• Serial femtosecond crystallography is a promising new technique for protein structure determination, where a liquid stream containing protein crystals is intersected with a high-intensity X-ray free electron laser beam that is 109 times brighter than traditional synchrotron X-ray sources. (spectroscopyonline.com)
  • How did the combination of serial femtosecond crystallography and high-intensity X-ray free electron laser take place? (spectroscopyonline.com)
  • The UK is a leading member of the serial femtosecond crystallography user consortium (SFX-UC), and through its role in the collaboration will deliver a dual instrument at the European XFEL that will enable visiting scientific users to image macromolecules from nanocrystals on the SFX instrument and single particles using scattering of coherent X-rays and detecting the coherent diffraction pattern on the SPB instrument . (diamond.ac.uk)
  • Serial femtosecond crystallography (SFX) was the term coined to describe the protocols used to collect the first diffraction data from nanocrystals at the LCLS in Stanford, US A . Scientists there were able to exploit the ultrashort pulses generated by LCLS to collect single shot diffraction images from nanocrystals. (diamond.ac.uk)
  • Formed in July of 2007, to support the research endeavors at Michigan State University, with resources for Single Crystal X-ray Diffraction (SCXRD), Powder X-ray Diffraction (PWXRD) and X-ray Fluorescence Spectroscopy (XRF). (msu.edu)
  • The building includes a microscopy suite and optical spectroscopy, nuclear magnetic resonance spectroscopy and X-ray crystallography laboratories. (rutgers.edu)
  • We use state-of-the-art facilities in X-ray crystallography, NMR spectroscopy, mass spectrometry, cryo-electron microscopy, imaging, biophysical and biochemical analysis, molecular and cell biology. (ucl.ac.uk)
  • In addition to a wide range of specialized equipment found in individual research laboratories (centrifuges, electrochemical, chromatography, electrophoresis, calorimetry, and Raman, fluorescence and UV-visible spectroscopy), the Department has a dedicated Nuclear Magnetic Resonance (NMR) Facility with Varian 200, 400 and 600MHz NMR spectrometers. (utoledo.edu)
  • The research activities of the CSB revolve around three major biophysical approaches for studying the structure and dynamics of complex biological macromolecules: NMR spectroscopy, X-ray crystallography, and electron cryo-microscopy. (stonybrook.edu)
  • Infrastructures for transmission- and scanning electron microscopy, photoelectron spectroscopy, nuclear magnetic resonance and magnetic resonance imaging, mass spectroscopy, crystallography, additive manufacturing, as well as dedicated fabrication and synthesis laboratories for electronic and circular materials are being financed. (lu.se)
  • One source with two high-flux wavelengths is the foundation of the revolutionary XtaLAB Synergy-DW VHF single crystal X-ray diffractometer. (rigaku.com)
  • The XtaLAB Synergy-DW VHF diffractometer is based on the proven, low-maintenance MicroMax-007 HF microfocus rotating anode X-ray generator . (rigaku.com)
  • XtaLAB Synergy-DW VHF systems are configured with a Hybrid Photon Counting (HPC) X-ray detector, which are ideal for macromolecular crystallography experiments because they are photon counting detectors that directly detect X-ray photons without the need for the intermediate step of converting X-ray photons to light with a phosphor or scintillator. (rigaku.com)
  • There are indeed other approaches to reducing sample waste, which all come at a price, such as either being too slow for very high XFEL repetition rates, not being compatible with time-resolved crystallography, not being compatible with many classes of proteins, or introducing large background. (spectroscopyonline.com)
  • Our method thus requires little to no adjustment compared to non-droplet approaches for the crystallographer and additionally can be adapted to time-resolved crystallography techniques, where sample requirements is a limiting factor. (spectroscopyonline.com)
  • Supports Laue and monochromatic time-resolved crystallography and time-resolved SAXS/WAXS. (rcsb.org)
  • Time-resolved crystallography and SAXS/WAXS with 100ps time resolution. (rcsb.org)
