AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation Science
Connective Tissue Growth FactorImmediate-Early ProteinsIntercellular Signaling Peptides and ProteinsConnective TissueNephroblastoma Overexpressed ProteinGrowth SubstancesTransforming Growth Factor betaFibrosisTransforming Growth Factor beta1Connective Tissue DiseasesCysteine-Rich Protein 61Connective Tissue CellsFibroblastsCCN Intercellular Signaling ProteinsRNA, MessengerCells, CulturedCollagen Type ICollagenExtracellular MatrixSignal TransductionGene Expression RegulationScleroderma, SystemicMixed Connective Tissue DiseaseFibronectinsReverse Transcriptase Polymerase Chain ReactionCorneal KeratocytesVascular Endothelial Growth Factor ASmad2 ProteinSkinHouttuyniaExtracellular Matrix ProteinsGene ExpressionMesangial CellsTransforming Growth Factor beta2Epidermal Growth FactorUp-RegulationSmad ProteinsBlotting, WesternGlomerular MesangiumCell ProliferationCollagen Type IIISmad3 ProteinReceptors, Transforming Growth Factor betaImmunohistochemistryActinsMitogensWound HealingDisease Models, AnimalCell LinePulmonary FibrosisReceptor, Epidermal Growth FactorInsulin-Like Growth Factor Binding ProteinsRats, Sprague-DawleyCollagen Type IVHepatic Stellate CellsDiabetic NephropathiesDiabetes Mellitus, ExperimentalKidneyRecombinant ProteinsIn Situ HybridizationCell DifferentiationFocal Epithelial HyperplasiaPhosphorylationFibroblast Growth Factor 2Fibromatosis, GingivalMice, Inbred C57BLEpithelial CellsCell MovementMyofibroblastsPolygelineDermisRNA, Small InterferingInsulin-Like Growth Factor IPromoter Regions, GeneticKidney TubulesAmino Acids, DicarboxylicHepatocyte Growth FactorPlatelet-Derived Growth FactorBlotting, NorthernChondrocytesrhoA GTP-Binding ProteinTime FactorsCulture Media, ConditionedFibroblast Growth FactorsPericytesTransforming Growth FactorsMice, TransgenicMAP Kinase Signaling SystemOligonucleotides, AntisenseNeovascularization, PhysiologicCell DivisionLysophospholipidsTransfectionProteoglycansEnzyme-Linked Immunosorbent AssayRats, WistarTrabecular MeshworkBase SequenceFiltering SurgeryBleomycin
CTGFCCN2FibrosisPlatelet deriveDiseasesSecretionAbnormalitiesExpressionAbnormalPulmonaryDisruptsProteinsGeneFibroblastsCytokinesMediatesDrug-inducedBenignFibrous tissueWoundProliferation and differentiationPromotesExtracellularPathwaysVascular endothResiduesMesenchymalAutosomal dominantSerumTumor growthPrognosticFibroblastEpidermalCellsExcessiveAngiotensinAmniotic fluidThyroidKeloidTransforming growTherapeuticDiseasePathwayLung developmentSpecies
CTGF22
CCN21
  • Downregulation of CCN2 expression in these cells was associated with a growth arrest at the G1/S transition while over-expression of CCN2 induced a two-fold increase of the number of cells in the G1 phase. (neuromics.com)
Fibrosis11
  • [ 5 ] Cohen and colleagues have found that in-utero overexpression of the cystic fibrosis transmembrane conductance regulator (CFTR) increased liquid secretion into the lung, accelerating lung growth in a rat model. (medscape.com)
  • Pamrevlumab, an anti-connective tissue growth factor therapy, for idiopathic pulmonary fibrosis (PRAISE): a phase 2, randomised, double-blind, placebo-controlled trial. (nih.gov)
  • Moreover, GATA2 was identified as a cardiac fibrosis-associated upstream positive transcription factor of miR-409-3p. (hindawi.com)
  • Inflammation, oxidative stress, and aging have been proven to contribute to cardiac fibrosis, which is regulated by multiple factors [ 7 - 9 ]. (hindawi.com)
  • For instance, miR-409-3p promotes epithelial to mesenchymal transition and tumor growth in prostate cancer and also accelerates osteoblastic differentiation through the Wnt/ β -catenin pathway [ 17 , 18 ], a crucial pathway in regulating cardiac fibrosis. (hindawi.com)
  • Yang D, Yuan J, Liu G, Ling Z, Zeng H, Chen Y, Zhang Y, She Q, Zhou X. Angiotensin Receptor Blockers and Statins Could Alleviate Atrial Fibrosis via Regulating Platelet-Derived Growth Factor/Rac1 /Nuclear Factor-Kappa B Axis. (medsci.org)
  • To investigate whether the administration of renin-angiotensin system (RAS) inhibitors and statins could alleviate atrial fibrosis via platelet-derived growth factor (PDGF)/Rac1 /nuclear factor-kappa B (NF-κB) axis. (medsci.org)
  • In addition, other studies demonstrated that AngII activated platelet-derived growth factor-A (PDGF-A), a novel contributor to cardiac remodelling, to result in atrial fibrosis in pressure-overloaded mouse model [ 13 ] . (medsci.org)
