• Our recent research indicates that pancreatic CSCs are maintained by direct interactions with certain proteins in the tumor microenvironment (TME) and focal adhesion kinase (FAK) signaling. (grantome.com)
  • We identified several extracellular matrix (ECM) proteins including, fibronectin, TGFBI, periostin, annexin A2 and PAI-1 that were processed as a result of the ovarian cancer-peritoneal cell interaction. (endocrinology-journals.org)
  • The research themes rank around molecular mechanisms matrix proteins and fibers exert in disorders affecting blood vessels, bone, skin and adipose tissue. (mcgill.ca)
  • We are interested how extracellular matrix proteins instruct cells to differentiate, migrate, and proliferate, and how cells sense normal and pathologically altered extracellular matrix. (mcgill.ca)
  • GO analysis shows that the differential abundant proteins are associated with cell junction and signal transducer activity from extracellular to intracellular. (nature.com)
  • Of particular interest to our group are the mechanisms by which Bcl-2 family proteins and other factors regulate programmed cell death, particularly in the nervous system, in cancer and in virus infections. (hopkinsmedicine.org)
  • We have reported that many insults can trigger cells to activate a cellular death pathway (Nature, 361:739-742, 1993), that several viruses encode proteins to block attempted cell suicide (Proc. (hopkinsmedicine.org)
  • We have shown that anti-apoptotic Bcl-2 family proteins can be converted into killer molecules (Science 278:1966-8, 1997), that Bcl-2 family proteins interact with regulators of caspases and regulators of cell cycle check point activation (Molecular Cell 6:31-40, 2000). (hopkinsmedicine.org)
  • Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction and focal adhesion, suggesting high complexity in terms of structure and cellular interactions in embryos prior to midblastula transition (MBT). (biomedcentral.com)
  • The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
  • Special attention was paid to molecular mechanisms through which cell activation was induced by RG-I, such as RG1-cell direct or indirect interaction via extracellular matrix proteins. (europa.eu)
  • And the internal surface has actin filaments such as talin, paxillin, vinculin, tensin and proteins that provide interactions between membrane receptor proteins [ 1 - 3 ]. (omicsonline.org)
  • Peptide analysis identified products from known matrix protease substrates and secretory proteins, which offered functional relevance to immunoinflammatory responses, extracellular matrix remodeling, and receptor interactions. (cdc.gov)
  • The extracellular matrix is a dynamic environment where a plethora of structural proteins, ligands, enzymes, inorganic ions, and secreted factors are stored. (lu.se)
  • These models need to be modified continuously for each cell type, as many proteins and polysaccharide components are absent in engineered or decellularized ECM. (lu.se)
  • A cartilage cell is surrounded by extracellular matrix consisting of proteins (collagen fibers), non-proteoglycan polysaccharides (hyaluronic acid), and proteoglycan (aggrecan). (lu.se)
  • The extracellular matrix is a network of proteins and sugar molecules and contains a large proportion of water. (lu.se)
  • The z-Movi ® is a useful tool to obtain insights into cell adhesion processes. (lumicks.com)
  • Overall strength of adhesion is thought to be mediated by a combinatorial mechanism, involving adhesion of a cell to a variety of binding sites on the target glycoproteins. (silverchair.com)
  • KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
  • Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
  • Rasipl null angioblasts fail to properly localize the polarity determinant Par3 and display defective cell polarity, resulting in mislocalized junctional complexes and loss of adhesion to extracellular matrix ( ECM ). (xenbase.org)
  • Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. (embl.de)
  • In this study, it was observed that the ion implantation stimulated the neural proliferation and the implantation of different ions on cell culture surfaces was essential to determine the effects of this technique on adhesion, proliferation, differentiation and apoptosis properties of cells in details. (omicsonline.org)
  • The adhesions between cultured cells and the material surface are called focal attachments or adhesion plaques. (omicsonline.org)
