Extracellular matrix protein phosphate binding proteins. Medical search. Frequent questions

A nanoscale modular design strategy was employed to synthesize six engineered, recombinant proteins intended to mimic aspects of the extracellular matrix proteins fibronectin, laminin, and elastin as well as the cell-cell adhesive protein neural cell adhesion molecule. (frontiersin.org)
How are these quantitative aspects of the extracellular signal regulated? (nature.com)

This is accompanied by increased, VAMP3-dependent secretion of MT1-MMP, enhanced degradation of extracellular matrix, and increased cell invasion. (nature.com)
Collective motility leads to movement of cohorts of cells which maintain the adherens junctions and move by photolytic degradation of matrix barriers. (biomedcentral.com)
Incredibly overexpression of Tks5 in LNCaP cells was adequate to induce invadopodia CK-1827452 (Omecamtiv mecarbil) development and connected matrix degradation. (healthanddietblog.info)
In Personal computer-3 cells we proven that Tks5 phosphorylation at these websites was required and adequate for invadopodia-associated matrix degradation and invasion. (healthanddietblog.info)
Tumor cell motility and extracellular matrix SAT1 degradation are backed by cytoskeletal constructions known as invadopodia [2 3 Invadopodia as well as the related podosomes of regular cell types are actin-based cell surface area protrusions that enable adherence to and degradation of extracellular matrix proteins. (healthanddietblog.info)
We while others possess proven that Tks5 phosphorylation can be important for podosome development and associated matrix degradation in macrophages and osteoclasts [24 25 In melanoma cells Src-dependent phosphorylation of Tks5 at tyrosine 557 is important for binding to Nck for Nck recruitment to invadopodia and for invadopodia-associated matrix degradation activity [16]. (healthanddietblog.info)
The inflammatory environment is correlated with extracellular matrix (ECM) degradation and chondrocyte hypertrophy in the development of osteoarthritis (OA). (oncotarget.com)

But with SCPP genes it's not the DNA sequence, or the amino acid sequences that the DNA codes for that are important to mineralization, but instead their ability to bind calcium. (blogspot.com)
The nonphosphorylated cytoplasmic DMP1 protein translocates to the cell nucleus and initially acts as a transcriptional factor to enhance gene transcription of the osteoblast-specific genes such as alkaline phosphatase and osteocalcin and then moves out to the extracellular matrix during the osteoblast to osteocyte transition phase to promote mineralization and phosphate homeostasis. (benthamscience.com)
Multifunctional Role of Dentin Matrix Protein 1 in Vertebrate Mineralization, Frontiers Between Science and Clinic in Odontology Volume Title: Phosphorylated Extracellular Matrix Proteins of Bone and Dentin (2012) 2: 231. (benthamscience.com)
May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. (abcam.com)
Non-collagenous proteins (NCPs) in the extracellular matrix (ECM) of bone and dentin are known to play a critical regulatory role in the induction of collagen fibril mineralization and are embedded in hyaluronic acid (HA), which acts as a water-retaining glycosaminoglycan and provides necessary biochemical and biomechanical cues. (bvsalud.org)
The HA modification can significantly promote intrafibrillar collagen mineralization by reducing the electronegativity of the collagen surface to enhance calcium ions (Ca2+) binding capacity to create a local higher supersaturation. (bvsalud.org)
In addition, the HA also provides additional nucleation sites and shortens the induction time of amorphous calcium phosphate (ACP)-mediated hydroxyapatite (HAP) crystallization, which benefits mineralization. (bvsalud.org)

Overexpression of the complementary DNA for human glutamine:fructose-6-phosphate amidotransferase in mesangial cells enhances glucose-induced fibronectin synthesis and transcription factor cyclic adenosine monophosphate-responsive element binding phosphorylation. (cdna-clone.com)
The TP53 role anything, which is as heterodimerization of the RUNX1: loop repeat, was identified to directly eventually heat Phosphorylation of several proteins that are diseases of intellectual stages. (erik-mill.de)
The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)

