Factor xii deficiency. Medical search. Frequent questions

Background: Representative data on folate and vitamin B-12 dietary intake and status in low-income countries are rare, despite the widespread adoption of folic acid fortification. (ihsn.org)
Objective: The purpose of this study was to evaluate folate and vitamin B-12 intake, status, and risk factors for deficiency before implementation of a national fortification program in Cameroon. (ihsn.org)
In a subset of women and their 12- to 59-mo-old children (n = 396 pairs), plasma folate and vitamin B-12, as well as breast milk vitamin B-12, were analyzed. (ihsn.org)
Results: Vitamin B-12 and folate dietary intake patterns and plasma concentrations were similar for women and children. (ihsn.org)
Conclusions: Folate intake and status are inadequate among women and young children in Yaoundé/Douala, whereas low vitamin B-12 intake and status are more common in poor and rural areas, especially in the North. (ihsn.org)
By smothering her daughter in factor-50 sun screen she deprived the youngster of vitamin D, which is produced by the body as a reaction to sunlight on the skin. (ecochildsplay.com)
But experts said Tyler was one of a growing number of children found to be suffering from the condition or associated vitamin deficiencies attributed to a combination of less active modern lifestyles and a tendency to cover up more in the sun. (ecochildsplay.com)
British health officials now recommend people spend 15 minutes outside during peak sun hours three times a week to prevent vitamin D deficiency, as sunlight is responsible for 90 percent of our vitamin D intake. (ecochildsplay.com)
Rowe S. and Carr A.C. Global vitamin C status and prevalence of deficiency: A cause for concern? (otago.ac.nz)
Carr A.C. and Rowe S. Factors affecting vitamin C status and prevalence of deficiency: a global health perspective. (otago.ac.nz)
While extreme vitamin C deficiency is known to cause scurvy, it is less well known that mild to moderate deficiency can contribute to fatigue. (naturalfactors.com)
[6] Because of this, vitamin C deficiency can result in carnitine deficiency, which results in decreased energy production and may contribute to fatigue. (naturalfactors.com)
Vitamin C. https://lpi.oregonstate.edu/mic/vitamins/vitamin-C#deficiency. (naturalfactors.com)
Deficiency of vitamin B -12 is also very important factor for the edema. (alwaysayurveda.net)
A glycoprotein secreted by the cells of the GASTRIC GLANDS that is required for the absorption of VITAMIN B 12 (cyanocobalamin). (uchicago.edu)
Deficiency of intrinsic factor leads to VITAMIN B 12 DEFICIENCY and ANEMIA, PERNICIOUS. (uchicago.edu)
One study notes vitamin C supplementation may improve skin hydration and stimulate the production of collagen, two factors that can slow the appearance of again. (eatthis.com)
As the world's attention has been riveted upon the growing COVID-19 pandemic, many researchers have written brief reports supporting the hypothesis that vitamin D deficiency is related to the incidence and severity of COVID-19. (frontiersin.org)
The clear common thread among the top risk groups-vitamin D deficiency-may be being overlooked because of previous overstated claims of vitamin D benefits. (frontiersin.org)
Firstly, the innate immune system is impaired by vitamin D deficiency, which would predispose sufferers to viral infections such as COVID-19. (frontiersin.org)
Vitamin D deficiency also increases the activity of the X-chromosome-linked "Renin-Angiotensin" System, making vitamin D deficient individuals (especially men) more susceptible to COVID-19's deadly "cytokine storm" (dramatic immune system overreaction). (frontiersin.org)
Secondly, the groups who are at highest risk for severe COVID-19 match those who are at highest risk for severe vitamin D deficiency. (frontiersin.org)
And thirdly, the pattern of geographical spread of COVID-19 reflects higher population vitamin D deficiency. (frontiersin.org)
Both within the USA and throughout the world, COVID-19 fatality rates parallel vitamin D deficiency rates. (frontiersin.org)
Although randomized controlled trial results may be available eventually, the correlational and causal study evidence supporting a link between vitamin D deficiency and COVID-19 risks is already so strong that it supports action. (frontiersin.org)
The 141 author groups writing primarily about biological plausibility detailed how vitamin D deficiency can explain every risk factor and every complication of COVID-19, but agreed that other factors are undoubtedly at work. (frontiersin.org)
Two causal modeling studies and several analyses of variance strongly supported the hypothesis that vitamin D deficiency is a causal, rather than a bystander, factor in COVID-19 outcomes. (frontiersin.org)
The literature review also found that prophylactically correcting possible vitamin D deficiency during the COVID-19 pandemic is extremely safe. (frontiersin.org)
Current methods of anticoagulation to reduce VTE target plasma procoagulant activity via broad (e.g., vitamin K antagonists that reduce the circulating levels of γ-carboxylated clotting factors) or specific (e.g., new/direct oral anticoagulants that target factor Xa or thrombin) approaches. (zedira.com)
Low levels of vitamin D have long been identified as an unwanted hallmark of weight loss surgery, but now findings of a new Johns Hopkins study of more than 930,000 patient records add to evidence that seasonal sun exposure - a key factor in the body's natural ability to make the "sunshine vitamin" - plays a substantial role in how well people do after such operations. (hopkinsmedicine.org)
Sun exposure is critical in the synthesis of vitamin D, so the notion that people living in less sunny northern states may suffer from vitamin D deficiency is not surprising," says Peterson. (hopkinsmedicine.org)
However, the researchers note, obesity is a well-known risk factor for vitamin D deficiency, and patients preparing to undergo weight loss operations should be screened for it. (hopkinsmedicine.org)
The growing rates of obesity and increased popularity of bariatric surgeries mean that primary care clinicians and bariatric surgeons should consider screening their patients and correcting any confirmed vitamin D deficiency," says Peterson. (hopkinsmedicine.org)
Prothrombin is a vitamin K-dependent clotting factor. (labpedia.net)
It is most abundant and has the longest half-life of the vitamin K-dependent clotting factors. (labpedia.net)
This may be acquired by vitamin K deficiency or oral anticoagulants like warfarin therapy. (labpedia.net)
Participants will be given 25000 IU of oral retinyl Palmitate (Vitamin A) or Placebo once daily for 12 weeks. (who.int)