  • Prominent among the molecular adhesion components are integrins (β1 and β2), that mediate the interactions of a variety of immune cells to extracellular matrices, and to other immune cells, respectively. (weizmann.ac.il)
  • Cell Adhesion & Migration, 3 (1). (reading.ac.uk)
  • Physiologically, the MUC1 protein may be involved in cell adhesion by decreasing the degree of cell-to-extracellular matrix and cell-to-cell interactions. (medscape.com)
  • 9 Fraction cells bound as a function of time, plotted for non-activated and IL-7-activated CD4 on glass functionalized or not with fibronectin. (lumicks.com)
  • Her research work was focused on investigating the role of an extracellular matrix protein (fibronectin) on mediating cell-material interactions. (gla.ac.uk)
  • Whereas endothelial cells plated on fibronectin or fibrinogen activate NF-κB in response to flow, cells on collagen or laminin do not. (rupress.org)
  • Furthermore, altering the extracellular matrix to promote p38 activation in cells on fibronectin suppresses NF-κB activation, suggesting a novel therapeutic strategy for treating atherosclerosis. (rupress.org)
  • The cystein-rich domain is responsible for attachment, for example, to integrins of different cell membranes. (wikipedia.org)
  • Flow-induced NF-κB activation is downstream of conformational activation of integrins, resulting in new integrin binding to the subendothelial extracellular matrix and signaling. (rupress.org)
  • In this proposal we will investigate signaling pathways that regulate extracellular matrix-induced CSC maintenance and function, and develop therapeutic strategies to disrupt these critical interactions. (grantome.com)
  • Therefore, many genetically programmed cell suicide pathways have evolved to promote long-term survival of species from yeast to humans. (hopkinsmedicine.org)
  • Although ApoA-I amyloidosis is systemic, the different amyloidogenic variants show a preferential tissue accumulation that appears to correlate with the location of the mutation in the protein sequence and with the local extracellular microenvironment. (lu.se)
  • The tumour microenvironment is composed of both cellular components including cancer cells, immune cells, endothelial cells, fibroblasts, and many more cell types, as well as acellular components of the tissue including extracellular matrix components, metabolites, oxygen, acidity, and nutrition's among others. (lu.se)
  • Extracellular matrix and vascular dynamics in the kidney of a murine model for Marfan syndrome. (mcgill.ca)
  • However, release of FGF into the circulation, where there has been 'compromise' in the vascular system, indicate a dramatic influence on the rate of proliferation of vascular cells at the injured sites. (nih.gov)
  • The atherosclerotic process is accelerated by a myriad of factors, such as the release of inflammatory chemokines and cytokines, the generation of reactive oxygen species (ROS), growth factors, and the proliferation of vascular smooth muscle cells. (hindawi.com)
  • Alterations in the extracellular environment are critical for tumour initiation, progression and intra-peritoneal dissemination. (endocrinology-journals.org)
  • Interactions between tumour cells and surrounding extracellular matrix (ECM) influence the growth of tumour cells and their ability to metastasise. (nih.gov)
  • Both stromal and tumour cells synthesise TN-C. On the contrary, TN-X RNAs decreased 30-fold on average in melanoma. (nih.gov)
  • Whereas pig normal skin displayed a discrete TN-C signal at the dermo-epidermal junction, around blood vessels and hair bulbs, the swine tumour showed enhanced expression of TN-C in these areas and around stromal and tumour cells. (nih.gov)
  • HA can bind with CD44 in the presence of LYVE1, and therefore, LYVE1 could act as a substrate for tumour cells or migrating CD44+ leukocytes. (prospecbio.com)
  • Tumour cells are able to recruit macrophages and change their behaviour. (lu.se)
  • Metastasis is a complex prosess in which cancer cells leave the original tumour site and migrate to other parts of the body and establish a secondary tumour. (lu.se)
  • The antibody stains epithelial cell and T and b lymphocytes. (bdbiosciences.com)
  • CD44 isoforms encoded by variable exons are expressed on epithelial cells, but only at low levels on most leukocytes. (bdbiosciences.com)
  • Epithelial cells growing on a patterned adhesive surface with the shape of the Weizmann Institute tree. (weizmann.ac.il)
  • The MUC1 protein, also known as polymorphic epithelial mucin or epithelial membrane antigen, has a large extracellular region, a transmembrane sequence, and a cytosolic domain. (medscape.com)
