• Biochemical and molecular aspects of cellular function, interactions and communication including cell cycle, apoptosis, cancer, neuronal transmission and the signal transduction pathways that integrate them. (sfu.ca)
  • The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. (bio2009.org)
  • On the other end of the spectrum, the microvascular endothelial cells are the first cells to undergo apoptosis at the onset of corpus luteum regression. (biomedcentral.com)
  • Both cell lines received an hCG and angiotensin peptides 24-hour treatment, in combina tion or alone followed by cell viability, apoptosis and cell cycle assays performed by flow cytometer (GUAVA). (scirp.org)
  • After hCG, Ang-(1 - 7), hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments, MCF7 displayed cell viability decrease and mid-apoptosis increase. (scirp.org)
  • These cells had an increase in late apoptosis and necrosis after AngII Toac, hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments. (scirp.org)
  • In summary, cell viability was decreased and apoptosis (initial, mid and late) was in creased after hCG and/or Ang-(1 - 7) peptides treatments. (scirp.org)
  • These results point out hCG and Ang-(1 - 7) as effective compounds to inhibit cell proliferation, since they decrease cell viability and increase apoptosis in both normal and in tumoral breast cells, being the effect more pronounced in the tumoral cell line. (scirp.org)
  • In addition, cell cycle distribution analysis revealed that G0/G1 phase arrest was induced following pristimerin treatment in CAL‑27 and SCC‑25 cells, which was strongly associated with upregulation of p21 and p27, coupled with downregulation of cyclin D1 and cyclin E. Meanwhile, pristimerin induced significant apoptosis of CAL‑27 and SCC‑25 cells, alongside decreased levels of caspase‑3 and specific cleavage of poly (ADP‑ribose) polymerase. (spandidos-publications.com)
  • Pristimerin has also been reported to induce apoptosis of various human cancer cells, including in multiple myeloma ( 10 ), breast ( 11 ), liver ( 12 ), pancreatic ( 13 ) and prostate cancer ( 14 ). (spandidos-publications.com)
  • Pristimerin exhibited potent anti-proliferative and apoptosis-inducing effects on the OSCC cell lines CAL-27 and SCC-25. (spandidos-publications.com)
  • Only a few follicles in the human ovary survive to complete the cytodifferentiation process, with 99.9% dying by a programmed cell death mechanism called apoptosis. (glowm.com)
  • But how do the cells coordinate the extracellular formation of a contact with the intracellular movement of organelles? (rupress.org)
  • describe the interaction of neural cell adhesion molecule (NCAM) clusters with intracellular organelle aggregates derived from the trans-Golgi network (TGN). (rupress.org)
  • The work is the first demonstration that recognition molecules such as NCAM directly link extracellular signals to intracellular organelle movement at developing synapses. (rupress.org)
  • This suggests a model in which intracellular motor proteins move the TGN organelles along the intracellular sides of the neurites, pulling NCAM across the extracellular surface of the membrane at the same time. (rupress.org)
  • NEUROBIOTIN is an amino derivative of biotin that can be used as an intracellular label for cells, particularly neurons and some have fluorophores conjugated enabling direct visualisation as well as an alternative label via the biotin. (2bscientific.com)
  • Scientific background Connexins (Cx) are integral membrane proteins consisting of four transmembrane domains, two extracellular loops, one intracellular loop and intracellular N- and C-termini. (alomone.com)
  • Excretory system:Volume and ionic composition of the intracellular and extracellular compartments. (uninsubria.eu)
  • Chlamydiae are small gram-negative obligate intracellular microorganisms that preferentially infect squamocolumnar epithelial cells. (medscape.com)
  • Chlamydiae have a unique biphasic life cycle that is adaptable to both intracellular and extracellular environments. (medscape.com)
  • Cellular communication: Regulation of hematopoiesis, general principles of cell communication, cell adhesion and roles of different adhesion molecules, gap junctions, extracellular matrix, integrins, neurotransmission and its regulation. (pathfinderacademy.in)
