org)
  • Morphorgens such as Wnt, fibroblast growth factor (FGF), retinoic acid (RA) and bone morphogenetic protein (BMP) secreted from the paraxial mesoderm and epidermis regulates the expression of a group of transcription factors ( Pax3, Zic1, Msx1 ) whereby defines the boarder of neural crest. (biomedcentral.com)
  • The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
  • MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
  • HD binding specificity increases by protein-protein interactions with a diversity of cofactors that outline the Hox interactome and determine the transcriptional landscape of the selected target genes. (biomedcentral.com)
  • Of particular interest are the protein interactions that occur between Hox proteins and general transcription factors (GTF) from the RNA Pol II basal transcription machinery. (biomedcentral.com)
  • This plethora of Hox protein-protein interactions clearly points to a Hox-driven transcription process in which every Hox homeoprotein could selectively recruit GTFs to achieve specificity and activate or repress target genes during Drosophila development, although the precise molecular mechanisms remain elusive [ 25 ]. (biomedcentral.com)
  • Four members of the mouse Dlx protein family (Dlx1, 2, 5 and 6), part of the Antennapedia class of non-Hox homeodomain transcription factors, are expressed in the embryonic subpallium (Panganiban and Rubenstein 2002 ). (biomedcentral.com)
  • Families of molecules such as those of Wnt, Hh (hedgehog), FGFs (Fibroblast Growth Factor) and BMPs (Bone Morphogenetic Protein, of TGFßs - Transforming Growth Factor family) have been identified, in different proportions and sites, with tissue-specific and stage-specific functions 1-2 . (bvsalud.org)
  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. (cancer-genetics.org)
  • The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. (cancer-genetics.org)
  • What does this gene/protein do? (cancer-genetics.org)
  • What pathways are this gene/protein implicaed in? (cancer-genetics.org)
  • As master transcriptional regulators, Hox proteins recognize DNA through the homeodomain (HD) and interact with a multitude of proteins, including general transcription factors and other cofactors. (biomedcentral.com)
  • We also examined the number of appearances of the 'regulator chain backbone', which represents a simple two-regulator one-way connection irrespective of the presence of a target gene common to the two regulators. (biomedcentral.com)
  • A frameshift mutation recently identified within the paired domain of the transcription factor, PAX9, has been linked to a unique form of oligodontia in a single, multigenerational family (Stockton et al. (nih.gov)
  • Although the etiology of dental agenesis The association between AXIN2 and CRC involves defects in the involved genetic and environmental factors, the genes more canonical WNT signaling pathway, which regulates and coordi- frequently associated with hypodontia in different populations are nates the AXIN complex for the degradation of β-catenin under 2,3 AXIN2, MSX1, PAX9, EDA, and WNT10. (sagepub.com)
  • They also modify transcription factors and CHROMATIN through ACETYLATION. (childrensmercy.org)
  • As a pluripotent and dynamic cell population, the cranial neural crest undergoes vast transcriptional and epigenomic alterations throughout the formation of facial structures pointing to an essential role of factors regulating chromatin state or transcription levels. (bvsalud.org)
  • Signaling events that establish the neural plate border lead to the expression of a set of transcription factors delineated here as neural plate border specifiers. (wikipedia.org)
  • The downstream signal transduction toward Eda-A1 involves the canonical Wnt/β-catenin pathway (Clevers 2006 ) and requires lymphoid enhancer-binding factor-1 (Lef-1) for activation of the Ed1 ( Ta ) expression (Durmowicz et al. (springer.com)
  • Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)
  • We established at mRNA level the expression of 84 genes partici pating inside the MAPK signaling network and cell cycle regulation employing Human MAP kinase RT2 Profile PCR Array. (chk1inhibitor.com)
  • The main ity of genes studied enhanced their expression in 40AF cells, and the 27 genes upregulated more than 2 fold, 10 with statistical significance, are listed in Table one. (chk1inhibitor.com)
  • N. lugens PGRP and GRP genes showed much higher expression levels in male adults than in female grownups. (chk1inhibitor.com)
