• Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. (mdpi.com)
  • Extracellular Vesicles (EVs) - which have been recently recognized as the universal agent of intercellular communication, being involved in many physiological and pathological processes and interkingdom biochemical communication - are nanoparticles, but this key aspect has never been rationally addressed. (nih.gov)
  • Recent studies have shown that extracellular vesicles (EVs) can be exploited by tumors to assist in cancer cell growth, proliferation, migration, invasion and metastasis. (springer.com)
  • Anand S, Samuel M, Kumar S, Mathivanan S (2019) Ticket to a bubble ride: cargo sorting into exosomes and extracellular vesicles. (springer.com)
  • Becker A, Thakur BK, Weiss JM, Kim HS, Peinado H, Lyden D (2016) Extracellular vesicles in cancer: cell-to-cell mediators of metastasis. (springer.com)
  • Catalano M, O'Driscoll L (2020) Inhibiting extracellular vesicles formation and release: a review of EV inhibitors. (springer.com)
  • Journal of Extracellular Vesicles 9(1):1703244. (springer.com)
  • A team of researchers at The University of Texas MD Anderson Cancer Center has developed a new method for using extracellular vesicles to enhance responses to immunotherapy in glioblastoma, potentially opening the door for wider use of engineered messenger RNA (mRNA) for cancer therapy. (mdanderson.org)
  • Earlier this year, a team of researchers led by Betty Kim, M.D., Ph.D. , and Wen Jiang, M.D., Ph.D .,developed a novel method for loading mRNA into extracellular vesicles, small structures created by cells to transport biomolecules and nucleic acids within the body. (mdanderson.org)
  • The current study builds on that research by demonstrating the anti-tumor potential of mRNA-loaded extracellular vesicles. (mdanderson.org)
  • The quantity problem is solved by using a high-throughput system to produce mRNA-loaded extracellular vesicles from engineered cells. (mdanderson.org)
  • This leads the cells to secrete many extracellular vesicles loaded with mRNA material that can then be collected. (mdanderson.org)
  • For this study, the researchers engineered the extracellular vesicles to express the CD64 protein on their surface, which serves as a docking mechanism to load both anti-CD71 and anti-PD-L1 antibodies. (mdanderson.org)
  • These extracellular vesicles were loaded with mRNA encoding interferon-gamma, an immune signaling protein. (mdanderson.org)
  • Extracellular vesicles (EVs) play a crucial role in intercellular communication by transferring bioactive molecules from donor to recipient cells. (lu.se)
  • Extracellular vesicles (EVs) play a key role in propagating the spread of disease-related proteins in neurodegenerative diseases - that was one of the key messages delivered during ISEV2021's first plenary session by Andrew Hill of La Trobe University , Australia. (izon.com)
  • The presentation titled 'Extracellular vesicles and their role in neurodegenerative diseases' covered a series of landmark studies investigating EVs and their role in spreading disease-associated proteins, and the diagnostic potential of EV miRNA profiles for the diagnosis of neurodegenerative diseases. (izon.com)
  • Several aspects of MSC function have been attributed to the paracrine effects of MSC derived extracellular vesicles (EVs). (frontiersin.org)
  • Extracellular vesicles (EVs)/exosomes can satisfy these criteria ( Marcus and Leonard, 2013 ). (frontiersin.org)
  • Since the discovery that extracellular vesicles (EVs) mediate intercellular communication, there is an exponential increase in the interest on EVs, especially in pathological settings. (nih.gov)
  • Nanosized extracellular vesicles (EVs, ∼30-2000 nm) have emerged as important mediators of intercellular communication, offering opportunities for both diagnostics and therapeutics. (kth.se)
  • Extracellular vesicles (EVs) are lipid membranous vesicles released from almost all cell types, and they provide a tremendous opportunity as sources of novel biomarkers from liquid biopsies, as well as agents for tissue repair and wound healing in regenerative medicine. (selectbiosciences.com)
  • Exosomes are endogenous nanoparticles that constitute a fraction of extracellular vesicles that are secreted by all cell types into the extracellular environment, and play an important role in intercellular signaling. (selectbiosciences.com)
  • We use plasma extracellular vesicle (EV) protein content of vesicles from plasma sub-fractions on plasma of stroke and peripheral artery disease(PAD) patients, patients after carotid atherectomy (CEA) and patients suspected for chronic coronary syndrome (CCS). (selectbiosciences.com)
  • Extracellular vesicles (EVs) are nanosized biomolecular packages involved in intercellular communication. (uniquest.com.au)
  • The cells actively release extracellular vesicles (EVs), nano-sized (.05-1 μm) membrane-bound vesicles, into the maternal and the fetal circulation. (rochester.edu)
  • Evidence indicates that Alix, an accessory protein of the endosomal sorting complex required for transport (ESCRT), is involved in the biogenesis of extracellular vesicles (EVs). (spandidos-publications.com)