  • Biofilms, a complex aggregation of cells embedded in a polysaccharide matrix, have been of interest for a long time in history - right when Antoine van Leuwenhoek examined a scraping of his tooth plaqueunder a microscope that he had built 1 . (nature.com)
  • Adjacent junctions (or contiguous zonula, indirect junction, or "strip desmosome") are protein complexes that occur in cell-cell junctions, cell-matrix junctions in epithelial and endothelial tissues usually more basic than tight connections. (mormonwoman.org)
  • CD44, a cell surface component that interacts with the extracellular matrix, has been found to be highly expressed in CSCs of several solid tumors. (elsevierpure.com)
  • Lymph capillaries can still stay open and expand with the help of anchoring filaments , fibrillar structures that connect the abluminal surface of endothelial cells to the extracellular matrix . (turkupetcentre.net)
  • Functional PDC can form in mitochondria outside of the matrix in some cancer cells and PDHK1 is commonly tyrosine phosphorylated in human cancers by diverse oncogenic tyrosine kinases localized to different mitochondrial compartments. (bvsalud.org)
  • Endothelial cells migrated into the extracellular matrix in the direction to angiogenic stimulus, 5. (dicella.com)
  • Matrigel matrix is reconstituted basement membrane specimen, which is extracted from tumors enriched in extracellular matrix proteins (e.g. (dicella.com)
  • In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. (thermofisher.com)
  • In the central nervous system, synapses form when specific organelles and proteins are recruited to a site where the axon of one cell contacts a dendrite of another. (rupress.org)
  • Increased vessel permeability leads also to extravasation of white blood cells and plasma proteins into the tissue. (turkupetcentre.net)
  • In this epithelium, as well as in the more fragile single cell layer epithelium of endocervix, the cells are held together by proteins that form desmosomes, tight junctions, and adherens junctions, which decrease its permeability [ 19 ]. (hindawi.com)
  • A cells cycle is positively regulated promoting progress through the stages via the interaction of two classes of proteins found in the cytoplasm. (jove.com)
  • The communication at each stage occurs via cell signalling-an information network of messenger proteins, ion channels and lipids. (bmj.com)
  • The cytoskeleton is a highly dynamic network of filamentous proteins that enables the active transport of cellular cargo, transduces force, and when assembled into higher-order structures, forms the basis for motile cellular structures that promote cell movement. (mechanobio.info)
  • A 40-kd major outer membrane protein (MOMP) and 10- and 60-kd chlamydial heat-shock proteins (cHSPs) have been implicated in the immunopathologic response, but further studies are needed to provide a better understanding of these cell-mediated immune responses. (medscape.com)
  • The RB synthesizes its own DNA, RNA, and proteins but requires energy in the form of adenosine triphosphate (ATP) from the host cell. (medscape.com)
  • Lymphatic capillaries consist of overlapping endothelial cells , and lack pericytes and smooth muscle cells. (turkupetcentre.net)
  • Lymphatic endothelial cells express chemokines and adhesion molecules, and can direct the leukocytes into lymphatics or into interstitial space. (turkupetcentre.net)
  • JAM-B, alternatively named vascular endothelial JAM (VE-JAM), is expressed prominently on high endothelial venules of lymphoid organs where it is localized to the intercellular boundaries of high endothelial cells. (rndsystems.com)
  • The cyclic nature of the capillary bed in the corpus luteum offers a unique experimental model to examine the life cycle of endothelial cells, involving discrete physiologically regulated steps of angiogenesis, blood vessel maturation and blood vessel regression. (biomedcentral.com)
  • Important insights on the morphology and function of luteal endothelial cells have been gained from a combination of in vitro and in vivo studies on endothelial cells. (biomedcentral.com)
