• Transforming growth factor-beta (TGF-beta) plays a critical role in the regulation of extracellular matrix gene expression. (nih.gov)
  • For example, a half dozen biologists could easily supply a half dozen conflicting definitions for the terms "gene," or "metabolic pathway. (ecocyc.org)
  • The DB consists of a collection of frames , where each frame encodes information about a single object, such as an enzyme, a gene, or a biochemical pathway. (ecocyc.org)
  • Instance frames describe specific biological objects, such as a specific gene or a specific metabolic pathway. (ecocyc.org)
  • Mutations in the ribosome biogenesis factor gene LTV1 are linked to LIPHAK syndrome, a novel poikiloderma-like disorder. (nih.gov)
  • This gene encodes one of the mitochondrial translation elongation factors. (nih.gov)
  • We evaluate our method using three key pathways related to cancer and demonstrate that it is capable of finding meaningful alterations in gene relations. (hindawi.com)
  • Our focus on the interactions and pathways of cancer-related genes is important since changes in gene relations and key pathways are more relevant to carcinogenesis than individual genes alone. (hindawi.com)
  • Using gene knock out, complementary DNA rescue, and inhibitor assays, we found that perturbation of these pathways greatly reduces the growth of NPC cell lines but does not affect growth of SV40-immortalized normal nasopharyngeal epithelial cells. (hku.hk)
  • High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6. (atlasgeneticsoncology.org)
  • A number of studies have explored how regulation of generally, and at least to a first approximation, it is obvious that metabolic pathways affects the growth rate of microorganisms, gene regulation only is useful if the environmental conditions vary both in the steady state and in response to changes in the local with time. (lu.se)
  • Vascular endothelial growth factor (VEGF) is an essential angiogenic factor for formation of the embryonic vasculature, and also has important roles in pathological conditions such as diabetic retinopthy, rheumatoid arthritis and cancer. (figshare.com)
  • Phosphorylation of vascular endothelial growth factor receptor 2 (pVEGFR2) via PI3K/Akt signaling plays a key role in mediating cellular processes involved in repair, such as mitogenesis, angiogenesis, and vascular permeability. (biomedcentral.com)
  • During angiogenesis, a highly regulated process, the most potent pro-angiogenic signaling cascades are initiated by vascular endothelial growth factor (VEGF) binding to EC-resident VEGF receptors (VEGFR) like VEGFR1, VEGFR2 and VEGFR3 [ 9 ]. (biomedcentral.com)
  • Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling. (atlasgeneticsoncology.org)
  • Tissue factor (TF), or thromboplastin, is the primary activating moiety for the extrinsic pathway of coagulation. (medscape.com)
  • Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of the extrinsic coagulation pathway. (bvsalud.org)
  • In patients with hemophilia A or B, inhibition of TFPI is an alternative therapeutic approach that augments the extrinsic coagulation pathway. (bvsalud.org)
  • Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). (wikipedia.org)
  • Online Mendelian Inheritance in Man (OMIM): 152310 (TFPI1), Online Mendelian Inheritance in Man (OMIM): 600033 (TFPI2) Overview of all the structural information available in the PDB for UniProt: P10646 (Tissue factor pathway inhibitor) at the PDBe-KB. (wikipedia.org)
  • Tissue-factor-pathway-Inhibitor: Biochemie, Molekularbiologie, Physiologie und Pathophysiologie" [Tissue factor pathway inhibitor: biochemistry, molecular biology, physiology and physiopathology]. (wikipedia.org)
  • However, in 82As2 cells, LIF production was significantly increased by stimulation with TLR5, which was suppressed by an inhibitor of interleukin-1 receptor-associated kinase-1/4, which are important factors in the TLR5 signaling pathway. (oncotarget.com)
  • This mechanism includes generation of activated protein C and protein S and the activation of tissue-type plasminogen activator (tPA), with subsequent inhibition of activated factors V and VIII, plasminogen activator inhibitor-1 (PAI-1), and thrombin-activated fibrinolysis inhibitor (TAFI). (medscape.com)
  • Evolution of Antidrug Antibody Assays During the Development of Anti-Tissue Factor Pathway Inhibitor Monoclonal Antibody Marstacimab. (bvsalud.org)
  • 1493-1537) that binds tissue factor pathway inhibitor alpha (TFPIα). (lu.se)
