Expression significantly more accumulation. Medical search. Frequent questions

OBJECTIVE In severely obese individuals and patients with diabetes, accumulation and activation of macrophages in adipose tissue has been implicated in the development of obesity-associated complications, including insulin resistance. (bioinbrief.com)
adipose tissue expression of plasminogen activator inhibitor type-1 (PAI-1) and CD11 antigen-like family member C (CD11c), markers produced by macrophages, were negatively correlated with adjusted glucose disposal rate (= ?0.28, = 0.05 and = ?0.31, = 0.03). (bioinbrief.com)
In addition, we investigated the relationship of ATMc and subcutaneous adipose tissue expression of genes potentially involved in attraction of macrophages into adipose tissue. (bioinbrief.com)
Moreover, I3C exerts anti-obesity effects by reducing body weight and fat accumulation in epididymal adipose tissue in HFD-induced obese mice and thereby improves hyperglycemia and hyperinsulinemia [126]. (researchgate.net)
This research questions the contribution of lipid droplet accumulation in adipose tissue macrophages in obesityinduced inflammation and metabolic disfunction. (wur.nl)
We recently showed that the severity of histological liver lesions related to obesity increases with the amount of macrophage accumulation in visceral adipose tissue (VAT), while no association was found with the subcutaneous adipose tissue (SAT). In the abdominal region, SAT is anatomically divided into two layers, i.e. superficial (sSAT) and deep (dSAT). (nih.gov)

The increased intestinal permeability was accompanied by augmented expression of genes marking immune cell infiltration and encoding key proteins for immune cell adhesion, antigen presentation, and cytokine signaling in the orbital tissue. (frontiersin.org)
The expression of 459 circRNAs was determined to be distinct from the expression of linear RNAs from the same host genes, demonstrating host gene independence of circRNA age-accumulation. (ox.ac.uk)
Previously, our in silico analyses identified four candidate genes that might be involved in uptake and/or accumulation of arsenics in plants: arsenate reductase 2 ( ACR2 ), phytochelatin synthase 1 ( PCS1 ) and two multi-drug resistant proteins ( MRP1 and MRP2 ) [Lund et al. (diva-portal.org)
In order to enhance berry coloration of bright-red grape cultivars, the effects of abscisic acid (ABA) treatment on the quantity and composition of anthocyanins as well as the expression of genes related to flavonoid biosynthesis in the berry were examined. (scirp.org)
Gene expression studies performed on PPARα null mice have shed light into a variety of genes regulated by PPARα. (wur.nl)
We analyzed twenty fecal samples taken from four premature infants (4-6 time points from each infant), and found significantly higher diametric ratios of genes associated with low oxygen levels in samples of infants later diagnosed with NEC than in samples without NEC. (osti.gov)
The genes Cs RafS1 and CsGolS1 showed similar or greater expression in one of the transgenic lines with respect to control plants. (springer.com)
In this study, Cara cara navel orange fruit at four development stages were used to identify the key genes and TFs for carotenoids and flavonoids accumulation. (researchsquare.com)
Furthermore, 15/15 candidate TFs might regulate at least three key genes and contribute to carotenoids/flavonoids accumulation in CNO fruit. (researchsquare.com)
Collectively, our results suggest that DXS1 , DXR , GGPPS2 , PSY1 and LCYB genes were the most important genes for carotenoids accumulation, while PAL-1 , PAL-4 , 4CL-2 , 4CL-5 , CHS-1 and CHI for flavonoids biosynthesis. (researchsquare.com)
In addition, they also interfere with the expression of regulator genes, CHOP , ATF4 , and XBP , which further alters lipid metabolism and autophagy. (medscape.com)