  • Endothelial cells communicate with cells comprising the functional unit of the corpus luteum, i.e ., other vascular cells, steroidogenic cells, and immune cells. (biomedcentral.com)
  • This review is designed to provide an overview of the types of endothelial cells present in the corpus luteum and their involvement in corpus luteum development and regression. (biomedcentral.com)
  • Available evidence indicates that microvascular endothelial cells of the corpus luteum are not alike, and may differ during the process of angiogenesis and angioregression. (biomedcentral.com)
  • The contributions of vasoactive peptides generated by the luteal endothelin-1 and the renin-angiotensin systems are discussed in context with the function of endothelial cells during corpus luteum formation and regression. (biomedcentral.com)
  • The review highlights areas for future investigation of ovarian microvascular endothelial cells. (biomedcentral.com)
  • The potential clinical applications of research directed on corpus luteum endothelial cells are intriguing considering reproductive processes in which vascular dysfunctions may play a role such as ovarian failure, polycystic ovary syndrome (PCOS), and ovarian hyperstimulation syndrome (OHSS). (biomedcentral.com)
  • Evidence of proliferating endothelial cells was determined by the presence of Ki-67 antigen-positive cells, bromodeoxyuridine-positive cells, or [ 3 H] thymidine-positive cells. (biomedcentral.com)
  • Activation of endothelial cells by different growth factors, 2. (dicella.com)
  • Endothelial cells form new tubules with a central lumen, 6. (dicella.com)
  • The matrigel might cause differentiation of a variety of cell types like endothelial cells (e.g. (dicella.com)
  • The present work introduces a computational implementation of some principles of a theory of organism development, namely that the default state of cells is proliferation and motility, and includes the principle of variation and organization by closure of constraints. (nature.com)
  • In the present model, the bioelectric context of cells and tissue is the field responsible for organization, as it regulates cell proliferation and the level of communication driving the system's evolution. (nature.com)
  • Starting from a depolarized (proliferative) cell, the organism grows to a certain size, limited by the increasingly polarized state after successive proliferation events. (nature.com)
  • Our previous work showed that upon the alteration of the blood-retina barrier, the serine protease thrombin could contribute to the transformation, proliferation, and migration of RPE cells. (molvis.org)
  • Collectively, these studies demonstrate that the rate of endothelial cell proliferation is highest during corpus luteum formation, then decreases and remains low during the mid-luteal phase and structural regression of the corpus luteum. (biomedcentral.com)
  • The regulation of endothelial cell proliferation in the corpus luteum of pregnancy is less clear. (biomedcentral.com)
  • Many tumor cells rely on aerobic glycolysis instead of oxidative phosphorylation for their continued proliferation and survival. (bvsalud.org)
  • Expression of phosphorylation-deficient, catalytic hypomorph PDHK1 mutants in cancer cells leads to decreased cell proliferation under hypoxia and increased oxidative phosphorylation with enhanced mitochondrial utilization of pyruvate and reduced tumor growth in xenograft nude mice. (bvsalud.org)
  • Y10 rescue cells show decreased cell proliferation and ATP levels under hypoxia and reduced tumor growth in xenograft nude mice. (bvsalud.org)
  • Results demonstrated that pristimerin was toxic against the two cell lines, and exhibited inhibitory effects against proliferation. (spandidos-publications.com)
  • During the course of folliculogenesis, growth is achieved by cell proliferation and formation of follicular fluid, whereas development involves cytodifferentiation of all the cells and tissues in the follicle. (glowm.com)
  • Previous work has already shown that NCAM is required for the proper mobilization and cycling of synaptic vesicles at neuromuscular junctions. (rupress.org)