  • This pathway is regulated by C1 inhibitor (C1-INH). (msdmanuals.com)
  • Two interrelated branches of the piRNA system exist: somatic cells that support oogenesis only employ Piwi, whereas germ cells utilize a more elaborate pathway centered on the three gonad-specific Argonaute proteins (Piwi, Aubergine, and Argonaute 3). (nih.gov)
  • The recent identification of Smad proteins, TGF-beta receptor kinase substrates that translocate into the cell nucleus to act as transcription factors, has increased our understanding of the molecular mechanisms underlying TGF-beta action. (nih.gov)
  • The expression of transforming growth factor‑β/Smad pathway proteins, α‑smooth muscle actin (α‑SMA), collagen I and collagen III was observed in fibrotic livers using western blot analysis. (spandidos-publications.com)
  • Here we outline the current status of the viral evasion mechanism underlying the regulation of the cGAS-STING pathway, focusing on how post-transcriptional modifications, viral proteins, and non-coding RNAs involve innate immunity during viral infection, attempting to inspire new targets discovery and uncover potential clinical antiviral treatments. (frontiersin.org)
  • These results suggest that targeting these pathways/proteins may hold promise for achieving better treatment of patients with NPC. (hku.hk)
  • The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
  • In clinical depression, however, a transition occurs to sensitization of immuno-inflammatory pathways, progressive damage by oxidative and nitrosative stress to lipids, proteins, and DNA, and autoimmune responses directed against self-epitopes. (biomedcentral.com)
  • Since the identification of biological pathways is significantly influenced by those differentially expressed genes from different datasets or different statistical methods [ 16 , 17 ], we reason here that an integration of multiple cancer microarray datasets and identification of the most common pathways from these data would reveal key relationships between crucial genes in carcinogenesis. (hindawi.com)
  • The Ecologically-Driven Exposure Pathways team identifies internal and external pathways and processes that can alter exposure and toxicity of contaminants and pathogens to wildlife the environment. (usgs.gov)
  • The Ecologically-Driven Exposure Pathways Integrated Science Team identifies how ecological pathways and physiological processes within a single organism can alter exposure and toxicity of contaminants and pathogens and seek to understand outcomes at different scales from individuals to populations and ecosystems. (usgs.gov)
  • Our results show multiple pathways to initiation, with orders of arrival of tRNA and IF2 dependent on factor concentration and composition. (pacb.com)
  • The results highlight the importance of multiple pathways in the transmission of the included pathogens and can be used to guide prioritization of public health interventions. (cdc.gov)
  • Conservation of the genes belonging to the photoperiod, gibberellin and autonomous pathways was observed, while orthologues of the key genes found in the vernalisation pathway (FRI, FLC) were absent from the quinoa genome. (springer.com)
  • However, current knowledge of the molecular basis of quinoa flowering is limited and the details of flowering genes and associated pathways in quinoa remain elusive (Jarvis et al. (springer.com)
  • The nuclear factor NF-kappaB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappaB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. (bioseek.eu)
  • NF-κB has long been considered a prototypical proinflammatory signaling pathway, largely based on the activation of NF-κB by proinflammatory cytokines such as interleukin 1 (IL-1) and tumor necrosis factor α (TNFα), and the role of NF-κB in the expression of other proinflammatory genes including cytokines, chemokines, and adhesion molecules, which has been extensively reviewed elsewhere. (bioseek.eu)
  • It is well known that in a biological system genes interact with each other forming various biological pathways in order to carry out a multitude of biological processes. (hindawi.com)
  • To better understand the roles of these differentially expressed genes and their interactions in a complex biological system, a comprehensive pathway analysis is needed. (hindawi.com)
  • The cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is a critical defender to sense various pathogens and trigger innate immunity of mammalian cells. (frontiersin.org)
