SplenomegalySpleenMyelofibrosisOrgansMyeloidIneffective hematopoiesisBoneMarrowHepatosplenomegalyAnemiaHepaticTumorsRarelyLiverTumorThrombocytopeniaImmunityHematologicalVenousMutationsHepatomegalyComplicationsPlateletsThrombosisHaematopoieticPatientsRegulationCongenitalNormalInfectionIncidenceIncludeBlood cellsFrequencyLesionsChronicResultCasesFatigue
Splenomegaly7
- This process, called extramedullary hematopoiesis, often leads to an enlarged spleen (splenomegaly) or an enlarged liver (hepatomegaly). (medlineplus.gov)
- Splenomegaly most often occurs as a secondary manifestation of a primary disease process. (thebloodproject.com)
- May rarely occur with a normal-sized spleen (though some include splenomegaly as part of the definition). (thebloodproject.com)
- Hepatomegaly also occurs, although less commonly than splenomegaly. (medscape.com)
- attacks abate with treatment response is characterized by marrow brosis, myeloid metaplasia with extramedullary hematopoiesis, and splenomegaly. (surgicalimpex.com)
- MF is characterized by variable degrees of cytopenias, a leukoerythroblastic blood picture, and extramedullary hematopoiesis resulting in progressive splenomegaly and debilitating disease-related constitutional symptoms, compromising quality of life. (haematologica.org)
- This results in extramedullary hematopoiesis with resultant symptomatic and sometimes massive splenomegaly. (fda.gov)
Spleen11
- As development progresses, blood formation occurs in the spleen, liver and lymph nodes. (wikipedia.org)
- Because blood cell formation (hematopoiesis) in the bone marrow is disrupted, other organs such as the spleen or liver may begin to produce blood cells. (medlineplus.gov)
- Myelofibrosis is a reactive, reversible increase in bone marrow collagen often with extramedullary hematopoiesis (primarily in the spleen). (msdmanuals.com)
- The spleen works as the primary site of extramedullary hematopoiesis. (picmonic.com)
- Left upper quadrant abdominal pain described as "gripping" may occur from spleen infarction. (medscape.com)
- Hepatomegaly is usually part of the extramedullary hematopoiesis occurring in the spleen. (medscape.com)
- Extramedullary hematopoiesis (EMH) is likely the result of abnormal trafficking of hematopoietic stem cells (HSC) from the bone marrow to organs such as the spleen, liver, and lung, causing organomegaly and sometimes organ dysfunction. (cancernetwork.com)
- In addition, the spleen performs extramedullary hematopoiesis. (healthjade.net)
- The spleen plays a significant role in hematopoiesis and immunosurveillance. (healthjade.net)
- Some affected individuals with the malignant infantile type of osteopetrosis may also experience consequences of reduced bone marrow space: marked deficiency of all types of blood cells (pancytopenia), the formation and development of blood cells outside the bone marrow, as in the spleen and liver (extramedullary hematopoiesis), and the occurrence of myeloid tissue in extramedullary sites (myeloid metaplasia). (orthopedicshealth.com)
- The abnormal expansion of cortical and trabecular bone physically limits the availability of medullary space for hematopoietic activity, leading to life-threatening cytopenia and secondary expansion of extramedullary hematopoiesis at sites such as the liver and spleen (summary by Aker et al. (nih.gov)
Myelofibrosis7
- Primary myelofibrosis is most commonly diagnosed in people aged 50 to 80 but can occur at any age. (medlineplus.gov)
- In primary myelofibrosis, nucleated red blood cells (normoblasts) and myelocytes are released into the circulation (leukoerythroblastosis) when there is extramedullary hematopoiesis (ie, non-marrow organs have taken over blood cell production because of the fibrosed marrow). (msdmanuals.com)
- Primary myelofibrosis (PMF) is a type of cancer of bone marrow and is characterized by bone marrow fibrosis, extramedullary hematopoiesis, and JAK2 tyrosine kinase mutations. (picmonic.com)
- Extramedullary hematopoiesis occurs over the course of primary myelofibrosis. (picmonic.com)
- Myelofibrosis appears to be part of the natural history of the disease but is a reactive, reversible process that does not itself impede hematopoiesis and by itself has no prognostic significance. (basicmedicalkey.com)
- In approximately 15% of patients, however, myelofibrosis is accompanied by significant extramedullary hematopoiesis, hepatosplenomegaly, and transfusion-dependent anemia, which are manifestations of stem cell failure. (basicmedicalkey.com)
- Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
Organs3
