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Eye NeoplasmsEyeMelanomaMelanoma, ExperimentalSkin NeoplasmsEye DiseasesEye MovementsEye InjuriesUveal NeoplasmsDry Eye SyndromesMelanoma, AmelanoticEye Enucleationgp100 Melanoma AntigenEye ColorEye AbnormalitiesEye BurnsChoroid NeoplasmsNeoplasmsPancreatic NeoplasmsNevus, PigmentedAntigens, NeoplasmEye BanksNeoplasms, Cystic, Mucinous, and SerousNeoplasm ProteinsNeoplasm MetastasisVisual AcuityMART-1 AntigenMonophenol MonooxygenaseCell Line, TumorProto-Oncogene Proteins B-rafMelanoma-Specific AntigensNeoplasms, Multiple PrimaryImmunohistochemistryOcular Physiological PhenomenaCompound Eye, ArthropodEye Protective DevicesTumor Cells, CulturedMelaninsLung NeoplasmsDysplastic Nevus SyndromeRetinaNeoplasm InvasivenessDNA, NeoplasmKidney NeoplasmsNeoplasms, Second PrimaryIntraocular PressureNeoplasm TransplantationEye Injuries, PenetratingNeoplasm StagingNeoplasms, ExperimentalVitreous BodyOphthalmic SolutionsEye Foreign BodiesEye Movement MeasurementsFixation, OcularPosterior Eye SegmentScleraGlaucomaIris NeoplasmsTumor Markers, BiologicalCiliary BodyGene Expression Regulation, NeoplasticEye InfectionsLiver NeoplasmsAnterior ChamberAxial Length, EyeThyroid NeoplasmsAdenocarcinoma, MucinousNeoplasms, Radiation-InducedMyopiaAqueous HumorIrisMyeloproliferative DisordersRetrospective StudiesTime FactorsPrognosisMutationEye Infections, BacterialChoroidConjunctival NeoplasmsNose NeoplasmsParotid NeoplasmsAntineoplastic AgentsOvarian NeoplasmsTearsDermoscopyCystadenomaLens, CrystallineMicrophthalmia-Associated Transcription FactorNeoplasms, Connective and Soft TissueDisease ProgressionVisual FieldsNeoplasms, Plasma CellPursuit, SmoothCataractSunlightAppendiceal NeoplasmsVision, BinocularMice, Inbred C57BLMelanosis
ChoroidalTumorsMalignant neoplasmsChoroidMetastasisCutaneous melanomaCiliary body melTumorCarcinomaRetinoblastomaNevusLesionsLymphomaMelanocytesMalignancyTumourConjunctival neoplasms2020ClinicalHumansTissueCancerRadiotherapyMesothelialOphthalmologyDiagnosis of conjunctivalConjunctivaLiverPathologyPeripheralRetinaLesionOrgansPathophysiologyAggressive
Choroidal21
  • Melanomas (choroidal, ciliary body and uveal) - In the early stages there may be no symptoms (the person does not know there is a tumor until an ophthalmologist or optometrist looks into the eye with an ophthalmoscope during a routine test). (wikipedia.org)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • A diagnosis of choroidal melanoma was established based on the identification of ophthalmoscopic, imaging, and histological characteristics of the tumor. (bvsalud.org)
  • Conclusion: Choroidal melanomas usually occur in males, clear-eyed, and older individuals. (bvsalud.org)
  • The classic appearance of choroidal melanoma is a pigmented dome-shaped or collar button-shaped tumor with an associated exudative retinal detachment. (nih.gov)
  • Choroidal melanoma is usually pigmented, but can be variably pigmented and even amelanotic (non-pigmented). (nih.gov)
  • Laser treatment for choroidal melanoma: Current concepts. (nih.gov)
  • Photodynamic therapy in treatment of cutaneous and choroidal melanoma. (nih.gov)
  • Choroidal melanoma: clinical features, classification, and top 10 pseudomelanomas. (nih.gov)
  • A large choroidal melanoma is present displacing the ciliary body forward, but not invading the angle of the anterior chamber. (ox.ac.uk)
  • No choroidal melanomas were observed in the comparison populations. (cdc.gov)
  • In the facility population, one patient with a suspected choroidal melanoma had evidence of size and color change since 1978. (cdc.gov)
  • Choroidal melanoma is the second most common intraocular tumor - metastasis being the most frequent - and the most common primary intraocular malignancy in the adult population. (eyewiki.org)
  • The presence of symptoms is more commonly found in melanomas than in choroidal nevi. (eyewiki.org)
  • Thickness: choroidal melanomas tend to be lesions more than 2 mm thick. (eyewiki.org)
