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MoxalactamCephamycinsbeta-LactamasesCephalosporinsEnterobacteriaceae InfectionsCefotaximeMicrobial Sensitivity TestsEnterobacteriaceaeAnti-Bacterial AgentsKlebsiella pneumoniaebeta-Lactam Resistancebeta-LactamsKlebsiella InfectionsCeftazidimeCefoperazoneCephalosporin ResistanceMacauDrug Resistance, Multiple, BacterialSerratia InfectionsGram-Negative BacteriaEscherichia coli InfectionsGram-Negative Bacterial InfectionsCross InfectionEnterobacter cloacaeEscherichia coliDrug Resistance, BacterialCefoxitinIndiaCefazolinMeningitisBacteremiaHospitalsBacteriaLactamsImipenemCefotetanElectrophoresis, Gel, Pulsed-FieldBacterial InfectionsDrug Resistance, MicrobialBacterial ProteinsTobramycinCefamandolePuerperal InfectionCefmenoximeCephalosporinaseBacteroides fragilisPiperacillin

ImipenemESBLBroad-spectrumResistantColiActivityCephalosporins

Imipenem6

• Crystal structure of the extended-spectrum β-lactamase BEL-1, in native form and in complex with imipenem and moxalactam. (unisi.it)
• This enzyme is efficiently inhibited by clavulanate, imipenem and moxalactam. (unisi.it)
• Crystals of BEL-1 were obtained at pH 5.6, and subsequently soaked with imipenem and moxalactam for 30-60 min. (unisi.it)
• The structure of BEL-1, in the native form and in complex with imipenem and moxalactam, was obtained at 1.6-1.9-angstroms resolution. (unisi.it)
• In the acyl-enzyme complexes with imipenem and moxalactam, the C6 α-substituent interacts with conserved residue Asn-132. (unisi.it)
• The structure of BEL-1 in complex with imipenem and moxalactam shows an important variation in the conformation adopted by the omega-loop. (unisi.it)

ESBL2

• Activity is retained against most isolates that produce high-level AmpC β-lactamases (cephalosporinases) and clavulanic-acid-inhibited extended-spectrum β-lactamases (ESBL) ( 1 ). (cdc.gov)
• Those enzymes are called extended-spectrum β-lactamase (ESBL) and they are usually represented by TEM-52. (biomedcentral.com)

Broad-spectrum1

• The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. (lookformedical.com)

Resistant1

• The E. coli CO strain was resistant to extended-spectrum cephalosporins, cefoxitin, and moxalactam. (cdc.gov)

Coli1

• Incidence of multidrug resistance (MDR) is not uniform across the phylogenetic spectrum of E. coli. (bvsalud.org)

Activity2

• Crystal structure of Mox-1, a unique plasmid-mediated class C β-lactamase with hydrolytic activity towards moxalactam. (kanagawa-u.ac.jp)
• Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria , including many multiresistant strains. (lookformedical.com)

Cephalosporins2

• The E. coli CO strain was resistant to extended-spectrum cephalosporins, cefoxitin, and moxalactam. (cdc.gov)
• They conferred resistance to amoxicillin and ticarcillin, whereas pCO-1 conferred additional resistance to extended-spectrum cephalosporins ( Table ). (cdc.gov)