Extrinsic pathway activates caspases. Medical search. Frequent questions

The pro-domain of the intrinsic initiator caspases and the inflammatory caspases contains a single death fold known as caspase recruitment domain (CARD), while the pro-domain of the extrinsic initiator caspases contains two death folds known as death effector domains (DED). (wikipedia.org)
These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. (kegg.jp)
Activation of apical caspases then leads to cleavage and activation of the effector caspases 3, 6, and 7 and subsequently to apoptosis (6). (eotp.org)
Both intrinsic and extrinsic pathways a re doing the same work that activate the effector capsases (caspase 3,6,7).The only difference is that caspapase 9 used to activate effector caspase in intrinsic and caspase 8, used in extrinsic pathway. (cellinsight.online)
It act on effector caspases. (cellinsight.online)
In turn, caspase 8 activates effector caspases by catalytic cleavage. (biomedcentral.com)
The effector caspases cleave their cellular specific substrates and generate the typical morphology of apoptosis. (biomedcentral.com)
Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
C8 activates the effector caspases C3 that starts the degradation cascade that leads again to cell death by apoptosis. (parathyroid-hormone1-34.com)

The extrinsic pathway is mediated by a variety of death receptor ligands, including tumor necrosis factor (TNF) and Fas ligand (FaSL), that trigger apoptosis by binding to cell surface receptors. (cdc.gov)
Ligand binding to cognate receptors activates initiator caspases directly in a death-inducing signaling complex. (deathbase.org)
Extracellular signals activating death receptors triggers the extrinsic pathway, and intracellular stress activates the intrinsic pathway. (cancer-research-network.com)
The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. (kegg.jp)
Apoptosis can be induced via two main pathways: interference with mitochondrial function, also called the intrinsic pathway, or triggering of cell surface death receptors, also called the extrinsic pathway (2,3). (eotp.org)
The extrinsic or receptor-dependent pathway is usually induced by members of the tumor necrosis factor (TNF) family of proteins, where a ligand binds to one of the death receptors that subsequently recruit the death-inducing signaling complex (DISC) and the apical caspase 8 (4,5). (eotp.org)
It usually involves activation of caspases, and is commonly divided into intrinsic or extrinsic pathways, depending on whether it is activated by the mitochondria with subsequent release of cytochrome C (intrinsic apoptotic pathway) or whether it is activated by death receptors (extrinsic apoptotic pathway). (epigentek.com)
Apoptosis can be activated through two pathways: The extrinsic pathway (mediated by death receptors) or the intrinsic pathway (mediated by mitochondria). (biomedcentral.com)
The former is activated in response to the engagement of ligands such as CD95 or TNF-α with their receptors. (biomedcentral.com)

Activation involves dimerization and often oligomerisation of pro-caspases, followed by cleavage into a small subunit and large subunit. (wikipedia.org)
However, the cleavage of caspase‑3 showed an opposing change at different concentrations. (spandidos-publications.com)
These results indicated that P. gingivalis HSP60 may induce dysfunction and apoptosis in HUVECs via downregulating the expression levels of VE‑cadherin and eNOS, and promoting the cleavage of caspase‑3. (spandidos-publications.com)
Communication between the pathways exists through cleavage of Bcl-2 interacting domain (Bid) by active caspase-8 to form truncated Bid (tBid). (cdc.gov)
Triggering of both extrinsic and intrinsic apoptotic pathways was witnessed by cleavage of caspase-8 and -9, which in turn activated caspase-3 and PARP. (unime.it)
Thus, the induction of apoptosis via the extrinsic pathway requires additional cleavage of the proapoptotic Bcl-2 family member BID through caspase 8, which activates the intrinsic pathway and subsequently apoptosis (type II cell mechanism) (7,8). (eotp.org)
During apoptosis these inactive procaspases or precursors activated by proteolytic cleavage by another member of caspase family. (cellinsight.online)

The activation of initiator caspases and inflammatory caspases is initiated by dimerisation, which is facilitated by binding to adaptor proteins via protein-protein interaction motifs that are collectively referred to as death folds. (wikipedia.org)
In Drosophila, TNF ligand binding activates initiator caspases indirectly, through JNK. (deathbase.org)
EMB activated extrinsic and intrinsic pathways of apoptosis as shown by the activation of initiator and executioner caspases. (bvsalud.org)
The proteolytic activation of initiator caspases leads to the subsequent activation of executioner caspases (e.g. caspase-3), which ultimately results in apoptosis in Type I Cells. (biomedcentral.com)