  • In people with germline mutations, changes in other genes, together with environmental and lifestyle factors, also influence whether a person will develop breast cancer. (medlineplus.gov)
  • Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
  • While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. (wikipedia.org)
  • The mechanism of action of APE is hypothesized to proceed via scavenging free radicals, decreasing TGF‑β1 levels and blocking of the TGF‑β/Smad signaling pathway. (spandidos-publications.com)
  • Myostatin, a member of the transforming growth factor-β superfamily, is a negative regulator of skeletal muscle growth in vertebrates that exerts its inhibitory function by activating Smad transcription factors. (unab.cl)
  • Marstacimab is an investigational fully human monoclonal antibody that binds and neutralizes TFPI and is being evaluated as a prophylactic treatment to prevent or reduce the frequency of bleeding episodes in patients with severe hemophilia A or B, with or without inhibitors ( antibodies against coagulation factors ). (bvsalud.org)
  • Protein S also interacts with TFPIα and serves as TFPIα-cofactor in factor Xa (FXa) inhibition. (lu.se)
  • Endotoxin, tumor necrosis factor (TNF), interleukin-1 (IL-1), and other inflammatory mediators induce expression of TF in endothelial cells and monocytes, where only small amounts are normally expressed. (medscape.com)
  • In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway. (bioseek.eu)
  • Thus, shared immuno-inflammatory pathways underpin the physiology of sickness behavior and the pathophysiology of clinical depression explaining their partially overlapping phenomenology. (biomedcentral.com)
  • The initiation and propagation of procoagulant pathways, with simultaneous impairment of natural anticoagulant systems and suppression of endogenous fibrinolysis as a result of systemic inflammatory activation, lead to platelet activation and fibrin deposition. (medscape.com)
  • Heterogeneous pathways and timing of factor departure during translation initiation. (pacb.com)
  • Initiation involves factor-driven assembly at a start codon of a messenger RNA of an elongation-competent 70S ribosomal particle (in bacteria) from separated 30S and 50S subunits and initiator transfer RNA. (pacb.com)
  • Numerous studies demonstrate that these immune responses involve distinct immune cells, various pathologic factors, and specific functions and play crucial roles in the initiation and progression of inflammation and fibrosis in the lung exposed to CNTs. (cdc.gov)
  • When a second nutrient and its metabolic pathway are introduced, the system must further decide whether and how to activate both pathways. (lu.se)
  • 5 , 6 ] Stimulation of osteoclast precursors with RANKL recruits cytoplasmic tumor necrosis factor receptor-associated factors (TRAFs) and activates downstream signaling pathways. (e-jbm.org)
  • It is a heterodimeric transcription factor composed of α and β subunits. (northwestern.edu)
  • Solitary cell transcript validation and analyses research implicate the transcription factor PU.1 in neutrophil to nAPC transformation. (thekingsfoundation.org)
  • 7 - 9 ] Activation of these signaling pathways induces the expression of transcription factors such as c-Fos and nuclear factor of activated T cells (NFATc1), a master transcription factor for osteoclastogenesis. (e-jbm.org)
  • Transforming growth factor (TGF)-beta represents a prototype of multifunctional cytokine. (nih.gov)
  • The expression of α-smooth muscle actin (α-SMA), collagen I, transforming growth factor-β1 (TGF-β1) and Smad2 were measured by western blotting. (spandidos-publications.com)
  • Dobaczewski M, Chen W and Frangogiannis NG: Transforming growth factor (TGF)-β signaling in cardiac remodeling. (spandidos-publications.com)
  • Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K and Imaizumi T: Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. (spandidos-publications.com)
  • Organ coefficients, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), hexadecenoic acid (HA), laminin (LN), procollagen type III (PCIII), hydroxyproline (Hyp), glutathione (GSH‑Px), malondialdehyde (MDA), superoxide dismutase (SOD) and transforming growth factor β1 (TGF‑β1) levels were measured in rats with hepatic fibrosis. (spandidos-publications.com)
  • Early in the progression of hepatic fibrosis, a potent, fibrinogenic cytokine, transforming growth factor-β (TGF-β), was demonstrated to be locally and systemically increased in response to acute as well as chronic liver injury ( 7 ). (spandidos-publications.com)