The influx of macrophages and accumulation of T-cells and myofibroblast were quantified in orbital connective tissue. (frontiersin.org)
However the adipocyte may be the determining cell of adipose tissues and does donate to the creation of inflammatory substances (7), it would appear that macrophages donate to the inflammatory indicators that are induced by weight problems (5 significantly,8C11). (bioinbrief.com)
Among the inflammatory elements whose expression is certainly upregulated in adipose tissues using the starting point of weight problems, some have already been implicated in recruitment of macrophages to adipose tissues, including chemokines, BIX 02189 ic50 while some seem to be derived mainly from adipose tissues macrophages (ATMs). (bioinbrief.com)
APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice. (omicsdi.org)
With impaired reverse cholesterol transport, lipid accumulation occurs and macrophages morphologically transform into foam cells, releasing inflammatory factors. (omicsdi.org)
Kidney, spleen, and bone marrow-derived macrophages from APOL1-G1 and -G2 mice showed increased cholesterol accumulation and decreased ABCA1 and ABCG1 mRNA levels. (omicsdi.org)
BM-derived macrophages from APOL1-G1 and -G2 mice showed significantly reduced cholesterol efflux compared to WT or APOL1-G0 macrophages. (omicsdi.org)
In diet-induced obese mice, HILPDA deficiency in macrophages markedly reduced lipid accumulation in macrophages yet it did not alter any measured inflammatory or metabolic parameters. (wur.nl)
Treatment with the ATGL inhibitor Atglistatin rescued lipid accumulation inside lipid droplets in HILPDA-deficient macrophages. (wur.nl)
The abundance of macrophages in dSAT, but not in sSAT, was significantly increased in patients with non-alcoholic steatohepatitis (NASH) and/or fibroinflammatory hepatic lesions. (nih.gov)
Sivelestat significantly inhibited the increase in lung collagen content, fibrotic changes, the numbers of total cells (including macrophages, neutrophils and lymphocytes), the levels of the active form of TGF-β1 and phospho-Smad2 in bleomycin-induced early-stage pulmonary fibrosis. (ersjournals.com)
We extracted gene expression profiles from mouse macrophages from the GEO dataset, GSE152795 using the GEO2R webtool. (degruyter.com)

We first asked whether a cell-autonomous mechanism could contribute to exhaled biomarkers, so we began by searching for thematic differences in metabolic gene expression between EAC and relevant control tissue in archived transcriptomic datasets. (nature.com)
To understand the dynamics of bacterial growth physiology and size control in dynamic nutrient environments, we have developed a coarse-grained proteome sector model which connects gene expression to growth rate and division control, and accurately predicts the cell-level E. coli response to nutrient perturbations in both exponential and stationary phase seen in experimental data 5 , 25 . (nature.com)
Second and third, they can be analyzed by standard Gene expression techniques, or surveyed using SAGE. (wikipedia.org)
In human monocyte THP-1 cells, transient overexpression of ApoL1 (G0, G1, G2) by transfection resulted in a 5- to 11-fold increase in CD14 and CD68 gene expression, similar to that seen with phorbol-12-myristate acetate treatment. (omicsdi.org)
Notably, we discovered that the gene expression that is related to beta-glucosidase and endoglucanase was up-regulated in fruits. (uibk.ac.at)
In addition, defense-related gene expression and metabolite accumulation were significantly down-regulated in infected fruits. (uibk.ac.at)
Large scale gene expression analysis was performed to identify the pathways that discriminate sSAT from dSAT. (nih.gov)
Aberrant accumulation of TMEM43 accompanied by perturbed transmural gene expression in arrhythmogenic cardiomyopathy. (nih.gov)
Manipulation of UPR markers has been made possible by the use of knockout mice, pharmacological agents, and viral vector-mediated augmentation of gene expression. (molvis.org)
Additionally, adeno-associated virus-mediated gene delivery is a safe and effective method for modulating gene expression, and thus is a useful research tool for manipulating individual UPR markers in affected retinas and a promising delivery vector for gene therapy in retinal degenerative disorders. (molvis.org)