Most intracellular phosphate is either complexed or bound to proteins and lipids. (medscape.com)
Tks5 is a substrate of Src and an adaptor protein for proteins and lipids [19]. (healthanddietblog.info)
Like lipids, proteins are an important constituent of the cell membrane. (rincondelvago.com)

Here, we have studied the function of WDFY2, a cytosolic protein that has been described to reside on endocytic vesicles close to the plasma membrane 6 . (nature.com)
Transport vesicles can move molecules between locations inside the cell, e.g., proteins from the rough endoplasmic reticulum to the Golgi apparatus . (wikipedia.org)
These proteins travel within the cell inside of transport vesicles. (wikipedia.org)
We profiled plasma-derived extracellular vesicles from a heart transplant patient with chronic Chagas disease and showed the potential of this approach for discovering such biomarkers. (cdc.gov)
Extracellular vesicles (EVs) are cell-derived membranous nanoparticles present in most biologic fluids. (cdc.gov)

As confirmation that ligand density in these engineered systems impacts neuronal cell behavior, we demonstrate that increasing the density of fibronectin-derived RGD ligands on coated surfaces while maintaining uniform protein surface coverage results in enhanced neurite extension of PC-12 cells. (frontiersin.org)
Interaction with extracellular ligands induces receptor clustering at the nanoscale, assembly of the signaling complexes in the cytosol and activation of downstream signaling pathways, regulating cell response. (ibecbarcelona.eu)

Both SPARC and SPARCL1 code for a calcium-binding protein that occupies a space between cells, called extracellular matrix. (blogspot.com)

The direction of transport was from the apical to the basolateral compartment, which is in line with the unidirectional LCL161 transport and the localization of both recombinant proteins in the MDCKII cells. (chk1inhibitor.com)
The HuProt microarray results showed that the signals of 343 proteins were higher in the recombinant CRYAA group than in the control group. (molvis.org)
The proteins are synthesized using recombinant, genetic engineering techniques, allowing for the creation of biocompatible polymers with nanoscale precision that impart highly specific protein functionalities. (frontiersin.org)
We make use of a highly flexible multi-step cloning strategy in order to allow for the rapid synthesis of new recombinant proteins that can introduce many different biofunctionalities. (frontiersin.org)

Matrix metalloproteinases (MMPs) play a critical role in progression of cancer by degrading and remodeling ECM, enabling cells to overcome tissue barriers, travel within the circulatory system before extravasating to produce a secondary tumor 3 , 4 . (nature.com)
Burosumab, an IgG1 monoclonal antibody that binds excess fibroblast growth factor 23 (FGF23), is approved for treatment of X-linked hypophosphatemia and of FGF23-related hypophosphatemia in tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors that cannot be curatively resected or localized, in adults and pediatric patients aged 2 years or older. (medscape.com)
manifestation and activity of wild-type and mutant Src and Tks5 constructs in the LNCaP and Personal computer-3 prostate tumor cell lines to be able to ascertain the part of Src-Tks5 signaling in invadopodia advancement matrix-remodeling activity motility and invasion. (healthanddietblog.info)
CONCLUSIONS Our outcomes suggest an over-all part for Src-Tks5 signaling in prostate tumor development and the energy of Tks5 like a marker proteins for the staging of the disease. (healthanddietblog.info)
Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts and is involved in a variety of tumor-promoting activities such as matrix remodeling, angiogenesis, chemotherapy resistance, and immunosuppression. (snmjournals.org)
First, via its peptidase activity, FAP leads to matrix digestion and remodeling of the tumor microenvironment, enabling invasion and migration of tumor cells ( 9 ). (snmjournals.org)
Evidence suggests that the protein plays a role in tumor invasion. (bvsalud.org)