  • Like cell division and differentiation, cell death is also critical for normal development and maintenance of healthy tissues. (hopkinsmedicine.org)
  • Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)
  • Trained as both a physician and engineer at Harvard, MIT, and Brown University, Sangeeta Bhatia leverages 'tiny technologies' of miniaturization to yield inventions with new applications in tissue regeneration, stem cell differentiation, medical diagnostics, predictive toxicology and drug delivery. (pictet.com)
  • By using a combinatorial approach involving both in vivo and in vitro models as well as the advanced genetic and biochemical tools in our repertoire, we examine how matrisome landscape can control cell fate. (lu.se)
  • To increase our understanding of the molecular mechanisms involved in ovarian cancer metastasis and to identify novel therapeutic targets, we recently studied the interaction of ovarian cancer and peritoneal cells using a proteomic approach. (endocrinology-journals.org)
  • Our findings together with published literature support the notion that ECM processing via the plasminogen-plasmin pathway promotes the colonisation and attachment of ovarian cancer cells to the peritoneum and actively contributes to the early steps of ovarian cancer metastasis. (endocrinology-journals.org)
  • These findings have led to the suggestion that matrix-associated FGF represents an extracellular reservoir that may be released by the action of heparan sulfate degrading enzymes introduced during inflammation or tumor metastasis or by heparin that is released from mast cells. (nih.gov)
  • The results presented here describe a dramatic alteration of the ECM composition in swine malignant melanoma which might have a large influence on tumourigenesis or invasion and metastasis of melanoma cells. (nih.gov)
  • It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. (cshlpress.com)
  • Our group takes a strong collaborative approach to understanding the regenerative capacity of the human body, how cells, the extracellular matrix and local environment drive natural wound healing and tissue regeneration. (dal.ca)
  • Therefore, we investigated the impact of ApoA-I variants on cell physiology and the mechanisms driving the observed tissue specificity. (lu.se)
  • HA is an abundant, naturally occurring component found in the skin and connective tissue cells. (prospecbio.com)
  • LYVE1 has also been found to play a role in HA localisation to the surface of the endothelial cells that line the lymphatic tissue. (prospecbio.com)
  • Lung tissue showed significant 2-fold or greater increases in 12 matrix proteases supporting a pulmonary origin of peptide proteolytic products released into circulation. (cdc.gov)
  • The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. (cshlpress.com)
  • It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. (cshlpress.com)
  • The three germ layers and the body plan of the mature organism are established during gastrulation, and the period is characterized by extensive cell movements and intracellular communications [ 21 , 22 ]. (biomedcentral.com)
  • Matrix metalloproteinases (MMPs) are enzymes degrading ECM. (lu.se)
  • Changing surface characteristics of scaffolds was a way to promote regeneration and ion implantation was one of the methods to modify surface properties which play a huge role in enhancing the proliferation and integration of cells. (omicsonline.org)
  • By imaging the dynamic behavior of T cells in human lung tumor explants, we have recently established the importance of the extracellular matrix in limiting access of T cells to tumor cells. (mssm.edu)
  • Salmon, H & Donnadieu, E 2012, ' Within tumors, interactions between T cells and tumor cells are impeded by the extracellular matrix ', OncoImmunology , vol. 1, no. 6, pp. 992-994. (mssm.edu)
  • We and others identified several phenotypically distinct pancreatic cancer cell populations that are enriched in tumor-initiating capacity, defining them as cancer stem cells (CSCs). (grantome.com)
  • In this area, our recent research has included studying cutaneous shave biopsies for diagnosing primary colonic adenocarcinoma as well as growth inhibition and apoptosis in human brain tumor cell lines using selenium. (hopkinsmedicine.org)
  • Telomerase is required for cells that undergo many rounds of divisions, especially tumor cells and some stem cells. (hopkinsmedicine.org)