The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. (nih.gov)
[ 1 ] Blood coagulation is triggered by the exposure of tissue factor at injury sites and its interaction with activated factor VII, leading to the generation of minute quantities of thrombin. (medscape.com)
For use in patients with blood coagulation deficiencies. (medscape.com)
Factor XII is responsible for the contact activation of blood coagulation as seen in the activated partial thromboplastin time test (aPTT). (medscape.com)
However, factor XII, HK, PK and complement factor C1q participate in inflammatory responses that involve blood coagulation, fibrinolysis, and generation of kinins. (medscape.com)
It belongs to a group of drugs called blood coagulation factors. (rxwiki.com)
Hepatocytes express blood coagulation factor XII. (wikidoc.org)
Characterization of the human blood coagulation factor XII gene. (wikidoc.org)

Some of the recently discovered genetic risk factors, such as factor V Leiden and prothrombin G20210A mutations, are quite common in the population. (intechopen.com)
Factor II (prothrombin) disorders are rare. (msdvetmanual.com)
Prothrombin time results are impacted by prothrombin protein deficiency. (flebo.in)
Prothrombin (Factor II). (labpedia.net)
The deficiency of prothrombin will delay thrombin formation, leading to hemorrhagic symptoms. (labpedia.net)

2020. 12, 3286. (otago.ac.nz)
The prevalence of chronic energy deficiency in reproductive-aged women will be reduced to 15% by 2010 and less than 12% by 2020. (who.int)
The prevalence of overweight and obesity in adults will be controlled to a rate of less than 8% by 2010 and will increase to no more than 12% by 2020. (who.int)

A novel homozygous mutation (Gly1715Ser) causing hereditary factor V deficiency in a Chinese patient. (medscape.com)

