• Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin family and a glycoprotein enriched on the surface of tumor cells, promotes invasion, metastasis, and growth and survival of malignant cells and confers resistance to some chemotherapeutic drugs. (elsevier.com)
  • Neutrophil Extracellular Traps in Host Defense. (nih.gov)
  • Diverse extracellular and intracellular microbes induce neutrophils to extrude neutrophil extracellular traps (NETs) through the process of NETosis. (nih.gov)
  • These neutrophil extracellular traps (NETs) degrade virulence factors and kill bacteria. (sciencemag.org)
  • Here, we show that neutrophils generate extracellular fibers, or neutrophil extracellular traps (NETs), which are structures composed of granule and nuclear constituents that disarm and kill bacteria extracellularly. (sciencemag.org)
  • Researchers at Children's Hospital of Philadelphia (CHOP) have developed a novel treatment for sepsis - one of the leading causes of hospital death - that enhances the body's bacteria-capturing neutrophil extracellular traps (NETs) so that they more effectively capture infectious bacteria, resist degradation, and improve sepsis outcomes and survival. (news-medical.net)
  • While neutrophil extracellular traps help guard the body from infection, they also can contribute to a range of diseases. (the-scientist.com)
  • When a neutrophil encounters a pathogen, it can respond in several ways: phagocytosis, degranulation, or by releasing neutrophil extracellular traps (NETs). (the-scientist.com)
  • In cultured human neutrophils, the webs were able to trap the bacteria that had triggered their formation, thereby limiting infection, so Zychlinsky and colleagues dubbed them neutrophil extracellular traps , or NETs. (the-scientist.com)
  • Enhanced formation of neutrophil extracellular traps in Kawasaki disease. (bioportfolio.com)
  • Neutrophils contribute to the clearance of pathogens through the formation of neutrophil extracellular traps (NETs) in a process known as NETosis, but the excessive release of NETs has been reported to be involved in the pathogenesis of various diseases, including vasculitis, by inducing tissue injury. (bioportfolio.com)
  • Neutrophil Extracellular Traps and Liver Disease. (bioportfolio.com)
  • Neutrophil Extracellular Traps Induce Intestinal Damage and Thrombotic Tendency in Inflammatory Bowel Disease. (bioportfolio.com)
  • Despite the presence of neutrophil extracellular traps (NETs) in inflamed colon has been confirmed, the role of NETs, especially the circulating NETs, in the progression and thrombotic tendency of inf. (bioportfolio.com)
  • Markers of endothelial cell activation and neutrophil extracellular traps are elevated in immune thrombocytopenia but are not enhanced by thrombopoietin receptor agonists. (bioportfolio.com)
  • Effective decellularization uses agents that lyse cells and remove all cellular materials, leaving intact collagenous extracellular matrices (ECMs). (aiche.org)
  • The Gordon Research Conference (GRC) on Signal Transduction by Engineered Extracellular Matrices was established in 2000 to enhance the intersection of bioengineering and cell biology with an aim to foster translation of cell-based technologies into practice. (grc.org)
  • This GRC will be held in conjunction with the "Signal Transduction by Engineered Extracellular Matrices (GRS)" Gordon Research Seminar (GRS). (grc.org)
  • Today I'd like to talk about several of the extracellular matrices, ECM in mammalian skin. (hstalks.com)
  • Surprisingly, we found that activated neutrophils but not naïve cells made prominent extracellular structures (arrows, Fig. 1, B and D ). These fibers, or NETs, were very fragile, and specimens had to be washed and fixed carefully to preserve them. (sciencemag.org)
  • In an effort to seek new treatments that would improve survival, CHOP researchers developed a treatment that targets NETs, extracellular webs of DNA that are released during infection as part of the body's inflammatory response. (news-medical.net)
  • The abstract deadline for the Keystone Meeting on The Extracellular Matri= x of Plants: Molecular, Cellular and Developmental Biology HAS BEEN EXTENDED to November 20, 1995. (bio.net)
  • Technological advances in genomics, proteomics, and imaging of extracellular proteolytic systems will be presented. (grc.org)
  • Chimeric and mutational studies indicate that high-affinity binding of [ 3 H]AS to dog NPC1L1 depends on molecular determinants present in a 61-aa region of a large extracellular domain (loop C), where Phe-532 and Met-543 appear to be key contributors. (pnas.org)
  • Qin and colleagues 4 have discovered that ATP7A plays an important role in the regulation of extracellular superoxide dismutase (EC-SOD) activity and the influence that altered steady-state concentrations of the substrate for EC-SOD, superoxide (O 2 ·− ), has on vascular NO signaling. (ahajournals.org)
  • Biological properties of extracellular vesicles and their physiological functions. (nature.com)
  • In biological samples, such as urine the extracellular vesicles may be diluted to a large extent. (news-medical.net)
  • The GRC on Plasminogen Activation and Extracellular Proteolysis presents breakthrough findings on the biological functions of these proteases and discusses their translational importance in key scientific areas: aging, cardiovascular diseases and angiogenesis, neurological and neuropsychiatric diseases, cell death, inflammation, infection, tissue homeostasis and regeneration, tumor biology, and renal function. (grc.org)
