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  • ECM1
  • ECM1 protein is divided in a signal sequence (19 aa) (black box) and four different domains based on the presence or absence of cysteines: an N-terminal cysteine-free domain (white box), two tandem repeats (green and gray box), and a C-terminal region (blue box). (atlasgeneticsoncology.org)
  • Important remark: ECM1 antibodies available to detect ECM1 protein are not able to discriminate between ECM1a and ECM1c. (atlasgeneticsoncology.org)
  • ECM1 inhibits the hypertrophy of chondrocytes as well as mineralization of the matrix and endochondral bone formation. (atlasgeneticsoncology.org)
  • Molecular
  • Some experimental evidence( 14 ) and many predictions 15 , 16 have shown that forced unfolding may alter binding sites or expose otherwise cryptic molecular recognition sites of extracellular matrix (ECM) proteins. (biomedsearch.com)
  • Treatment of multiple-band-containing eluted fractions with a reducing agent or with trypsin led to accumulation of a unique protein species with an estimated molecular mass of 61 kDa, corresponding most likely to mature autoprocessed Cwp84 (mCwp84). (asm.org)
  • The bacterium expresses an S-layer on the outer cell surface, which is composed of two major proteins of the bacterial surface: the high-molecular-weight protein P47 and the low-molecular-weight protein P36 ( 6 ). (asm.org)
  • Angiogenesis
  • In this study we tested the hypothesis that while hypoxia combined with prolonged VEGF-A/C treatment would induce early lymphangiogenesis in addition to angiogenesis in mouse EBs, under similar conditions specific extracellular matrix (ECM) proteins would promote lymphatic vessel-like structures over angiogenesis. (frontiersin.org)
  • Collectively, our data demonstrate that hypoxia combined with growth factors promotes angiogenesis, whereas combination of these conditions with specific ECM proteins favors lymphangiogenesis processes in mouse EBs. (frontiersin.org)
  • Airway remodeling, including alterations in the thickness of the basement membrane, an increase in the number of mucus producing cells, an increase in the number of blood vessels (angiogenesis), and a change in the extracellular matrix (ECM) protein profile and hypertrophy/hyperplasia resulting in an increase in the bulk of the airway smooth muscle (ASM), is now recognized as a hallmark feature of asthma. (biomedsearch.com)
  • A return to an immature, more soluble matrix during tumor growth could facilitate tumor cell motility and angiogenesis. (jneurosci.org)
  • endothelial cells
  • Here we investigated the potential of selenium-containing indoles to afford protection against these oxidants, by determining rate constants (k) for their reaction, and quantifying the extent of damage on isolated ECM proteins and ECM generated by human coronary artery endothelial cells (HCAECs). (ovid.com)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • tumor
  • Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model," Proceedings of the National Academy of Sciences of the United States of America , vol. 97, no. 8, pp. 3884-3889, 2000. (hindawi.com)
  • ECM protein/integrin binding may initiate a complex network of signal transduction cascades that, depending on the context, play an important role in cell spreading, migration, proliferation, and differentiation during embryogenesis, wound healing, and tumor development. (rndsystems.com)
  • Willebrand
  • Moreover, the amino acid sequence contained several possible functional domains that would participate in protein-protein interactions, including an RGD sequence, a von Willebrand factor domain (VWFC), and a leucine-rich repeat. (biomedsearch.com)
  • bacterial
  • The protein binding was dependent on the broth used for bacterial growth. (ovid.com)
  • Measured surface hydrophobicity correlated well with the bacterial binding strength to the proteins. (ovid.com)
  • species
  • Using fractionation experiments followed by immunoblot detection, the protease was found to be associated with the S-layer proteins, mostly as a nonmature species. (asm.org)
  • cells
  • Many proteins of the extracellular matrix interact with cells primarily via cell surface integrin family receptors. (rndsystems.com)
  • While evidence is mounting that cells exploit protein unfolding for mechanochemical signal conversion (mechanotransduction), what mechanisms are in place to deal with the unwanted consequences of exposing hydrophobic residues upon force-induced protein unfolding? (biomedsearch.com)
  • While it is increasingly recognized that force-induced protein unfolding is an important motif by which cells can sense and respond to mechanical forces (mechanotransduction processes), protein unfolding may also have deleterious consequences. (biomedsearch.com)
  • Behaviors characteristic of cells in the developing brain, such as cell proliferation and migration, neuronal and glial process outgrowth, and the elaboration of the capillary network, take place in a soluble matrix that is permissive for cell movement. (jneurosci.org)
  • Stromal cells are then added and the cells are cultured to immobilize the cells on the carriers containing the bound protein. (google.com)
  • Sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • factor
  • Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. (nih.gov)
  • structures
  • Nell16R mutant mice are a new tool for elucidating basic mechanisms in osteoblast and chrondrocyte differentiation in the developing skull and vertebral column and understanding how perturbations in the production of ECM proteins can lead to anomalies in these structures. (ovid.com)
  • bound
  • The amount of protein bound could also be controlled by the concentration of the crosslinking agents and coating solutions used. (arvojournals.org)