• We used RNA sequencing coupled with chromatin immunoprecipitation sequencing to analyze primed microglial inflammatory gene expression and modifications to histone H3 lysine 4 trimethylation (H3K4me3) at the promoters of primed genes. (frontiersin.org)
  • They are encoded by separate but linked genes termed regulation of complement activation (RCA) genes, located on the q32 region of chromosome 1. (medscape.com)
  • Expression profiles analysis identifies the values of carcinogenesis and the prognostic prediction of three genes in adrenocortical carcinoma. (cancerindex.org)
  • Significantly differentially expressed (SDE) immunological genes and transcription factor (TF) were selected for functional pathways and transcriptional signaling identification. (frontiersin.org)
  • Poor clinical outcome was correlated with elevated HIF-1α and podoplanin expression whilst expression of inflammatory and complement genes was predictive of extended survival. (elifesciences.org)
  • While the sequencing of metagenomes provides an overview of the genes present in specific environments that can potentially play a role in adaptation, the analysis of expression provides a more precise picture of what functions are expressed and active in a particular moment of the environment. (biomedcentral.com)
  • The reduced expression of most of these genes in htz1Delta cells was reversed by the deletion of SIR2 (sir2Delta) suggesting that H2A.Z antagonizes telomeric silencing. (sdbonline.org)
  • The major event of MBT was the activation of a large group of histones and other genes that modify chromatin structure preceding massive gene expression changes. (biomedcentral.com)
  • Overexpression of the IGF-II/M6P receptor in mouse fibroblast cell lines differentially alters expression profiles of genes involved in Alzheimer's disease-related pathology. (nih.gov)
  • The expression of CRH-BP and CRH-R1 genes in the gills and in the skin is downregulated after both infection and restraint. (silverchair.com)
  • As a consequence, both factors are transported to the nucleus to induce the expression of their target genes. (hindawi.com)
  • Among the arterial genes were 8 transcription factors, including HEY2, a downstream target of Notch signaling and the current golden standard pathway for arterial EC specification. (refine.bio)
  • Each transcription factor had a different impact on gene regulation, with some stimulating only few and others boosting a large proportion of arterial genes. (refine.bio)
  • Continued studies focused on genes showing minimal changes in the TMA-induced model but with clear up-regulation in the ovalbumin model. (cdc.gov)
  • The major events in the regulation of the host response on a transcriptional level occur within the first 3 days after infection. (biomedcentral.com)
  • Finally, we established 3 groups of transcriptional models to describe Ly6C high to Ly6C low MC subset differentiation, immune checkpoint regulation, Ly6C high MC to MΦ subset differentiation and Ly6C low MC to lymphocyte functional adaptation. (frontiersin.org)
  • We propose a model in which association of NHR-67 with the Groucho/TCF complex suppresses the default invasive state in non-invasive cells, which complements transcriptional regulation to add robustness to the proliferative-invasive cellular switch in vivo . (elifesciences.org)
  • This valuable data study presents convincing data that expression of the C. elegans transcription factor NHR-67 is sufficient to drive an invasive fate, and that the alternative proliferative fate is associated with NHR-67 transcriptional down-regulation. (elifesciences.org)
  • Recent studies have revealed that variants of histone H2A and histone H3 play important roles not only in gene expression but also in the repair of DNA breaks and the assembly of chromosome centromeres. (sdbonline.org)
  • This integrated analysis led to the discovery of microenvironment-dependent and tumor-specific secretion of interleukin-32 beta (IL32β), whose expression was confirmed in situ within MCL lymph nodes by multiplex immunohistochemistry. (haematologica.org)
  • We highlighted that while IL32β-stimulated macrophages secreted several protumoral factors, they supported tumor survival through a soluble dialog, mostly driven by BAFF. (haematologica.org)
  • In contrast, inflammatory CAFs were dominant within tumor-distal subsets and expressed complement components and the Wnt-inhibitor SFRP2. (elifesciences.org)
  • The plasticity and heterogeneity of fibroblasts in the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) has emerged as a key factor in determining tumor growth and therapeutic response. (elifesciences.org)
  • An alcohol-induced increase of tumor necrosis factor (TNF) α, a pro-inflammatory cytokine, in the mouse brain is closely linked to neurodegeneration[ 4 ]. (wjgnet.com)
  • mechanistically, IRF8 directly regulated expression of ZBTB32, a transcription factor essential for the virus-specific NK cell proliferative burst 3 . (nature.com)