- Severe extramedullary hematopoiesis can disturb the function of organs in which it occurs, including the brain. (msdmanuals.com)
- Due to bone marrow failure, accessory organs participate in hematopoiesis. (picmonic.com)
- Perivascular epithelioid cell tumours (PEComas) belongs to the family of mesenchymal neoplasms that can occur in many organs, but rarely found in liver. (medpharmres.com)
Myeloid1
- Splenic macrophages and adhesion molecules may be involved in regulation of extramedullary myeloid cell generation in cardiovascular disease. (wikipedia.org)
Ineffective hematopoiesis1
- In 30-50% of patients, the lymphoblasts infiltrate bone marrow, causing ineffective hematopoiesis. (medscape.com)
Bone8
- If the bone marrow is affected, thrombocytopenia with purpura and petechiae occur. (medscape.com)
- Bone marrow failure eventually occurs, with consequent anemia and thrombocytopenia. (msdmanuals.com)
- Using a fresh optical approach, our interactive haematopoiesis graphic illustrates this development from the pluripotent stem cell via progenitor and precursor cells in bone marrow, lymph nodes and thymus to the mature blood cells circulating in peripheral blood. (sysmex.es)
- In adults, more than 95% of haematopoiesis takes place in bone marrow. (sysmex.es)
- In the presence of defective or insufficient haematopoiesis in bone marrow, expansion of the red marrow may occur. (sysmex.es)
- Extramedullary hematopoiesis usually occurs in hematological diseases but may also be found as an uncommon complication of Paget's disease , probably due to bone effraction mechanism. (lookfordiagnosis.com)
- AN: Hairy cell leukemia is a rare and incurable malignancy in which malignant "hairy" B-cell lymphocytes accumulate in bone marrow and interfere with trilineage hematopoiesis. (fda.gov)
- Bone Marrow Diseases can occur in any gender. (tabletwise.net)
Marrow2
- In children, haematopoiesis occurs in the marrow of the long bones such as the femur and tibia. (wikipedia.org)
- With ageing, the increase in yellow marrow restricts the sites of haematopoiesis to the axial skeleton and proximal ends of long bones (e.g. femur and humerus). (sysmex.es)
Hepatosplenomegaly1
- Affected individuals may also experience rhinitis, hepatosplenomegaly, anemia and extramedullary hematopoiesis. (orthopedicshealth.com)
Anemia2
- Fetal anemia (in presence of red cell incompatibility) may also occur. (checkorphan.org)
- It occurs due to anemia and cytokines. (picmonic.com)
Hepatic1
- This report aims to announce a case of hepatic PEComa with extramedullary hematopoiesis. (medpharmres.com)
Tumors3
- Bilateral tumors occur in about two thirds of patients with familial retinoblastoma. (entokey.com)
- [ 1 ] Meningiomas are also the most common extra-axial tumors in the brain and the most frequently occurring tumors of mesodermal or meningeal origin. (medscape.com)
- Flat tumors, termed en plaque, infiltrate the dura and grow as a thin carpet or sheet of tumor along the convexity dura, falx, or tentorium. (medscape.com)
Rarely1
- 17 ] Very rarely, hemangioblastoma may occur in the cerebellopontine angle (CPA). (surgicalneurologyint.com)
Liver2
- Liver and lymph node enlargement can also occur due to the extramedullary hematopoiesis. (picmonic.com)
- Histopathologic examination showed diffused liver fibrosis with cystic dilatation of the bile ducts and focal extramedullary hematopoiesis. (cdc.gov)
Tumor4
- Congestive heart failure and a low cardiac output can occur when the tumor extensively involves the myocardium or the ventricular papillary muscles. (medscape.com)
- Death occurs because of obstruction of ventricular blood flow, arrhythmias, valve stenosis, or loss of functional myocardium secondary to extensive tumor involvement. (medscape.com)
- Most Wilms tumor occurs in children between the ages of 2 and 4 years ( 3 ). (abdominalkey.com)
- The gross appearance of the tumor was suggestive of a highly vascular lesion, and so intraoperatively, a decision was made to attempt an en-bloc resection. (surgicalneurologyint.com)
Thrombocytopenia2
- In utero intracranial hemorrhage occurs in about 10% to 30% of affected cases (and NAIT is thought to be the underlying cause in the majority of cases of intracranial hemorrhage due to thrommbocytopenia- greater than all other causes of thrombocytopenia combined). (checkorphan.org)
- The dysregulation of haematopoiesis may lead to deficiencies (e.g. anaemia, leucocytopenia, thrombocytopenia) or over-production (e.g. haematological malignancies). (sysmex.es)
Immunity1