  • Our objective was a longitudinal comparison of osteoblastic behavior on different materials, in terms of mineralization volume and actin cytoskeleton status, associated with the proteomic analysis of the extracellular matrix. (usp.br)
  • The Extracellular RNA Communication (ERC) program is working to understand exRNA biology and accelerate development of exRNAs as potential therapeutics and diagnostics. (nih.gov)
  • The exRNA program was approved for continuation in 2019 and focuses tool and technology development to address major roadblocks to understanding exRNAs, including better understanding of the larger complexes like Extracellular Vesicles (EVs) that carry exRNA through the body. (nih.gov)
  • This funding opportunity announcement proposes to develop reference profiles for non-coding regulatory extracellular RNAs (exRNA) from healthy human blood and other body fluid samples such as saliva, urine, breast milk, semen, amniotic fluid, cerebrospinal fluid, ascites and pleural effusions. (nih.gov)
  • Recent advances in RNA sequencing technologies have identified a large and diverse population of extracellular RNA (exRNA) including microRNA and long non-coding RNA (lncRNAs). (nih.gov)
  • Membrane vesicles released in the extracellular space are composed of a lipid bilayer enclosing soluble cytosolic material and nuclear components. (nih.gov)
  • Increasing attention has been given to secreted extracellular vesicles (EVs) in the past decades, especially in the portrayal of their molecular cargo and role as messengers in both homeostasis and pathophysiological conditions. (frontiersin.org)
  • However, miRNAs can be detected in the circulation and in cerebrospinal fluid and are recognized by Toll-like receptor 7 (TLR7), and extracellular application of the miRNA let-7b triggers TLR7-mediated apoptosis of cortical neurons. (sciencemag.org)
  • In the present work, we performed a comprehensive classification of different extracellular circulating miRNA types. (bioinformatics.org)
  • C.-K. Park, Z.-Z. Xu, T. Berta, Q. Han, G.-C. Chen, X.-J. Liu, R.-R. Ji, Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. (sciencemag.org)
  • The conclusion is that the time course of dopamine within the extracellular space of the VTA is dependent on both diffusion and reuptake, whereas the activation of D 2 receptors on dopamine neurons is primarily limited by reuptake. (jneurosci.org)
  • QIAGEN provides a broad range of assay technologies for extracellular matrix and adhesion molecule research that enable analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • During studies of alginate biosynthesis in P. aeruginosa , we discovered that the majority of the extracellular material that reacted in the carbazole colorimetric assay was not exopolysaccharide but DNA [as determined by its peak absorbance at 260 nm, by electrophoretic display, and by its deoxyribonuclease (DNase) but not ribonuclease sensitivity] and therefore hypothesized that this DNA may play a functional role in P. aeruginosa biofilms. (sciencemag.org)
  • miRNAs circulate in the bloodstream in a highly stable, extracellular form, thus they may be used as blood-based biomarkers for cancer and other diseases. (bioinformatics.org)
  • Neutrophils also degranulate, releasing antimicrobial factors into the extracellular medium ( 3 ). (sciencemag.org)
  • Neutrophils were activated with 10 ng of IL-8 for 30 min and stained for neutrophil elastase ( A ), DNA ( B ), and the complex formed by H2A-H2B-DNA ( C ). Extracellular fibrous material is stained brightly. (sciencemag.org)
  • This meeting will present and debate the latest developments in our understanding of the biochemistry that underpins extracellular electron transfer. (rsc.org)
  • By establishing a Tamoxifen (Tx) inducible knockout mouse, we have demonstrated that the extracellular matrix glycoprotein fibronectin (Fn), activates critical survival signals via ß1 integrin following myocardial infarction (1). (uni-heidelberg.de)
  • apoptotic blebs (50 nm−2 μm), oncosomes (1-10 μm), and other EV subsets, as reviewed by the International Society of Extracellular Vesicles (ISEV, www.isev.org ). (frontiersin.org)
  • The course is organized in collaboration between the International Society for Extracellular Vesicles (ISEV), University of California Irvine (USA), University of Gothenburg (Sweden) and Pohang University of Science and Technology (South Korea). (coursera.org)
  • Human immunodeficiency virus (HIV) induces infected lymphocytes to synthesize an extracellular mesh that contains viral particles, and protects them against the immune system and antiretroviral drugs. (pasteur.fr)
  • Specifically, EZE binding to an extracellular site distinct from where cholesterol binds prevents conformational changes in NPC1L1 that are necessary for the translocation of cholesterol across the membrane. (pnas.org)
  • Scientists led by joint senior authors David Holtzman and Marc Diamond at Washington University in St. Louis, Missouri, screened a panel of tau antibodies and identified those that appear to specifically interfere with tau's extracellular spread from neuron to neuron. (alzforum.org)