  • The laboratory of Dr. Bhattacharyya is also studying vesicular trafficking in early secretory pathways as well as the biogenesis of exosomes, a class of nano-sized extracellular vesicles implicated in cancer metastasis. (actrec.gov.in)
  • Analogous to events occurring in the corpus luteum, the vascular endothelium of other tissues responds to extracellular signals during the physiologic processes of embryonic development and wound healing, and in the pathologic process of tumor angiogenesis. (biomedcentral.com)
  • However, how oncogenic signals activate LDH-A to regulate cancer cell metabolism remains unclear. (bvsalud.org)
  • 1995). Reflexive space junctions at the paranodes and incisures would greatly shorten the distance for diffusion of nutrients or signals within myelinating Schwann cells. (acp2018.org)
  • The underlying mechanisms of these effects were primarily mediated by G 1 phase cell cycle arrest and inhibition of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulate kinase 1/2 (Erk 1/2) and protein kinase B (Akt) signaling pathways. (spandidos-publications.com)
  • Angiotensin II Activates Extracellular Signal Regulated Kinases via Protein Kinase C and Epidermal Growth Factor Receptor in Breast Cancer Cells," Journal of Cellular Physiology, Vol. 196, No. 2, 2003, pp. 370-377. (scirp.org)
  • These effects were associated with inhibition of the mitogen‑activated protein kinase/extracellular signal‑regulated kinase 1/2 and protein kinase B signaling pathways. (spandidos-publications.com)
  • Cells and cell theory, the differences between prokaryotic and eukaryotic cells, the plasma membrane and organelles. (londonmet.ac.uk)
  • The prokaryotic cell-structure/function, principles of cell membrane transport and cells and energy (mitochondria and chloroplasts) (LOs 1-3). (londonmet.ac.uk)
  • ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. (thermofisher.com)
  • The cells of the heart muscle are equipped with three different types of extracellular cells intersections intermittently "point" desmosomes and "sheet" desmosomes (or adjacent fascia) - located in a specialized part of the plasma membrane, the intercalated disk. (mormonwoman.org)
  • His research is focused on Cell surface receptors, Ligand-receptor networks, Signalling pathways and inhibition, Signal transduction, Trafficking mechanisms. (hoajonline.com)
  • Cell signaling: Hormones and their receptors, cell surface receptor, signaling through G-protein coupled receptors, signal transduction pathways, second messengers, regulation of signaling pathways, bacterial and plant two-component signaling systems, bacterial chemotaxis and quorum sensing. (pathfinderacademy.in)
  • Moreover, these receptors are functional, as treatment of FRT tissue cells with ligands for TLR and NOD induces production of proinflammatory CXCL8 [ 13 ], and those receptors actively participate in immune response to pathogens, as Neisseria gonorrhea and HIV-1 [ 14 ]. (hindawi.com)
  • Cell membranes are highly enriched in signaling receptors, transmembrane mechanosensors, pumps and channels, and, depending on their makeup, can recruit and retain a pool of mechanosensors important in the field of mechanobiology. (mechanobio.info)
  • From left: Panel 1 shows formation of nascent adhesions at the cell periphery. (mechanobio.info)
  • Molecular Biology of the Cell , 7th edition. (sfu.ca)
  • GRE Subject Biochemistry, Cell and Molecular Biology was a standardized exam provided by ETS (Educational Testing Service) that was discontinued in December 2016. (wikipedia.org)
  • After learning that test content from editions of the GRE® Biochemistry, Cell and Molecular Biology (BCM) Test has been compromised in Israel, ETS made the decision not to administer this test worldwide in 2016-17. (wikipedia.org)
  • Tutorials will consolidate the foundation learnt in lectures but will seek to link the content to the impact of modern cell biology on medicine and agriculture in a social and cultural context in the modern day environment. (londonmet.ac.uk)
  • Weblearn-assisted sessions will also seek to link the module content to the impact of modern cell biology on medicine and agriculture in a social and cultural context in the modern day environment but in a wider context than covered in the lectures in an aim to encourage self-directed learning. (londonmet.ac.uk)
