There are currently 6 known mammalian ARF proteins, which are divided into three classes of ARFs: class 1: ARF1, ARF2, ARF3 class 2: ARF4, ARF5 class 3: ARF6. (wikipedia.org)
ADP-ribosylation factors (ARFs) are approximately 20-kDa guanine nucleotide-binding proteins recognized as critical components in intracellular vesicular transport and phospholipase D activation. (embl.de)
Jackson, C. L. & Casanova, J. E. Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors. (nature.com)
Morinaga, N., Tsai, S.-C., Moss, J. & Vaughan, M. Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain. (nature.com)
Elongation1
Here we show, in articular chondrocytes, that IL-1β-induces primary cilia elongation with alterations to cilia trafficking of arl13b. (biomedcentral.com)
Protein6
Structural studies of Arf1 and Arf6 have revealed that although these proteins feature the switch 1 and 2 conformational changes, they depart from other small GTP-binding proteins in that they use an additional, unique switch to propagate structural information from one side of the protein to the other. (wikipedia.org)
Wang C, Timmons CL, Shao Q, Kinlock BL, Turner TM, Iwamoto A, Zhang H, Liu H, Liu B. GB virus type C E2 protein inhibits human immunodeficiency virus type 1 Gag assembly by downregulating human ADP-ribosylation factor 1. (ucdenver.edu)
Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1). (embl.de)
They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1. (lookformedical.com)
It is the catalytic subunit of two distinct large protein complexes, mTOR complex 1 (mTORC1) and mTORC2. (bvsalud.org)
Hypoxia maintains HIFα protein expression through inhibition of prolyl hydroxylases and IL-1 is suggested to effect subunit expression at the level of transcription and in a similarly post-translational fashion [ 26 ]. (biomedcentral.com)
Proteins3
The small ADP ribosylation factor (Arf) GTP-binding proteins are major regulators of vesicle biogenesis in intracellular traffic. (wikipedia.org)
In the GTP-bound form of these proteins, the interswitch undergoes a two-residue register shift that pulls switch 1 and switch 2 up, restoring an active conformation that can bind GTP. (wikipedia.org)
ADP-RIBOSYLATION FACTOR 1 is involved in regulating intracellular transport by modulating the interaction of coat proteins with organelle membranes in the early secretory pathway. (ucdenver.edu)
Regulation2
mTOR activity is subjected to tight regulation in response to external nutrition and growth factor stimulation. (bvsalud.org)
In this review, we will summarize the earlier work establishing the ability of cAMP to dampen mTORC1 activation in response to insulin and growth factors and then discuss our recent findings demonstrating the regulation of mTOR signaling by the PKA- and PKG-dependent signaling pathways. (bvsalud.org)
Drugs1
Finally, the molecular mechanism of FGF2 secretion is used in the lab to develop inhibitors of this process with great potential for the development of drugs for cancer therapy that block the function of FGF2 as a tumor cell survival factor. (db-engine.de)
ARF11
The GDP/GTP structural cycles of human Arf1 and Arf6 feature a unique conformational change that affects the beta2beta3 strands connecting switch 1 and switch 2 (interswitch) and also the amphipathic helical N-terminus. (wikipedia.org)
Tumor2
Fig. 1: Cis elements in FGF2 required for unconventional secretion from tumor cells. (db-engine.de)
Other high-risk groups include patients with cancer, especially those who are neutropenic and those receiving broad-spectrum antibiotics, and individuals receiving immunosuppressive agents, including oral or intravenous steroids and tumor necrosis factor (TNF)-alpha blockers (patients with rheumatoid disorders). (medscape.com)
Diseases1
Additionally, nonsterile tape and contaminated wooden splints are other risk factors for cutaneous diseases. (medscape.com)
Major1
This graph shows the total number of publications written about "ADP-Ribosylation Factor 1" by people in this website by year, and whether "ADP-Ribosylation Factor 1" was a major or minor topic of these publications. (ucdenver.edu)
Contribution1
An in-depth and comprehensive understanding of the contribution of amyloid beta and other factors of AD is crucial for developing novel pharmacotherapies. (biomedcentral.com)
Structural1
The classical structural GDP/GTP switch is characterised by conformational changes at the so-called switch 1 and switch 2 regions, which bind tightly to the gamma-phosphate of GTP but poorly or not at all to the GDP nucleotide. (wikipedia.org)
Clinical1
The amyloid hypothesis has been the mainstream explanation for AD pathogenesis for decades, but all the prior clinical trials involving amyloid burden reduction failed (Tables 1 and 2 ). (biomedcentral.com)
Growth1
ADP-ribosylation factor plays a significant role in the growth of Mucorales. (medscape.com)