  • These genes also had relatively large expression ranges in 2nd instar and/or 5th instar nymphs, even though extremely minimal levels were found in eggs. (chk1inhibitor.com)
  • Similarly, N. lugens CLIP genes also had substantially high expression levels in male grownups when when compared with the female adults. (chk1inhibitor.com)
  • The reeler gene showed a distinct expression pattern, together with the maximum transcript amounts staying detected from the 5th instar nymphs followed through the 2nd instar nymphs. (chk1inhibitor.com)
  • These novel interactions open the possibility to analyze promoter function and gene expression to measure transcription factor binding dynamics at target sites throughout the genome. (biomedcentral.com)
  • Within this region, their expression overlaps with that of Gad65 and Gad67 , genes encoding different forms of the rate-limiting enzyme required for production of GABA from glutamate. (biomedcentral.com)
  • regulating the expression of target genes. (sagepub.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancer-genetics.org)
  • Next, knockdown involving IPO7 canceled your upregulation associated with Msx1 caused by simply BMP4, whilst overexpression associated with Smad1 could recovery the particular Msx1 expression. (microtubule-signal.com)
  • There is an urgent need to update the names of brain stem structures to be consistent with the discovery of rhomobomeric segmentation based on gene expression. (edu.au)
  • Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression. (nih.gov)
  • There has been one previous report showing that overexpression of Sirt6 in aged human dermal fibroblasts could improve iPS generation via regulation of miR-766 transcription [ 19 ]. (biomedcentral.com)
  • Taken jointly, our information indicated that the actual regulation of Msx1 through BMP4/pSmad1/5 signaling is mediated through importin7 within mouse button dental care mesenchymal tissue.Cytokines communicate carefully with each other and also enjoy a crucial role in the continuing development of sepsis. (microtubule-signal.com)
  • Here, we focused on the interplay between Antp and the basal transcription machinery and show the direct interaction of Antp with TBP through the poly-glutamine (PolyQ) regions of both proteins. (biomedcentral.com)
  • They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. (childrensmercy.org)
  • In coherence with this observation, the promoter region of slug (a neural crest specific gene) contains a binding site for transcription factors involved in the activation of Wnt-dependent target genes, suggestive of a direct role of Wnt signaling in neural crest specification. (wikipedia.org)
  • Finally, ChIP along with Re-ChIP analysis revealed IPO7 helped the particular employment of pSmad1/5 for the Msx1 promoter. (microtubule-signal.com)
  • [ 5 ] The hindbrain is subsequently further segmented under the influence of Hox genes to give rise to rhombomeres, which are 8 transient neuroepithelial segments, denoted as r1 to r8. (medscape.com)
  • Based on human-mouse evolutionarily conserved transcription factor binding sites (TFBSs) in 76600 conserved blocks for 5169 genes, we compiled the human transcriptional connections into a matrix, and examined the number of FFC appearances in comparison with randomized networks. (biomedcentral.com)
  • A number sign (#) is used with this entry because pachyonychia congenita-4 (PC4) is caused by heterozygous mutation in the KRT6B gene (148042) on chromosome 12q13. (findzebra.com)
  • One of the simplest network motifs is autoregulation, in which a regulator (TF) regulates the gene that encodes the regulator itself. (biomedcentral.com)
  • We showed that knockdown of Xenopus RSF1, rsf1, not only induced gastrulation defects as reported previously, but specific targeted knockdown in prospective neural precursors induced neural and neural crest defects, with reductions of marker genes. (bvsalud.org)
  • Over 200 genes have been associated with odontogenesis 1-2 and dental defects 1,3 . (bvsalud.org)
  • Secreted from neighboring tissues, signaling molecules of the Wnt, Fgf, and Bmp families cooperate to activate a distinct combination of transcription factors at the neural plate border. (biomedcentral.com)
  • Many molecules and some gene cascades have been identified in the initial phases of tooth development: bud, cap, bell, and to a lesser degree, root formation 4-10 . (bvsalud.org)
  • Phylogeny: Evolutionary relationships between organisms or genes or molecules. (top5binarybrokers.com)