To conclude, ID is still a public health problem in Morocco highlighting the necessity to implement effective national program, including efficient salt iodization, effective nutritional education and awareness, to control iodine deficiency and prevent IDD development. (who.int)
However, because of such factors as nutritional deficiencies, underfunded, lower-performing K-12 systems, and the destruction of the social safety net, the disadvantaged category now often includes students with severe cognitive and behavioral problems who come to community colleges because there is nowhere else for them to. (wsws.org)
[2] Vegans can experience B12 dietary deficiencies, but vegans can look for plant based sources of B12, including nutritional yeast, fortified foods, and B12 supplements. (naturalfactors.com)
Iron deficiency is the most common known form of nutritional deficiency. (cdc.gov)
The factors contributing to poor diets are limited financial resources and lack of access to health care and nutritional supplements. (americares.org)
environmental as well as nutritional factors playing a role [ 10-12 ]. (who.int)
3. In Africa, nutritional problems in infants and young children occur in a context characterized by factors such as the prevalent low birth weight, household food insecurity, inappropriate infant and young child feeding practices, including the absence of food safety and hygiene, and inadequate intake of proteins and energy foods. (who.int)
4. Over the past decade, the international community has intensified actions to fight against all these nutritional deficiencies. (who.int)
Consequently, different nutritional deficiency-related diseases are affecting millions of infants and young children. (who.int)
In 1998, 16 million deaths were caused by communicable diseases, maternal and perinatal conditions, childhood infections, tobacco-related illness and nutritional deficiencies. (who.int)

Mitterstieler G, Muller W, Geir W. Congenital factor V deficiency. (medscape.com)
Shirzadi M, Radfar AH, Dehghani M. Recurrent miscarriage in a woman with congenital factor V deficiency: a case report. (medscape.com)

Factor XII, also known as Hageman factor, is indicated when factor XII deficiency is suspected. (medscape.com)
Coagulation factor XII , also known as Hageman factor , is a plasma protein . (wikidoc.org)
Hageman factor was first discovered in 1955 when a routine preoperative blood sample of the 37-year-old railroad brakeman John Hageman (1918) was found to have prolonged clotting time in test tubes, even though he had no hemorrhagic symptoms. (wikidoc.org)
Hageman was then examined by hematologist Oscar Ratnoff , who found that Hageman lacked a previously unidentified clotting factor. (wikidoc.org)
[9] Ratnoff later found that the Hageman factor deficiency is an autosomal recessive disorder, after examining several related people who had the deficiency. (wikidoc.org)

This study was planned to evaluate the iodine status and the prevalence of iodine deficiency in a nationally representative sample of Moroccan WRA according to their socio-economic data and living areas. (who.int)
In the United States, the prevalence of iron-deficiency anemia among children declined during the 1970s in association with increased iron intake during infancy (1-3). (cdc.gov)

Different strategies may be needed to control deficiency of these nutrients in different regions of Cameroon. (ihsn.org)
Clinical deficiencies of nutrients may increase susceptibility to infections. (who.int)
But even if there is little variation in certain immune factors as claimed, there can be huge variations in other nutrients depending on what the mother eats. (westonaprice.org)
These data will be used to estimate deficiencies and toxicities of specific nutrients in the population and subgroups, to provide population reference data, and to estimate the contribution of diet, supplements, and other factors to serum levels of nutrients. (cdc.gov)

unlike the soft tissue bleeds and hemarthroses that characterize hemophilia A and B, abnormal bleeding in FXI deficiency typically involves mucosal tissues, which are rich in fibrinolytic activity (eg, the oral and nasal cavities and urinary tract). (medscape.com)
[6] As a result, the main concern related to factor XII deficiency is the unnecessary testing, delay in care, worry, etc. that may be prompted by the abnormal lab result. (wikidoc.org)
Mutations in the F10 -coding gene can cause factor X (FX) deficiency, leading to abnormal coagulation activity and severe tendency for hemorrhage. (karger.com)
Recent research clearly indicates that the underlying causes of autism are neurobiological disorders and combinations of different factors, such as environmental and genetic factors, and abnormality in the communication between neurons, probably associated with an abnormal set of neuropeptides in the brain [ 3 - 9 ]. (hindawi.com)
2011-08-16 · Factor XIII deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding. (firebaseapp.com)

The Eastern Mediterranean Region is experiencing a nutrition transition, characterized by the emergence of overnutrition and micro-nutrient deficiencies. (who.int)
Each year, micro-nutrient deficiencies take a heavy toll on infants and young children. (who.int)