  • I have designed proof-of-concept experiments to validate this approach, including targeting of the transcription factor PDX1, followed by experiments designed to simultaneously target two regulatory elements of the key beta cell enzyme, PCSK1. (einsteinmed.edu)
  • Unraveling a novel transcription factor code determining the human arterial-specific endothelial cell signature. (refine.bio)
  • In particular, miR-23B, miR-93, miR-144, and miR-212 were found to play a role as NRF2 inhibitors, while miR-340 appears to have a role as an NRF1 and MAPK inhibitor with miR-383 and miR-510 having a less clear role in the regulation of NRF1 and NRF2 levels [ 7 ]. (hindawi.com)
  • Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs. (ouhsc.edu)
  • Angiopoietin-2 (ANG-2) is regulated by mechanical stress and is widely involved in the regulation of extracellular matrix metabolism. (bvsalud.org)
  • The following includes the top twenty Predicted Transcription Factors: DEPDC1B possesses 13 mRNA splice variants that form two isoforms. (wikipedia.org)
  • Even though the techniques for mRNA isolation and sequencing from metagenomic samples are still not able to provide comprehensive pictures of expression profiles, there have been important progresses in this direction and some interesting findings. (biomedcentral.com)
  • VDR mRNA levels were negatively correlated with SLEDAI-2 K (r = - 0.348, P = 0.001), Systemic Lupus International Collaborating Clinics (SLICC) renal activity scores (r = - 0.346, P = 0.014), and proteinuria (r = - 0.309, P = 0.002) and positively associated with serum complement C3 levels (r = 0.316, P = 0.002). (vitamindwiki.com)
  • Analysis from the Gene Expression Omnibus datasets supported the mRNA findings. (hindawi.com)
  • Furthermore, the miRNAs correlated negatively with the immunohistochemical expression of NRF1 and NRF2 but positively with their respective mRNA. (hindawi.com)
  • MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression by imperfect matching of mRNA [ 6 ]. (hindawi.com)
  • Moreover, alignment of cytokine mRNA expression from the cortex of these rats with a computational model of neuronglia interaction found that the moderate-severe TBI produced by the stainless-steel projectile strongly associated with the neuroinflammatory state, while the mild TBI existed in a state between normal and inflammatory neuronglia interactions. (cdc.gov)
  • We divide the field of genomics into genotyping (focused on the genome sequence), transcriptomics (focused on genomic expression) and epigenomics (focused on epigenetic regulation of genome expression). (bmj.com)
  • Rather, fine tuning is achieved through epigenetic factors that impact the accessibility of DNA sequences for enzymatic modifications, and through factors that participate in genome organization establishing a functional nuclear landscape. (duke.edu)
  • In the Yildirim lab, we study how epigenetic mechanisms, particularly those that are mediated by long noncoding RNAs (ncRNAs), complement gene expression, impact genome stability and define cell fate decisions. (duke.edu)
  • Our long-term goal is to delineate the molecular bases and order of genetic, epigenetic and cellular processes that link altered expression of long ncRNAs and pathways driven by these molecules to cancer. (duke.edu)
  • The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
  • In various organisms, components of the nuclear envelope interact with chromatin that is spatially organized within the nucleus (Fig 2) and subsequently regulate gene expression. (duke.edu)
  • The role of AP-1 members in regulating NK cell biology remains enigmatic and these new data underscore a need for further research into regulators of AP-1 transcription factors and their targets. (nature.com)
  • Angiogenic factors and their receptors are important regulators of placental vascular development [ 13 ]. (hindawi.com)
  • Transcriptomic analyses provide an efficient approach to explore the temporal gene expression profiles in embryos and to search for the developmental regulators. (biomedcentral.com)
  • In addition to their canonical functions in maintaining nuclear architecture and nucleocytoplasmic trafficking, components of the nuclear envelope (i.e. nuclear pore complex (NPC), nuclear lamina) are also involved in intracellular signaling, DNA repair, and gene expression. (duke.edu)
  • Our studies revealed novel functions of intracellular complement components in β cells, presenting a new link between complement and diabetes development. (lu.se)
  • Complement receptors have only been identified in the last 2 decades. (medscape.com)
  • Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
  • Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
  • Four distinct complement receptors, CR1, CR2, CR3, and CR4, have been described for the surface-bound complement fraction C3 and its cleavage fragments. (medscape.com)
  • Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
  • Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
  • Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
