Fabp4 adipocytes. Medical search. Frequent questions

aP2 is also called fatty acid binding protein 4 (FABP4). (wikipedia.org)
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. (wikipedia.org)
The protein that the researchers wanted to target was fatty acid-binding protein 4 (fabp4). (medicalnewstoday.com)
Cantley J , 2010 , 'Secreted adipocyte fatty acid binding protein (FABP4) forms the molecular basis of the adipo-insular axis' , in DIABETOLOGIA , SPRINGER , SWEDEN, Stockholm , pp. (edu.au)
In this study, we found that fatty acid-binding protein 4 (FABP4) overexpressed in serum of obese patients and was associated with poor overall survival. (bvsalud.org)
In the present study, we identified pimozide as a novel fatty acid binding protein 4 (FABP4) inhibitor using molecular docking simulation as well as biochemical characterizations. (ox.ac.uk)
We focused on three important regulators of metabolic homeostasis - fibroblast growth factors 21 and 19 (FGF-21 and FGF-19) and adipocyte fatty acid binding protein (FABP-4). (cuni.cz)

Catechin increased the mRNA levels of various adipogenic markers, such as adiponectin, peroxisome proliferator-activated receptor gamma (PPARgamma), FABP4, and LPL, as measured during adipocyte differentiation in hBM-MSCs. (nih.gov)

Here, we studied the effect of several major green tea polyphenols on adipocyte differentiation in human bone marrow mesenchymal stem cells (hBM-MSCs) and compared it to the effect of representative antidiabetic drugs. (nih.gov)
Catechin was the most potent of the eight green tea polyphenols evaluated in promoting adipocyte differentiation in hBM-MSCs, and this effect was dose-dependent. (nih.gov)
In conclusion, our data suggest that (-)-catechin promotes adipocyte differentiation and increased sensitivity to insulin in part by direct activation of PPARgamma, which could be at the basis of the observed pharmacological benefits of green tea intake in reducing the risk of type 2 diabetes. (nih.gov)
Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. (biomedcentral.com)
Thus, as an alternative, we produced EXIQON microarray of brown and white primary murine adipocytes (prior to and following differentiation) to yield global profiles of miRNAs. (biomedcentral.com)
Understanding the regulation of the pathways that lead to proliferation and differentiation of white and brown pre-adipocytes could be crucial for revealing the underlying mechanisms of obesity. (biomedcentral.com)
It has been suggested that adipogenesis is regulated by PPARβ/δ followed by PPARγ and C/EBPα promoting differentiation into mature adipocytes [ 12 ]. (biomedcentral.com)
The present study showed that the inhibitory effect of pimozide on FABP4 promoted adipocyte differentiation with the potency proportional to their propensities for weight gain. (ox.ac.uk)
Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
Therefore, growth of adipose tissue includes the hypertrophy of already existing adipocytes and the proliferation and differentiation of new ones from MSCs. (biomedcentral.com)
evidence suggest that this shape change happens early in the differentiation VCH-916 process and prior to the up-regulation of many adipocyte specific genes as well as individually of triglyceride build up [12] though the cause and mechanism for the morphological shift from fibroblastic to spherical have yet to be identified. (techuniq.com)
2007). PPARgamma and GLUT-4 expression as developmental regulators/markers for preadipocyte differentiation into an adipocyte. (geneticsmr.com)

The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)
Mature adipocytes are known to play an important role controlling energy balance in mammals by storing fatty acids in the form of triglycerides in periods of excess of energy and by releasing fatty acids when are needed. (biomedcentral.com)
Adipogenesis has been described as a two-step developmental process consisting on the commitment of undifferentiated MSCs into preadipocytes and the further development of these cells into fully functional mature adipocytes [ 4 ]. (biomedcentral.com)
We have previously shown that fish primary preadipocytes differentiate into mature adipocytes in vitro and that these cells represent a very helpful model system to study adipose tissue development in fish [ 5 , 6 ]. (biomedcentral.com)

CAAs release more FA to the media, accompanied by FATP, more exosomes than adipocytes and also the cargo of FABP4 and CD36 was increased. (urv.cat)
These results provide new insights into the role of FABP4 and CD36 within exosomes in the crosstalk of the tumour microenvironment. (urv.cat)
Els CAA alliberen més FA als mitjans, acompanyats de FATP, més exosomes que adipòcits i també es va augmentar la càrrega de FABP4 i CD36. (urv.cat)
Aquests resultats proporcionen noves idees sobre el paper de FABP4 i CD36 dins dels exosomes en la diafonia del microambient tumoral. (urv.cat)
When differentiated in HyStem-C in the presence of BMP4 alone, the cells express the adipocyte markers FABP4 and CD36 as well as BETATROPHIN/LIPASIN (C19orf80). (esibio.com)
The expression levels of peroxisome proliferator activated receptor (PPAR) gamma and several antioxidant metallothionein genes were decreased in MDM from all low HDL-C groups compared with controls, as was the expression of other genes regulated by PPARgamma, including CD36, adipocyte fatty acid binding protein (FABP4), and adipophilin (ADFP). (cims-ops.cz)

Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. (springer.com)
There is also evidence that the deleterious effects mediated by dysfunctional white adipocyte-induced lipid overspill can be halted by the pro-oxidative anti-lipotoxic effects mediated by brown adipose tissue (BAT) activation. (springer.com)
Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. (harvard.edu)
In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research. (geneticsmr.com)
Adipocyte Senp2 de﫿ciency resulted in less adipose lipid storage accompanied by an ectopic fat accumulation and insulin resistance under high-fat diet feed- ing. (deepdyve.com)
In adipocyte Senp2-de﫿ciency mice, accumulation of the SUMOylated Setdb1 suppressed the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes, which would decrease the ability of lipid storage in adipocytes. (deepdyve.com)
2003). Selective Cellular uptake of fatty acids and following storage in the form of disruption of Pparγ2 or adipocyte-speci﫿c Pparγ knockout leads TGs in adipocytes are key steps in lipid storage. (deepdyve.com)
Although less fat stor- adqcKO pose lipid storage in adipocyte-speci﫿c Senp2 knockout mice fed age was shown in Senp2 adipose tissues, the increased with high-fat diets (HFD). (deepdyve.com)
This mouse also showed an ectopic lipid in﫿ammation indicates that HFD induced adipocyte death would distribution and insulin resistance. (deepdyve.com)
adqcKO Mechanistically, adipocyte Senp2 de﫿ciency caused the downregula- Senp2 mice exhibit an ectopic lipid accumulation and tion of Pparg and Cebpa as well as their downstream target genes insulin resistance related to lipid storage. (deepdyve.com)

UCP-1-expressing multilocular adipocytes, termed 'beige' or 'brite' (brown-in-white) adipocytes, can also be found interspersed among white adipocytes within SAT under conditions requiring increased heat production (e.g. chronic cold exposure). (springer.com)
In iWAT, mTORC2 residual activity is partially required for the cold-induced increases in multilocular adipocytes, mitochondrial mass, and uncoupling protein 1 (UCP-1) content. (fapesp.br)

Cold acclimation inhibited mTORC2 in BAT and iWAT, but its residual activity is still required for the cold-induced increases in BAT adipocyte number, total UCP-1 content and mRNA levels of proliferation markers Ki67 and cyclin 1 D, and de novo lipogenesis enzymes ATP-citrate lyase and acetyl-Co A carboxylase. (fapesp.br)

WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)

BMS309403, a well-known FABP4 inhibitor, elevated the basal protein levels of PPARγ, therefore stimulating adipogenesis in adipocytes. (ox.ac.uk)

Additionally ASCs possess lengthy protrusions and a branched morphology not really unlike preadipocytes and VCH-916 as opposed to the spherical and huge (diameters up to 100 μm) older adipocytes [24]. (techuniq.com)
2009). Board-invited review: the biology and regulation of preadipocytes and adipocytes in meat animals. (geneticsmr.com)

We found 65 miRNAs regulated during in vitro adipogenesis in primary adipocytes. (biomedcentral.com)
When comparing primary adipocyte profiles, with those of cell lines reported in the literature, we found a high degree of difference in 'adipogenesis' regulated miRNAs suggesting that the model systems may not be accurately representing adipogenesis. (biomedcentral.com)

DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance. (uchicago.edu)

Better understanding of the cellular and molecular pathophysiological mechanisms regulating adipocyte size, number and depot-dependent expansion has become a focus of interest over recent decades. (springer.com)
Our results suggest that FABP4 in macrophages is a crucial regulator of the NLRP3/IL-1ß axis to promote the progression of PC under obese conditions, which could act as a promising molecular target for treating of PC patients with obesity. (bvsalud.org)

FABP4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human FABP4 genome location and FABP4 gene details page in the UCSC Genome Browser. (wikipedia.org)
Conditional gene targeting has been extensively used for in vivo analysis of gene function in adipocyte cell biology but often with debate over the tissue specificity and the efficacy of inactivation. (diabetesjournals.org)
To directly compare the specificity and efficacy of different Cre lines in mediating adipocyte specific recombination, transgenic Cre lines driven by the adipocyte protein 2 (aP2) and adiponectin (Adipoq) gene promoters, as well as a tamoxifen-inducible Cre driven by the aP2 gene promoter (iaP2), were bred to the Rosa26R (R26R) reporter. (diabetesjournals.org)
In this paper, he explains that adipocytes are difficult cells to target with such gene editing tools. (medicalnewstoday.com)
lipoprotein lipase (LPL) and fatty acidity binding proteins 4 (FABP4) gene manifestation aswell as adipocyte metabolic function (triglyceride synthesis and build up). (techuniq.com)