  • Despite significant advances in immune checkpoint blockade (ICB), immunosuppression mediated by tumor-associated myeloid cells (TAMCs) poses a major barrier to cancer immunotherapy. (bvsalud.org)
  • In addition, while immunogenic cell death (ICD) provides a viable approach to inducing anti-tumor immune response, it remains unknown how to effectively trigger ICD while addressing immunosuppressive TAMCs. (bvsalud.org)
  • Here, we show that SC144, a gp130 inhibitor that blocks the IL-6/gp130/STAT3 pathway, induces ICD of tumor cells and polarizes macrophages to M1-phenotype in vitro. (bvsalud.org)
  • However, as SC144 also induces killing of CD8+ T-cells, we sought to deliver SC144 selectively to tumor cells and TAMCs. (bvsalud.org)
  • Toward this goal, we have developed hyaluronic acid-bilirubin nanoparticles (HABN) that accumulate in CD44hi tumor cells and TAMCs. (bvsalud.org)
  • Systemic administration of SC144 loaded in HABN (SC144@HABN) induces apoptosis and ICD of tumor cells, increases the ratio of M1-like to M2-like macrophages, and decreases the frequency of myeloid-derived suppressor cells and CD4+ regulatory T-cells, while promoting anti-tumor CD8+ T-cells. (bvsalud.org)
  • MnOx@HMSN(CDA) carrying cancer neoantigens elicited robust antitumor T-cell immunity with therapeutic efficacy in two different murine tumor models. (bvsalud.org)
  • CSCs are a small subpopulation of tumor cells that can self-renew, differentiate into the majority of tumor cells, and maintain tumorigenicity. (bvsalud.org)
  • Nanodisc vaccination effectively reduced tumor growth and significantly extended animal survival without toxicity toward normal stem cells. (bvsalud.org)
  • Consideration may be given to ordering multiple tumor markers due to the heterogeneity in cell composition of each tumor. (medscape.com)
  • Proteomic results were analyzed with gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interactions (PPI). (nature.com)
  • Longitudinal unbiased proteomic analysis of plasma and single-cell transcriptomics of peripheral blood cells conducted prior to and at multiple times after convalescent plasma transfusion identified the key biological processes associated with the transition from severe disease to disease-free state. (frontiersin.org)
  • The lab also focuses on how the extracellular matrix regulates key growth factors of the TGF-beta superfamily, and on deciphering regulatory mechanisms mediated by microRNAs. (mcgill.ca)
  • however, our recent data provides evidence that decorin directly regulates endothelial cell-matrix interactions. (reading.ac.uk)
  • These studies will enhance our understanding of mechanistic interactions with the TME that regulate pancreatic CSCs, and will guide the clinical development of novel CSC-directed therapies. (grantome.com)
  • Interestingly, cell death regulators also regulate many other cellular processes prior to a death stimulus, including neuronal activity, mitochondrial dynamics and energetics. (hopkinsmedicine.org)
  • These molecules, collectively referred to as the matrisome, regulate cell fate by providing extrinsic biochemical and biomechanical signals to cells. (lu.se)
  • By using this approach, we will explore how extracellular molecules collectively regulate cell fate. (lu.se)
  • Our goal is to advance science and improve human health by providing tools that unlock the measurement of forces and interactions in biology. (lumicks.com)
  • Methodologically, the lab employs a wide spectrum of techniques ranging from in vitro biochemical and biophysical assays, to cell biology methods with primary cells and transformed cell lines, to light and electron microscopic techniques, to in vivo studies with genetically modified mouse models. (mcgill.ca)
  • Matrix Biology Plus , 6-7 , Article 100020. (lu.se)
  • In addition to teaching, he runs a molecular biology research lab focused on cell to extracellular matrix interactions (LaNts and laminins). (leanpub.com)
  • The alphaM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. (embl.de)
  • This new technology provides you with predictive, reproducible, and fast high-throughput results at a single-cell resolution without compromising cell viability. (lumicks.com)
  • The lab also is using the telomerase null mice to explore the essential role of telomerase stem cell viability. (hopkinsmedicine.org)
  • To determine the safety of the fermented extracts, their cytotoxicity was analyzed by measuring the cell viability of CCD-966SK and human epidermal melanocytes (HEMn) after exposure. (hindawi.com)