  • 4, 5 Until recently, the only known contiguous gene syndrome involving the COL4A5 gene was Alport syndrome and diffuse leiomyomatosis (ATS-DL, OMIM 308940), 6- 9 in which the deletion extends towards the centromere to include the first two exons of the adjacent COL4A6 gene. (bmj.com)
  • In cells receive the WNT signal, β-catenin is stabilized and joins the addition, AXIN2 has also been independently associated with DNA-bound T-cell factor family of transcription proteins for tooth agenesis and non-syndromic cleft lip palate (NSCLP). (sagepub.com)
  • Odontogenesis is the result of a manifestation of an polygenic system, in which the development genes manifest themselves in a sequential, cyclic pattern 1-2 . (bvsalud.org)
  • Hox proteins finely coordinate antero-posterior axis during embryonic development and through their action specific target genes are expressed at the right time and space to determine the embryo body plan. (biomedcentral.com)
  • The identification of neural crest specification genes expressed in the neural plate of basal chordates, in addition to the discovery of pigmented migratory cells in ascidians, has challenged this hypothesis. (biomedcentral.com)
  • The HOXD9 gene was highly expressed in a side population (SP) of SK-MG-1 cells that was previously identified as an enriched-cell fraction of glioma cancer stem-like cells. (123dok.net)
  • Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
  • The 1,25D delicate HL60 cells had been compared with 1,25D resistant 40AF cells, and this recognized, for the first time, hematopoietic progenitor kinase one as the most upregulated MAPK gene within the one,25D resistant cells. (chk1inhibitor.com)
  • We initiated this review by investigating gene alterations in vitamin D resistant 40AF cells in contrast with their parental vitamin D delicate HL60 G cells, which might reversible PARP inhibitor explain the acquisition of resistance. (chk1inhibitor.com)
  • In that regard, recent studies in non-neural cells have suggested the existence of functional interactions between Dlx proteins and Smad transcription factors, which are critical mediators of transforming growth factor-β (TGF-β) superfamily signaling pathways (Chiba et al. (biomedcentral.com)
  • RNA sequencing was measured to identify the differential expressed genes due to loss of Sirt6 in somatic and pluripotent cells. (biomedcentral.com)
  • In RA, synovial cells express genes and erosive enzymes that contribute to joint degradation. (cellapplications.com)
  • We found that transcripts were increased in MGR cells, whereas coactivation of HGR+MGR caused a significant increase in (-found that some of the transcription factors associated with the development of the NC are coexpressed with pluripotency factors at the blastula and gastrula stages. (globaltechbiz.com)
  • It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS. (bvsalud.org)
  • González, F. 2019-10-16 00:00:00 BDJOpen www.nature.com/bdjopen ARTICLE OPEN Variations in AXIN2 predict risk and prognosis of colorectal cancer 1 2 3 4 3 5 L. Otero , E. Lacunza , V. Vasquez , V. Arbelaez , F. Cardier and F. González OBJECTIVE: Colorectal cancer (CRC) and hypodontia are frequent and different diseases with common genes are involved in their etiology. (sagepub.com)
  • Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. (cusabio.cn)
  • When we reviewed pretransplantation factorHD, individual aspects including HCT-CI as well as Ps3 had been from the progression of candidemia, which implies which significantly not well patients together with transplantation-associated complications will build candidemia.Msx1 is vital for your upkeep of the actual odontogenic fate regarding dentistry mesenchymal cellular material, which is regulated simply by BMP/Smad1/5 signaling in a Smad4-independent way. (microtubule-signal.com)
  • 1- 3 Contiguous gene syndromes are phenotypically complex disorders associated with the deletion of multiple adjacent genes. (bmj.com)
  • NC development is tightly regulated by finely tuned gene regulatory network (GRN) and orchestrated hierarchically. (biomedcentral.com)
  • Together, these results suggest that TGF-β superfamily signaling plays a role in telencephalic GABAergic neuron development through functional interactions with Dlx transcription factors. (biomedcentral.com)
  • Real-world patient-reported outcomes and physician satisfaction with poly (ADP-ribose) polymerase inhibitors versus chemotherapy in patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2-negative advanced breast cancer from the United States, Europe, and Israel. (jefferson.edu)