Within their GTPase domains, they share approximately 30% amino acid identity with the Ras proteins and 40-95% identity within the family. (biomedcentral.com)
In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
The sequence encoded a novel protein rich in alanine (25%) and proline (20%), which contained regions similar to proteins of comparable amino acid composition such as extracellular matrix components or the membrane-cytoskeletal linker synapsin. (lookformedical.com)
In practice, the Scalar Light Amino Acid & Protein Program administers scalar light instructions in order to assemble and maintain amino acids and proteins inside the quantum body or scalar light force field. (scalarlight.com)
Below are the lists of amino acids and proteins that are assembled by way of the Scalar Light Amino Acid and Protein Program. (scalarlight.com)
The Scalar Light Amino Acid and Protein Program operates twenty-four (24) hours per day seven (7) days per week thereby assuring a constant creation and delivery of amino acids and proteins to the quantum, human body. (scalarlight.com)
The Scalar Light Amino Acid & Protein Program administers scalar light upon photographs of people, animals, plants, and objects. (scalarlight.com)

One of these proteins is the fibroblast activation protein (FAP), a type II transmembrane serine protease with both dipeptidyl peptidase activity and endopeptidase activity ( 2 - 4 ). (snmjournals.org)
Some cytokines act as competence rather than progression factors, some lack secretory signals, and some must be processed and released from the pericellular matrix or basement membranes (eg transforming growth factor beta [TGF-β ] binding to chondroitin or the keratan sulfate of biglycan, decorin and fibromodulin, or basic fibroblast growth factor and platelet derived growth factor binding to the heparin sulfate of glypican, perlecan and syndecan). (biomedcentral.com)
The TGF-β family forms an important group of growth factors, consisting of three isoforms in man, and is important for matrix deposition because it modulates fibroblast recruitment and proliferation. (biomedcentral.com)
Plasma 1,25-dihydroxyvitamin D (1,25(OH) 2 D) is tightly controlled by plasma parathyroid hormone (PTH), serum calcium, serum phosphate, and fibroblast-like growth factor 23 (FGF-23). (medscape.com)

COMP is a non-collagenous glycoprotein and is belongs to the thrombospondin family of extracellular proteins. (prospecbio.com)
Deletion of Pofut2 (Protein O -fucosyltransferase 2) in mouse developing limb mesenchyme blocks O -fucosylation of Thrombospondin type-1 repeats (TSR) and significantly shortens limb bones. (sstis.org)
Many extracellular matrix (ECM) associated proteins that influence ECM properties have Thrombospondin type 1 repeats (TSRs) which are modified with O- linked fucose. (sstis.org)
This growth factor also stimulates production of collagens, proteoglycans, elastin, fibronectin, tenascin and thrombospondin, diminishes production of extracellularly active neutral endoproteinases belonging to the matrix metalloproteinase (MMP) and serine proteinase families, and stimulates production of endogenous MMP inhibitors (tissue inhibitor of metallo-proteinase [TIMP]) and serpins (plasminogen activator inhibitor-1). (biomedcentral.com)
Moreover, wogonoside promoted the expression of anabolic factors Sox-9, type two collagen and aggrecan while inhibiting the expression of catabolic factors such as matrix metalloproteinases (MMPs) and thrombospondin motifs 5 (ADAMTS-5) in mouse chondrocytes. (oncotarget.com)

WDFY2 localizes to endosomal tubules by binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns3P). (nature.com)
WDFY2 localizes to actin-stabilized endosome tubules positive for the small GTPase RAB4 and shows a preference for highly curved membranes enriched for the lipid phosphatidylinositol 3-phosphate (PtdIns3P). (nature.com)

In response to kinases and phosphatases, these phosphate ions attach and detach from different molecules, forming a constantly shifting pool. (medscape.com)
To define the whole panel of fungal complement-evasion molecules, C. albicans cell extract was absorbed to a factor H-coupled matrix. (leibniz-hki.de)
They are small (21-25 kDa) molecules that share structural homology and become activated only when bound to GTP. (biomedcentral.com)
Rho GTPases are key integrating molecules from different extracellular signals, as they can be activated by different GEFs. (biomedcentral.com)
Rho GTPase effectors are a large group of proteins and include actin nucleation promoting molecules, adaptors, as well as kinases. (biomedcentral.com)
Scalar light instructions are able to assemble and maintain molecules of amino acids and proteins crucial to human and animal quantum health. (scalarlight.com)
Frankfurt am Main, Germany about half of the crystallographically visible water molecules appear to be expelled by the ligand, we find that ligand binding actually increases the number of water molecules within the cavity. (lu.se)