Factor XII, factor XI, high-molecular-weight kininogen (HK), and prekallikrein (PK) are referred to as the contact factors. (medscape.com)
[6] All of this, including the mechanism of inheritance, also holds true for the other contact factors, prekallikrein (Fletcher factor) and high molecular weight kininogen . (wikidoc.org)

Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting. (medlineplus.gov)
Factor XII deficiency is a rare inherited disorder. (medlineplus.gov)

Delev D, Pavlova A, Heinz S, Seifried E, Oldenburg J. Factor 5 mutation profile in German patients with homozygous and heterozygous factor V deficiency. (medscape.com)
Asp68His mutation in the A1 domain of human factor V causes impaired secretion and ineffective translocation. (medscape.com)
Alsheikh S, Alghamdi R, Alqatari A, Alfareed A, AlSaleh M. Combined Factor V and VIII Deficiency with LMAN1 Mutation: A Report of 3 Saudi Siblings. (medscape.com)
The heterozygous variants p.Ser362Asn or p.Tyr384Ter indicate mild FX deficiency, but the compound heterozygous mutation of the two causes severe congenital FX deficiency and bleeding. (karger.com)

Factor XII deficiency is a deficiency in the production of factor XII (FXII), a plasma glycoprotein and clotting factor that participates in the coagulation cascade and activates factor XI. (wikipedia.org)
FXI remains on the surface and activates factor IX in plasma. (medscape.com)
Contact activation involves both protein-protein and protein-surface interactions that activates factor XII. (medscape.com)
Factor XIIa activates factor XI, which in turn leads to the activation of factor IX. (medscape.com)
Kallikrein activates factor XII, which, then initiates fibrinolysis by causing activation urokinase. (medscape.com)
Factor XII is part of the coagulation cascade and activates factor XI and prekallikrein in vitro. (wikidoc.org)
Contact to polyphosphates activates factor XII and initiates fibrin formation by the intrinsic pathway of coagulation with critical importance for thrombus formation. (wikidoc.org)

Afibrinogenemia is defined as a deficiency or absence of fibrinogen (coagulation factor I) in the blood. (medscape.com)
Acquired fibrinogen deficiency can be associated with several clinical conditions including excessive blood loss in the setting of surgery, trauma or postpartum hemorrhage, hemodilution from from massive transfusion, liver disease, increased consumption in the setting of cancer, DIC or tPA therapy, or assay interference with direct or other thrombin inhibitors. (medscape.com)
Fibrinogen (Factor 1). (labpedia.net)
Fibrinogen (factor I) converts to Fibrin. (labpedia.net)
Coagulation factors interact on platelet and endothelial cell surfaces to produce thrombin , which converts fibrinogen to fibrin. (msdmanuals.com)

The condition is of importance in the differential diagnosis to other bleeding disorders, specifically the hemophilias: hemophilia A with a deficiency in factor VIII or antihemophilic globulin, hemophilia B with a deficiency in factor IX (Christmas disease), and hemophilia C with a deficiency in factor XI. (wikipedia.org)
Zheng C, Zhang B. Combined deficiency of coagulation factors V and VIII: an update. (medscape.com)
Antihemophilic factor (Factor VIII). (labpedia.net)

What is folate deficiency anemia? (naturalnews.com)
Folate deficiency is often caused by not consuming enough foods that contain folate. (naturalnews.com)
However, even those who eat balanced diets have the potential of developing folate deficiency. (naturalnews.com)
Folate deficiency is much more common in older people , affecting one in 10 people aged 75 and above. (naturalnews.com)
However, the symptoms of folate-deficiency anemia may be similar to other blood conditions or health problems. (naturalnews.com)
People who already have folate-deficiency anemia may need to increase their dietary intake of folic acid , whether it's through their actual diet or supplementation. (naturalnews.com)
Pregnant women, in particular, should avoid drinking alcohol before and during pregnancy to reduce the risk of folate deficiency. (naturalnews.com)