  • Moreover, following contact of the APPJ treated medium with cells, delayed effects are observed which lead to 100% bone cancer cell death through apoptosis (decreased cell viability with incubation time in contact with APPJ treated medium from 24 h to 72 h), while healthy cells remain fully viable and unaffected by the treatment. (ibecbarcelona.eu)
  • The z-Movi ® is a unique instrument that measures the avidity between immune cells and their targets, enabling you to identify the most potent immunotherapeutic effector cells. (lumicks.com)
  • a) Lymph node-residing and infiltrating T-cells and dendritic cells (DC) migrate on a 3D network of fibroblastic reticular cells (FRCs) and their associated ECM. (weizmann.ac.il)
  • MnOx@HMSN(CDA) amplified the activation of the STING pathway and enhanced the production of type-I interferons and other proinflammatory cytokines from dendritic cells. (bvsalud.org)
  • Recent observations have revealed that heparin influences endothelial cell proliferation in a number of ways unrelated to its anticoagulant properties. (nih.gov)
  • Porcine aortic endothelial cell, double-labeled for actin (green) and phospho-tyrosine (red). (weizmann.ac.il)
  • Regulated control of these interactions is crucial to sustain normal responses in this rapidly changing environment, and dysfunctional endothelial cell behaviour results in angiogenic disorders. (reading.ac.uk)
  • When acting as a transporter for HA, LYVE1 can take on various roles, including moderating the uptake for catabolism within the lymphatic endothelial cells or delivering HA into the lumen of lymphatic vessels for reuptake in the lymph nodes. (prospecbio.com)
  • a2,3) Both DCs and T cells interact with FRCs and their secreted chemokines (CCL19, CCL21), as well as cytokines (IL-6, IL-7), which promote their migration and survival. (weizmann.ac.il)
  • The immune responses associated with severe and fatal COVID-19 manifestations include defective antiviral mechanisms such as type I interferon (IFN) responses ( 3 , 4 ), imbalanced T cell responses ( 5 , 6 ), abnormal expansion of potentially dysfunctional B cells ( 7 ), exuberant inflammation driven by altered myeloid responses ( 8 , 9 ), and production of potentially pathogenic antibodies (autoantibodies and/or proinflammatory antibodies) ( 10 - 12 ). (frontiersin.org)
  • Vaccination with nanodiscs containing six CSC antigen peptides elicited robust T cell responses against CSC-associated antigens and promoted intratumoral infiltration of CD8+ T cells, while reducing the frequency of CSCs and CD4+ regulatory T cells within melanoma tumors. (bvsalud.org)
  • However, tumors have the ability to escape T cell attack. (mssm.edu)
  • Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas , multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)
  • During migration in embryos, cells must alter their overall adhesiveness to the substrate to allow locomotion. (silverchair.com)
  • M2 macrophages derived from human monocyte cell line THP-1 secreted high levels of IL-8 and leukotriene D4 (LTD4), which induced colon cancer cell migration, and Th2 cytokines (IL-4, IL-10) to maintain a tumoral immunosuppressive environment. (lu.se)
  • This interaction enhanced cell migration of CRC cells and TAMs. (lu.se)
  • The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices. (xenbase.org)
  • Interactions between endothelial cells and the surrounding extracellular matrix are continuously adapted during angiogenesis, from early sprouting through to lumen formation and vessel maturation. (reading.ac.uk)
  • a1) T cells can also interact with, and be activated by, DCs presenting via MHC/HLA a specific antigen matching the T-cell receptor, and accompanied by co-stimulatory (CD80/CD86 DCs, and CD28 T cells) and adhesive molecules (ICAM-1/LFA-3 DCs, and LFA-1/CD2 T cells). (weizmann.ac.il)
  • Improvement of cell-cell interactions between epithelium and mesenchyme is a potential approach to address this phenotype issue. (ca.gov)
  • Once ovarian cancer cells adhere to the peritoneal cells, they migrate through the peritoneal layer and invade the local organs. (endocrinology-journals.org)
  • In the later generations, when telomeres are short, cells die via apoptosis or senescence. (hopkinsmedicine.org)
  • Apoptosis and other forms of cell death are required for trimming excess, expired and damaged cells. (hopkinsmedicine.org)
  • The CUB domains take part in protein-protein interactions with VWF domains, which become exposed under shear stress, and are also involved in the binding and cleavage of VWF. (wikipedia.org)