Phosphate is an integral component of the nucleic acids that comprise DNA and RNA. (medscape.com)

or a shift of phosphate from the extracellular to the intracellular space. (medscape.com)
Most often it is caused by long-term, relatively low phosphate intake in the setting of a sudden increase in intracellular phosphate requirements. (medscape.com)
Phosphate is a predominantly intracellular anion with a concentration of approximately 100 mmol/L, although determination of the precise intracellular concentration has been difficult. (medscape.com)
however, because the intracellular concentration of phosphate is greater than the extracellular concentration, phosphate entry into cells requires a facilitated transport process. (medscape.com)
Several sodium-coupled transport proteins have been identified that enable intracellular uptake of phosphate by taking advantage of the steep extracellular-to-intracellular sodium gradient. (medscape.com)
We show here that photosynthesis is stimulated by a novel, intracellular alpha-CA bound to the chloroplast thylakoids. (lookformedical.com)
I-FABP) and bovine heart fatty acid-binding pro- tissues and in intracellular as well as extracellular tein (H-FABP). (lu.se)
for example, H-FABP makes up 3% of the plasmic intracellular LBPs from three different cytoplasmic protein content in rat heart. (lu.se)

BACKGROUND The Src tyrosine kinase substrate and adaptor proteins Tks5 had previously been implicated in the invasive phenotype of normal and transformed cell types via rules of cytoskeletal constructions called podosomes/invadopodia. (healthanddietblog.info)
Though they talk about a number of the same cytoskeletal regulatory equipment (integrins tyrosine kinases Arp2/3 WASp) as additional adhesion constructions they are recognized by marker protein CK-1827452 (Omecamtiv mecarbil) (cortactin dynamin2 Tks5) and metalloproteinases (MT1-MMP) that distinctively support focalized matrix redesigning activity [2-5]. (healthanddietblog.info)
Src activation also frequently promotes podosome/invadopod development [4 11 That is backed by the current presence of tyrosine phosphorylated proteins at these constructions many of that are Src substrates [14-18]. (healthanddietblog.info)
The RUNX1: target side can begin with the known association sulfate dystrophy( ESR1) through binding tyrosine between RUNX1 and ESR1. (erik-mill.de)
Cytokines bind to their receptors, activating signal transduction pathways such as adenylate cyclase/cAMP, phospholipase C/inositol trisphosphate, and Ca 2+ and tyrosine kinases. (biomedcentral.com)

The addition and deletion of phosphate groups to enzymes and proteins are common mechanisms for the regulation of their activity. (medscape.com)
Particularly important are those cellular proteins called enzymes, which catalyze the chemical reactions necessary for life. (rincondelvago.com)
Additionally, enzymes and micro-nutrients are likewise assembled as these nutrients serve to abet and catalyze the assembling of amino acids and proteins. (scalarlight.com)

3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
The RUNX1: type pyrophosphate directly is change of the dendritic receptor, quantifying DNA transcription protein 1( CD35)( Kim et al. (erik-mill.de)
Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). (abcam.com)

In addition to serum phosphate studies, serum calcium and magnesium studies can be helpful for identifying underlying causes. (medscape.com)

The identification of the transport proteins responsible for the uptake and the efflux of nucleosides and their metabolites enables the characterization of their vectorial transport and a better understanding of their absorption, distribution, and elimination. (chk1inhibitor.com)

Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. (biomedcentral.com)

The membrane-bound matrix metalloproteinase MT1-MMP (MMP14) is internalized by endocytosis and recycled in endosomal compartments. (nature.com)

DMP1encodes a serine-rich acidic protein and is a member of Small Integrin- Binding Ligand, N-linked, Glycoprotein family (SIBLING) which mineralizes tissues such as bones and teeth by binding strongly to hydroxyapatite. (benthamscience.com)
Single cell mesenchymal-type movement is characterized by an elongated cellular shape and again requires extracellular proteolysis and integrin engagement. (biomedcentral.com)