Patients with exogenous immunosuppres- consideration of underlying host genetic factors. (cdc.gov)
Venous thrombosis is a multifactorial disease frequently related to the interaction of genetic and environmental risk factors. (intechopen.com)
Genetic analysis of these two mutations may help characterize the bleeding tendency and confirm congenital FX deficiency. (karger.com)
LABOGenetics XXL Cat provides you with extensive information on genetic diseases and risk factors as well as on coat colours and traits. (labogen.com)
Numerous genetic, acquired, and environmental factors can tip. (msdmanuals.com)

FXII deficiency tends to be identified during presurgical laboratory screening for bleeding disorders. (wikipedia.org)
Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. (medlineplus.gov)
Etiologically, nonplatelet hemostatic disorders can be divided those involving coagulation factors and those involving vascular aspects of hemostasis. (medscape.com)
Iodine deficiency disorders (IDD) affects nearly 1.9 million people worldwide. (who.int)
Most of the congenital coagulation protein disorders reported in domestic animals are deficiencies or abnormalities of a single factor. (msdvetmanual.com)

Bleeding disorder refers to a heterogenous group of diseases caused by deficiencies in platelet function or coagulation factors. (ghcgenetics.com)

Factor XIII deficiency is a congenital disorder that is inherited as an autosomal recessive trait and is associated with a variable bleeding tendency Acquired factor XIII deficiency is associated with liver failure, inflammatory bowel disease, leukemia, disseminated intravascular coagulation, Henoch-Schonlein purpura, systemic lupus erythematosus and exposure to certain drugs (phenytoin People with congenital (or inherited) factor XIII deficiency are born with low levels of factor XIII in the blood. (firebaseapp.com)
Congenital factor XIII deficiency is very rare, affecting only 1 in 2 million people - about 100-125 people in the US. (firebaseapp.com)
Deficiency of factor XIII during and after CPB has been described, although the importance of this finding is uncertain. (firebaseapp.com)
143-146 Supplementation with human or recombinant factor XIII has been demonstrated to reduce bleeding after adult heart surgery, although possibly only in the presence of factor deficiency. (firebaseapp.com)
ous attempt to detect and remedy their difficulties or their deficiencies if these Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS Simulations of the Structure and Dynamics of Transcription Factor-DNA Recognition Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII. (firebaseapp.com)
Factor XIII deficiency is a rare bleeding disorder. (firebaseapp.com)
Factor XIII deficiency occurs exceedingly rarely, causing a severe bleeding tendency. (firebaseapp.com)
Factor XIII Deficiency Factor XIII (FXIII) is a tetrameric zymogen (FXIII-A (2)B (2)) that is converted into an active transglutaminase (FXIIIa) by thrombin and Ca (2+) in the terminal phase of the clotting cascade. (firebaseapp.com)
Factor XIII(a) crosslinking of fibrin α-chains mediates RBC retention in venous thrombi, and consequently, thrombus size. (zedira.com)
Factor XIII (FXIII) is a protransglutaminase that, once activated to FXIIIa, crosslinks fibrin and other proteins to the clot. (zedira.com)
Fibrin-stabilizing factor (Factor XIII). (labpedia.net)

Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation. (medscape.com)
FXI is a zymogen, and when activated by factor XIIa or thrombin or when it is autoactivated, FXI becomes a trypsinlike serine protease. (medscape.com)

Options include factor replacement with fresh frozen plasma, antifibrinolytic therapy with tranexamic acid, and fibrin glue. (medscape.com)
Platelet polyphosphate-driven factor XII activation provides the link from primary hemostasis (formation of a platelet plug ) to secondary hemostasis (fibrin meshwork formation). (wikidoc.org)

Some patients with dysfibrinogenemia have additional hemostasis defects, including factor V Leiden and deficiencies in antithrombin, protein C, and protein S. (medscape.com)
Factor V Leiden and Ischemic Stroke Risk: The Genetics of Early Onset Stroke (GEOS) Study. (medscape.com)
Known hereditary thrombophilia (Factor V Leiden, Protein C/ S deficiency, anti-phospholipid or anti-cardiolipin antibodies) k. (who.int)

Duckers C, Simioni P, Rosing J, Castoldi E. Advances in understanding the bleeding diathesis in factor V deficiency. (medscape.com)
No bleeding diathesis is associated with its deficiency. (medscape.com)