  • Dr. Paul Robert Fisher holds the Chair in Microbiology at La Trobe University, where he leads the Microbial Cell Biology Group. (hoajonline.com)
  • This volume covers the most up-to-date methods and techniques used to further the understanding of chromaffin cell biology and pharmacology. (emedicalbooks.com)
  • Molecular Biology of the Cell , Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. (emedicalbooks.com)
  • The Sixth Edition has been extensively revised and updated with the latest research in cell biology, and it provides an exceptional framework for teaching and learning. (emedicalbooks.com)
  • Medical Biology - Cell Biology is a one semester subject for students of Dentistry. (semmelweis.hu)
  • Medical Biology - Cell Biology has theoretical (lecture) and laboratory (practice) parts. (semmelweis.hu)
  • Final exam (Medical Biology - Cell Biology) consists of an oral test (preparations, electron micrographs, methods applied in cell biology) and a written test (multiple choice, essays, drawings, etc. covering theoretical part of the subject). (semmelweis.hu)
  • This group focuses on the cell biology of normal and tumor cells and how these differences can explain tumor progression and possibly identify potential targets for therapeutic intervention. (actrec.gov.in)
  • Human JAM-B cDNA predicts a 298 amino acid (aa) precursor protein with a putative 28 aa signal peptide, a 209 aa extracellular region containing two Ig domains, a 23 aa transmembrane domain and a 38 aa cytoplasmic domain containing a PDZ-binding motif and a PKC phosphorylation site. (rndsystems.com)
  • Similar to normal tissue stem cells, cancer stem cells (CSCs) are thought to be quiescent or slow-cycling and, thereby, insensitive to chemo- and radiotherapies. (elsevierpure.com)
  • Existing lymphatic networks can be expanded, venous structures can be reprogrammed, or lymphatic progenitor cells are recruited. (turkupetcentre.net)
  • When this complex forms the CDK can phosphorylate a target protein which alters it's function and initiates the cell to advance to the next phase. (jove.com)
  • Positive regulators include two protein groups that allow cells to pass through regulatory checkpoints: cyclins and cyclin-dependent kinases (CDKs). (jove.com)
  • In multiple disease states the connexin43 (Cx43) hemichannel protein is overexpressed and the hemichannel opens prematurely allowing for ATP to enter the extracellular space. (ois.net)
  • Innate and adaptive immune system: Cells and molecules involved in innate and adaptive immunity, antigens, antigenicity and immunogenicity. (pathfinderacademy.in)
  • Cells in the interior, on the other hand, depend on the leftover glutamate that diffuses inwards in the biofilm, but do not lose gaseous molecules as rapidly as the peripheral cells. (nature.com)
  • At a developing contact site, the NCAM molecules of the two cells cluster, trapping the TGN organelles and stabilizing the nascent synapse. (rupress.org)
  • In support of the presence of reflexive junctions, junction-permeant molecules microinjected into the perinuclear cytoplasm diffuse rapidly into periaxonal regions, whereas junction-impermeant molecules do not (Balice-Gordon et al. (acp2018.org)
  • These cells possess both differentiation plasticity (stemness) and tissue supportive functions (stromalness) that can coexist and overlap, with differences depending on tissue source, donor characteristics, culture conditions and delivery strategies, leading to alternative best fittings for the term "stem" or "stromal" [ 7 ] . (encyclopedia.pub)
  • IL-21 regulates Th17 cell homeostasis enhances the differentiation of storage B cells and antibody-secreting plasma cells and promotes the maintenance of Compact disc8+ T-cell replies. (bio2009.org)
  • In the earliest stages of development, the physical properties of the microenvironment can direct cell differentiation, and initiate the coordinated movement of groups of cells to establish the patterns that will define how the body is arranged. (mechanobio.info)
  • Mesenchymal stem/stromal cells (MSCs) are a reservoir for tissue homeostasis and repair that age during organismal aging. (encyclopedia.pub)