  • Orange pigment: Lipofuscin accumulation in the RPE overlying choroidal melanomas is a frequent finding. (eyewiki.org)
  • A biopsy for gene expression profiling can be performed similarly for choroidal melanoma (see choroidal melanoma). (aao.org)
  • Choroidal nevi are pigmented spots in the back of the eye. (firebaseapp.com)
  • This kind of cancer is called choroidal melanoma. (firebaseapp.com)
  • A choroidal nevus (or benign neoplasm of the choroid) is a grayish-brown pigmented lesion with slightly blurred margins. (firebaseapp.com)
  • Slit lamp biomicroscopy image of the left eye shows pigmented lesion (asterisk) A definitive diagnosis of conjunctival naevus, primary A choroidal nevus is a flat, benign and brown-green colored area at the back of the eye, often seen in the pigmented layer beneath the retina called the choroid. (firebaseapp.com)
Tumors13
  • Tumors in the eye and orbit can be benign like dermoid cysts, or malignant like rhabdomyosarcoma and retinoblastoma. (wikipedia.org)
  • Iris and conjuctival tumors (melanomas) - Present as a dark spot. (wikipedia.org)
  • While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
  • Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
  • Mucosal melanomas show far more aggressive behavior relative to skin melanomas, and these tumors are more inclined to metastasize into regional and distant sites or recur locally, regionally, or in distant locations, resulting in a high rate of cause-specific death. (medscape.com)
  • Explanation: melanocytic naevi are the most common tumors of the conjunctiva, accounting for up to 28% of all conjunctival neoplasms. (surajeyeinstitute.org)
  • At the cellular level, the molecular expression for metastasis is heavily biased towards one of the three cell types that make up uveal melanoma tumors. (eyewiki.org)
  • Melanocytoma and malignant melanoma are the most typical eye tumors in dogs and cats. (iranjournals.ir)
  • My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)
  • Most iris melanomas are composed of spindle cells (Fig. 1B, C) and are, therefore, regarded as low-grade tumors. (aao.org)
  • Ocular oncology is the branch of managing tumors identifying with the eye and its adnexa . (ophthalmologyconferences.com)
  • Consequently, tumors are smaller, allowing for novel eye-preserving treatments. (eur.nl)
  • Tumors of the eye. (thieme-connect.de)
Malignant neoplasms5
  • Introduction: Melanomas are malignant neoplasms that occur in various anatomical sites, including the eye. (bvsalud.org)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. (lookformedical.com)
  • The data presented in this edition of Cancer Incidence in Five The CI5 data include all invasive malignant neoplasms and Continents (CI5) are mainly organised according to anatomical some non-invasive malignant neoplasms For most morphology site However, for some sites, the histological type of cancer codes, a fifth digit /1 or /2 automatically excludes the data entry. (who.int)
  • The main structure of the histological grouping is that Morphology codes specific types of malignant neoplasms are listed as wel as Grouping of morphological codes presents several difficulties. (who.int)
  • Among the 6.4 million malignant neoplasms diagnosed in workers are at high risk for cancer of the tongue2,9. (bvsalud.org)
Choroid8
  • Methods: Inclusion criteria were the presence of a melanoma of the choroid or ciliary body and the availability of data from peripheral blood samples taken before treatment of the melanoma. (eyehospital.nl)
  • This study describes the clinical and pathological characteristics of uveal (choroid) melanoma in a Caucasian patient. (bvsalud.org)
  • Lymphocytic markers applied to the biopsy specimen and to the enucleated eye revealed a highly malignant T-cell lymphoma infiltrating the iris, ciliary body, anterior choroid, retina and the adjacent vitreous body. (nih.gov)
  • The sections show a large nodule of malignant melanoma apparently centred in the anterior choroid extending from the vicinity of the equator to the middle portion of the ciliary body, the latter being reflected axially by the tumour. (ox.ac.uk)