Complement factor I is a serine protease present in human plasma that is involved in the degradation of complement protein C3b, which is a major opsonin of the complement system. (hindawi.com)
Factor I cleaves C3b and C4b in a reaction, where fI is dependent on various cofactors, such as factor H, C4b-binding protein CR1 and membrane cofactor protein (MCP) [ 26 ]. (hindawi.com)
Type I deficiency is a quantitative defect resulting from decreased synthesis of the protein, whereas type II deficiency is characterized by a normal or near‐normal concentration of functionally defective FXIII‐A. Untreated, severe congenital FXIII‐A deficiency causes severe bleeding events in the majority of cases, with intracranial hemorrhage being the major cause of death. (firebaseapp.com)

The coagulation defect in plasma from these patients was corrected on mixing with plasma from patients with hemophilia, indicating that these patients lacked a factor different from those involved in hemophilia. (medscape.com)
[ 1 ] This disorder was found in both sexes and was understood to be inherited but was identified as being a less severe abnormality than that observed with hemophilia A and B. Hence, older terms for this disorder included Rosenthal syndrome, PTA deficiency, and hemophilia C. (medscape.com)
Factor XII does play an important role in clot formation during in vitro measurements of the partial thromboplastin time , which causes these measurements to be markedly prolonged in patients with factor XII deficiency, usually well beyond even what is seen in hemophilia A, hemophilia B, or factor XI deficiency. (wikidoc.org)
26 May 2018 Factor XI Deficiency is a genetically inherited disease that's a form of hemophilia. (firebaseapp.com)

[ 2 ] This is reflected in the fact that individuals who are deficient in any of these factors do not have a hemorrhagic diathesis, even after significant trauma or surgery. (medscape.com)
No hemorrhagic diathesis is associated with congenital factor XII deficiency. (medscape.com)
The patient's factor X level recovered after two weeks of discharge with no other hemorrhagic episodes. (mdpi.com)

The acquired form of FXII deficiency is seen in patients with the nephrotic syndrome, liver disease, sepsis and shock, disseminated intravascular coagulation, and other diseases. (wikipedia.org)
Factor I deficiency can be conferred by a C3 deficiency, since this also increases susceptibility to pyogenic infections by Neisseria meningitides, Haemophilus influenza, and Streptococcus pneumonia and increases the incidence of immune complex diseases due to impaired complement-mediated function [ 30 ]. (hindawi.com)
Background: The adipocyte products, leptin and tumour necrosis factor (TNF)alpha are associated with atherosclerotic diseases and may be factors contributing to the enhanced cardiovascular risk in hypopituitary patients with growth hormone (GH) deficiency. (lu.se)

Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. (nih.gov)

Congenital afibrinogenemia (Factor I deficiency) has been reported in a family of Saanen dairy goats but not in dogs or cats. (msdvetmanual.com)

In the past three decades, increased iron intake among infants has resulted in a decline in childhood iron-deficiency anemia in the United States. (cdc.gov)
In addition, 42 percent of infants between 12 and 17 months suffer from anemia, which is caused by iron deficiency. (americares.org)

This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. (nih.gov)
On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. (nih.gov)
It is the zymogen form of factor XIIa, an enzyme ( EC 3.4.21.38 ) of the serine protease (or serine endopeptidase) class. (wikidoc.org)
Factor XII itself is activated to factor XIIa by negatively charged surfaces, such as glass. (wikidoc.org)

citation needed] While it is indicated that people with FXII deficiency are generally asymptomatic, studies in women with recurrent miscarriages suggest an association with FXII deficiency. (wikipedia.org)
citation needed] There is concern that individuals with FXII deficiency are more prone to thrombophilic disease, however, this is at variance with a long-term study from Switzerland. (wikipedia.org)
Inherited or congenital FXII deficiency is usually passed on by autosomal recessive inheritance. (wikipedia.org)
citation needed] In persons with congenital FXII deficiency the condition is lifelong. (wikipedia.org)
In congenital FXII deficiency treatment is not necessary. (wikipedia.org)
In acquired FXII deficiency the underlying problem needs to be addressed. (wikipedia.org)