  • It has been recognized that under physiological and pathological conditions, cells may release vesicles that may be instrumental in intercellular communication as they carry biologically active molecules ( 1 - 4 ). (spandidos-publications.com)
  • Given the heterogeneity of the released vesicles and the overlapping features of molecules carried by exosomes and microvesicles, it has been suggested that they be collectively termed extracellular vesicles (EVs) ( 7 ). (spandidos-publications.com)
  • ABSTRACT The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. (scienceopen.com)
  • The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. (scienceopen.com)
  • Introduction A growing body of research has implicated extracellular vesicles (EVs), membraneous sacs released by a variety of cells, in diverse physiological and patho-physiological conditions [1]-[9]. (scienceopen.com)
  • Extracellular vesicles (EVs) are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication tools. (wjgnet.com)
  • Extracellular vesicles act as a cell's transfer signals - these nanoparticles, which contain protein, sugars, and other biological materials, communicate with adjacent cells and tissues to transmit messages, such as whether a cell is healthy or in distress. (corning.com)
  • Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection. (usda.gov)
  • Cell-cell communication via extracellular vesicles. (exosome-rna.com)
  • Extracellular vesicles such as exosomes, microvesicles, apoptotic bodies, and large oncosomes have been shown to participate in a wide variety of biological processes and are currently under intense investigation in many different fields of biomedicine. (exosome-rna.com)
  • An article Timegated® Raman spectroscopy and proteomics analyses of hypoxic and normoxic renal carcinoma extracellular vesicles is published in Nature - Scientific Reports. (timegate.com)
  • This publication highlights the important research topic of extracellular vesicles (EVs) which were studied using Timegated® Raman (TG-Raman) and surface-enhanced Timegated® Raman spectroscopy (TG-SERS). (timegate.com)
  • Extracellular vesicles (EVs) represent a diverse group of small membrane-encapsulated particles involved in cell-cell communication, but the technologies to characterize EVs are still limited. (timegate.com)
  • What I learned from the research I did in Nagoya University is extracellular vesicles from human dental pulp stem cells play a role in preventing senescence in the process of salivary gland hypofunction. (lu.se)
  • Furthermore, MVs are used for intercellular communication, which is achieved through fusion to target cells. (nature.com)
  • The complexity of the intercellular communication network obscures analysis and understanding of its function. (weizmann.ac.il)
  • Our research focuses on the study of simple building blocks of the immune intercellular communication network, combining experimental approaches and mathematical modeling. (weizmann.ac.il)
  • This is the simplest module of the intercellular cytokine communication network, and is abundantly found throughout the network. (weizmann.ac.il)
  • Nature Communications , Vol. 14, no.1 (2023). (uclouvain.be)
  • 3) the deposition of extracellular matrix and 4) the progression to fibrosis with subsequent organ failure by excessive accumulation of extracellular matrix without sufficient degradation [2]. (omicsonline.org)
  • The brain extracellular matrix (ECM), consisting of proteins and glycosaminoglycans, is a critical scaffold in the development, homeostasis, and disorders of the central nervous system (CNS) and undergoes remodeling in response to environmental cues. (biorxiv.org)
  • [2] [3] The cells within the biofilm produce the EPS components, which are typically a polymeric conglomeration of extracellular polysaccharides , proteins , lipids and DNA . (wikipedia.org)
  • Extracellular polymeric substances (EPSs) are natural polymers of high molecular weight secreted by microorganisms into their environment. (wikipedia.org)
  • Aggregate of microorganisms in which cells that are frequently embedded within a self-produced matrix of extracellular polymeric substances (EPSs) adhere to each other and/or to a surface. (wikipedia.org)
  • The self-produced matrix of extracellular polymeric substances , which is also referred to as slime, is a polymeric conglomeration generally composed of extracellular biopolymers in various structural forms. (wikipedia.org)
  • [2] [3] These adherent cells become embedded within a slimy extracellular matrix that is composed of extracellular polymeric substances (EPSs). (wikipedia.org)
  • Beghein E, Devriese D, Van Hoey E, Gettemans J (2018) Cortactin and fascin-1 regulate extracellular vesicle release by controlling endosomal trafficking or invadopodia formation and function. (springer.com)
  • In the adult vertebrate brain, enzymatic removal of the extracellular matrix (ECM) is increasingly recognized to promote learning, memory recall, and restorative plasticity. (nature.com)
  • In the vertebrate brain, long-lasting structural tenacity of neuronal networks is supported by the extracellular matrix (ECM). (nature.com)
  • Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids. (lifeboat.com)
  • Fibrosis is a dynamic process of abnormal connective tissue formation as a result of excessive wound healing and extracellular matrix deposition. (omicsonline.org)