  • Big'-insulin-like growth factor-II signaling is an autocrine survival pathway in gastrointestinal stromal tumors. (ru.nl)
  • Insulin-like growth factor (IGF)-II acts as an autocrine factor in several tumor types by binding to IGF receptor type 1 (IGF-1R) and/or the insulin receptor (IR) isoform A. The aim of the present study was to investigate the putative role of unprocessed pro-IGF-II, called 'big'-IGF-II, in GISTs. (ru.nl)
  • IR isoform A mRNA and protein expression, but not that of IGF-1R, was found in these KIT mutant cell lines and in KIT and platelet-derived growth factor receptor alpha-mutant GIST specimens. (ru.nl)
  • Hepatocyte growth factor (HGF) signaling through its receptor Met has been implicated in hepatocellular carcinoma tumorigenesis and progression. (ebi.ac.uk)
  • A model is proposed where the relative levels of active antagonist (RsbV1) and switch-protein anti-sigma factor (RsbW) control the availability of σ 66 and subsequently act as a molecular 'throttle' for Chlamydia growth and development. (plos.org)
  • By manipulating the levels of different pathway components, we were able to accelerate and restrict the growth and development of this pathogen. (plos.org)
  • The disruption of this pathway could generate a strain incapable of surviving a typical human immune response and would represent an attractive candidate as an attenuated growth vaccine. (plos.org)
  • This event is autocrine/paracrine regulated by growth factors, principally Myostatin (MSTN) and Insulin-like Growth Factor-1 (IGF-1). (unab.cl)
  • These results demonstrate that the IGF-1/PI3K/Akt pathway may inhibit MSTN signaling during myoblast differentiation, providing new insight to existing knowledge on the complex crosstalk between both growth factors. (unab.cl)
  • We show that maximal growth is achieved when pathway activation is a more or less steeply graded function of the nutrient concentration. (lu.se)
  • Published September 5, 2007 transcription factors and replicating extra DNA, rather than going directly into growth of the cell. (lu.se)
  • Other signaling mechanisms, such as the MAP/SAP kinase or Ras pathways, although potentially important for transmission of some of the TGF-beta signals, will not be described. (nih.gov)
  • The molecular mechanism involved in the anti-fibrotic effect of acetazolamide possibly was through inhibiting TGF-β1/Smad2 signaling pathway. (spandidos-publications.com)
  • Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2. (oncotarget.com)
  • The increase in LIF production resulting from activation of the TLR5 signaling pathway may contribute to the cachexia-inducing ability of 85As2 cells. (oncotarget.com)
  • In this study, we developed a mechanistically detailed systems biology model of HGF/Met signaling pathway that incorporated specific interactions with integrins to investigate the efficacy of integrin-binding peptide, AXT050, as monotherapy and in combination with other therapeutics targeting this pathway. (ebi.ac.uk)
  • This study aimed to investigate the potential effects of Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine formula, on angiogenesis by VEGFR2 activation through the phosphatidylinositol 3 kinase (PI3K)/Akt signaling pathway in a mouse model of ICH. (biomedcentral.com)
  • SU5416 treatment and assessment of VEGFR2 phosphorylation as well as alterations in PI3K/Akt signaling were performed to determine whether the effect of BYHWD on angiogenesis was partly mediated by phosphorylation of VEGFR2 via the PI3K/Akt signaling pathway. (biomedcentral.com)
  • BYHWD promoted neurological recovery and angiogenesis after ICH in mice by enhancing VEGFR2 phosphorylation through the PI3K/Akt signaling pathway. (biomedcentral.com)
  • These results demonstrate that corticotroph LIF action is receptor mediated and involves activation of STAT signaling pathways. (manchester.ac.uk)
  • In contrast, IGF-1 promotes the differentiation of skeletal myoblasts by activating the PI3K/Akt signaling pathway. (unab.cl)
  • This study reports on a novel functional crosstalk between the IGF-1 and MSTN signaling pathways, as mediated through interaction between PI3K/Akt and Smad3. (unab.cl)
  • This inhibitory effect of IGF-1 on the MSTN signaling pathway was dependent on IGF-1 receptor, PI3K, and Akt activities. (unab.cl)
  • Our study suggested that the ethanol extract of the root part of IKN suppressed osteoclast differentiation and function partly by downregulating the p38 MAPK/c-Fos/NFATc1 signaling pathways. (e-jbm.org)