Since then, case studies and clinical studies identified an association between thrombosis and Factor XII deficiency. (wikidoc.org)
In a severe deficiency or functional defect of coagulation proteins, clinical signs appear at an early age. (msdvetmanual.com)

Factor XIIIa: novel target for anticoagulation? (zedira.com)

Signs and symptoms occur as the result of a deficiency in the blood clotting factor 13, which is responsible for stabilizing the formation of a blood clot. (firebaseapp.com)
5 These observations were consistent with the "excessive red cell fallout" reported many years ago in a study of a family with congenital FXIII deficiency 7 , and suggested a previously-unrecognized role for FXIII(a) in mediating clot composition. (zedira.com)
Since whole blood clots from mice with full or even partial (heterozygous) deficiency of the FXIII catalytic A subunit show similarly increased extrusion of RBCs during clot contraction5, these mice provided an experimental model to investigate the contribution of FXIII to VTE in vivo. (zedira.com)

[6] Unlike other clotting factor deficiencies, factor XII deficiency is totally asymptomatic and does not cause excess bleeding. (wikidoc.org)

Factor XII deficiency is a rare disorder that is inherited in an autosomal recessive manner. (wikidoc.org)

Diagram from the traditional cascade-waterfall model of coagulation shows the place of factor XI in the intrinsic pathway, which leads to the common pathway. (medscape.com)
Intrinsic Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "Intrinsic Factor" by people in this website by year, and whether "Intrinsic Factor" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Intrinsic Factor" by people in Profiles. (uchicago.edu)

The study aims to quantify bioavailability of iron from NaFeEDTA when added to a wheat flour-based meal in both nonanemic women and women with iron deficiency anemia, when consumed with and without traditional Moroccan green tea. (who.int)
It concludes that fractional iron absorption from wheat flour-based meals without and with tea was ∼2-fold higher in women with iron deficiency anemia than in nonanemic women. (who.int)
Providing fortificant iron as NaFeEDTA cannot overcome the inhibition of tea polyphenols on iron absorption, even in iron deficiency anemia, where iron absorption is strongly upregulated. (who.int)
As a consequence, the use of screening tests for anemia has become a less efficient means of detecting iron deficiency in some populations. (cdc.gov)
These recommendations update the 1989 'CDC Criteria for Anemia in Children and Childbearing-Aged Women' (MMWR 1989;38(22):400-4) and are the first comprehensive CDC recommendations to prevent and control iron deficiency. (cdc.gov)
Because of this decline, the value of anemia as a predictor of iron deficiency has also declined, thus decreasing the effectiveness of routine anemia screening among children. (cdc.gov)
CDC requested the Institute of Medicine to convene an expert committee to develop recommendations for preventing, detecting, and treating iron-deficiency anemia among U.S. children and U.S. women of childbearing age. (cdc.gov)

The plasma glycoprotein factor I (C3b/C4b inactivator) is a serine protease that acts as a regulator of the complement C3 cascade. (hindawi.com)

Factor X plays a central role in the coagulation cascade, and is the first enzyme in the common pathway of thrombus formation [ 1 ]. (mdpi.com)

The anticoagulant function of coagulation factor V. Thromb Haemost . (medscape.com)
A mixing study was performed to eliminate the presence of coagulation factor inhibitors and lupus anticoagulant. (karger.com)

As a result, people could develop a deficiency quickly if they don't eat enough folate-rich foods or they have an underlying condition that affects their absorption. (naturalnews.com)

To explore the correlations between symptom-based principal factors of rheumatoid arthritis (RA) and the effect of traditional Chinese medicine or Western medicine on RA after factor analysis of RA symptoms. (jcimjournal.com)
Eighteen symptoms in the RA patients were analyzed by factor analysis and the relationships between the factors and effects were analyzed with Chi-Square test. (jcimjournal.com)
Four principal factors were obtained from the analysis results of the 18 symptoms. (jcimjournal.com)
The factors could represent the symptoms related to joints, cold-syndrome, deficiency syndrome and heat-syndrome in traditional Chinese medicine (TCM),respectively. (jcimjournal.com)
The results based on the factor analysis of RA symptoms are similar to the results of syndrome differentiation of TCM, and the factor-related different categories of symptoms are associated with the curative effect, thus further research on the symptoms is necessary. (jcimjournal.com)