  • The discovery that aHUS is a disease of complement dysregulation has led to a specific interest in complement genetics. (ncl.ac.uk)
  • Both genetics and environmental factors influence the expression of asthma, and not all asthma is the result of a specific immune response to allergen. (cdc.gov)
  • Both host factors (genetics) and low molecular weight allergens. (cdc.gov)
  • The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
  • Human MC were initially divided into three subsets based on the cell surface expression of CD14 and CD16, and recently classified based on CD40 expression ( 2 - 5 ). (frontiersin.org)
  • Murine MC are divided into three subsets based on surface expression of lymphocyte antigen 6 complex, locus C (Ly6C) ( 3 , 4 ). (frontiersin.org)
  • These transcription factors possess a central theme of cellular proliferation, cell cycle regulation, apoptosis, and differentiation. (wikipedia.org)
  • They are single-chain molecules present on host cellular membranes and belong to the complement control protein family. (medscape.com)
  • 0.001) compared to immortalized aortic endothelial cells, suggesting that porcine SCs are able to escape cellular lysis associated with complement activation by producing one or more immunoprotective factors that may be capable of inhibiting membrane attack complex formation. (johnshopkins.edu)
  • Predicted to act upstream of or within cellular response to leukemia inhibitory factor. (nih.gov)
  • not unique for the embryonic system but are shared by other ogenesis regulation must consider different scales of multi-cellular modeling areas. (lu.se)
  • CR1 also regulates complement activation by acting as a cofactor for factor I in the cleavage and degradation of bound C3b and C4b to its inactive forms. (medscape.com)
  • The DEP domain is primarily found in proteins involved in G-protein signalling pathways and regulation of GTPase. (wikipedia.org)
  • Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • The analyzed gene datasets were downloaded from the Gene Expression Omnibus and The Cancer Genome Atlas (TCGA) database. (cancerindex.org)
  • We, therefore, tested the hypothesis that hypoxia would enhance or "prime" microglial pro-inflammatory gene expression in response to a later inflammatory challenge without programmatically increasing basal levels of pro-inflammatory cytokine expression. (frontiersin.org)
  • High throughput phenotypic assays are needed to complement the sequence-based analysis of circulating viruses and improve pandemic preparedness. (cdc.gov)
  • Inversely, high ID50 values are associated with motile and fast-growing bacteria that use quorum-sensing based regulation of virulence factors expression. (pasteur.fr)
  • Infectious dose is not associated with genome size and shows insignificant phylogenetic inertia, in line with frequent virulence shifts associated with the horizontal gene transfer of a small number of virulence factors. (pasteur.fr)
  • Differential expression profiles suggest that DEPDC1B is higher expressed in many cancerous disease states, including: papillary thyroid cancer, breast cancer, synovial sarcoma, and prostatic cancer progression. (wikipedia.org)
  • Short-term culture of HUAEC or HUVEC abrogated differential gene expression resulting in a default state. (refine.bio)
  • Activation of the complement cascade always leads to the enzymatic cleavage of complement fraction C3, which is important in host defense to bacterial infections and phagocytosis. (medscape.com)
  • The prothrombinase complex is the enzymatic complex responsible for timely thrombin formation at the place of vascular injury and is composed of the enzyme, factor Xa (fXa), the non-enzymatic cofactor factor Va (fVa), and the substrate prothrombin assembled on a lipid membrane in the presence of divalent metal ions. (csuohio.edu)
  • In addition, the effect of inhibiting ANG-2 expression by siRNA or monoclonal antibody on delaying IVDD was investigated at in vitro and in vivo levels. (bvsalud.org)
  • Moreover, injection of neutralizing antibody or treatment with siRNA to inhibit the expression of ANG-2 improved the matrix metabolism of AF and inhibited IVDD progression by regulating the HIF-1α/NF-κB signaling pathway. (bvsalud.org)
  • [ 2 ] T cell-derived complement C3a and CD46 activation is required for Th1 induction. (medscape.com)
  • Whereas in the acute phase of the disease immunoregulatory processes prevail in the hippocampus and the cortex, we observed a strong activation of neurogenic processes in the hippocampal dentate gyrus, both by gene expression and immunohistology starting as early as 3 days after infection. (biomedcentral.com)
  • and regulation of complement activation, alternative pathway. (jax.org)
  • 2019 ) KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits. (neurotree.org)
  • We are interested in defining the molecular bases of these interactions and delineating their significance in driving gene expression and genome functions. (duke.edu)
