• The diagnostic criteria for EPSCC require that the tumor demonstrate histolgic features of small cell carcinoma in the absence of small cell lung cancer (SCLC). (medscape.com)
  • EPSCC may have a similar prognosis to that of small cell lung cancer. (medscape.com)
  • Small-cell carcinoma is a type of highly malignant cancer that most commonly arises within the lung, although it can occasionally arise in other body sites, such as the cervix, prostate, and gastrointestinal tract. (wikipedia.org)
  • Extensive stage small cell lung cancer (SCLC) is classified as a rare disorder. (wikipedia.org)
  • Small-cell lung carcinoma has long been divided into two clinicopathological stages, termed limited stage (LS) and extensive stage (ES). (wikipedia.org)
  • In ES-SCLC, platinum-based combination chemotherapy is the standard of care, with radiotherapy added only to palliate symptoms such as dyspnea, pain from liver or bone metastases, or for treatment of brain metastases, which, in small-cell lung carcinoma, typically have a rapid, if temporary, response to whole brain radiotherapy. (wikipedia.org)
  • citation needed] In August 2018, the FDA approved nivolumab to treat patients with metastatic small cell lung cancer (SCLC) who failed to respond to platinum-based chemotherapy and at least one other line of treatment. (wikipedia.org)
  • Atezolizumab was associated with a significant improvement in overall survival (HR for death = 0.70) Small-cell carcinoma of the lung usually presents in the central airways and infiltrates the submucosa leading to narrowing of bronchial airways. (wikipedia.org)
  • Data from a phase 1 trial highlight a clinically acceptable safety profile for BI 764532 in patients with extensive-stage small cell lung cancer and extrapulmonary neuroendocrine carcinomas. (cancernetwork.com)
  • Most small cell carcinomas usually arise from the lung and rarely from the gastrointestinal tract [ 1 , 2 ]. (e-ce.org)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • 2004. Evaluation if immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers. (zju.edu.cn)
  • Pre-treatment and treatment-induced neuron-specific enolase in patients with small-cell lung cancer: an open prospective study[J]. Arch Bronconeumol, 2010, 46(7):364-369. (sdu.edu.cn)
  • Expression of the multidrug resistance protein MRP and the lung-resistance protein LRP in nasal NK/T cell lymphoma: further exploring the role of P53 and WT1 gene[J]. Pathology, 2009, 41(2):127-132. (sdu.edu.cn)
  • The occurrence of small intestinal metastases from primary lung cancer is rare. (spandidos-publications.com)
  • Postoperative pathological analysis confirmed the final diagnosis to be small intestinal metastasis from primary lung cancer. (spandidos-publications.com)
  • However, the lung tumor spread to the small intestine, causing intestinal obstruction. (spandidos-publications.com)
  • Although small intestinal metastasis from lung cancer is rare and difficult to diagnose accurately, it should be considered when encountering a patient with lung cancer exhibiting abdominal symptoms and associated imaging findings. (spandidos-publications.com)
  • The present report describes an uncommon case of small intestinal metastasis from lung cancer. (spandidos-publications.com)
  • Low-dose anlotinib combined with EGFR-TKI can be used as an alternative for EGFR-TKI-resistant non-small cell lung cancer in elderly patients. (edu.ni)
  • citation needed] Because SCLC usually metastasizes widely very early on in the natural history of the tumor, and because nearly all cases respond dramatically to chemotherapy and/or radiotherapy, there has been little role for surgery in this disease since the 1970s. (wikipedia.org)
  • While the tumor is often considered to arise from neuroendocrine proliferation or possibly dedifferentiation of an acinar carcinoma, the precise etiology remains uncertain. (karger.com)
  • The morphologic features characteristic of the disease's pathology include small tumor cells with minimal cytoplasm, nuclear molding, fine chromatin pattern, extensive tumor necrosis/apoptosis, and a brisk mitotic rate. (medscape.com)
  • Primary gastric small cell carcinoma (GSCC) is a rare and the most poorly differentiated neuroendocrine tumor, accounting for less than 0.1% of all gastric cancers and 15% of all gastric neuroendocrine tumors [ 1 ]. (e-ce.org)