  • Posterior uveal melanoma has distinct clinical characteristics that facilitate its differentiation from other pigmented and non-pigmented lesions of the choroid. (eyewiki.org)
  • Posterior uveal melanomas typically present as an elevated domed-shaped gray-brown colored lesion of the choroid with irregular margins not sharply demarcated. (eyewiki.org)
  • Color: Grayish-to-brownish neoplasm located in the choroid with overlying retinal vessels. (eyewiki.org)
  • The choroid is the layer around the back part of the eye between the retina and the sclera. (firebaseapp.com)
Metastasis2
  • Purpose: To determine whether peripheral blood leukocyte numbers and serum markers of inflammation can be used to predict which patients with primary uveal melanoma will develop metastasis. (eyehospital.nl)
  • In melanoma, i have focused in acral lentiginous melanoma for which we described KIT mutation and protein expression status in a large series of cases and described TERT amplification in progression to metastasis. (mdanderson.org)
Cutaneous melanoma3
  • The treatment of choice for mucosal melanoma, like cutaneous melanoma, is complete excision with adequate negative margins. (medscape.com)
  • Melanoma is an aggressive cancer originating from melanocytes located in the skin (cutaneous melanoma), in the uveal tract of the eye (uveal melanoma) or in mucosal membranes (mucosal melanoma). (uniroma1.it)
  • Integrating additional factors into the TNM staging for cutaneous melanoma by machine learning. (cdc.gov)
Ciliary body mel4
Tumor10
  • Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). (wikipedia.org)
  • This tumor can grow around the eye but rarely spreads to other parts of the body. (wikipedia.org)
  • The most common malignant primary intraocular tumor in adults is uveal melanoma. (wikipedia.org)
  • Check photographs, normal healthy eyes would have the red eye reflex, but a white/yellow dot instead of the red eye reflex can indicate a tumor or some other kind of eye disease. (wikipedia.org)
  • While in that time period (I) did not sufficiently accumulate in the melanoma to compete with the high background activities, especially in the abdominal organs, (IV) had its highest tumor concentration 1 h after administration. (curehunter.com)
  • Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
  • 1. What is the most common type of tumor among conjunctival neoplasms? (surajeyeinstitute.org)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • Computed tomography (CT) scans were performed following eye fixation, immediately prior to and following GK-SRS, to validate the accuracy of the tumor localization. (tmu.edu.tw)
  • Our observations suggest that well-planned initial surgical management using this technique decreases the chance of tumor recurrence for conjunctival melanoma and squamous cell carcinoma. (nih.gov)
Carcinoma3
  • Other types of common eyelid cancers include squamous carcinoma, sebaceous carcinoma and malignant melanoma. (wikipedia.org)
  • At autopsy, melanoma metastases were found within a renal cell carcinoma which had also metastasised to the lungs. (duke.edu)
  • We describe our current approach to the surgical management of squamous cell carcinoma (intraepithelial or invasive), localized melanoma, and primary acquired melanosis of the conjunctiva. (nih.gov)
Retinoblastoma2
  • Retinoblastoma - Strabismus (crossed eyes), a whitish or yellowish glow through the pupil, decreasing/loss of vision, sometimes the eye may be red and painful. (wikipedia.org)
  • Retinoblastoma can occur in one or both eyes. (wikipedia.org)
Nevus4
  • A nevus is a benign, freckle in the eye. (wikipedia.org)
  • Other conditions with an increased incidence of uveal melanoma include dysplastic nevi and Nevus of Ota (estimated that 1:400 will develop uveal melanoma). (eyewiki.org)
  • We analyzed the expression of 84 miRNAs in 27 primary melanoma and 5 nevus formalin-fixed paraffin-embedded (FFPE) samples using the Human Cancer PathwayFinder miScript miRNA PCR Array. (bjbms.org)