  • The Hamill lab's work encompasses a range of scales from whole organism work on human disease samples and transgenic animals, to ex vivo, 2D and 3D cell cultures, and molecular or protein biochemistry studies measuring alternative splicing and protein-protein interactions in vitro. (leanpub.com)
  • A majority of the nonanticoagulant actions of heparin on the endothelium appear to be related to heparin interactions with the fibroblast growth factors (FGFs). (nih.gov)
  • Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
  • In principle, T cells can recognize and kill cancer cells. (mssm.edu)
  • that pancreatic cancer cells are functionally heterogeneous. (grantome.com)
  • Ovarian cancer has a distinct tendency for metastasising via shedding of cancerous cells into the peritoneal cavity and implanting onto the peritoneum that lines the pelvic organs. (endocrinology-journals.org)
  • Insufficient cell death underlies human cancer and autoimmune disease, while excessive cell death underlies human neurological disorders and aging. (hopkinsmedicine.org)
  • Myeloma cancer cell responding to shear flow (by scanning electron microscope). (weizmann.ac.il)
  • CD47 is involved in crosstalk between colon cancer cells and macrophages by interacting with its ligand signal-regulatory protein α on macrophages. (lu.se)
  • The enhanced levels of MMP-7 and -9 mRNA expressions and increased cell invasion into matrigel were observed in colon cancer cells upon stimulation with TAM-conditioned medium. (lu.se)
  • CD47, as a key regulator of crosstalk between colon cancer cells and TAMs, could thus be a therapeutic target for CRC. (lu.se)
  • One of the major reasons for poor cancer outcomes is the existence of cancer stem cells (CSCs). (bvsalud.org)
  • This protein is frequently overexpressed and aberrantly glycosylated on its extracellular region in breast cancer. (medscape.com)
  • The CA 15-3 antigen (also known as MUC1, from which it is derived) represents sequences of mucins that are often overexpressed in malignant glandular cells, such as breast cancer. (medscape.com)
  • Increased knowledge between these interactions is important to develop new concepts and advances in basic, translational, and clinical cancer immunology and immunotherapy. (lu.se)
  • Understanding how these molecules control cell fate in vivo will provide us with the tools to improve current cell culture models used in stem cell research. (lu.se)
  • By introducing random mutations into EGFRs and starving cells of IL-3, only those with EGFR-activating mutations survived. (asbmb.org)
  • In the last part, information about cell-penetrating peptides that can be used as molecular carries is mentioned with providing classification and cellular uptake mechanism of them. (intechopen.com)
  • To investigate the single molecular switches defining the identity of cells. (lu.se)
  • People with this disease die of bone marrow failure, likely due to stem cell loss. (hopkinsmedicine.org)
  • For his PhD, David worked at MIT on stem cell-based therapies at the Koch Institute. (pictet.com)
  • Even though the integration of stem cells was promising, neural stem cell studies still have many milestones to reach. (omicsonline.org)
  • To identify the roles of inorganic elements during stem cell development. (lu.se)
  • The progress of stem cell models has facilitated the understanding of development and disease over the last decade. (lu.se)
  • Current stem cell models that possess different types of extracellular matrix, have improved our understanding of cell fate vastly. (lu.se)
  • Our work includes decellularization technologies, cell and extracellular matrix interactions, cell communication, structural and mechanical properties of tissues, biomedical device design, technology transfer and commercialization. (dal.ca)
  • However, the factors leading to cell/tissues damage, as well as the mechanisms behind the observed organ specificity are mostly unknown. (lu.se)
  • We focused on four ApoA-I amyloidogenic variants and analyzed their cytotoxicity as well as their ability to alter redox homeostasis in cell lines from different tissues (liver, kidney, heart, skin). (lu.se)
  • Blood from exposed animals can cause inflammation and dysfunction in naïve cells and tissues, yet the carbon nanotube material itself is restricted principally to the lung. (cdc.gov)
  • The use of human mesenchymal stromal cells (hMSC) for treating diseased tissues with poor vascularization has received significant attention, but low cell survival has hampered its translation to the clinic. (ibecbarcelona.eu)