Functional annotation clustering showed that they belong to cell cycle, organelle or nuclear lumen, protein transport, and DNA binding and repair clusters. (molvis.org)

The 3 human complement regulators, when attached to candida Gpd2, became functionally active, and the attached host proteins assist in inactivation of the complement cascade or cleave fibrinogen in the extracellular matrix component fibrinogen. (leibniz-hki.de)

The O- fucose is added in the endoplasmic reticulum to folded TSRs by the enzyme Protein O- fucosyltransferase-2 (POFUT2) and is proposed to promote efficient trafficking of substrates. (sstis.org)
To overcome early lethality and investigate the impact of the Pofut2 knockout on the secretion of POFUT2 substrates and on extracellular matrix properties in vivo , we deleted Pofut2 in the developing limb mesenchyme using Prrx1-Cre recombinase. (sstis.org)
In addition, these observations raise the possibility that the O- fucose modification on TSRs extends beyond promoting efficient trafficking of POFUT2 substrates and has the potential to influence their function in the extracellular environment. (sstis.org)

These genes encode proteins that regulate the calcium (Ca) phosphate concentration in the extracellular matrix. (blogspot.com)

Physical adsorption isotherms were experimentally determined for these engineered proteins, allowing for direct calculation of the available ligand density present on coated surfaces. (frontiersin.org)
Therefore, this engineered protein adsorption approach allows for the facile preparation of tunable, quantifiable, and reproducible surfaces for in vitro studies of cell-ligand interactions and for potential application as coatings on neural implants. (frontiersin.org)

To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
A HuProt microarray composed of 17,225 human full-length proteins with N-terminal glutathione S-transferase (GST) tags was used to identify protein-protein interactions. (molvis.org)
The protein-protein interactions may help CRYAA carry out multifaceted functions. (molvis.org)
To understand the functions of CRYAA and how these are regulated, protein-protein interactions need to be investigated. (molvis.org)

In view of the sheer breadth of influence of this mineral, the fact that phosphate homeostasis is a highly regulated process is not surprising. (medscape.com)

Phosphate is critical for a remarkably wide array of cellular processes. (medscape.com)
Phosphate bonds of adenosine triphosphate (ATP) carry the energy required for all cellular functions. (medscape.com)
In turn, GTP-bound active GTPases can interact with a plethora of different effectors which mediate the different cellular functions of this family of proteins. (biomedcentral.com)

Calcium ions outside cells are important for maintaining the potential difference across excitable cell membranes, protein synthesis, and bone formation. (wikipedia.org)
However, phosphate retention and FGF-23 also contribute to the decreased synthesis of 1,25(OH) 2 D. (medscape.com)

and binds plasminogen, via lysine residues. (leibniz-hki.de)
Typically Rho proteins are 190-250 residues long and consist only of the GTPase domain and short terminal C-terminal extensions. (biomedcentral.com)

The physical substance of the human organism, composed of living cells and extracellular materials and organized into tissues, organs, and systems. (rincondelvago.com)

All members contain the sequence motifs characteristic of all GTP-binding proteins, bind to GDP and GTP with high affinity. (biomedcentral.com)

Therefore, natural selection has conserved not the sequence, but the calcium-binding properties of each duplicate gene. (blogspot.com)

Hyperglycemia-induced alterations in mesangial cell perform and extracellular matrix protein (ECM) accumulation are seen in diabetic glomerulopathy. (cdna-clone.com)
CRYAA interacted with these proteins to maintain their solubility and decrease the accumulation of denatured target proteins. (molvis.org)

Loss of Pofut2 in the limb mesenchyme caused significant shortening of the limbs, long bones and tendons and stiff joint resembling the musculoskeletal dysplasias in human and in mice with mutations in ADAMTS or ADAMTSL proteins. (sstis.org)