  • During aging of the organism, MSCs also age, and this implies an impairment of stem cell functions contributing to the progressive decrease in tissue maintenance and repair, a characteristic of the aging process. (encyclopedia.pub)
  • Due to the low abundance of MSCs in human adult tissues (about 1/10 6 cells in adult bone marrow and 1/10 3-4 cells in adipose tissue and umbilical cord) [ 16 ] , frequently ex-vivo expansion precedes therapeutic administration, to obtain a clinically relevant number of cells. (encyclopedia.pub)
  • Carcinogenesis is introduced through a localized event (a spot of depolarized cells) or by random depolarization of cells in the tissue, which returns cells to their initial proliferative state. (nature.com)
  • This simplified model of embryogenesis, tissue organization and carcinogenesis, based on non-excitable cells' bioelectric properties, can be made more realistic with the introduction of other components, like biochemical fields and mechanical interactions, which are fundamental for a more faithful representation of reality. (nature.com)
  • An organism's growth and transformation during its life cycle is a tremendously complex succession of processes and events but even a simplistic and limited theory, dealing with only the general trend and generating a broad vision of tissue organization, can drive specific studies and experiments to further inform this field of research. (nature.com)
  • ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. (thermofisher.com)
  • Skeletal muscle tissue cells define four characteristics: they are voluntary, striated, unbranched and multi-nuclear. (mormonwoman.org)
  • Intercalated disks represent wavy double membranes in which two cells are tightly bound together by desmosomes and connected by gap junctions, allowing electrical impulses to pass from cell to cell . (mormonwoman.org)
  • Emerging techniques using the analysis of circulating tumor cells show promising results in predicting and identifying the early stages of breast cancer metastasis in patients. (iiarjournals.org)
  • An emerging method to detect metastasis is the analysis of circulating tumor cells (CTCs), which has shown promise in filling the gaps left by other diagnostic methods. (iiarjournals.org)
  • HSV1 infects a broad range of cells and shows fast trans-neuronal spread in the central nervous system and can lead to meningitis or encephalitis. (2bscientific.com)
  • In this condition, elevated extracellular glutamate causes neuronal loss in many retinal disorders, including glaucoma, ischemia, diabetic retinopathy, and inherited photoreceptor degeneration. (molvis.org)
  • Slotted nodes they are found in virtually all tissues of the body with the exception of adult, fully developed skeletal muscle and mobile cell types such as sperm or erythrocytes. (mormonwoman.org)
  • The ability of two cytokines, tumor necrosis factor alpha and interferon gamma, are evaluated as paracrine mediators of endothelial cell function during angioregression. (biomedcentral.com)
  • These observations suggest that PGE 2 -mediated inflammatory signaling and Wnt signaling cooperatively trigger the expansion of CD44 + slow-cycling stem-like cells in SCJ, leading to development of lethal gastric tumors in mice. (elsevierpure.com)
  • Nucleus, cell cycle, mitosis and meiosis. (londonmet.ac.uk)
  • Smooth muscle cells they are spindle-shaped, have a single, centrally located nucleus and no striations. (mormonwoman.org)
  • The heart muscle has branched fibers, one nucleus per cell, striations and intercalated discs. (mormonwoman.org)
  • Cell nucleus. (semmelweis.hu)
  • The laboratories of Dr. Bhattacharyya and Dr. Dalal study the biogenesis and size and copy control mechanisms of organelles such as the Golgi complex, the endoplasmic reticulum, the nucleus, the centrosome and the cell-cell adhesion junction the desmosome. (actrec.gov.in)
  • In skeletal muscle cells, T-tubules are three to four times narrower than in cardiac cells, and are 20 to 40 nm in diameter. (mormonwoman.org)
  • Ventricular pressure and volume during the cardiac cycle. (uninsubria.eu)
  • Additionally, a viable therapeutic strategy may involve triggering the cell death mechanism in cancer cells by blocking mitochondrial metabolism with a natural substance. (scientificarchives.com)
