Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome c oxidase expression and nuclear control of mitochondrial function. (wikipedia.org)
3. Is nuclear respiratory factor 2 a master transcriptional coordinator for all ten nuclear-encoded cytochrome c oxidase subunits in neurons? (nih.gov)
SDHD encodes subunit D of the succinate dehydrogenase complex, an integral membrane protein. (nih.gov)
This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. (cancerindex.org)
Mitochondrial5
In this report, we investigated the in vivo function of nuclear respiratory factor 1 (Nrf1), a major transcriptional regulator of mitochondrial biogenesis in both proliferating retinal progenitor cells (RPCs) and postmitotic rod photoreceptor cells (PRs). (biomedcentral.com)
Nrf1 binds to GC-rich DNA elements in promoters of many nuclear genes required for mitochondrial biogenesis and respiratory function [ 9 , 10 , 11 ]. (biomedcentral.com)
1. Nuclear respiratory factor 2 activates transcription of human mitochondrial translation initiation factor 2 gene. (nih.gov)
16. Transcription factor GABP/NRF-2 controlling biogenesis of mitochondria regulates basal expression of peroxiredoxin V but the mitochondrial function of peroxiredoxin V is dispensable in the dog. (nih.gov)
A heterotetrameric transcription factor composed of two distinct proteins. (nih.gov)
ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. (embl.de)
Like Ras, ARFs are active in their GTP-bound form, and their duration of activity is controlled by GTPase-activating proteins (GAPs), which assist ARFs in hydrolyzing GTP to GDP. (embl.de)
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. (lookformedical.com)
Nuclear respiratory3
2. p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene. (nih.gov)
12. Human synapsin I mediates the function of nuclear respiratory factor 1 in neurite outgrowth in neuroblastoma IMR-32 cells. (nih.gov)
13. Nuclear respiratory factor 2 senses changing cellular energy demands and its silencing down-regulates cytochrome oxidase and other target gene mRNAs. (nih.gov)
Transcriptional2
May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. (nih.gov)
14. Transcriptional activity and Sp 1/3 transcription factor binding to the P1 promoter sequences of the human AbetaH-J-J locus. (nih.gov)
Receptor2
PAPbeta, a protein that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modular signaling domains including a pleckstrin homology domain, an SH3 domain, ankyrin repeats and an ARF-GAP domain. (embl.de)
Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. (cusabio.com)
Motifs1
The promoter analysis yields 174 candidate motifs, including most previously known transcription-factor binding sites and 105 new motifs. (gsea-msigdb.org)
Ankyrin repeat1
The structure of the IkappaBalpha ankyrin repeat domain, bound to a partially truncated NF-kappaB heterodimer (p50/ p65), has been determined by X-ray crystallography at 2.7 A resolution. (embl.de)
10. Laminin reduces expression of the human alpha6 integrin subunit gene by altering the level of the transcription factors Sp1 and Sp3. (nih.gov)
Sequences1
Its name refers to the fact it binds to DNA sequences rich in GUANINE and ADENINE . (nih.gov)
Regulates1
GA-binding protein integrates a variety of SIGNAL TRANSDUCTION PATHWAYS and regulates expression of GENES involved in CELL CYCLE control, PROTEIN BIOSYNTHESIS , and cellular METABOLISM . (nih.gov)
As an example, 1D11 neutralizes all three leading energetic TGF B iso kinds, but doesn't bind other ligands inside the TGF B superfamily, this kind of as activins and BMPs. (plcsignaling.com)
Promoter2
Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter" (PDF). (wikipedia.org)
15. Identification of a responsible promoter region and a key transcription factor, CCAAT/enhancer-binding protein epsilon, for up-regulation of PHGPx in HL60 cells stimulated with TNF alpha. (nih.gov)
Leucine1
Our study also revealed that MSR triggered AKT/S6K signalling by activating mTORC2 via activating transcription factor 4/sestrin 2 activation whilst promoting leucine transporter and nutrient-induced mTORC1 activation. (bvsalud.org)
Beta1
In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. (cusabio.com)
Gene6
GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene. (wikipedia.org)
This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. (wikipedia.org)
5. NRF-1 is the major transcription factor regulating the expression of the human TOMM34 gene. (nih.gov)
9. Transcription factor hStaf/ZNF143 is required for expression of the human TFAM gene. (nih.gov)
18. NRF-2 transcription factor is essential in promoting human Tomm70 gene expression. (nih.gov)
Human1
We demonstrated that the MSR is activated in a significant proportion of human thyroid cancers via the upregulation of heat shock protein D family members and the mitokine, growth differentiation factor 15. (bvsalud.org)
Liver1
We used data from the Genotype-Tissue Expression portal to investigate RNA expression patterns of the thyroid gland according to the expression of growth differentiation factor 15 (GDF15) such as the muscles and liver. (bvsalud.org)