Angiogenesis was estimated by determining the wet weight of sponge tissues and the expression of proangiogenic factors including CD31, vascular endothelial growth factor (VEGF), and transforming growth factor β (TGF-β) in granulation tissues. (iiarjournals.org)
These findings suggest that the exceptional stability of circRNAs might explain age-accumulation trends observed from neural tissues of other organisms, which also have a high composition of post-mitotic cells. (ox.ac.uk)
Excessive triglyceride accumulation in lipid-metabolizing tissues is associated with an increased risk of a variety of metabolic diseases. (elsevierpure.com)
Our results suggest that the habitual intake of Kampo-containing PN contributes to the prevention of the onset of metabolic diseases by decreasing the excessive accumulation of triglycerides in lipid-metabolizing tissues. (elsevierpure.com)
Immunofluorescence and immunohistochemical staining were used to detect the expression of P-gp in DLBCL cells and tissues. (greenmedinfo.com)

Chronic exposure to IL-1β induces only partial expression of senescence markers and does not allow us to conclude on its ability to induce senescence in chondrocytes. (aging-us.com)
On the other hand, etoposide treatment reliably induces DNA damage-related senescence in human articular chondrocytes evidenced by loss of proliferative capacity, DNA damage accumulation, and expression of some SASP components. (aging-us.com)
Hilpda overexpression in turn induces triglyceride accumulation inside lipid droplets. (wur.nl)

In a small, interventional study, the subcutaneous expression of CD68, a macrophage marker, correlated with insulin resistance (10). (bioinbrief.com)
Taken together, the evidence suggests that APOL1-G1 and -G2 risk variants impaired reverse cholesterol transport through decreased expression of cholesterol efflux transporters suggesting a possible mechanism to promote macrophage foam cell formation, driving inflammation in the glomerulus and renal interstitium. (omicsdi.org)
In Phorbol 12-myristate 13-acetate stimulated THP-1 cells, orizabin suppressed macrophage differentiation, CD36 expression (1% at 10 μM), and NFκB transcriptional activity. (elsevierpure.com)
However, expression of macrophage/inflammatory markers and fibrosis were not different between HILPDA knockout and floxed mice. (wur.nl)
dSAT displayed an intermediate level of macrophage accumulation between sSAT and VAT. (nih.gov)

Niemann-Pick type C1 (NPC1) disease is a rare neurovisceral disorder characterized by intracellular accumulation of unesterified cholesterol, sphingolipids, and other lipids in the lysosomal compartment. (jneurosci.org)
AGT1, encoding an alpha-glucoside transporter involved in uptake and intracellular accumulation of trehalose in Saccharomyces cerevisiae. (insa-toulouse.fr)

demonstrated that RSV prevented high glucose-induced kidney mesangial cell proliferation and fibronectin expression through inhibition of high glucose-induced JNK and NF- B activation, NADPH oxidase activity elevation, and reactive oxygen species production [ 10 ]. (hindawi.com)
Furthermore, all transgenic lines exhibited significantly less accumulation of reactive oxygen species than WT plants. (springer.com)

Similarly, in diet-induced NASH mice, HILPDA hepatocyte deficiency modestly yet significantly reduced liver triglyceride accumulation and plasma ALT levels. (wur.nl)

5 μg/ml of BEs was enough to suppress lipid accumulation in the fatty liver model of the mouse hepatic AML12 cells. (nih.gov)
When the mice were fed supplemented with BEs (5% or 10%, w/w), hepatic steatosis, injury, and hypercholesterolemia/hyperglycemia were significantly improved. (nih.gov)
Hepatic lipid accumulation was also significantly reduced in caffeine treatment larvae. (biomedcentral.com)
WD is a rare, autosomal recessive inherited disorder of copper metabolism causing toxic hepatic and neural copper accumulation, according to the article. (medscape.com)

Cholesterol content, cholesterol efflux, and ABCA1 and ABCG1 mRNA expression were measured. (omicsdi.org)
Orizabin significantly inhibited the adhesion of THP-1 cells to human umbilical vein endothelial cells (HUVECs) and suppressed the mRNA expression of adhesion molecules in HUVECs. (elsevierpure.com)
BVRA KO cells exhibited increased levels of ROS generation and decreased levels of superoxide dismutase mRNA expression. (uky.edu)
The total TGF-β1 levels and relative changes of TGF-β1 mRNA expression, however, were not decreased significantly by sivelestat. (ersjournals.com)