  • GUS fusions to characterize promoters stemming from Arabidopsis, tomato ( Lycopersicon esculentum ) or L. japonicus with respect to their expression in major cell types of the L. japonicus root differentiation zone, which shows molecular and morphological responses to symbiotic bacteria and fungi. (biomedcentral.com)
  • We have identified the molecular defect in factor V Leiden and we have delineated specific amino acid regions on the factor V/Va molecule that are crucial for their functions. (csuohio.edu)
  • 2016 ) KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia. (neurotree.org)
  • Examples of high molecular environmental factors are known to influence the development weight occupational allergens include proteases used in the and expression of asthma, and a vast array of triggers of asthma detergent industry, laboratory animal allergens, and ovalbumin have been identified. (cdc.gov)
  • These responses were preserved when HUVECs were pretreated with tumour necrosis factor-α to mimic dysfunctional endothelium. (bmj.com)
  • DEPDC1B promoter region contains several transcription factors associated with proteins of ubiquitous expression. (wikipedia.org)
  • Experimental evidence suggests that DEPDC1B presents similar ubiquitous expression in all tissues. (wikipedia.org)
  • CHRNA5 expression research findings from the laboratory to CHRNA5 was among the markers with in bronchial cel s modulates cell the population. (who.int)
  • A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
  • Expression of DEPDC1B is reported to be largely ubiquitous throughout mouse tissue. (wikipedia.org)
  • Interestingly, although there was some overlap and cross-regulation, the transcription factors largely complemented each other in regulating the arterial EC gene profile. (refine.bio)
  • The most widely studied serum markers for PE, to date, are vascular endothelial growth factor (VEGF) and placental growth factor (PlGF). (hindawi.com)
  • But it is not known whether and how the regulation of gene expression also contributes to adaptation. (biomedcentral.com)
  • The central nervous system contributes to anti-inflammatory regulation through neuroimmunoendocrine actions. (wjgnet.com)
  • From the same family of transcription factors, NRF1 is generally far less studied and its role in carcinogenesis is insufficiently explored. (hindawi.com)
  • Agency is provided by the study of of carcinogenesis associated with the treatment of invasive cervical cancer the role of cutaneous HPV types in important risk factors for two common by decreasing recurrences of cancerous skin carcinogenesis, carried out by the human cancers. (who.int)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Like sFlt1, soluble endoglin (sEng) is an antiangiogenic factor capable of inhibiting capillary tube formation in vitro [ 17 ]. (hindawi.com)
  • Clearly, interspecies bacterial communication influences the regulation of gene expression. (asmblog.org)
  • 2021 ) Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model. (neurotree.org)
  • Predicted to be involved in positive regulation of peptidase activity. (nih.gov)
  • Also, DEPDC1B expression decreases in environments of beta-catenin depletion in multiple myeloma cell lines No interactions of DEPDC1B within any other protein product characterized by experimentation have been verified. (wikipedia.org)
  • Medium coexpression of DEPDC1B with ECT2 in cell cycle regulation and DNA synthesis was verified by similarity of expression in various tissues. (wikipedia.org)
  • VDR regulation was also studied in THP-1 and Jurkat cell lines. (vitamindwiki.com)
  • In monocyte and T lymphocyte cell lines, TNF-α suppressed VDR expression, whereas 1,25-dihydroxyvitamin D blocked TNF-α-induced VDR downregulation. (vitamindwiki.com)
  • Multiple studies have shown that transcription factors play a critical role in regulating β-cell maturation. (einsteinmed.edu)
  • To this end, we aimed to identify promoters exhibiting cell type enriched expression in roots of the model legume Lotus japonicus , as no comprehensive set of such promoters usable in legume roots is available to date. (biomedcentral.com)
  • Promoters are underlined to indicate the cell type of primary expression. (biomedcentral.com)
  • The common genetic variants associated with complex traits typically lie in noncoding DNA and may alter gene regulation in a cell type-specific manner. (nih.gov)
  • approximately 10(-3)) were tested for cis-association of gene expression in HObs and in lymphoblastoid cell lines (LCLs) using publicly available data and showed that HObs have a significantly greater enrichment (threefold) of converging cis-eQTLs as compared to LCLs. (nih.gov)
  • studies on cell cycle regulation and genome instability. (ncl.ac.uk)
  • Ident- cult to deduce interaction rules from observations of the ified transcription factors for specific cell fates are, for entire system. (lu.se)
  • Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
  • When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)
  • We found that C3 is upregulated in pancreatic islets during T2D as a factor against β cells dysfunction caused by attenuated autophagy. (lu.se)
