Factor vii. Medical search. Frequent questions

Modulation of factor VII levels by intron 7 polymorphisms: population and in vitro studies. (medscape.com)
The significance of published polymorphisms in 14 cases of mild factor VII deficiency. (medscape.com)
Factor VII gene polymorphisms may contribute to elevations in factor VII coagulant [‎FVIIc]‎ levels that have been associated with cardiovascular risk. (who.int)
Five identified allelic polymorphisms also affect plasma levels of factor VII and factor VIIa, with variations of as much as 25-30% in levels of activity and antigen. (medscape.com)
Investigations to determine the contribution by factor VII polymorphisms, other hemostatic proteins, and environmental factors have not yielded specific predictors of bleeding risk. (medscape.com)
Contribution of factor VII polymorphisms to coagulopathy in patients with isolated traumatic brain injury. (nih.gov)

Factor VII shares a common domain architecture with factors IX and X. The gene for factor VII is located on chromosome 13 (13q34). (wikipedia.org)
[ 1 ] The human factor VII gene is located on chromosome 13, very close to the gene for factor X. (medscape.com)
More than 100 mutations, mostly missense mutations, have been identified in the factor VII gene located on chromosome 13. (medscape.com)

The noninherited form of the disorder, called acquired factor VII deficiency, is less common than the congenital form. (medlineplus.gov)
Acquired factor VII deficiency can also be caused by certain drugs such as medicines that prevent clotting, or by a deficiency of vitamin K. (medlineplus.gov)
Acquired factor VII deficiency is not inherited. (medlineplus.gov)
There are two types of factor VII Deficiency: Inherited Factor VII Deficiency and Acquired Factor VII Deficiency, the latter which is the result of other physical disorders and may last only a short time. (q2labsolutions.com)
In addition, acquired Factor VII deficiency is associated with certain forms of cancer and autoimmune response to factor VII. (q2labsolutions.com)
Newly diagnosed with Acquired factor VII deficiency? (globalgenes.org)

In a survey, Peltier et al found that among 25 patients with congenital factor VII deficiency, initial bleeding symptoms included skin bruising (58%), epistaxis (56%), and menorrhagia (47% of reproductive-age females). (medscape.com)
Clinical phenotype and F7 gene genotype in 40 Tunisian patients with congenital factor VII deficiency. (nih.gov)

The main role of factor VII (FVII) is to initiate the process of coagulation in conjunction with tissue factor (TF/factor III). (wikipedia.org)
Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), factor Xa, IXa, XIIa, and the FVIIa-TF complex itself. (wikipedia.org)
Gene therapy approaches for treating FVII deficiency are very promising () Recombinant factor VIIa, marketed under the trade names AryoSeven and NovoSeven, is used for people with hemophilia (with Factor VIII or IX deficiency) who have developed antibodies against replacement coagulation factor. (wikipedia.org)
Molecular analysis of factor VII deficiency in Italy: a frequent mutation(FVII Lazio) in a repeated intronic region. (medscape.com)
Greifswald Factor FVII Deficiency Study Group. (medlineplus.gov)
The relationships between the Arterial and venous thrombosis, which clinical presentation and FVII levels and the clinically manifest as stroke, myocardial in- associated molecular genetic defects lack farction or pulmonary embolism are a ma- apparent consistency [ 7,10 ]. (who.int)
10976 in exon 8 in the catalytic region of ing factors that may increase cardiovascu- the FVII gene and an insertion of a decanu- lar disease. (who.int)
Upon contact with tissue ferences in FVII activity levels and in geno- factor exposed by vascular injury, FVII is type frequencies depend on the ethnic cleaved to its two-chain active form, which groups [ 15 ]. (who.int)
We studied FVII gene poly- then activates factors IX and X leading to morphisms in healthy Tunisians with the the generation of thrombin [ 2 ]. (who.int)
The complex formed between the procoagulant serine protease activated factor VII (FVII) and the membrane protein tissue factor, exposed on the vascular lumen upon injury, triggers the initiation of blood clotting. (nih.gov)
Inherited factor VII (FVII) deficiency is a rare autosomal recessive hemorrhagic disorder. (medscape.com)

Clinical and Laboratory Findings in Jewish and Bedouin Patients in Southern Israel Who Were Diagnosed with Factor VII Deficiency. (medscape.com)