Results: Angiogenesis was suppressed in mPGES-1 −/− mice compared with WT mice, which was associated with attenuated forkhead box P3 (Foxp3) expression and Foxp3 + Treg accumulation. (iiarjournals.org)
Neutralizing Tregs with antibodies (Abs) against CD25 or folate receptor 4 (FR4) inhibited the Foxp3+ Treg angiogenesis and accumulation in WT mice, but not in mPGES-1 −/− mice. (iiarjournals.org)
The topical application of PGE 2 into the implanted sponge enhanced angiogenesis and accumulation of Tregs expressing TGFβ and VEGF in WT and mPGES-1 −/− mice. (iiarjournals.org)
Expression of interferon gamma (IFN-γ) via plasmid tail vein injection results in upregulation of APOL1 protein levels together with robust induction of heavy proteinuria and glomerulosclerosis in G1/G1 and G2/G2 but not G0/G0 mice. (omicsdi.org)
Studies using additional mice (multicopy G2 and a non-isogenic G0 mouse) supported the notion that disease is largely a function of the level of risk variant APOL1 expression. (omicsdi.org)
In this study, administration of clinically relevant doses of FTY720 to mice increased expression of NPC1 and -2 in brain and liver and decreased cholesterol in an SphK2-dependent manner. (ox.ac.uk)
DIM also improved diabetic nephropathy by inhibiting the expression of PKC-α, the marker of albuminuria, and TGF-β1, an indicator of renal hypertrophy, in diabetic mice. (researchgate.net)
Additionally, immunohistochemistry results indicated that RSV treatment reduced the density of proliferating cell nuclear antigen-positive cells significantly in glomeruli of diabetic mice. (hindawi.com)
The researchers also examined the effect of PUFA-enriched oils on muscle PPARdelta expression in mice. (naturalnews.com)
With regard to PPAR-delta expression in the muscles, mice who ate a CSO-enriched diet displayed no changes in expression. (naturalnews.com)
When researchers performed metabolic analyses, they found that the livers of CSO-fed mice also did not differ from those of the chow-fed mice, but both significantly differed from the livers of SFA-fed mice and linoleic acid-fed mice. (naturalnews.com)
In C57BL/6 mice exposed to SWCNT, pulmonary toxicity was associated with a dose-dependent augmentation of biomarkers of cell injury and oxidative stress quantified by cell counts, total protein, lactate dehydrogenase and g-glutamyltranspeptidase activities, reduced level of GSH, total antioxidant reserve along with the accumulation of lipid peroxidation products found in bronchoalveolar lavage (BAL) fluid and in the lung. (cdc.gov)
In mice maintained on vitamin E deficient diet, SWCNT significantly enhanced collagen deposition as compared to the vitamin E sufficient group. (cdc.gov)
Overall, our data suggest that pharyngeal aspiration of SWCNT elicited a robust acute inflammatory response with early onset of progressive pulmonary fibrosis whose expression and severity was associated with the intensity of oxidative stress in the lung of the exposed C57BL/6 mice. (cdc.gov)

We studied the effect of bilberry ( Vaccinium myrtillus L.) fruits extracts (BEs) on the pathogenesis caused by lipid accumulation in fatty liver and non-alcoholic steatohepatitis (NASH). (nih.gov)
It is estimated that approximately 20-30 % of adults and 3-10 % of children in western countries suffer from excessive fat accumulation in the liver [ 1 ]. (biomedcentral.com)
Because of the advantage of transparent body in juvenile period suitable for identifying lipid accumulation in liver by whole-mount oil red O staining, in present study we attempted to determine whether juvenile zebrafish can be used as a model for diet-induced NAFLD. (biomedcentral.com)
The researchers believe that because it contains DHSA, CSO can be used to increase PPAR-delta expression and lower liver stearoyl-CoA desaturase-1 activity to prevent liver disease. (naturalnews.com)

