This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
Aquaporins (AQPs), a family of small integral membrane proteins responsible for facilitating water fluxes through the cell membrane, offer potential promising drug targets for sepsis treatment due to their role in water balance and inflammation. (bvsalud.org)
Aquaporins and aquaglyceroporins belong to the ancient superfamily of Major Intrinsic Proteins (MIPs) and facilitate passive transport of water and small solutes across membranes of various organisms [ 1 , 2 ]. (biomedcentral.com)
Aquaporins, also called water channels, are channel proteins from a larger family of major intrinsic proteins that form pores in the membrane of biological cells, mainly facilitating transport of water between cells. (wikipedia.org)
I have also provided preliminarily structural insights into the selectivity of aquaporins for NH3, CO2 and glycerol. (illinois.edu)
Aquaporins, widely known as membrane-facilitated water channels, also facilitate the permeation of gases and other molecules such as glycerol but with different degrees in selectivity. (illinois.edu)
According to their transport function, aquaporins can be divided into 'orthodox aquaporins', which allow the flux of water molecules only, and 'aquaglyceroporins', which facilitate the diffusion of glycerol and other small solutes in addition to water. (uniparthenope.it)
This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
Aquaporin 3 (AQP3) is a peroxiporin, a membrane protein that channels hydrogen peroxide in addition to water and glycerol. (bvsalud.org)
Molecules1
These MIP members could transport larger solute molecules. (biomedcentral.com)
Selectivity2
Analysis and comparison of ar/R selectivity filters suggest that rice and maize MIPs could transport more diverse solutes than Arabidopsis MIPs. (biomedcentral.com)
Interestingly, specific electrostatic profiles associated with the main selectivity to water or glycerol could be identified. (uniparthenope.it)
Membranes3
Due to the relatively high water permeability of some epithelial cells, it was long suspected that some additional mechanism for water transport across membranes must exist. (wikipedia.org)
However the first report of protein-mediated water transport through membranes was by Gheorghe Benga and others in 1986, prior to Agre's first publication on the topic. (wikipedia.org)
This study shows that membrane lipid compositions modulate the permeability of nonpolar gases, emphasizing the existence of gas-impermeable membranes and significance of membrane-facilitated gas channels. (illinois.edu)
AQPs3
Transport of NO and ROS by AQPs would be required for cell homeostasis to play a critical role in maintaining endothelial function. (hindawi.com)
This review focuses on an emerging topic, the functional involvement of AQPs in ROS membrane transport, with specific regard to the movement of hydrogen peroxide and NO into and out of cells, in both health and oxidative stress-induced diseases. (hindawi.com)
The recent crystal structure of human AQP7, an aquaglyceroporin, provided by colleagues at the Case Western Reserve University, has enabled further elucidations of AQPs in their permeability to glycerol. (illinois.edu)
Cellular2
These chemical species often act as substrates of enzymes and/or as ligands modulating biochemical cascades, so elucidating their delivery and transport is imminent towards understanding cellular functions. (illinois.edu)
FOXO proteins modulate expression of genes regulating vital cellular processes like apoptosis (programmed cell death), cell-cycle progression, and oxidative protection, by activating free radical quenchers catalase and manganese-dependant superoxide dismutase (MnSOD) and by facilitating DNA-repair process. (healthknot.com)
Proteins1
The major intrinsic proteins (MIPs) facilitate the transport of water and neutral solutes across the lipid bilayers. (biomedcentral.com)
Existence1
The mechanism of facilitated water transport and the probable existence of water pores has attracted researchers since 1957. (wikipedia.org)
Mechanism1
Here, molecular mechanism involved in the Si uptake by root and subsequent transport to areal tissues is also illustrated. (researchsquare.com)
Cell1
Plant MIPs are believed to be important in cell division and expansion and in water transport properties in response to environmental conditions. (biomedcentral.com)
Expression1
Based on these results and prior studies, increased AQP9 expression may lead to increased arsenic transport in the female fetal placenta, which in turn may alter the expression patterns of key developmental genes that we have previously shown to be associated with arsenic exposure. (biomedcentral.com)