  • Real-world study of patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2?Negative advanced breast cancer: Patient demographics, treatment patterns, adverse events, and physician-reported satisfaction in the United States, Europe, and Israel. (jefferson.edu)
  • Using a sequential blast pipeline, we phylogenetically classified these genes, as well as those associated with other tissues, in order to define tissue-specific profiles of gene emergence. (biomedcentral.com)
  • We propose that the evolution of the neural crest is linked not only to the recruitment of ancestral regulatory genes but also to the emergence of signaling peptides that control the increasingly complex lineage diversification of this plastic cell population. (biomedcentral.com)
  • In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)
  • The need for other pathways continues to be being researched: Notch signaling participation was founded through studies where gain- or loss-of-function of Notch signaling or the Notch effectors, genes, had been associated with standards, nC or induction migration [23,24,25,26]. (globaltechbiz.com)
  • We compiled the human transcriptional connections into a connection matrix, based on the computationally identified human-mouse conserved TF binding sites (TFBSs) of 82 well-annotated TFs in 76600 conserved blocks located within the 8-kb upstream sequences of 5169 human genes that were stringent orthologs to mouse counterpart genes. (biomedcentral.com)
  • 2000). We now describe the phenotypic and segregation analyses of this remarkable kindred, the initial approach taken to identify a candidate gene involved in this form of oligodontia, and the power of this single-family pedigree to generate significant linkage in a genome search. (nih.gov)
  • Mage-D1, also known as Dlxin-1 or NRAGE, was first cloned and identified as a new member of the type II melanoma-associated antigen gene family by Pold et al. (researchsquare.com)
  • Structurally, Mage-D1 possesses the N-terminal sequence Mage homology domain 2 (MHD2), which is a highly conserved structure of the type II Mage gene family. (researchsquare.com)
  • We also show that Dlx and Smad proteins localize to promoters/enhancers of a number of common telencephalic genes in vivo and that Smad proteins co-activate transcription with Dlx family members, except with certain mutated human DLX proteins identified in autistic individuals. (biomedcentral.com)
  • In 1998, we described a new Xq22.3 contiguous gene syndrome which we named AMME (OMIM 300194) because of the distinctive features observed in affected males: Alport syndrome (A), mental retardation (M), midface hypoplasia (M), and elliptocytosis (E). 10 After the original publication, clinical re-evaluation of the family showed alterations of cardiac rhythm and morphology on echocardiography. (bmj.com)
  • The prototype of this family is the mouse Brachyury (or T) gene product. (nih.gov)
  • This gene regulatory network can be subdivided into the following four sub-networks described below. (wikipedia.org)
  • The transcriptional regulatory network of a cell is a complex system in which many transcription factor (TF) proteins turn gene expressions on and off according to spatiotemporal contexts. (biomedcentral.com)
  • Particularly, by performing transcriptome analysis, we observed that several pluripotent transcriptional factors increase in knockout cell line, which explains the underlying loss of pluripotency in Sirt6-null iPS-like cell line. (biomedcentral.com)
  • Host Cell Factor C1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • This graph shows the total number of publications written about "Host Cell Factor C1" by people in this website by year, and whether "Host Cell Factor C1" was a major or minor topic of these publications. (rush.edu)
  • Below are the most recent publications written about "Host Cell Factor C1" by people in Profiles. (rush.edu)
  • Importin7 (IPO7) is amongst the critical members of importin β-superfamily, generally responsible for nucleocytoplasmic driving regarding RNAs and meats, which include transcription aspects. (microtubule-signal.com)
  • Two defensin genes possessed selleck the identical ex pression pattern,whilst their transcripts have been detected with the highest ranges in male adults followed by the 5th instar nymphs, but were hardly detected inside the eggs or the 2nd instar nymphs. (chk1inhibitor.com)