  • In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
  • Here we show that a gastric gland residing at the squamo-columnar junction (SCJ) in normal mouse stomach contains CD44 + stem cell-like slow-cycling cells and that this characteristic CD44 + gland was expanded by prostaglandin E2 (PGE 2 ) and Wnt signaling in K19-Wnt1/C2mE mouse, a genetic mouse model for gastric tumorigenesis. (elsevierpure.com)
  • Our study was served between subgroups, a high degree of variation was designed to examine the extent of genetic variation and the observed in the extracellular domain of the G gene of the circulation pattern of hMPV in a single South African virus. (cdc.gov)
  • Mucosal immunity consists of innate and adaptive immune responses that can be influenced by systemic immunity [ 15 ] and by hormonal changes during the menstrual cycle. (hindawi.com)
  • Typically, the human ovaries produce a single dominant follicle that results in a single ovulation each menstrual cycle (Fig. 1). (glowm.com)
  • 1 , 2 , 3 In each menstrual cycle, the dominant follicle that ovulates its egg originates from a primordial follicle that was recruited to initiate growth almost 1 year earlier (Fig. 2). (glowm.com)
  • It is performed in three basic steps: cell seeding, tube formation and angiogenesis observation. (dicella.com)
  • We also present a thorough analysis of the role of succinate in the initiation of metabolic and epigenetic changes that contribute to the development of cancer, as well as its effects on angiogenesis, cell invasion, and migration. (scientificarchives.com)
  • Physiologically hemichannels are continuously forming in cell membranes and remain closed until docked with a neighboring cell at which point they open to form gap junctions. (ois.net)
  • T lymphocytes for adoptive cell therapy against hematological cancer. (upstate.edu)
  • Cancer cells can travel via lymphatic system to distant sites. (turkupetcentre.net)
  • The Warburg effect describes an increase in aerobic glycolysis and enhanced lactate production in cancer cells. (bvsalud.org)
  • LDH-A gene expression is believed to be upregulated by both HIF and Myc in cancer cells to achieve increased lactate production. (bvsalud.org)
  • Moreover, Y10 phosphorylation of LDH-A is common in diverse human cancer cells, which correlates with activation of multiple oncogenic tyrosine kinases. (bvsalud.org)
  • Our findings suggest that tyrosine phosphorylation enhances LDH-A enzyme activity to promote the Warburg effect and tumor growth by regulating the NADH/NAD(+) redox homeostasis, representing an acute molecular mechanism underlying the enhanced lactate production in cancer cells. (bvsalud.org)
  • however, the antitumor effects and underlying mechanisms of pristimerin in oral cancer cells have not yet been identified. (spandidos-publications.com)
  • This method uses either epithelial cell-specific markers which are generally expressed in all tumor cells, or tumor markers expressed by specific types of cancer ( 13 ). (iiarjournals.org)
  • There are two main subcategories of lung cancer: nonsmall cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (hindawi.com)
  • NAR can be encapsulated by chitosan nanoparticles-TPP conjugates, thereby improving NAR cellular absorption and cytotoxicity against cancer cells. (scientificarchives.com)
  • Evidence indicating that OXPHOS plays a substantial role in the development of many cancer cells has led to the growing recognition of cancer as a metabolic disease. (scientificarchives.com)
  • To this day, many low dose radiation carcinogenesis studies assume that the probability that one cell of a multicellular organism will acquire multiple mutations transforming it into cancer and the ability of that cancer to thrive can be described by a curve plotted against an axis that shows total radiation dose. (cdc.gov)
  • Cell signalling and Trafficking emphasize current knowledge and information regarding cell response and reaction to signalling mechanisms and molecular transport system within the cell. (hoajonline.com)
  • However, the relevancy between CD44 + cells and slow-cycling cells and the underlying mechanisms for the emergence of CD44 + CSCs during tumorigenesis have not been elucidated. (elsevierpure.com)