  • p38, c-Jun N-terminal kinase, extracellular signal-regulated kinase), and phosphoinositide 3-kinase/Akt serine/threonine kinase (Akt) signaling pathways are known to be activated during osteoclast differentiation. (e-jbm.org)
  • Signaling pathways implicated in carbon nanotube -induced lung inflammation. (cdc.gov)
  • Activation of the HIF-1 pathway is a common feature of gliomas and may explain the intense vascular hyperplasia. (northwestern.edu)
  • It is characterized by abnormally increased activation of procoagulant pathways. (medscape.com)
  • Thrombin contributes to the activation of factors V, VIII, and XIII (fibrin-stabilizing factor) and has an activating effect on platelets. (medscape.com)
  • Platelet activation pathways. (medscape.com)
  • Mechanistically, the root part of IKN suppressed RANKL-induced p38 mitogen-activated protein kinase (MAPK) activation, effectively abrogating the induction of c-Fos and nuclear factor of activated T cells 1 (NFATc1) expression. (e-jbm.org)
  • Alternate pathway activation occurs when components of microbial cell surfaces (eg, yeast walls, bacterial cell wall lipopolysaccharide [endotoxin]) or immunoglobulin (eg, nephritic factor, aggregated IgA) cleave small amounts of C3. (msdmanuals.com)
  • Testing for inhibitors is indicated when bleeding is not controlled after infusion of adequate amounts of factor concentrate during a bleeding episode. (medscape.com)
  • Frailty and mobility limitation result from an interplay of different pathways including multiple anabolic deficiency, inflammation, oxidative stress, and a poor nutritional status. (mdpi.com)
  • The nuclear factor NF-kappaB pathway in inflammation. (bioseek.eu)
  • Our data put forth the big-IGF-II/IR isoform A axis as an autocrine survival pathway and potential therapeutic target in GISTs. (ru.nl)
  • Osteoclasts were formed by culturing mouse bone marrow macrophage (BMM) cells with macrophage colony-stimulating factor and receptor activator of nuclear factor-κB ligand (RANKL). (e-jbm.org)
  • 4 ] Macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) are key factors in osteoclastic differentiation. (e-jbm.org)
  • The resultant dimeric TF-factor VIIa complex then activates factors X and IX. (medscape.com)
  • How much does Functional Pathways Corporation pay? (payscale.com)
  • Functional Pathways Corporation pays its employees an average of $31.51 an hour. (payscale.com)
  • Hourly pay at Functional Pathways Corporation ranges from an average of $19.05 to $51.73 an hour. (payscale.com)
  • Functional Pathways Corporation employees with the job title Physical Therapist (PT) make the most with an average hourly rate of $39.09, while employees with the title Certified Occupational Therapy Assistant (COTA) make the least with an average hourly rate of $25.89. (payscale.com)
  • Are Functional Pathways Corporation employees satisfied with their compensation? (payscale.com)
  • Our Fair Pay score for Functional Pathways Corporation is 2.33. (payscale.com)
  • What is the highest salary at Functional Pathways Corporation? (payscale.com)
  • Do you work at Functional Pathways Corporation? (payscale.com)
  • Hemophilia A is an X-linked, recessive disorder caused by deficiency of functional plasma clotting factor VIII (FVIII), which may be inherited or arise from spontaneous mutation. (medscape.com)
  • Although the signalling pathways induced by VEGF have been well-studied, the precise molecular mechanisms remain to be determined, particularly with respect to the relative contribution of the individual receptors. (figshare.com)
  • However, through God's wisdom Nehemiah learned to combat these attacks, and in the following message, "Overcoming the Fear Factor," as part of the inspirational series "Living Your Dreams," a study in the life of Nehemiah, Dr. Robert Jeffress reveals to us as listeners how we can too. (clientqa.co)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Hypoxia-inducible factor 1 (HIF-1) is one of the master regulators that orchestrate the cellular responses to hypoxia. (northwestern.edu)
  • To better understand the molecular pathogenesis of NPC, here we used an NPC cell line in a genome-wide CRISPR-based knockout screen to identify the cellular factors and pathways essential for NPC (i.e. dependence factors). (hku.hk)
  • Despite these impairment factors, there are also endogenous mechanisms of brain self-repair after stroke, which include angiogenesis. (biomedcentral.com)