  • Among the mechanisms involved in fibrosis, a cornerstone for the progression of the fibrotic process is the differentiation of fibroblasts towards activated cells, namely myofibroblasts, which contribute in the production of abundant amount of extracellular matrix [ 2 ]. (omicsonline.org)
  • It has been well known that the extracellular matrix (ECM) is important to the aortic valve function and that mechanical forces and cell-cell communication can regulate ECM remodeling. (bl.uk)
  • This second mode of communication was given the placeholder moniker of 'spontaneous vesicle fusion', since its origin and use was unknown ( Fatt and Katz, 1952 ). (elifesciences.org)
  • Microorganisms synthesize a wide spectrum of multifunctional polysaccharides including intracellular polysaccharides, structural polysaccharides and extracellular polysaccharides or exopolysaccharides. (wikipedia.org)
  • The differentiating cells also actively alter these signals by producing relevant cytokines, thus influencing the differentiation process through extracellular feedbacks. (weizmann.ac.il)
  • Both the innate stimuli, such as lipopolysaccharides and Poly inositol-cytosine and adaptive stimuli, that is, cytokine mix, were able to induce the extracellular release of NPM in immortalized keratinocytes and human skin fibroblasts in the absence of cytotoxicity. (frontiersin.org)
  • Our data show that circulating miR-200c is physically associated with extracellular NPM, which most probably is responsible for its extracellular release and protection upon cytokine mix via a TLR4-mechanism. (frontiersin.org)
  • Extracellular feedback occurs when a cell expresses receptors to a cytokine that it secretes. (weizmann.ac.il)
  • We study extracellular feedback by the cytokine IL-2 in the context of T-cell activation. (weizmann.ac.il)
  • Illustration of membrane-embedded plant cell-surface receptors (white cartoons) that establish communication with symbiotic bacteria via secreted carbohydrate signaling molecules. (lu.se)
  • Cell-surface receptors in plants and animals are found within cells' plasma membrane where they enable a cell to receive, process, and transmit signals from its environment by binding to extracellular signaling molecules such as growth factors, hormones or neurotransmitters. (lu.se)
  • We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and that serum deprivation provokes NPM secretion from human endothelial cells, eliciting inflammation via nuclear factor kappa B (NF-kB) transcriptional activation. (frontiersin.org)
  • ATPOS should be useful to probe the extracellular ATP dynamics of diverse biological processes in vivo. (elifesciences.org)
  • In conclusion, this study reveals the unique functional phenotypes between the aortic and ventricular VECs, and the unique communication between VECs and VICs that is mediated by shear stress to regulate the specific production of ECM components. (bl.uk)
  • Communication between immune cells is necessary to control immune responses in time and space, and probably takes an important part in immune recognition and information processing as well. (weizmann.ac.il)
  • these cargoes are delivered to recipient cells and serve as a cell-to-cell communication system. (selectbiosciences.com)
  • The cells also play an important role in mediating the communication between the mother and the fetus including fetal brain development. (rochester.edu)
  • The horizontal transfer of extracellular RNAs carried by EVs has been shown to be able to reprogram hematopoietic progenitors ( 11 ) and to activate endothelial cells ( 12 ). (spandidos-publications.com)
  • Desmosomes help attach cells to one another and play a role in communication between cells. (medlineplus.gov)
  • The mutations associated with this condition can affect any part of the DSG4 protein, but these changes typically alter the extracellular domain, which is the region of the protein outside the cell that interacts with other cells. (medlineplus.gov)
  • Phospholipase A(2) activation by poultry particulate matter is mediated through extracellular signal-regulated kinase in lung epithelial cells: regulation of interleukin-8 release. (cdc.gov)
  • Methods for UV filter analysis followed the principles of European standardized methods for pesticide residue analysis (EN 15289). (researchgate.net)
  • The resulting ATPOS complex binds to neurons in cerebral cortex of living mice, and clearly visualized a concentrically propagating wave of extracellular ATP release in response to electrical stimulation. (elifesciences.org)
  • Nature Communications , 11, 4222. (gla.ac.uk)
  • Here, we describe a method for in-vivo imaging of extracellular ATP with high spatiotemporal resolution. (elifesciences.org)
  • ADSCs appear to have the capacity to express endothelial markers, but a full functional assessment of their communication with VICs remains to be investigated. (bl.uk)
  • We provide proof-of-concept for extracellular vesicle (EV) profiling as a strategy for non-invasive, liquid biopsy of brain tumors. (lu.se)
  • The projects center on the cellular biology of the malaria parasite, parasite-host interaction and the field of cell-cell communication. (weizmann.ac.il)