• Tumor
  • Endothelial cell-derived interleukin-6 regulates tumor growth. (nih.gov)
  • The hypothesis underlying this work is that specific disruption of endothelial cell-initiated signaling inhibits tumor growth. (nih.gov)
  • Collectively, these results demonstrate that IL-6 secreted by endothelial cells enhance tumor growth, and suggest that cancer patients might benefit from targeted approaches that block signaling events initiated by endothelial cells. (nih.gov)
  • mitogen-ac
  • A number of additional proteins also interact with MAPK15, including cyclin-dependent kinase 2 (CDK2), mitogen-activated protein kinase 12 (MAPK12), and lactotransferrin (LTF), among many others. (wikipedia.org)
  • receptors
  • Since these oligopeptides were produced by bacteria or synthetic analogs of such products, it was suggested that the N-formyl oligopeptides are important chemotatic factors and their receptors are important chemotactic factor receptors that act respectively as signaling and signal-recognizing elements to initiate Inflammation responses in order to defend against bacterial invasion. (wikipedia.org)
  • Dopamine receptors may also regulate ion channels and BDNF independent of cAMP, possibly through direct interactions. (wikipedia.org)