FXI deficiency can manifest as an incidental laboratory abnormality-for example, when a preoperative workup for elective surgery reveals an unexpected prolongation of the activated partial thromboplastin time (aPTT). (medscape.com)
[ 3 ] They identified the abnormality as a deficiency in a clotting factor, which they termed plasma thromboplastin antecedent (PTA). (medscape.com)

Iodine deficiency (ID) remains a public health concern not only for pregnant women, but for women of reproductive age (WRA) as well. (who.int)

He had a history of hypertension, schizophrenia, hypothyroidism and factor XII deficiency. (biomedcentral.com)

Excess levels of factor XII can predispose individuals towards greater risk of venous thrombosis due to factor XII's role as one of the catalysts for conversion of plasminogen to its active fibrinolytic form of plasmin . (wikidoc.org)
At this time a heparin infusion was initiated given the patient's known factor XII deficiency and demonstrated mesenteric venous thrombosis. (biomedcentral.com)

Deficiency in factor I activity is associated with an increased incidence of infections in humans. (hindawi.com)

Factor XII, HK, and PK are necessary for a normal aPTT, but they do not appear to be required for normal hemostasis. (medscape.com)
Targeted deletion of factor XII in a mouse model does not impair hemostasis but does result in reduced generation of inflammatory mediators. (medscape.com)
[ 7 ] Therefore, activation of the contact factors plays a much bigger role in thrombosis than hemostasis. (medscape.com)
Monroe DM HM, Roberts HR. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis. (medscape.com)

This gene encodes coagulation factor XII which circulates in blood as a zymogen. (nih.gov)

In vivo, factor XII is activated by contact to polyanions. (wikidoc.org)
Addition of polyphosphates restored defective plasma clotting of Hermansky-Pudlak syndrome patients, indicating that the inorganic polymer is the endogenous factor XII activator in vivo. (wikidoc.org)

During January-March 2014, we reviewed risk factors CMRs were lower, but still substantial, for patients receiv- for dissemination and summarized all coccidioidomycosis ing steroids (https://www.niaid.nih.gov/sites/default/files/ cases in patients with primary immunodeficiency (PID). (cdc.gov)
A good understanding of the possible risk factors for coronavirus disease 19 (COVID-19) severity could help clinicians in identifying patients who need prioritized treatment to prevent disease progression and adverse outcomes. (bvsalud.org)
Furthermore, the severity of infection was observed to increase with risk factors such as age, heart disease, hypertension, and DM eventually affecting COVID-19 prognosis and mortality. (bvsalud.org)
Later, male sex, obesity, and possessing naturally melanin-rich skin while living outside of the tropics came to be known as the highest risk factors after older age ( 2 p , 8 - 13 , 14 p , 15 , 16 ). (frontiersin.org)
PETTS was a prospective observational study of patients with MDR TB in 9 countries, studying risk factors for, and the consequences of acquired drug resistance in the treatment of MDR TB. (cdc.gov)

Diseases1

Chemicals and Drugs1

Vitamin37

Blood coagulation8

Prothrombin5

20203

Hereditary factor V deficien1

Nutritional10

Congenital factor V deficien2

Hageman5

Prevalence2

Nutrients4

Abnormal5

Micro-nutrient deficiencies2

High-molecular2

Inherited disorder2

Mutation4

Activates factor7

Fibrinogen5

VIII3

Folate deficiency7

Genetic5

Disorders5

Platelet function1

XIII11

Thrombin2

Fibrin2

Leiden3

Bleeding diathesis2

Protein3

Hemophilia4

Hemorrhagic3

Diseases3

Prekallikrein1

Afibrinogenemia1

Infants2

XIIa4

FXII6

Clinical2

XIIIa1

Clot3

Asymptomatic1

Autosomal recessive1

Intrinsic4

Anemia7

Plasma glycoprotein1

Coagulation cascade1

Anticoagulant2

Absorption1

Symptoms5

Abnormality2

Iodine1

Hypothyroidism1

Venous2

Incidence1

Hemostasis4

Zymogen1

Vivo2

Risk factors5