Some activating multiprotein complexes includes: The death-inducing signaling complex (DISC) during extrinsic apoptosis The apoptosome during intrinsic apoptosis The inflammasome during pyroptosis Once appropriately dimerised, the Caspases cleave at inter domain linker regions, forming a large and small subunit. (wikipedia.org)
Cytochrome c then forms a multi-protein complex known as the 'apoptosome' and initiates activation of the caspase cascade through caspase 9. (geneontology.org)
In the intrinsic pathway, several adverse factors act upon mitochondria to cause loss of the mitochondrial membrane potential, resulting in leakage into the cytosol of cytochrome C (Cyto C), which together with apoptotic protease activating factor 1 forms the apoptosome that activates caspase-9. (cdc.gov)
The subsequent release of Cytochrome C inside the citoplasm of the cells induces the formation of a multiprotein complex, called apoptosome, that activates the caspase cascade through caspase-9 (C9) leading to Apoptosis. (parathyroid-hormone1-34.com)

Some of these mitochondrial-activated inflammatory pathways can be traced back to the bacterial ancestry of mitochondria. (nature.com)
The bacterial origin of mitochondria suggests that inflammatory pathways found in cytosol-invading bacteria may be relevant to mitochondrial-driven inflammation after MOMP. (nature.com)
In addition, mitochondria harbour many damage-associated molecular patterns (DAMPs) that can initiate a variety of inflammatory signalling pathways [ 3 ]. (nature.com)
and the intrinsic pathway, which is activated by cellular stress and is regulated primarily at the level of mitochondria by the Bcl-2 family of proteins ( Fig. 1 ). (biologists.com)
By contrast, the extrinsic apoptotic pathway can activate caspases without the participation of mitochondria. (biologists.com)
The intrinsic apoptotic pathway is characterized by permeabilisation of the mitochondria and release of cytochrome c into the cytoplasm. (geneontology.org)
Activation of caspase-8 engages the mitochondria-amplified apoptosis machinery in Type II cells [ 7 ]. (biomedcentral.com)
Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. (biomedcentral.com)
Smac (Second mitochondria-derived activator of caspase) protein, also known as DIABLO (Direct Inhibitor of Apoptosis-Binding protein with LOw pI), is codified by a nuclear gene. (biomedcentral.com)
The activation of the intrinsic pathway starts with the permeabilization of the mitochondria and the release of cytochrome C (CytC) into the cytoplasm. (parathyroid-hormone1-34.com)

should the term ['GO:0006919] activation of caspase activity' be a child of positive regulation of apoptosis or induction of apoptosis rather than directly to apoptosis? (geneontology.org)
The induction of apoptosis and necrosis by midazolam is presumably unrelated to GABA A receptor pathway signaling. (bmj.com)
Solanum nigrum (SN) is a herb with anticancer effects such as destruction of tumor cell membrane, induction of apoptosis by NF-kappaB, caspase activation, nitric oxide production and inhibition of angiogenesis [ 3 ]. (ijpsonline.com)

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death. (wikipedia.org)
Breaching the mitochondrial OM releases apoptogenic factors, including cytochrome c and DIABLO (also known as Smac), which activate a group of aspartate-specific proteases known as caspases ( Youle and Strasser, 2008 ). (biologists.com)
Apoptosis is a programmed form of cell death involving the degradation of cellular constituents by a group of cysteine proteases called caspases. (geneontology.org)
Inhibition of zHDR, zOTR, the adaptor zFADD, or caspase-8-like proteases blocked ligand-induced apoptosis, as did antiapoptotic Bcl-2 family members. (deathbase.org)
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). (kegg.jp)
Caspases are any of the family of intra cellular proteases , which are synthesized inside the cells. (cellinsight.online)

Directly activates executioner caspases leading to apoptosis. (howmed.net)

Later the signalling complex force to cleave procaspase 8 and caspase 8 released to cystol. (cellinsight.online)

They are named caspases due to their specific cysteine protease activity - a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue. (wikipedia.org)
The levels of vascular endothelial (VE)‑cadherin, endothelial nitric oxide synthase (eNOS) and cysteinyl aspartate‑specific protease‑3 (caspase‑3) were measured using western blot analysis. (spandidos-publications.com)
Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. (kegg.jp)

Our previous report showed that FO inhibits HCC cell invasion via AKT-, mitogen-activated protein kinase- (MAPK-), and EMT-related signals [ 7 ]. (hindawi.com)
Therefore, we aimed to demonstrate the potential anticancer effects of Sangju honey on human oral squamous cell carcinoma (OSCC), particularly focusing on epithelial-mesenchymal transition (EMT) and apoptotic and mitogen-activated protein kinase (MAPK) signaling pathways. (jcpjournal.org)