  • The Drosophila piRNA pathway provides an RNA-based immune system that defends the germline genome against selfish genetic elements. (nih.gov)
  • The genome sequence of quinoa serves as an entry point for deciphering the complex molecular pathways that contribute to floral evocation. (springer.com)
  • All Pathway/Genome Databases (PGDBs) used by the Pathway Tools software -- including the EcoCyc and MetaCyc PGDBs -- must conform to the schema (ontology) described herein. (ecocyc.org)
  • Understanding the schema is essential for both users and developers of Pathway/Genome Databases who are using the Pathway Tools software. (ecocyc.org)
  • The current Pathway Tools ontology contains several hundred classes arranged in a taxonomic hierarchy. (ecocyc.org)
  • In a Polymerase Chain Reaction (PCR) array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of STAT3. (cdc.gov)
  • In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered by cells overexpressing DEFB1 , suggesting that this may be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)
  • Newman, Kahlan E. and Khalid, Syma (2023) Conformational dynamics and putative substrate extrusion pathways of the N-glycosylated outer membrane factor CmeC from Campylobacter jejuni. (soton.ac.uk)
  • Citation: Troein C, Ahre´n D, Krogh M, Peterson C (2007) Is Transcriptional Regulation of Metabolic Pathways an Optimal Strategy for Fitness? (lu.se)
  • Vitamin B6 is involved in numerous metabolic pathways as an enzyme cofactor. (cdc.gov)
  • Most researchers investigating factors associated with suboptimal diets limit their studies to developing nutritional risk profiles, and many conclude by advocating patient education. (uky.edu)
  • Using telephone surveys and in-depth interviews, this article identifies particularly vulnerable elders and explores the contextual and experiential pathways that place individuals at nutritional risk. (uky.edu)
  • In-depth interviews revealed four pathways to nutritional risk, including transitions in the social and physical significance of food, inaccessibility of resources, increased physical limitations, and inadequate or inappropriate dietary advice. (uky.edu)
  • Homocysteine (HCY), a risk factor for cardiovascular and other diseases, is converted to cysteine by PLP-dependent transsulfuration enzymes. (cdc.gov)
  • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (T h 1)-specific immune responses and inhibits the development of IL-4-producing Th cells. (nature.com)
  • Open Access pathways permitted by this journal's policy are listed below by article version. (sherpa.ac.uk)
  • To clarify the mechanism underlying the difference in the cachexia-inducing ability of these cells, we conducted DNA microarray analysis, focusing on cell proliferation and the production of leukemia inhibitory factor (LIF), a cachexia-inducing factor. (oncotarget.com)
  • We recently described the expression of leukemia inhibitory factor (LIF) in human fetal and murine corticotrophs. (manchester.ac.uk)
  • This results in intravascular fibrin deposition and decreased levels of hemostatic components, including platelets, fibrinogen, and other clotting factors. (medscape.com)
  • Factor I, with cofactors including membrane cofactor protein (CD46), inactivates C3b and C4b. (msdmanuals.com)
  • 2017. Evidence of a Sewer Vapor Transport Pathway at the USEPA Vapor Intrusion Research Duplex. (serdp-estcp.org)
  • Results International medical graduates who chose the "clerkship pathway" had greater success on certification examinations than those who started at the residency level did. (cfp.ca)
  • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. (nature.com)
  • The behavioural and biological responses of a child to the obesogenic environment can be shaped by processes even before birth, placing an even greater number of children on the pathway to becoming obese when faced with an unhealthy diet and low physical activity. (who.int)
  • 2022 Pathway to Victory, A Ministry of First Baptist Dallas. (clientqa.co)
  • While several key factors of each branch have been identified, our current knowledge is insufficient to explain the complex workings of the piRNA machinery. (nih.gov)
  • Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
  • Carisk's proprietary approach to managing acute catastrophic and complex workers' comp cases - dubbed Pathways 2 Recovery - is structured around evidence-based clinical pathways for both physical and behavioral treatment. (riskandinsurance.com)