  • In addition, fascial fibroblasts express transforming growth factor-beta I and connective-tissue growth factor mRNA, which may account for the clinical fibrosis. (medscape.com)
  • Hepatic fibrosis is overly exuberant wound healing in which excessive connective tissue builds up in the liver. (msdmanuals.com)
  • Commonly, fibrosis progresses, disrupting hepatic architecture and eventually function, as regenerating hepatocytes attempt to replace and repair damaged tissue. (msdmanuals.com)
Platelet derive2
Diseases3
  • Endothelial dysfunction is a critical initiating factor contributing to cardiovascular diseases, involving the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO). (nature.com)
  • Connective tissue diseases, hypersensitivity pneumonitis, asbestosis and sarcoidosis may progress to cause the histological lesion of UIP 1 . (ersjournals.com)
  • Prior to joining Surrey, her research centred around pulmonary hypertension and connective tissue diseases. (surrey.ac.uk)
Secretion1
  • They demonstrated that moderate and high AjA concentrations significantly suppressed tumor necrosis factor (TNF)-alpha secretion, whereas all AjA doses significantly reduced interferon (IFN)-alpha and INF-beta production. (aad.org)
Abnormalities1
Expression9
  • We found that the expression of miR-18a was abnormally reduced in the HBV-positive HCC tissue samples compared with HBV-negative HCC samples. (medscimonit.com)
  • Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma[J]. Oncol Rep,2019,42:2323-2332. (magtechjournal.com)
  • TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. (medscape.com)
  • Kutasy B, Friemacher F, Duess JW, Puri P. Prenatal administration of retinoic acid increases the trophoblastic insulin-like-growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia. (medscape.com)
  • Different regulatory mechanisms between mRNA and protein expression or localized changes missed due to homogenization of the tissue samples, may explain the discrepancy in findings. (cdc.gov)
  • Aortic tissue samples were collected from normal donors and AAD patients, and the expression of ADAMTS-5 was analyzed in all aortic tissues. (frontiersin.org)
  • Lung tissues were collected on day 21 to detect pathological changes and the expression of collagen content and regulator of G protein signaling 2(RGS2). (researchsquare.com)
  • The incubation of DSS fibroblasts with a synthetic cannabinoid receptor agonist (WIN55, 212- 2) decreased their expression in a dose-dependent manner, together with a parallel reduction in collagen production and pro- fibrotic cytokines, including transforming growth factor-beta (TGF-beta), connective tissue growth factor and interleukin-6 (IL-6). (aad.org)
  • Therefore, the expression of a number of growth factors and their receptors, all of which affect fetal lung development, is temporally and spatially regulated. (medscape.com)
Abnormal2
  • Keloids are benign fibrous growths that result from an abnormal connective tissue response in certain predisposed individuals. (ispub.com)
  • The drug mediates interactions between these receptors, growth factors, and proteins within that pathway to reduce new abnormal bone formation. (medscape.com)
Pulmonary6
  • Pulmonary hypoplasia (PH) or aplasia is a rare condition that is characterized by incomplete development of lung tissue, which can be unilateral or bilateral. (medscape.com)
  • Oligohydramnios is considered to be an independent risk factor for the development of pulmonary hypoplasia. (medscape.com)
  • Thyroid transcription factor 1 (TTF-1) is thought to be the earliest embryologic marker associated with cells committed to pulmonary development. (medscape.com)
  • Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)
  • Pulmonary hypoplasia or aplasia is part of the spectrum of malformations characterized by incomplete development of lung tissue. (medscape.com)
  • Postnatal diagnosis of pulmonary hypoplasia can be made with specific criteria such as clinical and radiologic criteria, or pathologic criteria such as lung weight or lung weight-to-body weight ratio, mean radial alveolar count, and DNA estimation for growth assessment at autopsy. (medscape.com)
Disrupts1
  • As a result, microfibril formation is reduced, which probably weakens the structure of connective tissue and disrupts regulation of growth factor activity. (medlineplus.gov)