  • Here, a method called time-resolved serial femtosecond X-ray crystallography (TR-SFX) can be used to study the ultra-fast movements of proteins. (lightsources.org)
  • LP3 was successful in its application for renewal of beamtime access at BioMAX (the X-ray macromolecular crystallography beamline of MAX IV). (lu.se)
  • He has been responsible for building the beamline FemtoMAX at MAX IV and is a frequent user of Synchrotron radiation facilities (including MAX IV) and Free-electron lasers. (lu.se)
  • This X-ray diffraction system features the PhotonMax high-flux 9 kW rotating anode X-ray source coupled with a 1D measurement modes. (fsu.edu)
  • Faster, accurate data collection due to high-speed kappa goniometer, high-flux rotating anode X-ray source, fast, low-noise X-ray detector, and highly optimized instrument control software. (rigaku.com)
  • Improve your ability to investigate small samples due to the increased flux from the rotating anode X-ray source as well as the extreme low noise of the HyPix X-ray detectors. (rigaku.com)
  • It combines the increased flux of a rotating anode X-ray source with the flexibility of two different wavelengths, making it ideal for laboratories exploring a wide range of research interests. (rigaku.com)
  • Our most popular diffractometer for Protein Crystallography , configured with a high-flux rotating anode X-ray source and an extremely low noise direct X-ray detection detector. (rigaku.com)
  • A bespoke, extremely high-flux diffractometer with custom enclosure and the flexibility to utilize both ports of the rotating anode X-ray source. (rigaku.com)
  • The emergence of serial crystallography at the X-ray free-electron lasers (XFELs) and its subsequent adaptation at the synchrotron X-ray sources allowed macromolecular crystallography (MX) expansion towards previously inaccessible structural biology targets such as membrane proteins or large complexes, which tend to crystallize as micrometre-sized crystals. (iucr.org)
  • The purpose of the X-ray Crystallography Shared Service is to provide equipment, training, assistance, and technological innovations for determining three-dimensional structures of protein and other macromolecules to understand the structural basis for biological function and dynamics. (umms.org)
  • The technique is able to yield high-resolution structural information from small micro- or nanocrystals, thus reducing the contribution of crystal defects and avoiding tedious (if not impossible) growth of large crystals as is required in traditional synchrotron based crystallography. (spectroscopyonline.com)
  • The Structural Biology team has expertise in macromolecular crystallography and works with investigators on all levels of structure determination. (ilabsolutions.com)
  • Brookhaven National Laboratory (BNL) has world-class facilities for structural biology that are available to students in the BSB Program. (stonybrook.edu)
  • The National Synchrotron Light Source (NSLS-II) at BNL is one of the newest and most advanced facilities for structural biology in the world. (stonybrook.edu)
  • Many aspects of discovery, design, development and formulation processes require structural information acquired by X-ray diffraction techniques. (rigaku.com)
  • The UK is taking a leading role in the development of a new structural biology facility (SFX) at the European X-ray Free Electron Laser (XFEL), in Hamburg, Germany, and a complementary facility at Diamond (The UK XFEL Hub) to help develop the required expertise. (diamond.ac.uk)
  • The system is based around the PhotonJet-S series of Cu and Mo microfocus X-ray sources that incorporate continuously variable divergence slits. (fsu.edu)
  • Our most popular diffractometer for Chemical Crystallography and Mineralogy , configured with either single or dual microfocus sealed tube X-ray sources and an extremely low noise direct X-ray detection detector. (rigaku.com)
  • An entry-level single crystal X-ray diffractometer for Chemical Crystallography configured with microfocus sealed tube technology and a direct X-ray detection detector. (rigaku.com)
  • LEAPS is the League of European Accelerator-based Photon Sources , a strategic consortium initiated by the Directors of the Synchrotron Radiation and Free Electron Laser (FEL) user facilities in Europe. (infn.it)
