• The solution structure of the amino-terminal domain of human DNA polymerase epsilon subunit B is homologous to C-domains of AAA+ proteins. (nih.gov)
  • Fig. 2: PKN2 facilitates mTORC1 activation by phosphorylating PI3KC2-β and triggering sequestration by 14-3-3 proteins. (nature.com)
  • Here, a genome-wide analysis of the human mitochondrial transcriptome shows that 2'- O -methylation is limited to residues of the mitoribosomal large subunit (mtLSU) 16S mt-rRNA, introduced by MRM1, MRM2 and MRM3, with the modifications installed by the latter two proteins being interdependent. (nature.com)
  • The Chromatin Accessibility Complex (CHRAC) consists of the ATPase ISWI, the large ACF1 subunit and a pair of small histone-like proteins, CHRAC-14/16. (cipsm.de)
  • The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. (curehunter.com)
  • The matrix exposed C-terminal α-helical domain of Oxa1 can bind mitochondrial ribosomes to facilitate co-translational insertion of proteins into the mitochondrial membrane ( Jia et al . (tcdb.org)
  • Mitochondrial TAT transports folded proteins in those eukaryotes with TatA and TatC subunits encoded in the mitochondrial genome. (tcdb.org)
  • However, the expression pattern of ACE2 does not coincide with the tissue tropism of SARS-CoV-2, hinting that other host proteins might be involved in facilitating SARS-CoV-2 entry. (flutrackers.com)
  • Using chimeric proteins in which CD4 is fused to the large intracellular loop of each of the AChR subunits we found that agrin induced clustering of only chimeras containing the β subunit loop. (jneurosci.org)
  • Each subunit has a large intracellular loop between the third and fourth transmembrane domains that is the likely site for regulated interactions with postsynaptic scaffolding proteins. (jneurosci.org)
  • The researchers used one of the three types of proteins that make up the chaperonin subunits. (trnmag.com)
  • They facilitate many cellular functions, from DNA replication to molecular motion, energy production, and even the production of other proteins. (lu.se)
  • By explicitly modelling the shapes of the subunits in the cage and matching the shapes with proteins from structural databases, we find that we can create structures with many different sizes, shapes, and porosities - including low porosities. (lu.se)
  • He noted that the authors identified several proteins as facilitating the neurodegeneration that is wrought by damaged mitochondrial DNA. (medscape.com)
  • Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
  • Similar to other systems, the mitochondrial ribosome is composed of a small (mtSSU) and a large (mtLSU) subunit, with their core rRNAs, 12S and 16S mitochondrial (mt-) rRNAs, respectively, surrounded by MRPs (30 for the mtSSU and 52 for the mtLSU). (nature.com)
  • by binding to the 50S subunit of the ribosome, they inhibit bacterial protein synthesis. (msdmanuals.com)
  • This may facilitate the formation of repressive chromatin. (cipsm.de)
  • Interleukin 20 receptor, alpha subunit, is a subunit of the interleukin-20 receptor, the interleukin-26 receptor, and the interleukin-24 receptor. (wikipedia.org)
  • The interleukin 20 receptor, alpha subunit is also referred to as IL20R1 or IL20RA. (wikipedia.org)
  • IL20RA, along with the IL-20 receptor, beta subunit, form the heterodimeric interleukin-20 receptor, which binds the cytokines IL-19, IL-20 and IL-24. (wikipedia.org)
  • IL20RA also forms a complex with the IL-10 receptor, beta subunit, which binds the cytokine IL-26. (wikipedia.org)
  • Two receptor subunits are known, receptor type I and type II subunits. (springer.com)
  • Thus, activated, type I subunits recruit and phosphorylate receptor SMADs (R-smad), which are the first intracellular mediators of TGF-β signalling. (springer.com)
  • The S1 subunit (PDB I.D-6VSB) of the spike protein being reported to acts as receptor binding domain (RBD), binding to ACE-2 receptor with higher affinity. (ijpsonline.com)
  • Together, these findings suggest that agrin-induced phosphorylation of the β subunit motif increases the stoichiometry of rapsyn binding to the AChR, thereby helping to stably cluster the receptor and anchor it at high density in the postsynaptic membrane. (jneurosci.org)
  • DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. (nih.gov)
  • Mutations/polymorphisms in the 55 kDa subunit of DNA polymerase epsilon in human colorectal cancer. (nih.gov)
  • Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. (nih.gov)
  • In this pathway, after a cytokine binds IL20RA and the beta subunit, JAKs linked to intracellular domains of IL20R activate and phosphorylate tyrosine residues found in the longer alpha chains of IL20RA. (wikipedia.org)
  • The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. (curehunter.com)
  • Through immunoprecipitation experiments, we demonstrated that ADAM9 binds to the S1 subunit of the SARS-CoV-2 Spike. (flutrackers.com)
  • RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit. (iric.ca)
  • RIOK2 phosphorylation facilitates its release from pre-40S particles and its nuclear re-import, prior to completion of small ribosomal subunits. (iric.ca)
  • Phosphorylation of the AChR β subunit is correlated with increased rapsyn/AChR binding, suggesting that the effect of βY390 phosphorylation on clustering is mediated by rapsyn. (jneurosci.org)
  • Indeed, we have shown previously that mutation of a tyrosine phosphorylation site in the long cytoplasmic loop of the β subunit impairs agrin-induced cytoskeletal anchoring and aggregation of mutant AChR in muscle cells ( Borges and Ferns, 2001 ). (jneurosci.org)
  • The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. (curehunter.com)
  • Deletions of multiple GID subunits compromise cell proliferation, and this defect is accompanied by deregulation of critical cell cycle markers such as the retinoblastoma (Rb) tumor suppressor, phospho-Histone H3 and Cyclin A. We identify the negative regulator of pro-proliferative genes Hbp1 as a bonafide GID/CTLH proteolytic substrate. (elifesciences.org)
  • They also identified mtDNA deletions in a "hotspot" in complex I respiratory chain subunits that were associated with dysregulation of oxidative stress and DNA damage response pathways in cohorts with sporadic PD and PDD. (medscape.com)
  • The muscle AChR is a pentamer of homologous subunits, with the stoichiometry α(2), β, δ and γ (fetal) or ε (adult) subunits. (jneurosci.org)
  • In the current study immunoinformatics procedures were employed to introduce a novel multi-epitope subunit vaccine. (ijpsonline.com)
  • Whole microbes, microbial subunits and extracts, and peptide and protein antigens have been the focus of much vaccine research and development. (cdc.gov)
  • Understanding the mechanistic aspects of the genetic control and the cellular pathways of the immune response to bacterial carbohydrate antigens should provide insights into ways to enhance the immune response and thus facilitate vaccine development. (cdc.gov)
  • Transition to a single bivalent COVID-19 vaccine dose for most persons, with additional doses for persons at increased risk for severe disease, facilitates implementation of simpler, more flexible recommendations. (cdc.gov)
  • Three COVID-19 vaccines are currently available for use in the United States and recommended by ACIP: 1) the bivalent mRNA Pfizer-BioNTech COVID-19 vaccine, 2) the bivalent mRNA Moderna COVID-19 vaccine, and 3) the monovalent adjuvanted, protein subunit-based Novavax COVID-19 vaccine. (cdc.gov)
  • Orthologous to human CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1). (nih.gov)
  • We demonstrate that protein kinase N (PKN) facilitates mTORC1 signalling by repressing PI3KC2-β-mediated phosphatidylinositol-3,4-bisphosphate synthesis downstream of mTORC2. (nature.com)
  • In SRP, three models have been suggested for proton translocation: H 2 cycling, formate cycling, and through "Mitchell-type" loops facilitated by respiratory menaquinone [ 2 , 14 , 15 ]. (hindawi.com)
  • Because the expression of the beta-3A subunit is normally ubiquitous, deficiency of the beta-3A subunit leads to a precise phenotype in cells with a large number of intracellular granules (eg, neutrophils, natural killer cells, cytotoxic T lymphocytes, platelets, melanocytes). (medscape.com)
  • Evolutionarily conserved untranslated regions facilitate the cloning of complete coding sequences of chondriogenes encoding NADH dehydrogenase subunits. (techscience.com)
  • Spike glycoprotein has two subunits, S1-responsible for its binding to host cell membrane receptors and S2-responsible for the fusion of viral and host cellular membrane[ 8 , 11 ]. (ijpsonline.com)
  • The S2' site is cleaved by host proteases, facilitating membrane fusion and viral entry into host cells. (news-medical.net)
  • The mutation at 25088bp occurred in the S2 subunit of the viral spike protein, which plays a vital role in virus-host membrane fusion and viral entry. (news-medical.net)
  • 2007 ). Several Oxa1-type insertases in the ER serve as catalytically active core subunits in the ER membrane protein complex (EMC), the guided entry of tail-anchored (GET) and the GET- and EMC-like (GEL) complex. (tcdb.org)
  • Extension and retraction of the pilus is hypothesized to occur through the interaction of cytoplasmic hexameric ATPases with the inner membrane platform of the pilus machine, whereby ATP hydrolysis likely facilitates turning of the platform in order to incorporate or remove major pilin subunits from the pilus fiber [ 7 - 9 ]. (biorxiv.org)
  • Many type IVa pilus systems also contain a retraction ATPase, called PilT, which depolymerizes the pilus fiber and recycles pilin subunits into the inner membrane. (biorxiv.org)
  • TGF-β1 binding to either subunit initiates their assembly into a heteromeric protein complex that consists of two type I and two type II subunits. (springer.com)