Proteins8
  • Connective Tissue Growth Factor belongs to the CCN family of proteins. (neuromics.com)
  • The full length protein consists of four modulesModule I shares partial identity with the N-terminal part of the Insulin-like Growth Factor Binding Proteins (IGFBPs). (neuromics.com)
  • Transforming growth factor family proteins like TGFß1 can oppose these effects. (medscape.com)
  • Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
  • These markers include a variety of proteins usually including growth factors, and hormones among others. (bvsalud.org)
  • A complex extracellular matrix with collagenous and non-collagenous proteins composes mineralized tissue. (bvsalud.org)
  • Three non-collagenous proteins, osteonectin, transforming growth factor β-1 (TGF-β1) and bone morphogenetic proteins (BMPs), have drawn much attention in the literature lately. (bvsalud.org)
  • Bone morphogenetic proteins (BMPs) form a unique group of proteins within the transforming growth factor beta (TGF-β) superfamily. (bvsalud.org)
Gene1
  • A gene highly expressed in fibrosing tissue is the serum- and glucocorticoid-inducible kinase SGK1. (amrita.edu)
Fibroblasts2
  • DFUs are caused, in part, by the deficiency in growth factors (GFs) implicated in keratinocytes and fibroblasts proliferation, migration, and extracellular matrix deposition. (pharmaceuticsconference.com)
  • We found that miR-409-3p was consistently increased in three fibrotic models, including heart tissues of postmyocardial infarction (MI) mice and neonatal rat cardiac fibroblasts treated with angiotensin II (Ang II) or transforming growth factor- β (TGF- β ). (hindawi.com)
Cytokines1
  • Induced EndoMT in PAECs by inflammatory cytokines IL-1β, tumor necrosis factor α, and transforming growth factor β led to actin cytoskeleton reorganization and the development of a mesenchymal morphology. (surrey.ac.uk)
Mediates1
  • Connective tissue growth factor mediates TGF-β1-induced low-grade serous ovarian tumor cell apoptosis[J]. Oncotarget, 2017,8:85224-85233. (magtechjournal.com)
Drug-induced1
  • Connective tissue disease, hypersensitivity pneumonitis, drug-induced lung disease, resolved acute respiratory distress syndrome and some cases of cryptogenic organising pneumonia may all produce a histological picture of NSIP 1 , 3 . (ersjournals.com)
Benign1
  • Background: Benign fibro-osseous lesions (BFOL) comprise a diverse group of pathologies characterized by the replacement of normal bone by fibrous tissue and a mineralized product. (bvsalud.org)
Fibrous tissue1
  • Keloids are the result of an overgrowth of dense fibrous tissue that usually develops after healing of a skin injury. (ispub.com)
Wound3
  • Commonly affecting those with skin of color, keloids are an aberrant wound response that leads to wound tissue expanding above and beyond the original cutaneous injury. (springer.com)
  • Keloids are a pathologic response to cutaneous injury in which wound tissue grows beyond the inciting insult. (springer.com)
  • 1 The tissue extends beyond the borders of the original wound, does not regress spontaneously, and tends to recur after excision. (ispub.com)
Proliferation and differentiation1
  • Signals from these growth factors are integrated with environmental influences, such as lung fluid volume and hyperoxia, to cause cellular proliferation and differentiation. (medscape.com)
Promotes1
  • Connective tissue growth factor promotes the proliferation and migration of human ovarian cancer cell line SKOV3[J]. Basic & Clinical Medicine, 2021, 41(2): 193-196. (magtechjournal.com)
Extracellular2
  • Module IV resembles the CT domain of several extracellular protein including, Von Willebrand's factor and mucins. (neuromics.com)
  • They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. (bvsalud.org)
Pathways1
  • However, the KEGG signalling pathways namely "tumour necrosis factor (TNF)" and "cytokine-cytokine receptor interaction" were downregulated at 24H but activated at 48H. (nature.com)
Vascular endoth1
  • Bedaiwy MA, Burlingame JM, Hussein M, Flyckt R, Assad R, Falcone T. Assessment of vascular endothelial growth factor, basic fibroblast growth factor and transforming growth factor levels in amniotic fluid. (medscape.com)
Residues1
  • Module II includes a stretch of 70amino acid residues - which shares sequence identity with the Von Willebrand Factor Type C repeat (VWC). (neuromics.com)