  • To this end, we use a wide range of neutron facilities and synchrotron radiation facilities in Europe and around the world, soon to include the European Spallation Source at Lund. (lu.se)
  • With the help of various forms of mass spectrometry, synchrotron radiation, protein production & labelling, and bioinformatics, our facilities provide the opportunity to study protein structure and dynamics, molecular probes and drug design. (lu.se)
  • Over the past two decades various new tools have been developed to perform in situ mechanical testing at synchrotrons X-ray and neutron facilities. (psi.ch)
  • The laboratory is equipped with start-of-the-art hardware and software to facilitate crystallography groups to determine their structures. (contractresearchmap.com)
  • The Materials Characterization Laboratory houses the departmental X-ray crystallography facilities and a brand new Analytical Ultracentrifuge. (ndsu.edu)
  • As a U.S. Department of Energy's (DOE) Office of Science user facility located at DOE's Brookhaven National Laboratory, NSLS-II offers its experimental capabilities to scientists from all over the world who use it to reveal the mysteries of materials for tomorrow's technology. (lightsources.org)
  • Department of Chemistry Research Facilities include a stockroom that provides routine reagents and supplies at reasonable cost, an NMR laboratory with a Bruker MSL 200/300 for multinuclear studies of solids at nominal field strengths of 200/300 MHz (protons) and Varian Inova 400 and JEOL Eclipse 500 spectrometers for high resolution proton, carbon, and multinuclear NMR solution studies. (vt.edu)
  • The Department of Chemistry, in collaboration with the Department of Geological Sciences, also maintains single-crystal X-ray diffractometers interfaced with a number of personal computers and PC-based structure determination software in a centralized Crystallography Laboratory which is available for use by members of the VT community on a fee basis. (vt.edu)
  • Depending on the nature of your project, you will have access to state-of-the art biochemical and biophysical research facilities, such as the MAX IV laboratory and the brand new NMR laboratory at the department of chemistry. (lu.se)
  • Single Crystal, Powder Diffraction and High Pressure Crystallography. (msu.edu)
  • Facility users also have access to the Cambridge Crystal Structure Database (CCSD) for organic and organometallic compounds and to the Inorganic Crystal Structure Database (ICSD) for inorganic materials, as well as to the extensive Powder Diffraction File (PDF) database. (fsu.edu)
  • New sixth generation MiniFlex benchtop X-ray diffractometer is a multipurpose powder diffraction analytical instrument that can determine: crystalline phase identification (phase ID) and quantification, percent (%) crystallinity, crystallite size and strain, lattice parameter refinement, Rietveld refinement, and molecular structure. (fsu.edu)
  • The departmental NMR facility comprises seven instruments (300 MHz-600MHz) tailored for various teaching/research activities within the Department. (ubc.ca)
  • At the Swiss Light Source macromolecular crystallography (MX) beamlines the collection of serial synchrotron crystallography (SSX) diffraction data is facilitated by the recent DA+ data acquisition and analysis software developments. (iucr.org)
  • The tools that were developed have been optimized for usage at PSI's large-scale facilities (the Swiss Light Source and the Swiss Neutron Spallation Source). (psi.ch)
  • The facility provides instrumentation and expertise for collecting and processing x-ray diffraction data from macromolecular single crystals and is available to all the research groups inside and outside the campus. (umms.org)
  • LS-CAT provides access to state-of-the-art x-ray diffraction facilities at Argonne National Laboratory's Advanced Photon Source where extremely intense beams of x-rays are focused using both mirrors and beryllium lenses onto tiny protein crystals. (msu.edu)
  • While the crystals diffract and immediately after are destroyed by the intense X-ray free electron lasers (XFELs) beam, the resulting diffraction patterns can be recorded with state-of-the-art detectors. (spectroscopyonline.com)
  • The X-ray facility has the latest robots and imaging equipment for preparing crystals of macromolecules. (stonybrook.edu)