  • Within this complex, type II subunits phosphorylate type I subunits at their N-terminal domain. (springer.com)
  • Here, we identified all subunits of the mammalian GID/CTLH complex and provide a comprehensive map of its hierarchical organization and step-wise assembly. (elifesciences.org)
  • Particularly in yeast, an organism where gluconeogenesis and glycolytic activity are intermittently coordinated, the multi-subunit GID E3 ligase complex specifically targets the surplus of gluconeogenic enzymes, including the conserved Fructose-1,6-bisphosphatase 1 (Fbp1), for proteasomal degradation. (elifesciences.org)
  • Additional in vitro and in vivo data show that PilT and PilU act as independent homo-hexamers that may form a complex to facilitate pilus retraction. (biorxiv.org)
  • HPS-2 is caused by a mutation in the gene encoding the beta-3A subunit of the heterotetrameric AP3 complex ( ADTB3A ), which resides on chromosome 5. (medscape.com)
  • The introduction of flexible chains bearing a terminal ester or based on polyethylene glycol insure a good solubility and import polarity which facilitates the purification procedures. (thieme-connect.com)
  • In the present study, genetic engineering approaches were used to facilitate isolation of this enzyme, termed Hyd-5. (rcsb.org)
  • Thus, an induction in proteolytic cleavage in the S2 subunit due to specific mutations can potentially increase the infectivity and virulence. (news-medical.net)
  • While studies of peptide and protein antigens have been facilitated by the rapid advances in genomics and proteomics, studies of sugar chains, which are abundantly expressed on the outer surfaces of viral, bacterial, protozoan, and fungal pathogens and on the membranes of mammalian cells, have not kept pace with technologic advances. (cdc.gov)
  • In contrast to metagenomic detection of unknown pathogens which sequences all available genetic material, 16S sequencing specifically targets the small ribosomal subunit. (folkhalsomyndigheten.se)
  • Rifampin is concentrated in polymorphonuclear granulocytes and macrophages, facilitating clearance of bacteria from abscesses. (msdmanuals.com)
  • The extent to which N-Methyl-d-aspartate (NMDA) receptors facilitate the motivation to voluntarily wheel-run in rodents has yet to be determined. (eurekamag.com)
  • Because of significant biochemical and structural variations between valine and phenylalanine, a G to T mutation may alter the local structural architecture, facilitate secondary structure stabilization, or introduce preferential binding motifs. (news-medical.net)
  • these tumors also showed an increased expression of the alpha(7) nAChR subunit. (nih.gov)
  • Expression of the signature subunit ACF1 is restricted during embryonic development, but remains high in primordial germ cells. (cipsm.de)
  • The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. (nih.gov)
  • The crystal structure was determined to a resolution of 3.2 Å and the hydro-genase was observed to comprise associated large and small subunits. (rcsb.org)
  • The structure indicated that His229 from the large subunit was close to the proximal [4Fe-3S] cluster in the small subunit. (rcsb.org)
  • It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. (curehunter.com)
  • His229 and Glu73 of the Hyd-5 large subunit were found to be important in both hydrogen oxidation activity and the oxygen-tolerance mechanism. (rcsb.org)
  • In contrast to the expectations of previous work, we found little evidence for subunit exchange upon activation, and no effect of restraining subunits to their parent holoenzymes. (elifesciences.org)
  • Multiple CODHs are often present in carboxidotrophs potentially facilitating separate, CO oxidation and CO 2 -assimilation reactions [ 8 ]. (hindawi.com)
  • This research will enhance our understanding of bovine host cell-mediated immune defense mechanisms and may facilitate development of subunit vaccines against neosporosis. (usda.gov)
  • All type IV pilus systems encode a predicted ATPase, often called PilB, that facilitates pilus extension [ 7 , 10 - 12 ]. (biorxiv.org)
  • Toutefois, la PCR (amplification en chaîne par polymérase) nichée a permis de détecter une infection mixte par P. vivax et P. falciparum dans 7,0 % des cas. (who.int)
  • Many polyaromatic subunits (pyrene, perylene, anthracene, naphtalene, ferrocene) were fused to the main central core of the Bodipy. (thieme-connect.com)
  • Conversely, the release of one oxygen molecule facilitates the release of the rest. (flashcardmachine.com)
  • Read Me File for Specifications for Help Screens, Prompts, Quesries, and Processing Interface on an Electronic Death Certificate (EDC) prepared by NCHS In order to facilitate the standardization of cause of death in death registration systems, the National Center for Health Statistics (NCHS) has prepared specifications for the format, structure, and content of the cause-of-death section to be incorporated into these systems. (cdc.gov)