Mitogen-activated protein kinases (MAPKs) comprise a large family of proteins activated by a wide range of proinflammatory cytokines and environmental stress. (molvis.org)

It contains a lipid-binding FYVE domain and seven WD40 repeats which can form a β-propeller. (nature.com)

A vesicle released from the cell is known as an extracellular vesicle . (wikipedia.org)
Most of these proteins mature in the Golgi apparatus before going to their final destination which may be to lysosomes , peroxisomes , or outside of the cell. (wikipedia.org)

Candida albicans uses human complement regulators such as factor H and factor H-like protein 1 (FHL-1) for immune evasion. (leibniz-hki.de)
Thus, candida Gpd2 is a novel fungal immune evasion protein that binds several human complement regulators and, in addition, binds human cells. (leibniz-hki.de)

In addition, candida Gpd2 bound to human nonphagocytic cells but not to phagocytic U937 cells. (leibniz-hki.de)
One-hundred and twenty-seven of 17,225 human full-length proteins were identified that interact with CRYAA. (molvis.org)
Thus, the evidence from this effect on fish suggests that glyphosate may interfere with the breakdown of complex proteins in the human stomach, leaving larger fragments of wheat in the human gut that will then trigger an autoimmune response, leading to the defects in the lining of the small intestine that are characteristic of these fish exposed to glyphosate and of celiac patients. (texasorganicresearchcenter.org)
FAPIs based on a quinoline structure were synthesized and characterized with respect to binding, internalization, and efflux in cells expressing human and murine FAP as well as CD26. (snmjournals.org)
This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)
The aluminum found in plants is organically bound colloidal aluminum and appears not to have any negative affect and in fact appears to be an essential element in human nutrition. (mighty-90.com)

Membrane-bound and secreted proteins are made on ribosomes found in the rough endoplasmic reticulum . (wikipedia.org)
Proteins found in any species of algae. (lookformedical.com)
Although heterogeneous in their origin, cancer-associated fibroblasts have common properties distinct from normal fibroblasts and show expression of proteins not found in their normal counterparts. (snmjournals.org)
500kDa) found in the extracellular matrix of articular, nasal and tracheal cartilage. (prospecbio.com)
Water is found in the extracellular fluids of the body (the blood plasma, the lymph, and the interstitial fluid) and within the cells themselves. (rincondelvago.com)

Cancer cells secrete matrix metalloproteinases to remodel the extracellular matrix, which enables them to overcome tissue barriers and form metastases. (nature.com)
One of the most life-threatening aspects of cancer is the ability of transformed cells to invade into the extracellular matrix (ECM) and neighboring tissue to form metastases 1 , 2 . (nature.com)
To define the localization of WDFY2 in the endocytic pathway, we transiently transfected hTERT-RPE1 cells with green flourescent protein (GFP)-WDFY2 and performed structured illumination microscopy (SIM) together with APPL1 and EEA1 visualized with antibodies (Fig. 1a ). (nature.com)
It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. (bvsalud.org)

I-LBP, ileal lipid-binding to the aqueous solubility of the fatty acid. (lu.se)

Also required for protein transport from the Golgi apparatus to the endosomes. (abcam.com)

Anatomy2

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes7

Information Science3

Aspects of the extracellular2

Degradation7

Mineralization7

Phosphorylation3

Lipids3

Vesicles5

Ligands2

Calcium-binding1

Recombinant4

Tumor7

Amino acid7

Fibroblast4

Thrombospondin5

Phosphatidylinositol2

Molecules7

Nucleic acids1

Intracellular8

Tyrosine5

Enzymes3

Receptor3

Serum calcium1

Transport proteins1

Cytoskeleton1

Metalloproteinase1

Integrin2

Annotation1

Fibrinogen1

Substrates3

Concentration1

Ligand2

Interactions4

Homeostasis1

Cellular3

Synthesis2

Residues2

Tissues1

Motifs1

Sequence1

Accumulation2

Mutations1

Cytokines1

Repeats1

Cell2

Regulators2

Human6

Found5

Cells4

Solubility1

Golgi1