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  • cell
  • Results were duplicated across cell lines representing microsatellite instability, CpG island methylator, and chromosomal instability phenotypes, suggesting immunologic elimination of cells expressing these proteins could impact the progression of all CRC phenotypes. (aacrjournals.org)
  • One challenge has been the difficulty in altering the mechanical properties of the extracellular matrix without simultaneously impacting other factors that influence cell behavior. (hindawi.com)
  • Integrin-mediated cell adhesions are critical in sensing and transmitting myosin-based cytoskeletal contractile forces and external forces from the matrix environment. (hindawi.com)
  • The overall mechanisms of action of both peptides are discussed in light of their differing modes of cell attachment and uptake fortified by RNA microarray analysis and electrophysiologic measurements of cell membrane conductance and resistance. (mdpi.com)
  • Fibrosis affects multiple organs and is associated with hyperproliferation, cell transdifferentiation, matrix modification and contraction. (royalsocietypublishing.org)
  • Articular cartilage ECM plays a crucial role in regulating chondrocyte metabolism and functions, such as organized cytoskeleton through integrin-mediated signaling via cell-matrix interaction. (hindawi.com)
  • Therefore, in addition to transmitting mechanical forces across otherwise vulnerable membranes, they are involved in cell signaling and the regulation of cell cycle, shape, and motility. (hindawi.com)
  • We characterized the de-epithelialized human amniotic membrane (HAM), and compared cell attachment and proliferation efficiencies. (arvojournals.org)
  • However, cell proliferation indices at day 10 of culture were similar among different HAM substrates, suggesting repair of ECM and basement membrane by growing epithelial cells. (arvojournals.org)
  • Urea denudation preserved the basement membrane integrity, ECM, and growth factor composition, and had higher cell attachment and proliferation efficiencies. (arvojournals.org)
  • Collagenases such as MMP-1, -8, and -13 can cleave the fibrils of collagen next encountered by the endothelial cell as it strives to form a new channel. (ahajournals.org)
  • antagonists
  • On the other hand, endothelium, like most other cells, can also synthesize tissue inhibitors of MMPs (TIMPs), the endogenous antagonists of this matrix-degrading family of enzymes. (ahajournals.org)
  • apical
  • Most epithelia, e.g., the nephron and the gastrointestinal tract, serve not only as a barrier that protects the extracellular fluid, but they also modify the composition of the fluid on the apical or luminal side by absorptive and secretory processes that transport solutes and water, respectively, out of or into the apical compartment. (centrallakesclinic.biz)
  • Most substances that utilize the transcellular route require specialized transporters that facilitate their movement across the apical and the basolateral membranes, and these transporters are generally regulated to produce physiologic changes in the rates of reabsorption or secretion. (centrallakesclinic.biz)
  • genes
  • We hypothesized that genes upregulated in adenoma relative to normal tissue, which maintained increased expression in CRC, would encode proteins suitable as putative targets for immunoprevention. (aacrjournals.org)
  • We further identified 23 genes that showed protein overexpression in colon adenoma and CRC based on literature review. (aacrjournals.org)
  • While most retinal prostheses in the current clinical trials rely on stimulation by electrical pulses from electrode arrays to locally excite the patient's retinal neurons, several research groups are also trying more biologically compatible stimulation methods termed "optogenetics" which deploy viruses to transduce light-activated stimulator protein genes into select groups of retinal neurons which when expressed modulate their neural activity. (utah.edu)
  • Recently, defective genes that produce proteins of the nuclear envelope, the double-layered membrane that covers the nucleus of certain cells, have also been linked to CMD. (rarediseases.org)
  • distinct
  • Podocyte-specific restoration of laminin α5 production using two distinct strategies in Lama5 neo/neo mice resulted in the resolution of proteinuria, hematuria, and PKD. (asnjournals.org)
  • neurons
  • While most retinal prostheses in the current clinical trials rely on stimulators producing electrical pulses from electrode arrays to locally excite the patient's retinal neurons, several research groups are also trying more biologically compatible stimulation methods termed "optogenetics" which deploy patches of light-activated stimulator proteins expressed in groups of retinal neurons to selectively modulate their neural activity. (utah.edu)
  • Fusion of BirA to an atoxic fragment of the TeNT (HcT) enables us to tag proteins coming into close contact with HcT during its recognition, internalisation and retrograde axonal transport in neurons. (ucl.ac.uk)
  • cells
  • The percentage of cells displaying the pericellular presence of the protein was graded semiquantitatively. (harvard.edu)
  • Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. (selectscience.net)
  • This was shown both in haptotaxis experiments (the migration of cells to surfaces coated with protein) and in chemotaxis experiments (the migration of cells to attractants in solution). (arvojournals.org)
  • The process is activated, though perhaps not exclusively, by cells responding to fragments of damaged ECM, and the repairs are made by reassembling the matrix by cells growing on and through it. (wikipedia.org)
  • Rather, a complex and often dense extracellular matrix invests the parenchymal cells and microvascular channels of most organs. (ahajournals.org)
  • fibroblasts
  • Dermal skin is primarily a combination of fibroblasts growing in this matrix. (wikipedia.org)
  • In the Inflammatory phase, neutrophils and macrophages recruit and activate fibroblasts which in subsequent granulation phase migrate into the wound, laying down new collagen of the subtypes I and III. (wikipedia.org)
  • include
  • Currently, three spliced variants of LIF have been identified which include membrane-associated, diffusible, and truncated forms acting as paracrine factors in embryo implantation [ 2 ]. (hindawi.com)
  • widely
  • Laminin α5 is widely expressed, 17 and Lama5 −/− mice die at late fetal stages with multiple developmental defects. (asnjournals.org)
  • Whereas
  • Whereas the total absence of laminin α5 results in breakdown of the glomerular basement membrane (GBM) and failed glomerular vascularization, a hypomorphic Lama5 mutation (the Lama5 neo allele) results in proteinuria, hematuria, polycystic kidney disease (PKD), and death 3 to 4 weeks after birth. (asnjournals.org)
  • kidney
  • Carlson, E. C., Brendel, K., Hjelle, J. T. and Meezan E., "Ultrastructural and Biochemical Analysis of Isolated Basement Membranes from Kidney Glomeruli ruli and Tubules, and Brain and Retinal Microvessels. (patentgenius.com)