The caspases can be activated through either the intrinsic (mitochondrial mediated) or extrinsic (death receptor mediated) apoptotic pathways. (geneontology.org)
Upon activation of either the intrinsic or extrinsic pathway of the coagulation cascade, thrombin forms and cleaves fibrinopeptide A and B from fibrinogen, resulting in soluble fibrin monomers, which then associate and form fibrin polymers. (medscape.com)

Apoptotic caspase activity inhibits cell death-associated inflammation. (nature.com)
Sangju honey inhibits Ca9-22 and YD-10B cell proliferation by regulating EMT, inducing apoptosis, and suppressing the MAPK signaling pathway. (jcpjournal.org)
The linker region between the BIR1 and BIR2 is implicated in the inhibition of caspase-3 and -7 whereas the BIR2 domain inhibits caspase-7 in a non-competitive manner [ 9 ]. (biomedcentral.com)

Note that in addition to apoptosis, caspase-8 is also required for the inhibition of another form of programmed cell death called necroptosis. (wikipedia.org)
MOMP results from an ordered series of steps beginning with the activation of one or more Bcl-2 homology 3 proteins (BH3-proteins) or releasing previously activated pro-apoptotic proteins Bax or Bak from inhibition by an anti-apoptotic protein of the Bcl-2 family. (cancer-research-network.com)

However, in certain cell types, the extrinsic pathway also induces mitochondrial damage by cleaving the pro-apoptotic Bcl-2 family protein Bid to its activated truncated form (tBid), which leads to Bak and Bax activation. (biologists.com)
Midazolam induces apoptosis via activation of the mitochondrial pathway in a concentration-dependent manner. (bmj.com)
This in turn induces the recruitment of adapter proteins (FADD, TRADD o RAIDD) to form the so-called death-inducing signal complex (DISC), which activates caspase-8. (biomedcentral.com)

Tumour growth can occur by a combination of factors, including a mutation in a cell cycle gene which removes the restraints on cell growth, combined with mutations in apoptotic proteins such as caspases that would respond by inducing cell death in abnormally growing cells. (wikipedia.org)
The intrinsic apoptotic pathway is initiated in response to a variety of stress signals ( Willis and Adams, 2005 ), and a complex interplay of Bcl-2 proteins relays this signal to the mitochondrial outer membrane (OM) to initiate Bak and Bax activation, oligomerisation and OM damage ( Fig. 1 ). (biologists.com)
BCL2 proteins are described as 'crucial regulators of apoptosis' (PMID:15868100)and the intrinsic apoptosis pathway is initiated by the release of mitochondrial cytochrome c into the cytoplasm, which results in the activation of caspases (15102863) - help in generating a defintion for intrinsic apoptosis? (geneontology.org)
does all activation of caspases require other proteins also involved in apoptosis - therefore shouldn't this term be a part of apoptosis? (geneontology.org)
The intrinsic pathway is usually triggered by stress or chemotherapeutic brokers and is regulated by the balance of pro- and antiapoptotic members of the Bcl-2 family of proteins. (eotp.org)
Western blot analysis revealed that VALD-3 upregulated pro-apoptotic proteins (Bad and Bax), downregulated anti-apoptotic proteins (Bcl-2, Bcl-xl, survivin and XIAP) and increased the expression of cleaved caspase-3, cleaved caspase-8, Cyto-c and cleaved PARP. (researchsquare.com)
In the cytosol, Smac/DIABLO interacts and antagonizes inhibitors of apoptosis proteins (IAPs), thus allowing the activation of caspases and apoptosis. (biomedcentral.com)

Hence, evidenced the blocking of phosphatidylinositol 3-kinase/protein kinase B signaling pathway. (ijpsonline.com)
It induced apoptosis, suppressed cell migration and invasion, blocked cell cycle and phosphatidylinositol 3-kinase/ protein kinase B signaling pathway. (ijpsonline.com)
4 Upon dissociation from GRP78, the transmembrane kinase PERK is activated by oligomerisation and autophosphorylation. (distantreader.org)

RCD, referring to apoptosis, necrosis and autophagy, can be triggered either via intrinsic or extrinsic cell stimuli. (parasite-journal.org)
The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. (kegg.jp)
The intrinsic pathway is induced by several different stimuli like antineoplastic drugs, hypoxia, irradiation, growth factor withdrawal and heat shock. (biomedcentral.com)

There is two well known apoptosis pathways which are the intrinsic and extrinsic pathways. (cellinsight.online)
The analysis of apoptosis in a tumor region is obtained by studying the apoptosis pathways in a connected group of Pimasertib that interact which each other. (parathyroid-hormone1-34.com)