  • When the FEL X-ray light shines on these crystals, the information is captured in time before the crystals and their proteins are destroyed by the pulse of light. (lightsources.org)
  • The aim of protein crystallization is to produce well-ordered protein mono-crystals large enough to diffract X-ray beam. (weizmann.ac.il)
  • The centre also stands out for large research installations, such as its animal facility, greenhouse and one of the few high-level biocontainment (BSL-3) laboratories currently operative in Spain. (csic.es)
  • Wolfe Hall, which opened in 1998 adjacent to Bowman-Oddy Laboratories, is a 165,000 square foot research and teaching facility for the Departments of Chemistry and Biochemistry, Biological Sciences, and Environmental Sciences in the College of Natural Sciences and Mathematics, as well as the College of Pharmacy and Pharmaceutical Sciences. (utoledo.edu)
  • The facility contains state-of-the art research laboratories, modern mediated lecture rooms, a greenhouse, and a fully operational teaching pharmacy. (utoledo.edu)
  • The University maintains core facilities available to students in MCP program laboratories. (stonybrook.edu)
  • The main office, core facilities, and most research laboratories of the Department of Biochemistry are located in Engel Hall and the adjacent Fralin Biotechnology Center . (vt.edu)
  • The multi-user protein crystallography facility at the Department of Chemistry and Biochemistry provides the instrumentation and expertise from X-ray diffraction data collection and processing to structure solution and refinement. (contractresearchmap.com)
  • The four-story, 144,000-square-foot facility will help accelerate innovative work in biophysical chemistry related to human health, drug design and synthesis, alternative energy, biomaterials, nanotechnology and other fields. (rutgers.edu)
  • Research is conducted for 10 weeks in the summer in our state-of-the-art chemistry facility with highly interactive faculty. (pathwaystoscience.org)
  • Also, two daylong hands-on workshops on single crystal X-ray crystallography and computational chemistry round out the experience. (pathwaystoscience.org)
  • The Department of Chemistry and Biochemistry research facilities are housed in the Bowman-Oddy/Wolfe Hall complex. (utoledo.edu)
  • Abhijeet joined Lonza in 2020 from Kansas State University's Chemistry Department, where he served as a Senior Scientist and Director of the university's x-ray crystallography facility. (lonza.com)
  • Abhijeet's expertise includes molecular modeling, in silico screening of active pharmaceutical ingredients (APIs) and polymorphs, particle engineering, industrial crystallization, organic and inorganic chemistry, and x-ray crystallography. (lonza.com)
  • At ActiveSight we have built a technology platform that combines high-throughput X-ray structure determination, combinatorial chemistry automated FBS and chemi-informatics approaches to rapidly invent new and novel inhibitors. (parc.com)
  • X-ray free electron lasers (XFELs) are pulsed and since the protein suspensions are typically injected in a continuous flow, sample injected in-between the XFEL's pulses is wasted. (spectroscopyonline.com)
  • Laser facility (ps and ns lasers) is available. (rcsb.org)
  • In order to investigate these dynamic processes more precisely than before, researchers have developed a new algorithm that can be used to evaluate measurements at X-ray free-electron lasers such as the SwissFEL more efficiently. (lightsources.org)
  • With their method, called "low-pass spectral analysis", the data collected when proteins are measured at X-ray free-electron lasers can be evaluated more efficiently than before. (lightsources.org)
  • In addition to materials characterization, a Core Biology Facility that serves multiple users is housed within the department for performing bioassays, cell and tissue culture work, and molecular biology experiments. (ndsu.edu)
  • The SCS is organising the ICDD® Workshop on 'Materials Characterization Using Powder X-ray Diffraction' under 'Goa University Crystallography Workshop' series. (unigoa.ac.in)
  • Also, our approach is compatible with all current operating XFEL facilities. (spectroscopyonline.com)