  • melanomas, which arise from large pigmented nevus. (firebaseapp.com)
Lesions6
  • 3. Which term is used for a group of lesions showing intraepithelial melanocytic proliferation with cytologic atypia, which is associated with a risk of progression to melanoma? (surajeyeinstitute.org)
  • Explanation: Primary acquired melanosis (PAM) with atypia refers to a group of lesions showing intraepithelial melanocytic proliferation and/or increased cellularity and is associated with a risk of 36% -75% progression to melanoma. (surajeyeinstitute.org)
  • Follow-up Examinations for Occular Neoplasms and Pigmented Ocular Lesions, at the Dupont, West Virginia Plant. (cdc.gov)
  • Active and retired workers at the duPont Belle chemicals facility in West Virginia were ophthalmologically surveyed first in 1978 and again in 1979 in a follow-up study to identify cases of ocular neoplasms and determine the prevalence of ocular pigmented lesions. (cdc.gov)
  • Symptoms are not a common initial presentation of small melanomas, but can be present in larger lesions and melanomas that affect the macula. (eyewiki.org)
  • In contrast, cutaneous lesions are linked directly to fair-skinned and blue-eyed persons with a history of blistering sunburns, and the incidence has increased dramatically (approximately 4-6% per year) over the same period. (medscape.com)
Lymphoma3
  • Second Neoplasms in Children Following a Treatment for Acute Leukemia and/or Lymphoma: 29 Years of Experience in a Single Institution in Argentina. (nih.gov)
  • Intraocular T-cell lymphoma mimicking a ring melanoma. (nih.gov)
  • A case is presented of an intraocular T-cell lymphoma mimicking a ring melanoma of the iris and being the first manifestation of systemic disease. (nih.gov)
Melanocytes3
  • it shows pigmented cells close to the neoplasm but these cells have the appearance of normal dendritic melanocytes of the uvea: the large cells with prominent nucleoli representing the outer limit of the tumour are found close by but not within the scleral loop. (ox.ac.uk)
  • Oral melanomas are uncommon (1.2 cases per 10 million population per year in the United States), and, similar to their cutaneous counterparts, they are thought to arise primarily from melanocytes in the basal layer of the squamous mucosa. (medscape.com)
  • Melanoma can occur in any tissue that contains melanocytes. (bjbms.org)
Malignancy1
Tumour1
  • Other specified malignant neoplasm (Other specified cancer tumour Other codes are obsolete, ie the entities have been in the previous edition). (who.int)
Conjunctival neoplasms1
20201
  • Participants: Medical records of patients with uveal melanoma (UM) who received treatment for primary UM between February 1992 and December 2020 at the Erasmus University Medical Center (Rotterdam, The Netherlands) and the Rotterdam Eye Hospital (Rotterdam, The Netherlands) were reviewed. (eyehospital.nl)
Clinical6
  • This is a retrospective record based on a clinical analysis of 25 cases of patients who presented to the eye outpatient department with unilateral proptosis during a period of 3 years. (hindawi.com)
  • For later onset prcd, clinical signs (or even eye changes) may not be seen until the dog is 4 years of age or older. (malamute-health.org)
  • These three subtypes of melanoma represent distinct neoplasms in terms of biology, epidemiology, aetiology, molecular profile and clinical features.In this review, the latest progress in hypoxia-regulated pathways involved in the development and progression of all melanoma subtypes were discussed. (uniroma1.it)
  • The FFPE samples were obtained from the archives of the Municipal Clinical Emergency Hospital of Timisoara and included 10 cutaneous melanomas, 10 uveal melanomas, 7 mucosal melanomas, and 5 cutaneous nevi. (bjbms.org)
  • There are several clinical variations including circumscribed, diffuse, and tapioca iris melanoma. (aao.org)