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Factor VII deficiency (congenital proconvertin deficiency) is rare and inherited recessively. (wikipedia.org)
The inherited form of factor VII deficiency, known as congenital factor VII deficiency, is caused by mutations in the F7 gene, which provides instructions for making a protein called coagulation factor VII. (medlineplus.gov)
Mariani G, Herrmann FH, Bernardi F, Schved JF, Auerswald G, Ingerslev J. Clinical manifestations, management, and molecular genetics in congenital factor VII deficiency: the International Registry on Congenital Factor VII Deficiency (IRF7). (medlineplus.gov)
It has also been approved for such use in acquired hemophilia, congenital factor VII deficiency, and Glanzmann thrombasthenia with refractoriness to platelets. (medscape.com)

The seven factors for Awakening (bojjhanga) are closely related to the practice of the four frames of reference. (buddhist-spirituality.net)
The first pattern is a spiral, showing how the seven factors for Awakening build on the four frames of reference [ §92 ]. (buddhist-spirituality.net)
The second pattern for describing the relationship between the factors for Awakening and the four frames of reference is more holographic. (buddhist-spirituality.net)
The texts themselves make this point by saying that the development of any one of the frames of reference brings the factors for Awakening to the culmination of their development [ §92 ]. (buddhist-spirituality.net)

Once bound to tissue factor released from damaged tissues, it is converted to factor VIIa (or blood-coagulation factor VIIa, activated blood coagulation factor VII), which in turn activates factor IX and factor X. Using genetic recombination a recombinant factor VIIa (eptacog alfa) (trade names include NovoSeven) has been approved by the FDA for the control of bleeding in hemophilia. (wikipedia.org)
The complex of factor VIIa with TF catalyzes the conversion of factor IX and factor X into the active proteases, factor IXa and factor Xa, respectively. (wikipedia.org)
It is treated with recombinant factor VIIa (NovoSeven or AryoSeven). (wikipedia.org)
Laurian Y. Treatment of bleeding in patients with platelet disorders: is there a place for recombinant factor VIIa? (medscape.com)
The physiologic activator of factor VII is thought to be factor Xa, although significant auto-activation by factor VIIa can occur. (medscape.com)
[ 6 ] The factor VIIa/TF complex activates both factors IX and X. It is inhibited by tissue factor pathway inhibitor (TFPI) in complex with factor Xa. (medscape.com)
The ability of factor VIIa to cleave other clotting factors depends on binding to its cofactor tissue factor (TF), which is expressed on the surface of endothelial cells and monocytes in response to injury or inflammation. (medscape.com)
With formation of the TF/VIIa complex, factor VIIa rapidly activates clotting factors VII, IX, and X, initiating the coagulation cascade. (medscape.com)

This in turn leads to four factors associated with jhāna: rapture, serenity, concentration, and equanimity. (buddhist-spirituality.net)
It is identical with the equanimity in the fourth jhāna [ §149 ] and with the inherent equanimity in the fifth factor of five-factored noble concentration [ §150 ], which can develop out of any of the four jhanas. (buddhist-spirituality.net)

Genetic and environmental determinants of factor VII coagulant activity in ethnic groups at differing risk of coronary heart disease. (medscape.com)
Genetic factors levels vary significantly in the general pop- contribute significantly to the development ulation and are influenced by environmental of these diseases. (who.int)
By cataloging genetic variations associated with AMD, scientists are better equipped to target corresponding biological pathways and study how they might interact and change with age or other factors, such as smoking. (nih.gov)
Factor VII plasma levels are influenced by both environmental and genetic factors. (medscape.com)
IRF-7 undergoes PHOSPHORYLATION prior to nuclear translocation and it activates GENETIC TRANSCRIPTION of multiple interferon GENES. (umassmed.edu)

However, coagulation factor VII activity and antigen decreased significantly (P (experts123.com)

Factor VII plays a role in the coagulation cascade, the chain reaction that is set in motion when there is an injury to a blood vessel. (q2labsolutions.com)

Factor VII deficiency is a rare bleeding disorder that varies in severity among affected individuals. (medlineplus.gov)