In vivo and in vitro experiments have revealed that FABP4 induces macrophage-related inflammation to promote cancer cell migration, invasion and metastasis under obese conditions. (bvsalud.org)

Mechanistically, FABP4 participates in transferring saturated fatty acid to induce macrophages pyroptosis in a caspase-1/GSDMD-dependent manner and mediates NOD-like receptor thermal protein domain associated protein 3 (NLRP3)/IL-1ß axis in macrophages, which further regulates epithelial-mesenchymal transition signals to promote the migration, invasion, and metastasis of PC cells. (bvsalud.org)

In a previous study , Kim developed a method to deliver genetically modifying agents to white fat cells, or adipocytes. (medicalnewstoday.com)
Making use of a short peptide that specifically docks with white adipocytes, the team was able to deliver the CRISPRi components to 99% of cells in a cell culture model. (medicalnewstoday.com)
In addition to the classic brown adipocytes, a different type of brown fat cells seems to exist in tissues where WAT predominates. (biomedcentral.com)
Adipocytes are the most abundant cell type in the breast tissue and exosomes are being discussed as participants of the communication between cells, owing to the fact that they transfer cellular components to paracrine cells. (urv.cat)

aP2 (adipocyte Protein 2) is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. (wikipedia.org)

Deletion of mechanistic target of rapamycin complex 2 (mTORC2) essential component rapamycin insensitive companion of mTOR (Rictor) by a Cre recombinase under control of the broad, nonadipocyte-specific aP2/FABP4 promoter impairs thermoregulation and brown adipose tissue (BAT) glucose uptake on acute cold exposure. (fapesp.br)
We investigated herein whether adipocyte-specific mTORC2 deficiency affects BAT and inguinal white adipose tissue (iWAT) signaling, metabolism, and thermogenesis in cold-acclimated mice. (fapesp.br)

For this, 8-wk-old male mice bearing Rictor deletion and therefore mTORC2 deficiency in adipocytes (adiponectin-Cre) and littermates controls were either kept at thermoneutrality (30 +/- 1 degrees C) or cold-acclimated (10 +/- 1 degrees C) for 14 days and evaluated for BAT and iWAT signaling, metabolism, and thermogenesis. (fapesp.br)

FABP4, also known as aP2, is an essential molecule that integrates adipocyte biology with systemic metabolic regulation. (harvard.edu)
FABP4, also known as aP2, is an essential molecule for integration of adipocyte biology with systemic metabolic regulation. (harvard.edu)

The Hotamışlıgil Lab is interested specifically in the mechanisms by which FABP4 acts as a hormone, as well as how it is secreted. (harvard.edu)

This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)

Orbital pre-adipocytes and fibroblasts also express the TSH receptor, resulting in expanded retro-orbital tissue and causing exophthalmos and limited eye movement. (frontiersin.org)

A previous study in Science Translational Medicine showed that reducing the levels of fabp4 in diabetic mice using an antibody resulted in improvements in blood sugar levels, as well as in fat and insulin metabolism. (medicalnewstoday.com)

Thus, different "adipocyte-specific" Cre lines display different degrees of efficiency and specificity, illustrating important differences that must be taken into account in their use for studying adipose biology. (diabetesjournals.org)

This study aims to examine the role of FABP4 in adipocytes-derived exosomes and its role in the crosstalk of the tumour microenvironment. (urv.cat)

Correspondence to: Jinke Cheng, E-mail: [email protected] Edited by Feng Liu One major function of adipocytes is to store excess energy in the form of triglycerides. (deepdyve.com)

In order to study the role of exosomes in the tumour microenvironment, we isolated adipocyte-derived exosomes after their treatment with different conditions and analysed them by Western Blot. (urv.cat)

Adipocyte-specific mTORC2 deficiency impairs BAT a. (fapesp.br)

Aquest estudi té com a objectiu examinar el paper de FABP4 en els exosomes derivats dels adipòcits i el seu paper en la diafonia del microambient tumoral. (urv.cat)
Per tal d'estudiar el paper dels exosomes en el microambient tumoral, vam aïllar els exosomes derivats d'adipòcits després del seu tractament amb diferents condicions i els vam analitzar mitjançant Western Blot. (urv.cat)

Further, we provide a novel transcriptomics database of EXIQON and Affymetrix adipocyte profiles to facilitate data mining. (biomedcentral.com)

Anatomy24

Organisms8

Diseases5

Chemicals and Drugs95

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes34

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Fatty acid bi7

Measured during adipocyte differen1

Differentiation13

Mature adipocytes4

CD366

Lipid11

Multilocular adipocytes2

MRNA1

Hypertrophy1

PPAR1

Preadipocytes2

Adipogenesis2

Expression2

Molecular2

Gene5

Vitro1

Mechanistically1

Cells4

Macrophages1

Adipose tissue2

Adiponectin1

Metabolic2

Mechanisms1

Glucose uptake2

Receptor1

Mice1

Biology1

Examine1

Function1

Study1

Specific1

Paper2

Data1