- This the most severe and important complication of rubella and occurs in the fetus of a pregnant woman without immunity to the virus. (medscape.com)
Hematological1
- Adrenal hemorrhage is rare but appears to occur more frequently in patients with underlying hematological conditions. (jofem.org)
Venous2
- An increased rate of thrombotic complications is associated with MF and can occur in the venous or arterial circulation. (cancernetwork.com)
- The differential diagnosis for brain meningioma includes dural metastasis (with breast and prostate cancer being the most common primary malignancies), hemangiopericytoma, granulomatous disease (including sarcoidosis and tuberculosis), idiopathic hypertrophic pachymeningitis, extramedullary hematopoiesis, hemangioma, and dura/venous sinuses. (medscape.com)
Mutations1
- This condition is generally not inherited but arises from gene mutations that occur in early blood-forming cells after conception. (medlineplus.gov)
Hepatomegaly1
- Hepatomegaly occurs in some patients. (msdmanuals.com)
Complications1
- hominissuis may not lead to tuberculous lesions in birds, particularly when the infection occurs without complications. (cdc.gov)
Platelets1
- Thrombopoiesis is haematopoiesis of thrombocytes (platelets). (wikipedia.org)
Thrombosis1
- These patients often require thromboprophylaxis such as antiplatelet medications and, if thrombosis has occurred, coumarin [ 1 ]. (jofem.org)
Haematopoietic1
- Haematopoiesis is the process by which uncommitted haematopoietic stem cells proliferate and differentiate into all the cellular components of the blood. (sysmex.es)
Patients3
- As opposed to thalassemia major, where transfusional induced iron overload is targeted towards the reticuloendothelial system and parenchyma, iron is amassed in patients with NTDT that differ, primarily occurs in hepatocytes [ 10 - 13 ]. (hindawi.com)
- Physical findings of leukostasis and hyperviscosity can occur in some patients, with extraordinary elevation of their WBC counts, exceeding 300,000-600,000 cells/μL. (medscape.com)
- Complete visual loss invariably occurs in all untreated patients, and hearing loss is estimated to affect 78% of patients with OPT. (nih.gov)
Regulation1
- The regulation of haematopoiesis is dependent on glycoprotein growth factors which drive the proliferation and differentiation of progenitor cells. (sysmex.es)
Congenital3
- Cardiac rhabdomyomas can occur sporadically, in association with congenital heart malformations, or in the setting of certain genetic disorders. (medscape.com)
- Immunoglobulin is not recommended unless termination of the pregnancy is not an option because cases of congenital rubella syndrome have occurred in infants born to mothers who received immunoglobulin shortly after exposure. (medscape.com)
- May occur during the history and examination suggestive of cardiac enlargement with right ventricular contour, prominent pulmonary artery, congenital as (loudest at apex) or ps (upper left sternal border (along right sternal border. (surgicalimpex.com)
Normal1
- The biology behind normal haematopoiesis is rather complex, involving extensive coordination of numerous molecular programs involved in cell division and the determination of cell fate. (sysmex.es)
Infection1
- Of infants infected in the first trimester, 50% are affected, and the severity depends on how early the infection occurs. (medscape.com)
Incidence1
- The highest incidence occurs in individuals of African descent, followed by eastern Mediterranean and Middle Eastern populations. (radiopaedia.org)
Include1
- The fetal response to NAIT is variable and may include compensatory extramedullary hematopoiesis. (checkorphan.org)
Blood cells1
- In developing embryos, blood formation occurs in aggregates of blood cells in the yolk sac, called blood islands. (wikipedia.org)
Frequency1
- These can occur with varying frequency, depending on the underlying MPN. (amboss.com)
Lesions1
- 34062569 ) This is most closely associated with demyelinating lesions, but may also occur with other pathologies. (emcrit.org)
Chronic1
- Loss of energy and decreased exercise tolerance may occur during the chronic phase after several months. (medscape.com)
Result1
- In contrast, only occasionally does a reaction occur among idiosyncratic agents that result in the suppression of one or more cell lines (1 in 100 to 1 in a million). (eistria.com)
Cases2
- only 300 cases occur yearly in the United States. (entokey.com)
- Strabismus occurs in about one third of cases. (entokey.com)
Fatigue1
- Nonspecific symptoms of fatigue and weight loss may occur long after the onset of the disease. (medscape.com)