  • By incorporating both human mesenchymal stem cells and glass-ceramic particles in an implantable hydrogel, this study provides insights into the vasculogenic potential in soft tissues of the combined strategies. (ibecbarcelona.eu)
  • Identification of disease mechanisms in heritable diseases originating in the extracellular matrix. (mcgill.ca)
  • The Reinhardt laboratory is interested in components and mechanisms involved in the biogenesis, function and pathological aspects of the extracellular matrix and its interactions with cells. (mcgill.ca)
  • Further investigation of their regulative roles and interaction may provide new insights into the pathological mechanisms and therapeutic targets for KBD. (nature.com)
  • We aim to understand the mechanisms underlying the matrisome's control of cell fate in an organism. (lu.se)
  • Results: Cytotoxicity following direct interaction of APPJ with cells is comparable to indirect interaction when only liquid medium is treated and subsequently added to the cells, especially on the long-term (72 h of cell culture). (ibecbarcelona.eu)
  • Conclusions: The high efficiency of the indirect treatment indicates that an important role is played by the reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the gaseous plasma stage and then transmitted to the liquid phase, which overall lead to lethal and selective action towards osteosarcoma cells. (ibecbarcelona.eu)
  • In these studies, we tailor extracellular nanopatterns that can provide specific stimulation of cytokines, and reduce the rate of cell death. (weizmann.ac.il)
  • Human induced pluripotent stem (iPS) cells can differentiate into hepatocyte lineages, although the phenotype of the differentiated cells is immature compared to adult hepatocytes. (ca.gov)
  • b) In a novel approach for construction of a synthetic immune niche, many of the cell-bound and ECM-associated ligands are transferred to a synthetic 2D (left) or 3D scaffold (right), to which T cells can bind. (weizmann.ac.il)
  • In the synthetic niche, interactions with the functionalized scaffold are expected to provide the signals needed for T-cell activation (with or without antigen specificity), lineage selection, proliferation, and survival. (weizmann.ac.il)
  • check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)
  • In this study, we developed a model system for improving interactions between human iPS-derived hepatic progenitor cells (iPS-HPCs) and human iPS-derived hepatic stellate cell-like cells (iPS-HSCs). (ca.gov)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • However, both in vitro and in vivo studies have revealed that a significant proportion of the cell-synthesized FGF is found outside the cells, localized in the extracellular matrix bound to heparin-like glycosaminoglycans. (nih.gov)
  • Described here are some of the general requirements of in vitro test methods for skin sensitization, and progress that has been made in developing suitable approaches with particular emphasis on the utility of dendritic cell culture systems. (cdc.gov)
  • The dynamics of cell-extracellular matrix interactions in normal and pathological situations. (mcgill.ca)
  • They used the ability of Ba/F3 lymphoid cells to overcome their dependence on interleukin 3 with activated epidermal growth factor receptors, or EGFRs, which are perennially turned on in many cancers. (asbmb.org)
  • In our current attempts to create a synthetic "immune niche," we employ diverse surface patterning approaches that might mimic "partnering cells", which are regularly located in the immune niches, and replace them in the process of T-cell activation (Figure 1). (weizmann.ac.il)
  • Guided by the EU principles of innovative doctoral training, the ESRs will be educated in the context of a close interaction between academia, research institutes, commercial enterprises and unique large-scale research infrastructures to be able to tackle the interdisciplinary approaches needed to bring nanotechnology to the market place and to educate the workforce that will help solve the European Societal Challenges and the UN Sustainable Development Goals. (lu.se)
  • The foamy stromal cells between the capillaries stain positive for glial fibrillary acid protein and neuron-specific enolase. (medscape.com)
  • Human induced pluripotent stem cells (iPSCs) offer a potential unlimited source of adult cell types with numerous applications in regenerative medicine. (ca.gov)