A massive accumulation of circRNAs during aging was uncovered. (ox.ac.uk)
C3 was required to maintain autophagy activity in β cells, as evidenced by the massive accumulation of LC3-II puncta, indicating that in the absence of C3 autophagosomes do not fuse with lysosomes. (lu.se)

This chapter compares the physiological and molecular mechanisms of Fe, Zn, Cd, and Pb uptake, mobilization, and accumulation in rice and discusses the progress and strategies for not only increasing Fe/Zn but also decreasing Cd/Zn accumulation in rice. (intechopen.com)
Fat accumulation in muscle negatively impacts insulin-mediated glucose uptake. (biomedcentral.com)
Its uptake is largely dependent on the expression of AGT1, which encodes an alpha-glucoside transporter. (insa-toulouse.fr)
DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)

Further, we found that the cytokine interferon-β (IFN-β) can induce miR-1 expression in mammalian cells, reducing TBC1D15 levels, and safeguarding against proteotoxic challenges. (elifesciences.org)
The study found significant cytokine accumulation during 5 days of storage time in leukocyte contaminated platelet concentrates, suggesting that the platelet storage time has an effect on IL-2R levels. (who.int)
We undertook this study to investigate receptor (IL-2R) accumulation is related to whether the cytokine accumulation in PCs the leukocyte content of the platelet comc obtained from single apheresis donors was ponent and can be reduced by prestorage beyond the acceptable limits of WBC conc leukocyte depletion [ 3 ]. (who.int)

In conclusion, our data demonstrate a critical role for BVRA in protecting against lipid accumulation and oxidative stress in hepatocytes, which may serve as a future therapeutic target for NAFLD and its progression to NASH. (uky.edu)

CONCLUSIONS: We attribute the global scale of circRNA age-accumulation to the high composition of post-mitotic cells in adult C. elegans, coupled with the high resistance of circRNAs to decay. (ox.ac.uk)

SnCs exhibit irreversible growth arrest accompanied by increased expression of cyclin-dependent kinase inhibitors (CDKi) such as p16 INK4a , and p21 Cip1 , accumulation of DNA damages, and secretion of diverse bioactive molecules known as the senescence-associated secretory phenotype (SASP). (aging-us.com)
In paper II, we showed that silencing of CD59 expression in rat β cells significantly suppressed insulin secretion. (lu.se)

We show that CGS21680 raises lysosomal calcium levels and rescues mitochondrial functionality (mitochondrial inner membrane potential and expression of the complex IV of the mitochondrial respiratory chain), which is compromised in NPC1 cells. (jneurosci.org)
Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. (biomedcentral.com)
However, the role of mitofusion-2 (MFN2), a key factor in mitochondrial function and energy metabolism, in skeletal muscle lipid intermediate accumulation remains to be elucidated. (biomedcentral.com)
The loss of BVRA resulted in the reduction of mitochondria number, decreased expression of markers of mitochondrial biogenesis, uncoupling, oxidation, and fusion, which paralleled reduced mitochondrial oxygen consumption. (uky.edu)

Moreover, serum LBP levels significantly correlated with the abundance of specific Gram-negative gut bacteria, linking the gut to local orbital inflammation. (frontiersin.org)
Our findings presented that T. diversifolia-derived compound orizabin specifically contributes to the promotion of PTEN expression and suppression of Akt signal in cells, and acts to suppress inflammation by suppression of NFκB transcriptional activity. (elsevierpure.com)
Markers of pulmonary cytotoxicity corresponded to early development of acute inflammation, collagen accumulation, and progressive fibrosis. (cdc.gov)

Several hallmarks of cellular senescence, such as cell cycle arrest, expression of cyclin-dependent kinase inhibitors, DNA damages, and senescence-associated secretory profile were evaluated. (aging-us.com)