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These mutations reduce the amount of coagulation factor VII in the bloodstream. (medlineplus.gov)
Factor VII deficiency: clinical manifestation of 717 subjects from Europe and Latin America with mutations in the factor 7 gene. (medlineplus.gov)
Although individuals with the lowest factor VII levels are most likely to be symptomatic, patients with identical mutations may have marked differences in clinical bleeding, suggesting that other factors may contribute to the clinical manifestations of factor VII deficiency. (medscape.com)
Novel factor VII gene mutations in six families with hereditary coagulation factor VII deficiency. (nih.gov)

The action of the factor is impeded by tissue factor pathway inhibitor (TFPI), which is released almost immediately after initiation of coagulation. (wikipedia.org)

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Factor VII has been shown to interact with tissue factor and endothelial protein C receptor. (wikipedia.org)
The US Food and Drug Administration (FDA) approved recombinant activated factor VII (synthetic vitamin K -dependent protein) for the treatment of bleeding and perioperative management in patients with hemophilia A or B who have developed inhibitors against replacement coagulation factors. (medscape.com)
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. (nih.gov)
The diagnostic value of serum insulin-like growth factor binding protein 7 in gastric cancer. (nih.gov)
Dogs and humans alike can suffer from a rare bleeding disorder called factor VII deficiency, where lacking a vital coagulation protein, factor VII, can lead to extensive bleeding in the central nervous system or the gastrointestinal track, often after surgery or an injury. (labroots.com)
An interferon regulatory factor that is induced by INTERFERONS as well as LMP-1 protein from EPSTEIN-BARR VIRUS. (umassmed.edu)

This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. (nih.gov)
Phenotypic variation in severe hemophilia A is related to endogenous thrombin potential and plasma levels of factor VII. (nih.gov)
Do lowered factor VII levels at extremely high endogenous oestradiol levels protect against thrombin formation? (experts123.com)

Napolitano M, Siragusa S, Mariani G. Factor VII Deficiency: Clinical Phenotype, Genotype and Therapy. (medscape.com)
Correlations between the factor VII genotype, factor VII clotting activity and the clinical phenotype are not tight. (medscape.com)

Although factor VII deficiency is primarily associated with increased bleeding, some people with the condition have excessive blood clotting (thrombosis). (medlineplus.gov)
Anti-platelet factor 4 (PF4) antibodies that activate platelets via FcγRIIA drive the pathophysiology of vaccine-induced immune thrombocytopenia and thrombosis (VITT). (nih.gov)

[ 1 , 2 ] Clinical bleeding can widely vary and does not always correlate with the level of factor VII coagulant activity measured in plasma. (medscape.com)

citation needed] A coagulation enzyme cascade may begin with a few molecules of factor XII and culminate in the activation of millions of times more fibrin molecules. (wikipedia.org)

RÉSUMÉ Les polymorphismes du gène du facteur VII peuvent contribuer à l'élévation de la concentration en activité coagulante du facteur VII (FVIIc) qui a été associée au risque cardio-vasculaire. (who.int)
Nous avons donc étudié l'association de deux polymorphismes - R353Q au niveau du codon 353 intervenant sur la région catalytique et le polymorphisme d'insertion de 10 paires de bases (pb) impliquant la région du promoteur - avec les taux de FVIIc chez 176 Tunisiens en bonne santé. (who.int)
Les sujets ayant un génotype R/R avaient une concentration en FVIIc significativement plus élevée que les sujets hétérozy- gotes et homozygotes porteurs de l'allèle Q353 (96,36 vs 59,52). (who.int)
La concentration en FVIIc avec le polymor- phisme d'insertion de 10 pb n'était pas significativement différente. (who.int)

Coagulation factor VII (EC 3.4.21.21, formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade, and in humans is coded for by the gene F7. (wikipedia.org)
Factor VII deficiency has historically been treated with infusions of clotting factor to make up for the missing proteins, but after scientists saw success with gene therapies for hemophilia B, studies began to use a similar technique to solve this disorder. (labroots.com)

it does not appear to be related to the amount of coagulation factor VII in the bloodstream. (medlineplus.gov)
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. (nih.gov)
A significant increase in the plasma levels of coagulation factor VIII, von Willebrand factor and fibrinogen was found between samples drawn before stimulation and at the highest oestradiol levels (P (experts123.com)

The current analysis identified seven new loci near genes. (nih.gov)

Once bound to its cofactor, factor VII can be activated by a number of different proteases. (medscape.com)