  • According to the degree of differentiation, NENs have been divided into well differentiated NENs and poorly differentiated NENs in the 2010 World Health Organization classification of tumors of the digestive system, with the former being termed a neuroendocrine tumor (NET), and the latter, a neuroendocrine carcinoma (NEC) [ 1 ]. (biomedcentral.com)
  • Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition. (harvard.edu)
  • The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)
  • Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonarry neuroendocrine tumors. (zju.edu.cn)
  • Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5. (harvard.edu)
  • Hepatocellular carcinoma (HCC) is a common malignancy worldwide and treatment options are depended on the stage of the tumour. (biomedcentral.com)
  • Hypervascular Hepatocellular Carcinoma: Correlation between Biologic Features and Signal Intensity on Gadoxetic Acid-enhanced MR Images. (kanazawa-u.ac.jp)
  • Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma. (kanazawa-u.ac.jp)
  • Compared to non-small cell carcinoma, small cell carcinoma is more aggressive, with a shorter doubling time, higher growth fraction, and earlier development of metastases. (wikipedia.org)
  • Unlike prostatic adenocarcinoma, small cell carcinoma of the prostate may present with metastases in up to 25% of patients. (medscape.com)
  • Cutaneous metastases of colonic neuroendocrine carcinomas (NECs) are very infrequent, while cases of scalp metastasis are even fewer. (biomedcentral.com)
  • Pembrolizumab alone and pembrolizumab plus chemotherapy in previously treated, extrapulmonary poorly differentiated neuroendocrine carcinomas. (harvard.edu)
  • Histologic criteria for diagnosis of extrapulmonary small cell carcinoma (EPSCC) are same as those for pulmonary small cell carcinoma: the presence of uniform small cells with sparse cytoplasm, dense nuclei, and inconspicuous nucleoli. (medscape.com)
  • Utility of p40 in the differential diagnosis of small round blue cell tumors of the sinonasal tract[J]. Head Neck Pathol, 2014, 8(2):141-145. (sdu.edu.cn)
  • The application value of CT and MRI in the diagnosis of natural killer/T-cell lymphoma in nasal cavity[J]. J Chin Clin Med Imag, 2012, 23(1):32-34. (sdu.edu.cn)
  • Diagnosis and treatment of 11 cases with sinonasal neuroendocrine carcinoma[J]. Chin J Otorhinolaryngol Head Neck Surg, 2011, 46(12):1033-1035. (sdu.edu.cn)
  • Small cell carcinoma of the prostate is a high-grade malignant neoplasm with neuroendocrine differentiation. (medscape.com)
  • Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). (mdpi.com)
  • however, it is not uncommon for these cells to arise in nonpulmonary sites, as extrapulmonary small cell carcinoma (EPSCC). (medscape.com)
  • SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
  • The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer. (harvard.edu)
  • Approximately 1000 cases of extrapulmonary small cell carcinoma (EPSCC) are reported annually in the United States, with an overall incidence of 0.1-0.4% of all cancers and 2.5-5% of all small cell carcinomas. (medscape.com)
  • Global incidence of extrapulmonary small cell carcinoma is unknown. (medscape.com)
  • Neuroendocrine neoplasms (NENs) are rare tumors originating from neuroendocrine cells and include a series of heterogeneous tumors. (biomedcentral.com)
  • ENETS consensus guidelines for neuroendocrine neoplasms of the appendix(excluding goblet cell carcinomas)[J]. Neuroendocrinology, 2016, 103(2):144-152. (sdu.edu.cn)
  • Imaging of Small-Bowel Neuroendocrine Neoplasms: AJR Expert Panel Narrative Review. (harvard.edu)
  • High hormone levels above the physiologic range suggest ectopic secretion of ADH, most commonly by bronchogenic carcinoma. (medilib.ir)
  • Biological characteristics and treatment of nasal cavity, temporal bone neuroendocrine carcinoma[J]. J Modern Oncol, 2013,21(1):49-52. (sdu.edu.cn)
  • Paranasal sinus neuroendocrine carcinoma: a case report and review of the literature[J]. Case Rep Oncol Med, 2013: 728479. (sdu.edu.cn)
