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  • reaction
  • 3-9 Although the reaction with dioxygen is thermodynamically favourable, the electronic configuration of the O 2 molecule creates a strong kinetic barrier that requires activation, which is useful to prevent any spontaneous reaction of O 2 with organic molecules. (rsc.org)
  • enzyme
  • The enzyme 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase uses 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate and NAD+ to produce 3-methylcatechol, NADH and CO2. (wikipedia.org)
  • oxidation
  • In comparision, the oxidation of 4- t -butyl-catechol (4-TBC) that always required a basic media led to a total oxidation into the ortho -quinone, contrary to the molecular analogue. (rsc.org)
  • 2 In particular, several metalloenzymes called oxygenases perform the oxidation of organic compounds by activating molecular dioxygen. (rsc.org)
  • A non-heme [(L4Me4)Fe(III)] + 3 complex that mimics the reactivity of intradiol dioxygenases, and a heme [T(o-Cl)PPFe] complex catalyzing the stepwise oxidation of cyclohexane to adipic acid, were also studied. (diva-portal.org)
  • carbon
  • The Sphingomonas macrogolitabida strain TFA is a gram-negative bacterium that is able to grow on tetralin (1,2,3,4-tetrahydronaphthalene) as the only carbon and energy source ( 14 ). (pubmedcentralcanada.ca)
  • A 1,2-dihydroxynaphthalene dioxygenase (ThnC) is responsible for the extradiol cleavage of the catechol derivative ( 1 ), followed by hydrolytic cleavage (by ThnD) of the C-C bond that is part of the alicyclic ring of the fission product, resulting in a long dicarboxylic acid with 10 carbon atoms ( 12 ). (pubmedcentralcanada.ca)
  • SG-4G is capable of using carbendazim, 2-aminobenzimidazole, and 2-hydroxybenzimidazole as sole carbon and energy sources for growth. (ethz.ch)
  • selective
  • Examples of recent gene duplication events in signaling as well as dioxygenase clusters are present, indicating selective gene family expansion as a relatively recent event in D. aromatica 's evolutionary history. (biomedcentral.com)
  • Pathway
  • As shown in Fig. ​ Fig.1A, 1A , strain TFA metabolizes tetralin through a meta -cleavage pathway that involves an initial dioxygenation step (catalyzed by the enzymatic complex ThnA1A2A3A4), followed by a dehydrogenation step (catalyzed by ThnB) to produce 1,2-dihydroxytetralin ( 24 ). (pubmedcentralcanada.ca)
  • It follows the above pathway through 2-hydroxybenzimidazole. (ethz.ch)
  • The pathway followed is the same as for the above two organisms, through 2-hydroxybenzimidazole. (ethz.ch)
  • In contrast to the subsequent barrier-free intradiol C−C bond cleavage, the extradiol pathway proceeds via the formation of an epoxide, which requires an additional activation barrier. (diva-portal.org)
  • hydrocarbons
  • 1,2-CTD degrades phenolic hydrocarbons key to the synthesis lipid membranes. (wikipedia.org)
  • Therefore, 1,2-CTD may bind to the cell lipid membrane via its terminal phospholipids and thus have greater access to the phenolic hydrocarbons vital in lipid membrane structure. (wikipedia.org)
  • complexes
  • Lawrence Que Jr has been recently working on creating synthetic oxoiron(IV) complexes with S=2 spin. (wikipedia.org)
  • methyl
  • Benomyl, methyl N-[1-(butylcarbamoyl)benzimidazol-2-yl]carbamate, and its conversion product, carbendazim, methyl benzimidazol-2-yl carbamate, are systemic fungicides. (ethz.ch)
  • iron
  • Most mononculear iron dioxygenases are members of the cupin superfamily in which the overall domain structure is described as a six-stranded β-barrel fold (or jelly roll motif). (wikipedia.org)
  • At the center this barrel structure is a metal ion, most commonly ferrous iron, whose coordination environment is frequently provided by residues in two partially conserved structural motifs: G(X)5HXH(X)3-4E(X)6G and G(X)5-7PXG(X)2H(X)3N. (wikipedia.org)
  • Extradiol members utilize ferrous iron as the active redox state, and this center is commonly coordinated octahedrally through a 2-His-1-Glu motif with labile water ligands occupying empty positions. (wikipedia.org)
  • In the 2OG-dependent dioxygenases, ferrous iron (Fe(II)) is also coordinated by a (His)2(Glu/Asp)1 "facial triad" motif. (wikipedia.org)
  • Dioxygenase Model Studies: Reactionof Oxygen with Iron Catecholates", Lauffer, R. B. (umn.edu)
  • gene
  • Catechol 1,2-dioxygenase (EC 1.13.11.1 ) (gene catA or clcA). (expasy.org)
  • Chlorocatechol 1,2-dioxygenase (EC 1.13.11.1 ) (gene tfdC). (expasy.org)
  • With respect to the initial step of biphenyl degradation, expression of all sets of ring hydroxylating dioxygenase genes (bphA, etbAl, etbA2) likewise is induced by biphenyl, and gene disruption experiments suggested that all these genes are involved in biphenyl degradation (Takeda et al. (alpfmedical.info)
  • suppressor gene can be implicated in the control of the cell routine, DNA MK-4827 synthesis, and DNA restoration aswell as apoptosis [2]. (cancer-colorectal.com)
  • Antibodies against p53 could be recognized in sera from tumor individuals, and a correlation between your expression of anti-p53 mutations and antibodies inside the gene continues to be founded [3]. (cancer-colorectal.com)
  • Anti-p53 antibodies have already been extensively studied since it has been proven that anti-p53 antibodies correlate towards the mutational position from the gene [3]. (cancer-colorectal.com)
  • facial triad
  • This widespread structural motif is called the 2-His-1-carboxylate facial triad, and is found in many metalloproteins. (rsc.org)