We found that expression of both IRIS-1 and IRIS-2 is markedly reduced in islets isolated from T2D patients compared to healthy controls, suggesting that hyperglycaemia may be one of the factors resulting in reduced IRIS-1 and IRIS-2 expression in T2D individuals. (lu.se)

Lipohypertrophy in this syndrome is characterized by the presence of an enlarged dorsocervical fat pad, circumferential expansion of the neck, breast enlargement, and abdominal visceral fat accumulation. (medscape.com)

Theoretically, a decrease in fatty acid β-oxidation can lead to lipid accumulation. (biomedcentral.com)
In hepatoma cell lines, fatty acids increase Hilpda expression and protein levels. (wur.nl)
They hypothesized that increasing polyunsaturated fatty acid (PUFA) intake would increase peroxisome proliferator-activated receptor delta (PPAR-delta) expression and activity. (naturalnews.com)

BVRA activity and protein levels were significantly lower in BVRA KO vs. wild-type (WT) hepatocytes. (uky.edu)
We observed that human hepatocytes exhibited excessive lipid accumulation. (wur.nl)

Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder caused by mutations in NPC1 or NPC2 with decreased functions leading to lysosomal accumulation of cholesterol and sphingolipids. (ox.ac.uk)

Molecular, physiological, and quantitative real-time analyses showed high expression of AtCBF3 in three selected transgenic lines. (springer.com)

Finally, CGS21680 reduces cholesterol accumulation (Filipin III staining), which is the main criterion currently used for identification of a compound or pathway that would be beneficial for NPC disease, and such an effect is prevented by the Ca 2+ chelator BAPTA-AM. Our findings strongly support the hypothesis that A 2A R agonists may represent a therapeutic option for NPC1 and provide insights on their mechanisms of action. (jneurosci.org)
FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts. (ox.ac.uk)

As primary endpoints for PH-797804 efficacy, we evaluated protein levels of selected ISG and differences in expression of surface and intracellular molecules linked to immune activation and inflammatory cytokines plasma levels. (natap.org)
The p38 MAPK inhibitor used here, already in clinical trials for other inflammatory diseases, significantly reduced immune activation during ART and further reduced SIV-mediated immune system deterioration. (natap.org)

Furthermore, levels of antibodies to matrilin 1, an extracellular matrix protein predominantly expressed in tracheal cartilage, were significantly higher in patients with relapsing polychondritis, especially in those with respiratory symptoms, than in patients with Wegener granulomatosis , systemic lupus erythematosus , or RA and in healthy controls. (medscape.com)

The major splice variant of human 5-aminolevulinate synthase-2 contributes significantly to erythroid heme biosynthesis. (medlineplus.gov)

A high-fat diet resulted in insulin resistance as well as accumulation of cytosolic lipid intermediates and down-regulation of MFN2 and CPT1 in skeletal muscle in rats, while MFN2 overexpression improved insulin sensitivity and reduced lipid intermediates in muscle, possibly by upregulation of CPT1 expression. (biomedcentral.com)
MFN2 overexpression can rescue insulin resistance, possibly by upregulating CPT1 expression leading to reduction in the accumulation of lipid intermediates in skeletal muscle. (biomedcentral.com)
The hypothesis that insulin resistance is related to lipid accumulation in muscle dates back to studies reported 15-20 years ago showing that triglycerides accumulate in muscle in rats fed a high-fat diet, which is coincident with insulin resistance. (biomedcentral.com)
Since then the relevance of muscle lipid accumulation to insulin resistance in humans has been demonstrated, and basic studies have indicated plausible mechanisms whereby lipid accumulation could generate insulin resistance [ 5 ]. (biomedcentral.com)

In vitro , RSV attenuated high glucose-induced plasminogen activator inhibitor (PAI-1) expression and mesangial cell proliferation, as well as Akt and nuclear factor-kappa B (NF- κ B) activation. (hindawi.com)

Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival. (elifesciences.org)
It is believed that the neuropathogenesis of this disease may be triggered by the accumulation of toxic amyloid in the central nervous system (CNS). (hyperthermicwellness.com)