Moreover Caspase-6 (C6) cleaves C8 in a positive feedback loop that amplify this activation signal. (parathyroid-hormone1-34.com)

Inhibitors of apoptosis (IAPs) can prevent caspase activation under certain conditions. (cdc.gov)
Functional autophagy mitigates neuronal apoptosis, which is reflected by the alterations of IAPs, Bcl-2, caspase-3, and so forth. (biomedcentral.com)
There, Smac/DIABLO has a pro-apoptotic effect that is mediated by its interaction with IAPs and the release of caspases from them. (biomedcentral.com)

Additionally, scientists have used caspases as cancer therapy to kill unwanted cells in tumours. (wikipedia.org)
10 Galectins can function inside the cells by modulating signaling pathways, 11 although they also act extracellularly by establishing multivalent interactions with cell surface glycans and delivering signals that lead to disruption of cellular homeostasis. (nature.com)
Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
We hypothesized that FO might regulate related genes in apoptosis and PI3K-AKT pathways to mediate the proliferation and apoptosis of liver cancer cells. (hindawi.com)
Cells will adapt by activating the expression of genes involved in metabolic adaptation, such as those involved in glycolysis. (bmj.com)
B-cell lymphoma (Bcl2) protein overexpressing and caspase 9-deficient lymphoma cells were used to determine the role of the mitochondrial (intrinsic) pathway. (bmj.com)
Caspase 8-deficient and Fas-associated protein with death domain (FADD)-deficient cells were used to evaluate the death receptor (extrinsic) pathway. (bmj.com)
The protective effects of flumazenil and the caspase inhibitor N -(2-quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)-methylketone were investigated in neuroblastoma cells and primary rat neurons using metabolic activity assays (2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2 H -tetrazolium-5-carboxanilide) and immunofluorescence microscopy. (bmj.com)
A previous study reported that the extract of the whole plant of SN activated cell death in hepatoma cells through autophagy and apoptosis [ 7 ]. (ijpsonline.com)
The roles of apoptotic pathways in the low recovery rate after cryopreservation of dissociated human embryonic stem cells. (ox.ac.uk)
VALD-3 also regulated the Wnt/β-catenin signaling pathway in breast cancer cells, inhibiting the activation of downstream molecules. (researchsquare.com)
We previously reported that interaction of viable commensal bacteria with mammalian intestinal epithelial cells resulted in a rapid and reversible generation of reactive oxygen species (ROS) that modulated neddylation of Cullin-1 and resulted in suppressive effects on the NF-κB pathway. (emory.edu)

Many of the pro-inflammatory pathways activated during cell death occur upon mitochondrial outer membrane permeabilization (MOMP), the pivotal commitment point to cell death during mitochondrial apoptosis. (nature.com)
The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. (kegg.jp)

the Fas-Associated Death Domain (FADD) and caspases 8 or 10 are recruited to the DISC from the cytoplasm. (biomedcentral.com)

As of 2009, there are 12 confirmed caspases in humans and 10 in mice, carrying out a variety of cellular functions. (wikipedia.org)
Activation of caspases ensures that the cellular components are degraded in a controlled manner, carrying out cell death with minimal effect on surrounding tissues. (wikipedia.org)
Modification of emodin and synthesis of various derivatives have successfully increased efficacy of the molecule in regulating various cellular pathway like MAPK signaling pathway, NF-κβ signaling pathway, ROS mediated pathways and apoptotic pathways. (longdom.org)
Apoptosis largely divides into two pathways ultimately leading to caspase activation and subsequent cellular disintegration. (cancer-research-network.com)

In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
Western blot analysis was conducted to investigate protein expression related to EMT and apoptotic and MAPK signaling pathways. (jcpjournal.org)

Intracellular insults can initiate neuronal apoptosis via mitochondrial dysfunction or intrinsic pathway (Fig. 1 ). (biomedcentral.com)

Caspases also have a role in inflammation, whereby it directly processes pro-inflammatory cytokines such as pro-IL1β. (wikipedia.org)
Caspases involved with processing inflammatory signals are also implicated in disease. (wikipedia.org)
Caspases, while dispensable for cell death during mitochondrial apoptosis, inhibit activation of pro-inflammatory pathways after MOMP. (nature.com)
2012) . Sterile inflammation associat- The key mechanistic pathways and vation of inflammatory cel s (Balkwill, ed with inhalation of crystal ine silica mediators involved in inflamma- 2012 ). (who.int)
Activated inflammatory cel s, in- persistent inflammation cluding neutrophils and macrophag- es, produce reactive oxygen species and reactive nitrogen species. (who.int)