  • The treatment strategy of iris melanomas depends on the clinical impression and behavior. (aao.org)
Humans1
Tissue4
  • The affinity to the tyrosine hydroxylase and not the function as a melanin precursor lead to an accumulation of (IV) in the melanoma tissue. (curehunter.com)
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • The retina is the thin layer of tissue that lines the back of your eye. (firebaseapp.com)
Cancer5
  • Eye cancers can be primary (starts within the eye) or metastatic cancer (spread to the eye from another organ). (wikipedia.org)
  • The two most common cancers that spread to the eye from another organ are breast cancer and lung cancer. (wikipedia.org)
  • Case report: A 41-year-old Caucasian female patient, brown eyes, without history of ophthalmological diseases or family history of cancer experienced pain and loss of visual acuity in the left eye. (bvsalud.org)
  • Citing a study from the National Center for Biotechnology Information, Dr Delphine Lee of Harbor-UCLA Medical Center reminded Medscape that something as simple as a mild sunburn can increase the risk for melanoma, the deadliest form of skin cancer. (harrisdermatology.com)
  • Overall, we identified several miRNAs with significantly altered expression in primary melanomas, including those reported for the first time in this type of cancer. (bjbms.org)
Radiotherapy1
  • The role of radiotherapy in the treatment of mucosal melanoma is not clearly defined, and malignant melanoma has traditionally been regarded as relatively insensitive to radiation, but some studies have suggested a positive benefit. (medscape.com)
Mesothelial1
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
Ophthalmology2
  • The patient was referred to the Oncology Ophthalmology department for enucleation due to suspected uveal melanoma. (bvsalud.org)
  • According to Gelatt's Veterinary Ophthalmology (1999), PRA is a term for a group of hereditary diseases that are characterized by a degeneration or dysplasia (abnormal development) of the photoreceptors at the back of the eye. (malamute-health.org)
Diagnosis of conjunctival1
Conjunctiva2
Liver3
  • Liver neoplasms. (lookformedical.com)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • Multi-Center Follow-up Study to Develop a Classification System Which Differentiates Mucinous Cystic Neoplasm of the Liver and Benign Hepatic Cyst Using Machine Learning. (cdc.gov)
Pathology2
  • 1 Eye Pathology Institute, University of Copenhagen, Denmark. (nih.gov)
  • Ki-67 assessment of pancreatic neuroendocrine neoplasms: Systematic review and meta-analysis of manual vs. digital pathology scoring. (who.int)
Peripheral1
  • The cornea on the side of the neoplasm shows a peripheral vascular pannus and an inflammatory reaction is present in the ciliary body close to the base of the nerve loop. (ox.ac.uk)
Retina1
  • Electroretinograms (ERG) can detect changes in the function of the retina earlier than CERF examination can detect visible changes to the eye. (malamute-health.org)
Lesion2
  • Nodules had developed in the circumference and the lesion now imitated a malignant melanoma of the iris, which was also the diagnosis from a biopsy specimen with routine staining. (nih.gov)
  • The most useful architectural patterns suggestive of conjunctival melanoma include (1) intraepithelial component showing pagetoid growth (2) radial extension of the intraepithelial component beyond the lateral edge of subepithelial component, (3) patchy or bandlike inflammation at the base of the lesion, (4) mitotic activity, (5) lack of maturation toward the base of the lesion, (6) invasion of the sclera or cornea. (surajeyeinstitute.org)
Organs1
  • Besides the head and neck region, mucosal melanomas arise from the mucosal membranes of the female genital organs or the anorectal and urinary tracts. (medscape.com)
Pathophysiology1
Aggressive2
  • Monosomy 3 has long been known to be associated with development of aggressive uveal melanoma. (eyewiki.org)
  • More aggressive iris melanomas (Fig. 2B) exhibit a varying amount of epithelioid cells. (aao.org)