FTY720 greatly increased expression of NPC1 and -2 in human NPC1 mutant fibroblasts that correlated with formation of FTY720-P and significantly reduced the accumulation of cholesterol and glycosphingolipids. (ox.ac.uk)

There may be multiple metabolic causes for increased cytosolic lipid accumulation in muscle in insulin-resistant states. (biomedcentral.com)

afterward, we further revealed the most possible target gene SQUAMOSA promoter binding-like transcription factor 7 (SPL7) and it negatively regulates Nramp5 expression, which in turn regulates Cd metabolism . (bvsalud.org)
Taken together, the decreased amount of jasmonic acid, coupled with the reduced accumulation of phenylpropanoid and the increased proliferation of indole-3-acetic acid, salicylic acid, and abscisic acid, compared to leaf midribs, may contribute largely to the enrichment of CLas in fruit piths, resulting in disorders of photosynthesis and starch and sucrose metabolism. (uibk.ac.at)

This prompted us to investigate if mir-1 is required for preventing the accumulation of aggregation-prone proteins. (elifesciences.org)
We also found that MC and PN were responsible for the anti-adipogenetic effect of KSS and significantly suppressed the expression of CCAAT/enhancer-binding proteins-δ (C/EBP-δ) mRNA 3 days after the induction of differentiation. (elsevierpure.com)
These conditions include but are not limited to artery or vein occlusion in diabetic retinopathy, hypoxic retina in retinopathy of prematurity, aging in age-related macular degeneration, expression of mutant proteins in inherited retinal degeneration, traumatic injury leading to retinal detachment, and light sensitivity in the case of light-induced retinal degeneration. (molvis.org)
Accumulation of unfolded proteins in the ER lumen triggers the dissociation of GRP78 from its quiescent UPR mediators. (molvis.org)

GO patients displayed significantly higher LBP serum concentrations than healthy controls. (frontiersin.org)
We found that IRIS-1 expressing cells displayed significantly higher expression levels of Urocortin 3 and Pdx 1 (markers of mature β cells, which loss marks the beginning of β cells dedifferentiation), suggesting that IRIS-1 may be required for maintaining β cells identity and function. (lu.se)

Identifying key regulators related to cadmium (Cd) tolerance and accumulation is the main factor for genetic engineering to improve plants for bioremediation and ensure crop food safety . (bvsalud.org)
Together, these results suggest the potential for heterologous expression of the AtCBF3 gene to mediate tolerance to hydric and saline stress in citrus plants. (springer.com)

Taken together, these results suggest that PN suppresses C/EBP-δ expression by inhibiting Dex-induced GR promoter activity at the early stage of differentiation and, consequently, delays differentiation into mature adipocytes. (elsevierpure.com)
Our results demonstrated that melatonin inactivates the NF-κB pathway and downregulates the expression of P-gp, ultimately sensitizing DLBCL cells to the epirubicin that suppresses their growth. (greenmedinfo.com)
Lysosomal storage diseases describe a heterogeneous group of dozens of rare inherited disorders characterized by the accumulation of undigested or partially digested macromolecules, which ultimately results in cellular dysfunction and clinical abnormalities. (medscape.com)

Cadmium induced a non-coding RNA microRNA535 mediates Cd accumulation in rice. (bvsalud.org)

CD45RA+ CD27- CD4+ T cells have significantly reduced CD28, interleukin-7 receptor alpha (IL-7R alpha) and Bcl-2 expression, Akt (ser473) phosphorylation and reduced ability to survive after T-cell receptor activation compared with the other T-cell subsets in the same donors. (figshare.com)

Many hundreds of circRNAs were significantly increased among the aging time-points and increases of select circRNAs by over 40-fold during aging were quantified by RT-qPCR. (ox.ac.uk)
Thus, increases in the total amount and composition ratios of petunidin- and malvidin-type anthocyanins were mainly caused by ABA-induced upregulation of uridine diphosphate glucose flavonoid glucosyl transferase , glutathione S-transferase 4, O-methyl transferase and flavonoid 3', 5' hydroxylase expression, resulting in the deep coloration of berry of skin. (scirp.org)
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway. (greenmedinfo.com)