Can inflammation occur under caspase-proficient conditions? (nature.com)

TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. (kegg.jp)
As a transcription factor that both activates and represses target genes p53 demands a highly complicated network to control and fine-tune responses to the different stress-signals encountered [ 1 ]. (biomedcentral.com)

The mammalian extrinsic apoptosis pathway is triggered by Fas ligand (FasL) and Apo2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL). (deathbase.org)
FasL ,TNF receptor →caspase 8→ exec caspase. (howmed.net)

Multiprotein complexes often form during caspase activation. (wikipedia.org)

Additionally, JIB extract induced B16/F10 cell apoptosis via the caspase cascade. (medsci.org)
Does not use caspases cascade. (howmed.net)

Caspases have other identified roles in programmed cell death such as pyroptosis, necroptosis and PANoptosis. (wikipedia.org)
Conversely, over-activation of some caspases such as caspase-3 can lead to excessive programmed cell death. (wikipedia.org)
The integral role caspases play in cell death and disease has led to research on using caspases as a drug target. (wikipedia.org)
Most caspases play a role in programmed cell death. (wikipedia.org)
The death folds are located in a structural domain of the caspases known as the pro-domain, which is larger in those caspases that contain death folds than in those that do not. (wikipedia.org)
Although the presence of active caspases and DNA fragmentation is helpful in identifying possible apoptosis, they should not be employed as an exclusive means to demonstrate this process as apototic cell death can occur without DNA fragmentation or caspase activity. (geneontology.org)
Cell death is frequently considered to be 'caspase-dependent' when it is suppressed by broad-spectrum caspase inhibitors such as N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD-fmk). (geneontology.org)
Apoptotic pathways of cell death. (cdc.gov)
mitochondrial membrane permeability → cytochrome c & AIF → activates caspases → death. (howmed.net)
All these forms of cell death can be activated independently of apoptosis, or if apoptosis fails. (epigentek.com)
Extrinsic pathway initiated when death inducing signalling complex formed in the cell surface. (cellinsight.online)

Some cell SMIP004 types produce insufficient amounts of active caspase 8 at the receptor level. (eotp.org)

Based on meta-analysis and comprehensive review, high-profile studies support the theory that transplanted BMMSCs activate autophagy, as evidenced by the expression levels of signal molecules such as Beclin-1, Atg5, LC3-II, and mTOR. (biomedcentral.com)

Bcl2-overexpression and caspase 9 deficiency protected against toxicity, whereas caspase 8 or FADD deficiency had no effect. (bmj.com)

Usually the activation of the intrinsic pathway of apoptosis is modeled starting by directly releasing cytochrome C into the cytoplasm. (parathyroid-hormone1-34.com)

Apoptosis induction was further confirmed by morphological changes, an increase in Caspase 3/7 and a decrease in the ATP levels. (biomedcentral.com)

We recently reported that a key step leading to Bak homo-oligomerisation following an apoptotic stimulus involves transient exposure of the Bak BH3 domain before it binds to the hydrophobic groove of another activated Bak molecule to form a novel symmetric dimer. (biologists.com)

2011) activating the production of tBid. (parathyroid-hormone1-34.com)
Therefore, in our model the intrinsic pathway is activated with any initial concentration of tBid different from zero and this will be assumed proportional to the photodynamic damage. (parathyroid-hormone1-34.com)

There are other identified roles of caspases such as cell proliferation, tumour suppression, cell differentiation, neural development and axon guidance and ageing. (wikipedia.org)
Several pathways leading to the suppression of host immune response and the survival of the cysts in various hosts are known. (parasite-journal.org)

The study aims to evaluate the apoptotic pathway and to investigate the protective effects of the benzodiazepine antagonist flumazenil and the caspase inhibitor N -(2-quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)-methylketone. (bmj.com)

Anatomy11

Diseases2

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes19

Information Science2

Effector9

Receptors9

Cleavage7

Initiator4

Apoptosome4

Mitochondria10

Induction of apoptosis3

Proteases6

Executioner1

Cleave1

Protease3

Mitogen-activa2

Either the intrinsic2

Inhibits3

Inhibition2

Induces3

Proteins7

Kinase3

Stimuli3

Apoptosis pathways2

Cleaves1

IAPs3

Cells12

Mitochondrial outer membrane permeabilization2

DISC1

Cellular4

Protein2

Intracellular1

Inflammatory5

Inflammation1

Signals2

FasL2

Multiprotein1

Cascade2

Death11

Receptor1

Autophagy1

FADD1

Cytochrome c into the cytoplasm1

Morphological changes1

Oligomerisation1

TBid2

Suppression2

Inhibitor1