Mesenchymal2
  • Growth factors are produced by mesenchymal tissue and are present in amniotic fluid. (medscape.com)
  • TGF-β1 is a multifunctional regulator of cell growth which will either stimulate or inhibit proliferation of mesenchymal cells depending on the presence of other growth factors 7,8,9 . (bvsalud.org)
Autosomal dominant2
  • Multiple endocrine neoplasia (MEN) syndromes consist of rare, autosomal dominant mutations in genes regulating cell growth. (ispub.com)
  • Affecting roughly 400 people in the United States and 900 worldwide, FOP is an autosomal dominant condition in which bone develops in soft connective tissue areas of the body where it isn't normally present (heterotopic ossification), such as the ligaments, tendons, and skeletal muscles. (medscape.com)
Serum1
  • Other studies have shown elevated serum levels of manganese superoxide dismutase and tissue inhibitor of metalloproteinase (TIMP-1). (medscape.com)
Tumor growth1
  • The T category informs about tumor growth, depth and stage of adjacent tissues invasion. (biorxiv.org)
Prognostic3
  • The present study aimed to identify differentially expressed tissue miRs associated with prognostic factors in CRC patients, through a systematic review of the Literature. (biorxiv.org)
  • Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. (biorxiv.org)
  • Specific tissue miRs are shown to be promising prognostic biomarkers in patients with CRC, given their strong association with the prognostic aspects of these tumors, however, new studies are necessary to establish the sensibility and specificity of the miRs in order to use them in clinical practice. (biorxiv.org)
Fibroblast1
  • Enhances fibroblast growth factor-induced DNA synthesis. (joplink.net)
Epidermal1
  • Renal epidermal growth factor receptor (EGFR) signaling is activated in models of diabetic nephropathy (DN), and inhibition of the EGFR signaling pathway protects against the development of DN. (diabetesjournals.org)
Cells1
Excessive1
  • Keloids are defined as excessive scar tissue formation extending beyond the area of the original skin injury and occurring in predisposed individuals. (ispub.com)
Angiotensin1
  • Angiotensin II (Ang II) and transforming growth factor- β (TGF- β ) are the most important among these factors. (hindawi.com)
Amniotic fluid2
  • The presence of growth factors in amniotic fluid indicates that lung development is not solely a pressure phenomenon. (medscape.com)
  • Fetal urine is an important component of amniotic fluid during late gestation and contributes to lung growth. (medscape.com)
Thyroid1
  • Lung development is regulated by several transcription factors, such as thyroid transcription factor 1 (TTF-1) family, hepatocyte nuclear family, and peptide growth factors. (medscape.com)
Keloid2
  • However, because no treatment has been found to be fully effective at inducing regression of keloid tissue or at preventing postoperative recurrence, much work is being done to elucidate the underlying pathology of these lesions and to devise better treatments. (springer.com)
  • In addition, endocrinologic factors have also been associated with keloid formation. (ispub.com)
Transforming grow1
  • Further research into eosinophilic fasciitis has shown elevations of transforming growth factor-beta and interleukin 5, which normalize with corticosteroid therapy. (medscape.com)
Therapeutic1
  • These factors have drawn considerable interest to finding optimal therapeutic regimens for this infection, as well as to identifying the pathogenesis, ecology, and the reservoirs of this microorganism. (cdc.gov)
Disease2
  • Frequently, however, ILDs can also be associated with a specific environmental exposure or an underlying connective tissue disease. (ersjournals.com)
  • Since then, many clinicians and researchers from Taiwan have reported risk factors and the clinical spectrum of this disease on the basis of an increasing number of reported cases ( 4 - 12 ). (cdc.gov)
Pathway1
  • It has been postulated that the Rho-ROCK pathway can affect the growth of the lung epithelium. (medscape.com)
Lung development1
  • Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model. (medscape.com)
Species1
  • Borrelia species were not identified by direct microscopic examination of tissue samples or by polymerase chain reaction amplification of tissue samples in any of these reported cases of eosinophilic fasciitis. (medscape.com)