When combined with ART, numerous immune activation markers were significantly reduced compared to ART alone treatment. (natap.org)

Previous researches have shown that there are connections and discrepancies for metal absorption, translocation, and accumulation in rice. (intechopen.com)
In brown rice , the total Cd accumulation of OE535 and mir535 was about 78% greater and 35% lower than WT. (bvsalud.org)

CD38/HLA-DR and Ki-67 percentages in blood, lymph node and rectal CD4+ and CD8+ T cells and plasma levels of IFN-, IL-6, IL-8, and IP-10 were all significantly reduced. (natap.org)
Low hemoglobin levels and the resulting accumulation of iron in the body's organs lead to the characteristic features of X-linked sideroblastic anemia. (medlineplus.gov)

CD4+ memory T cells re-expressing CD45RA can be generated from the CD45RA- CD27+ population by the addition of IL-7 and during this process these cells down-regulated expression of IL-7R and Bcl-2 and so resemble their counterparts in vivo. (figshare.com)
Finally we showed that the proportion of CD45RA+ CD27- CD4+ T cells of multiple specificities was significantly higher in the bone marrow than the blood of the same individuals, suggesting that this may be a site where these cells are generated. (figshare.com)
KSS inhibited the accumulation of triglycerides in a dose-dependent manner in 3T3-L1 cells that were induced to differentiate into adipocytes. (elsevierpure.com)
This protein, localized to the plasma membrane of root stelar cells, has its expression reduced by salt or ABA, which are key predictions for a protein involved with loading Cl- into the root xylem. (edu.sa)
Further, melatonin synergized with epirubicin to promote the activation of the mitochondria-mediated apoptosis pathway and increased the accumulation of epirubicin in DLBCL cells by inhibiting the expression and function of P-gp. (greenmedinfo.com)
Epirubicin was subsequently discovered to upregulate the expression of P-gp by activating the NF-κB pathway in the DLBCL cells. (greenmedinfo.com)
When exposing the C3-knockout INS-1 cells to β cells autophagy inducers (palmitate and IAPP), we observed significantly increased cell death caused by autophagy insufficiency. (lu.se)

Heterologous expression of AtSLAH1 in Xenopus laevis oocytes led to no detectible transport, suggesting the need for post-translational modifications for AtSLAH1 to be active. (edu.sa)

Narirutin was the most abundant flavonoid in the flesh at the early stages, 60 DAF was the most important stage for the accumulation of flavonoids, and 17, 22, 14, 25, 24 and 16 TFs could potentially bind their promoters, respectively. (researchsquare.com)

In paper I, we revealed a high expression of C3 in human pancreatic islets. (lu.se)

Anatomy43

Organisms22

Diseases5

Chemicals and Drugs97

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Psychiatry and Psychology1

Phenomena and Processes65

Disciplines and Occupations1

Technology, Industry, Agriculture5

Information Science3

Health Care2

Adipose tissue6

Genes11

Macrophages12

Gene expression10

Tissues5

Induces3

Macrophage5

Intracellular accumulation2

Reactive Oxygen2

Triglyceride1

Hepatic4

MRNA expression4

Mice14

Liver4

Massive accumulation2

Uptake4

Cytokine3

Oxidative stress1

CONCLUSIONS1

Secretion2

Mitochondrial4

Inflammation3

Inhibitors1

Markedly reduced1

Visceral1

Fatty3

Hepatocytes2

Sphingolipids1

Transgenic1

Reduces cholesterol2

Inflammatory2

Extracellular1

Biosynthesis1

Insulin resistance4

Plasminogen activator1

Toxic2

Cholesterol1

Metabolic1

Metabolism2

Proteins4

Displayed significantly higher2

Tolerance2

Results3

Cadmium1

Receptor1

Increases3

Markers1

Rice2

Levels2

Cells7

Heterologous1

Flavonoid1

Pancreatic1