Liver disease, vitamin K deficiency, and oral coagulant-induced conditions: These conditions can be differentiated from factor VII deficiency by measuring other vitamin K-dependent factor levels, which are also decreased. (medscape.com)

[ 7 ] It has also been found useful in the treatment of obstetrical hemorrhage in women with or without hemophilia. (medscape.com)

Molecular biology and clinical manifestation of hereditary factor VIIdeficiency. (medscape.com)

As an rFVIIa product, eptacog beta works in a complex with tissue factor to activate factor X to Xa, thereby bypassing FVIII and FIX. (wikipedia.org)
Tissue factor is found on the outside of blood vessels - normally not exposed to the bloodstream. (wikipedia.org)
Upon vessel injury, tissue factor is exposed to the blood and circulating factor VII. (wikipedia.org)
Factor VII binds to tissue factor. (medscape.com)
Recombinant activated factor VII (rFVIIa) binds to exposed tissue factor at the place of tissue and vascular injury. (medscape.com)

It has the shortest half-life of the procoagulant factors, approximately 3-6 hours. (medscape.com)

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Levels of factor VII in this syndrome are lower than those in disorders with other vitamin K-dependent factors. (medscape.com)
At present, classification based on clinical history (age and type of presentation) rather than on factor VII activity levels has proved to be more useful in predicting future risk of bleeding. (medscape.com)
After treating dogs with the deficiency with a single injection of the corrective DNA vector, the scientists involved in this study saw the dogs expressing "levels of clotting factor VII that would be therapeutic in humans with long-term stability. (labroots.com)
The acquired form of Factor VII Deficiency is more common and can result from severe liver disease which reduces the function of the liver (factor VII is produced in the liver) or they have low vitamin K levels as a result of taking certain kinds of medication. (q2labsolutions.com)

Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. (nih.gov)

Factor X deficiency and some variants of factor IX deficiency: Patients with these conditions may also occasionally exhibit a prolonged prothrombin time (PT). (medscape.com)
Its shortest half-life of all the clotting factors is reflected in the initial rapid prolongation of prothrombin time (INR) in therapy with vitamin K antagonists. (medscape.com)

Recombinant human factor VII while initially looking promising in intracerebral hemorrhage failed to show benefit following further study and this is no longer recommended. (wikipedia.org)
Seven factors to help you get into the right mindset when conducting a human error investigation in pharma. (nsf.org)
How do we unpack an investigation in which there are clear human contributing factors? (nsf.org)
An international group of researchers has discovered seven new regions of the human genome-called loci-that are associated with increased risk of age-related macular degeneration (AMD), a leading cause of blindness. (nih.gov)
Scientists found that the same mutation causing factor VII deficiency in dogs also occurs in most human cases of the disease. (labroots.com)

Combined deficiency of factors VII and X: This has also been reported to occur, albeit rarely. (medscape.com)
We can almost predict if an error will occur based on these factors. (nsf.org)

The activation of Factor X to Xa initiates the coagulation cascade's common pathway, leading to clot formation at the site of hemorrhage. (wikipedia.org)
[ 1 ] Research indicates that embryos deficient in factor VII develop normally, without evidence of hemorrhage. (medscape.com)
Nevertheless, factor VII-deficient newborns sometimes develop fatal intra-abdominal or intracranial hemorrhage. (medscape.com)
Management of acute hemorrhage primarily consists of factor VII replacement therapy to treat bleeding. (medscape.com)

Diseases7

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes5

Polymorphisms6

Located on chromosome 133

Acquired factor VII defici6

Patients with congenital factor VII defici2

FVII11

Diagnosed with Factor VII Defici1

20203

Congenital4

Awakening4

VIIa8

Equanimity2

Genetic5

Activity and antigen1

Role in the coagulation1

Deficiency is a rare1

Success Factors2

Mutations4

Impeded by tissue factor pa1

Considerations2

Protein6

Thrombin3

Genotype2

Thrombosis2

Coagulant activity1

Citation1

FVIIc4

Proteins2

Coagulation factor3

Genes1

Cofactor1

Vitamin K-dependent factor1

Hemophilia1

Clinical manifestation1

Tissue5

Procoagulant1

Salary1

Levels4

Catalytic1

Prothrombin time2

Human5

Occur2

Hemorrhage4