  • Would you explain for our readers what developments make the high-intensity XFEL beam a billion times brighter than traditional synchrotron X-ray sources. (spectroscopyonline.com)
  • To further improve the understanding of protein movements, Casadei, together with other PSI researchers, a researcher at DESY in Hamburg and other colleagues at the University of Wisconsin in Milwaukee, USA, has developed an algorithm that evaluates data obtained in experiments at an X-ray free-electron laser (XFEL). (lightsources.org)
  • An XFEL is a large-scale research facility that delivers extremely intense and short flashes of laser-quality X-ray light. (lightsources.org)
  • COVID-19 research at Argonne continues at the laboratory's Advanced Photon Source (APS), a U.S. Department of Energy (DOE) Office of Science User Facility, to precisely determine the structures of the 28 unique proteins that make up the SARS-CoV-2 virus, which causes COVID-19. (interactions.org)
  • At the PETRA III facility, the diffraction pattern created behind a circular aperture with a diameter of 5μm irradiated by a beam with a photon energy of 500eV was. (lu.se)
  • At the PETRA III facility, the diffraction pattern created behind a circular aperture with a diameter of 5μm irradiated by a beam with a photon energy of 500eV was recorded on a LiF crystal. (lu.se)
  • 300 East University Drive Tempe, AZ, 85281 United States Department: School of Molecular Sciences (SOMS) College/Unit: COLLEGE OF LIBERAL ARTS AND SCIENCES Description: X-ray crystallography is one of the most powerful techniques to study the three-dimensional structures of biological macromolecules. (contractresearchmap.com)
  • We also provide services and training in every stage of structure determination process for non-crystallography groups who are interested in solving the structures of their favorite proteins. (contractresearchmap.com)
  • A new screening method fragment-based screening (FBS) which utilizes three-dimensional X-ray structures to find novel, custom-built inhibitors has led to several new drug candidates recently and has sparked interest in FBS throughout the industry. (parc.com)
  • Processing of X-ray data and solving structures are also in the LP3 portfolio. (lu.se)
  • The XCC facility houses three newly acquired Rigaku instruments: a Synergy-S four-circle single-crystal diffractometer with a dual-source Cu/Mo radiation, a SmartLab powder diffractometer, and a MiniFlex benchtop powder diffractometer (both with Cu sources). (fsu.edu)
  • The XtaLAB Synergy-S single crystal X-ray diffractometer comes with kappa goniometer that incorporates fast motor speeds and a unique telescopic two-theta arm to provide total flexibility for the diffraction experiment. (fsu.edu)
  • As a result, the XtaLAB Synergy DW systems offer outstanding performance for macromolecular single crystal X-ray diffraction experiments. (rigaku.com)
  • A benchtop single crystal X-ray diffractometer ideal for chemical crystallography and teaching. (rigaku.com)
  • A curved single crystal X-ray diffraction detector based on direct X-ray detection technology with a higher 2θ range compared to a flat detector. (rigaku.com)
  • Other facilities include a Scanning Transmission Electron Microscope (STEM) in the Department of Biology. (stonybrook.edu)
  • The new X-ray free electron laser facility. (psi.ch)
  • We focus on using scattering techniques to look at the structure and dynamics associated with these strong electron corrrelations, particularly neutron and X-ray methods. (lu.se)
  • The unique diagnostic possibilities of X-ray diffraction, small X-ray scattering and phase-contrast imaging techniques applied with high-intensity coherent X-ray synchrotron and X-ray free-electron laser radiation can only be fully realized if a sufficient dynamic range and/or spatial resolution of the detector is available. (lu.se)
  • Our PhD students have access to the cutting-edge central computing facilities at UCL which is a world leader in computational scientific research. (ucl.ac.uk)
  • The Crystallography and Computational Biosciences Shared Resource serves as a portal for access to state-of-the-art X-ray crystallographic equipment, technical support, high-performance computing, and scientific consultation for Cancer Center researchers. (ilabsolutions.com)