Present1
Risk factors such as diabetic ketoacidosis and neutropenia are present in most cases. (medscape.com)
Response2
Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β). (biomedcentral.com)
We have also shown the primary cilium elongates in response to IL-1β exposure. (biomedcentral.com)
Conditions1
Immunocompromising conditions are the main risk factors for mucormycosis. (medscape.com)
Cases1
Alzheimer disease (AD) is the most common dementia type and may account for 60-70% of dementia cases [ 1 ]. (biomedcentral.com)
Medical1
ADP-Ribosylation Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
Recent1
Below are the most recent publications written about "ADP-Ribosylation Factor 1" by people in Profiles. (ucdenver.edu)
Cholera toxin1
The name ADP-ribosylation factor derives from the discovery, in 1984, of the factor that confers sensitivity of the stimulator of adenylate cyclase (Gs) to cholera toxin, an ADP-ribosyltransferase (4). (nih.gov)
Gene2
In addition, it has been found that the epidermal growth factor receptor gene (EGFR) is frequently over-expressed and amplified in primary GBs. (cancerindex.org)
PDGF-BB stimulation decreased TMF-1 binding to the transcriptional regulator Brahma-related gene 1 (Brg-1) and released Brg-1 from the SWI-SNF chromatin remodeling complex. (silverchair.com)
Previously, treatment of a disease with biological factors and products which are treed in D24, required coordination of the disease with /therapy rather than /drug therapy. (nih.gov)
Transcriptional1
Previous study found that nuclear factor kappa B (NF-κB) is a major transcriptional factor in CCL5. (news-medical.net)
Golgi Apparatus1
The Golgi apparatus is a highly reactive organelle that exhibits functional and morphological perturbations in response to molecular-level and contextual factors. (molcells.org)
Family1
Furthermore, GRASP colocalized with endogenous ADP-ribosylation factors at the plasma membrane in transfected cells, suggesting that GRASP may modulate signaling by this family of small GTPases. (nih.gov)
Cytokines2
In addition, Dex carry MHC and T-cell costimulatory molecules to present allergens to induce the production of Th2 cytokines in allergic donors, which are important immunostimulatory factors of anaphylactic immune responses ( 17 , 18 ). (spandidos-publications.com)
Recent studies suggest that mast cells may also be involved in innate and adaptive immunity by producing high levels of chemokines and cytokines [ 1 - 3 ]. (biomedcentral.com)
1 Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shiver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. (nih.gov)
Small1
Moreover, knockdown of TMF-1 by small interfering RNA decreased nuclear translocation of PDGFRβ and caused significant up-regulation of the Brg-1/p53-regulated cell cycle inhibitor CDKN1A (encoding p21) without affecting PDGFRβ-inducible immediate-early genes. (silverchair.com)
Role3
Dendritic cells (DCs), which are a major subtype of antigen-presenting cells (APCs), serve a key role in the immunopathogenesis of AR ( 1 , 2 ). (spandidos-publications.com)
NSF, SNAPs, and synaptobrevins) that appear to serve a common role in membrane traffic, synaptic transmission, and organelle remodeling (1). (nih.gov)
Mast cells are best known for their role in immunoglobulin E (IgE)-dependent allergic responses as one of the most powerful reactions of the immune system [ 1 ]. (biomedcentral.com)
Structure1
The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms. (embl.de)
Vesicle1
We learned this from in vitro assays of membrane traffic, including those for intra-Golgi transport and nuclear vesicle and endosome fusion, which are inhibited by GTPgS and require the addition of cytosol or a cytosolic factor (7,8). (nih.gov)
Genetic2
Previously, it has been found that both genetic and epigenetic factors may play critical roles in its etiology and prognosis. (cancerindex.org)
It is likely that patient demographics and/or genetic factors influence the response to WTC dust injury and that these contribute to different pathological outcomes. (cdc.gov)
Nuclear1
In this paper, we show that a fraction of full-length cell surface platelet-derived growth factor (PDGF) receptor β (PDGFRβ) accumulates in the nucleus at the chromatin and the nuclear matrix after ligand stimulation. (silverchair.com)
Regions1
The classical structural GDP/GTP switch is characterised by conformational changes at the so-called switch 1 and switch 2 regions, which bind tightly to the gamma-phosphate of GTP but poorly or not at all to the GDP nucleotide. (wikipedia.org)
Active1
This suggests the presence of an additional activating factor in the active RalA-PLD1 complexes. (embl.de)
Disease1
Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa mediated by immunoglobulin E (IgE) ( 1 ). (spandidos-publications.com)