  • Ali SZ, Reuter VE, Zakowski MF: Small cell neuroendocrine carcinoma of the urinary bladder: a clinicopathologic study with emphasis on cytologic features. (karger.com)
  • Abbas F, Civantos F, Benedetto P, Soloway MS: Small cell carcinoma of the bladder and prostate. (karger.com)
  • Cross-section through the bladder, uterus, and vagina with squamous cell carcinoma of the bladder infiltrating through the bladder wall into the vaginal wall. (medscape.com)
  • Almost all bladder cancers originate in the urothelium, which is a 3- to 7-cell mucosal layer within the muscular bladder. (medscape.com)
  • Books These Permits are just with such little interviews. (lightseed.com)
  • Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. (harvard.edu)
  • [ 2 ] Since EPSCC has been reported in multiple sites, all cases are thought to have an identical cell of origin that derives from those originating in neural crest and then migrates to different epithelial sites within the body. (medscape.com)
  • Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)
  • Papandreou CN, Daliani DD, Thall PF, Tu SM, Wang X, Reyes A, Troncoso P, Logothetis CJ: Results of a phase II study with doxorubicin, etoposide, and cisplatin in patients with fully characterized small-cell carcinoma of the prostate. (karger.com)
  • Furtado P, Lima MVA, Nogueira C, Franco M, Tavora F: Review of small cell carcinomas of the prostate. (karger.com)
  • Brownback KR, Renzulli J, Myers JR: Small-cell prostate carcinoma: a retrospective analysis of five newly reported cases. (karger.com)
  • Rubenstein JH, Katin MJ, Mangano MM, Dauphin J, Salenius SA, Dosoretz DE, Blitzer PH: Small cell anaplastic carcinoma of the prostate: seven new cases, review of the literature and discussion of a therapeutic strategy. (karger.com)
  • Anker CJ, Dechet C, Isaac JC, Akerley W: Small cell carcinoma of the prostate. (karger.com)
  • Bolton DM, Chiu ST, Clarke S, Angus D: Primary small cell carcinoma of the prostate: unusual modes of presentation. (karger.com)
  • Hindson DA, Knight LL, Ocker JM: Small-cell carcinoma of prostate. (karger.com)
  • Small cell carcinoma of the prostate is rare, accounting for less than 1% of all prostate cancers. (medscape.com)
  • Clinical features and prognosis of advanced intra- and extra-pulmonary neuroendocrine carcinomas. (edu.ni)
  • Approximately 50% of patients have pure small cell carcinoma at initial presentation. (medscape.com)
  • S kin Sparing Mastectomy (SSM) and immediate breast reconstruction has become increasingly popular as an effective treatment for patients with breast carcinoma. (biomedcentral.com)
  • Splenic diffuse red pulp small-B cell lymphoma: toward the emergence of a new lymphoma entity[J]. Discov Med, 2012, 13(71):253-265. (sdu.edu.cn)
  • DSRCT is composed of small cells with round hyperchromatic nuclei and a dense fibrous or spindle cell stroma. (medscape.com)
  • Like pulmonary small cell carcinoma, small cell carcinomas arising from extrapulmonary sites may be associated with paraneoplastic syndromes , notably syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and hypercalcemia . (medscape.com)
  • However, deletions of chromosome arm 3p and c-myc amplification described in small cell pulmonary carcinoma have not been reported in extrapulmonary sites. (medscape.com)
  • Richardson RL, Weiland LH: Undifferentiated small cell carcinomas in extrapulmonary sites. (karger.com)
  • These cells are characterized by the presence of intracytoplasmic neurosecretory granules and positive staining with chromogranin. (medscape.com)
  • We have also reviewed the literature concerning gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs) in this article. (biomedcentral.com)
  • Extrapulmonary small cell neuroendocrine carcinoma of the paranasal sinuses: a case report and review of the literature[J]. J Oral Maxillofac Surg, 2012, 70(10):2347-2351. (sdu.edu.cn)
  • Small cell neuroendocrine carcinoma in the right nasal cavity: a report of one case and a literature review[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(1): 89-92. (sdu.edu.cn)
  • Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. (mdpi.com)
  • [ 1 ] Small cell carcinoma is a distinct clinical and pathologic entity that arises from cells of the amine precursor uptake and decarboxylation (APUD) system. (medscape.com)