  • The authors wish to acknowledge the support of the Wake Forest Baptist Crystallography and Computational Biosciences Shared Resource, supported by the National Cancer Institute's Cancer Center Support Grant award number P30CA012197. (ilabsolutions.com)
  • The facility has 96- and 384-well plate fluorimeters, culture changers, flow hoods, RT-PCR and FPLC protein purification instrumentation. (ndsu.edu)
  • This 7,000 square foot advanced instrumentation facility houses over $5 million of modern instrumentation and is staffed by three Ph.D.instrumentation specialists. (utoledo.edu)
  • The X-ray Crystallography Center (XCC) offers high-level instrumentation and expertise in sample analysis and crystal structure determination from X-ray diffraction data. (fsu.edu)
  • Protein X-ray crystallography is a high-resolution technique that allows us to study protein structure at atomic level. (csic.es)
  • we have selected this protein for structure determination by X-ray crystallography. (rcsb.org)
  • Our facility offers a complete service for the structure solution, refinement, analysis, and graphics output for small molecules. (ubc.ca)
  • The facility also provides services for protein purification, which is the first essential step for successful protein structure resolution. (umms.org)
  • The Life Sciences Collaborative Access Team (LS-CAT) formed in 2002 provides macromolecular crystallography resources for those with a need to determine the structure of proteins. (msu.edu)
  • Despite the shared 'Src module' of the SRC and TEC families, eighteen years passed before an autoinhibited structure of one of the TEC kinases was resolved by x-ray crystallography. (elifesciences.org)
  • In 2000 he joined Syrrx, a drug discovery company to build their high throughput protein structure facilities. (parc.com)
  • The Crystallography unit is offering services in protein crystallization, structure determination and analysis, by X-ray Crystallography. (weizmann.ac.il)
  • The x-ray photons can also interact directly with the spin of the electrons, and so they can scatter off the magnetic structure. (lu.se)
  • Our facilities provide the opportunity to study protein structure, molecular probes and drug design, system biology and molecular interactions in cells and tissues. (lu.se)
  • The Fralin fermentation facility contains equipment to grow large quantities of plants, microbes or animal cells under controlled conditions. (vt.edu)
  • The measurements are very complex for several reasons: the proteins are much too small to be imaged directly, their movements are incredibly fast, and the intense pulse of X-ray light of an FEL completely destroys the proteins. (lightsources.org)
  • In pink beam operation flux is 3x10^10 photons/100ps X-ray pulse in APS hybrid mode. (rcsb.org)
  • Today, there is an evolving need for more imaging methods and for biophysics that cannot be addressed with crystallisation and crystallography. (infn.it)
  • In this work, it is demonstrated that the use of lithium fluoride (LiF) as a photoluminescence (PL) imaging detector allows measuring of an X-ray diffraction image with a dynamic range of ∼10 7 within the sub-micrometre spatial resolution. (lu.se)
  • A large facility site that is well integrated with academic research can optimally provide this challenging interdisciplinary culture. (infn.it)
  • Traditionally, X-ray crystallography was dominating the interaction of large facilities with life sciences. (infn.it)
  • Synchrotron light large research facility. (psi.ch)
  • Another objective of FASEM is to promote the use of XR and neutron large-scale facilities, which are not yet currently used in biology. (lu.se)
  • Argonne is bringing the power of its scientific leadership and state-of-the-art user facilities to bear in the global battle against COVID-19. (interactions.org)
  • The Confocal Microscope Facility, located in the Fralin Biotechnology Center, has a state-of-the-art Zeiss LSM510 confocal microscope. (vt.edu)
  • King's core research facilities provide access to essential technology and equipment to enhance the research conducted by King's scientists. (kcl.ac.uk)
  • But how are they used at real research facilities? (lightsources.org)
  • This versatile facility, with capability to function simultaneously in various fields of modern biology, is available for students and researchers. (ubc.ca)