  • We analyzed the molecular mechanisms leading to glutamate release from rat primary cultures of RPE cells, under isosmotic conditions. (molvis.org)
  • The objectives of these studies are to provide novel insights into how the cell regulates organelle size and number, how these mechanisms are altered in tumor cells and the subsequent consequences for tumor progression. (actrec.gov.in)
  • We also observed cell viability decrease in MCF10A after Ang-(1 - 7), Ang-(1 - 7) Fmoc and hCG + AngII Toac treatments. (scirp.org)
  • Immunoreceptor signaling during development, homeostasis, and effector function of T cells and NK cells. (upstate.edu)
  • The analysis of three transgenic mouse lines, K19-Wnt1, K19-C2mE and K19-Wnt1/C2mE, revealed that the expansion of CD44 + SCJ cells is triggered by PGE 2 -mediated signaling and is prominently enhanced by the addition of Wnt activation. (elsevierpure.com)
  • Mechanotransduction is generally broken down into three steps: (1) mechanocoupling, (2) cell-cell communication and (3) the effector response. (bmj.com)
  • 1995). Freeze-fracture electron microscopy (EM) suggests that space junctions are not found between adjacent myelinating Schwann cells but instead may comprise reflexive space junctions that connect different regions of the same cell (Sandri et al. (acp2018.org)
  • For some, this is an impenetrable barrier for agents such as HIV, but Langerhans cells within the squamous layer have been shown to transmit the virus for target cells [ 20 ]. (hindawi.com)
  • In the present study, the anticancer potential of pristimerin was investigated in two oral squamous cell carcinoma (OSCC) cell lines, CAL‑27 and SCC‑25. (spandidos-publications.com)
  • 90% are squamous cell carcinomas. (spandidos-publications.com)
  • Because it is very invasive, the prognosis of oral squamous cell carcinoma (OSCC) is poor ( 5 ). (spandidos-publications.com)
  • There are three main subtypes of NSCLC which are adenocarcinoma (~40% of cases), squamous cell carcinoma (~25-30% of cases), and large-cell carcinoma (~10-15% of cases). (hindawi.com)
  • Innate immunity includes barriers such as the epithelium, mucus, pH, complement system, and cells of the immune system. (hindawi.com)
  • ATP assembles the innate inflammasome (NLRP3) pathway of inflammation resulting in release and continuing cycling of multiple proinflammatory cytokines. (ois.net)
  • The laboratories of Dr. Teni and Dr. Dalal study therapy resistance in oral, cervical and colorectal cancers with an emphasis on how tumor cells acquire resistance to radiation and commonly used chemotherapeutic agents and determining whether these can serve as targets for therapeutic intervention or prognostic markers that can predict the choice of therapy. (actrec.gov.in)
  • Together, these data show that Cx29 and Cx32 are expressed by myelinating glial cells with unique distributions. (acp2018.org)
  • This state is resilient to cell death (random or due to injure) and to limited depolarization (potentially carcinogenic) events. (nature.com)
  • Infection with chlamydial organisms invokes a humoral cell response, resulting in secretory immunoglobulin A (IgA) and circulatory immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies and a cellular immune response. (medscape.com)
  • The granulosa cells and theca cells of the developing antral follicle and the steroidogenic cells of the corpus luteum produce and respond to angiogenic factors and vasoactive peptides. (biomedcentral.com)
  • The remaining cells in the follicle wall ( i.e. granulosa, membrana and periantral, theca, the theca interna and externa) develop into the corpus luteum. (glowm.com)
  • Host parasite interaction: Recognition and entry processes of different pathogens like bacteria, viruses into animal and plant host cells, alteration of host cell behavior by pathogens, virus-induced cell transformation, pathogen-induced diseases in animals and plants, cell-cell fusion in both normal and abnormal cells. (pathfinderacademy.in)
  • how a cell can detect, measure and respond to the rigidity of its substrate and how these processes apply to larger biological systems. (mechanobio.info)