ToxicogeneticsGene Expression ProfilingCytokinesOligonucleotide Array Sequence AnalysisGene Expression RegulationGene ExpressionRNA, MessengerReverse Transcriptase Polymerase Chain ReactionGene Expression Regulation, PlantStress, PhysiologicalGene Regulatory NetworksGene Expression Regulation, FungalSignal TransductionCluster AnalysisTumor Necrosis Factor-alphaTranscription, GeneticInterleukin-6Inflammation MediatorsGenes, PlantInflammationInterleukin-1Time FactorsInterleukin-1betaTranscription FactorsCells, CulturedMolecular Sequence DataInterferon-gammaLipopolysaccharidesMice, Inbred C57BLInterleukin-8NF-kappa BMacrophagesInterleukin-10InterleukinsMice, KnockoutChemokinesDisease Models, AnimalMonocytesEnzyme-Linked Immunosorbent AssayMice, Inbred BALB CUp-RegulationCell LineChemokine CCL2Toll-Like Receptor 4Interleukin-4Anti-Inflammatory AgentsDendritic CellsImmunity, InnateToll-Like ReceptorsInterleukin-17Th2 CellsTh1 CellsInterleukin-12T-LymphocytesFlow CytometryInterleukin-1alphaLungBiological MarkersToll-Like Receptor 2Leukocytes, MononuclearDown-RegulationLymphocyte ActivationCell DifferentiationNitric Oxide Synthase Type IIApoptosisBlotting, WesternMice, TransgenicInterleukin 1 Receptor Antagonist ProteinReceptors, Interleukin-1Interleukin-18Macrophage ActivationEpithelial CellsMacrophages, PeritonealNeutrophilsCoculture TechniquesImmunohistochemistryMembrane GlycoproteinsNitric OxideGranulocyte-Macrophage Colony-Stimulating FactorTransforming Growth Factor betaCD4-Positive T-LymphocytesRecombinant Proteinsp38 Mitogen-Activated Protein KinasesReal-Time Polymerase Chain ReactionRats, Sprague-DawleyInterleukin-2Antigens, CDIntercellular Adhesion Molecule-1Endothelium, VascularCell ProliferationSynovial MembraneOncostatin MArthritis, RheumatoidInterleukin-13Th17 CellsReceptors, CytokineImmunologic FactorsFibroblastsSpleenDose-Response Relationship, Drug