  • In paper II, we showed that silencing of CD59 expression in rat β cells significantly suppressed insulin secretion. (lu.se)
  • We found that IRIS-1 expressing cells displayed significantly higher expression levels of Urocortin 3 and Pdx 1 (markers of mature β cells, which loss marks the beginning of β cells dedifferentiation), suggesting that IRIS-1 may be required for maintaining β cells identity and function. (lu.se)
  • They tend to enhance the effects of complement and are highly important in the binding of opsonized immune complexes on B cells. (medscape.com)
  • Being able to specifically eliminate pro-cancer fibroblasts requires a better understanding of the factors that shape the role of these cells, and how to identify them. (elifesciences.org)
  • The results of western blot assay showed mechanical stress significantly up-regulated the expression of ANG-2 in AF cells, and promoted matrix degradation by regulating the activity of HIF-1α/NF-κB pathway. (bvsalud.org)
  • Similarly, sEng is a truncated form of receptor for two subtypes of transforming growth factor beta (TGF β ) specifically, TGF β 1 and TGF β 2 which are highly expressed by vascular endothelial cells and syncytiotrophoblasts. (hindawi.com)
  • Vitamin D receptor expression in peripheral blood mononuclear cells is inversely associated with disease activity and inflammation in lupus patients. (vitamindwiki.com)
  • The expression of VDR and NF-κB p65 in peripheral blood mononuclear cells (PBMCs) was determined by quantitative RT-PCR and Western blotting. (vitamindwiki.com)
  • Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells. (nih.gov)
  • Our results suggest that primary cells relevant to disease phenotypes complement traditional approaches for prioritization and validation of GWAS hits for follow-up studies. (nih.gov)
  • Here, microarray analysis in peripheral blood cells in eight patients with AF and stroke and eight AF subjects without stroke identified a stroke related gene expression pattern. (refine.bio)
  • HHcy in Cbs -/- mice reinforced inflammatory features in Ly6C high MC by upregulating inflammatory TFs ( Ets1 and Tbx21 ) and strengthened lymphocytes functional adaptation in Ly6C low MC by increased expression of CD3, DR3, ICOS, and Fos . (frontiersin.org)
  • Specifically, elevated expression of HIF-1a and podoplanin predicted worse outcome while inflammatory gene expression correlated with increased survival, suggesting future interventions targeting proximal fibroblast populations to mitigate against PDAC. (elifesciences.org)
  • VDR expression was correlated with inflammatory and diseases parameters in SLE patients. (vitamindwiki.com)
  • What is the downstream regulation mechanism of iron in ferroptosis? (nature.com)
  • Expression profiles indicate that DEPDC1B is highly expressed ubiquitously throughout human tissue. (wikipedia.org)
  • Data from genome wide expression profiling studies of various human cancers have provided evidence for altered expression of long ncRNAs. (duke.edu)
  • In paper I, we revealed a high expression of C3 in human pancreatic islets. (lu.se)
  • Induction of glucotoxicity in primary, healthy human islets led to a significant decrease in IRIS-1 protein-level expression. (lu.se)
  • Following a more extensive analysis, I have now identified multiple additional human transcription factors (including RXRG, NR0B1, MXI1, ONECUT2 and ESR1) that, like SIX2 and SIX3, increase their expression with age in humans. (einsteinmed.edu)
  • Orthologous to human IGF2R (insulin like growth factor 2 receptor). (nih.gov)
  • 3. Kalafatis, M., Takahashi, Y., Girma, J.P., and Meyer, D. Localization of a collagen interactive domain of human von Willebrand Factor between amino acid residues Gly 911 and Glu 1365. (csuohio.edu)
  • Orthologous to human CFH (complement factor H). (jax.org)
  • We carried out an expression quantitative trait loci (eQTL) study of primary human osteoblasts (HOb) derived from 95 unrelated donors of Swedish origin, each represented by two independently derived primary lines to provide biological replication. (nih.gov)
  • Enables insulin-like growth factor binding activity and mannose binding activity. (nih.gov)
  • Enables complement component C3b binding activity and heparin binding activity. (jax.org)
  • How the immune response can activate the cascade process is still unknown but it is proposed to act in synergy with additional exacerbating factors such as predisposing maternal and ambient factors [ 12 ]. (hindawi.com)
  • Determining the expression of multiple cytokines in a single sample can be expensive, time consuming and can require specialized equipment. (rndsystems.com)
  • This in turn results in an exponential production of multiple factors such as cytokines and growth factors leading to the clinical manifestations of PE [ 11 ]. (hindawi.com)
  • While Xist expression is crucial for initiation of XCI, its role in maintenance of XCI is not clear. (duke.edu)
  • The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. (sdbonline.org)
  • Regulation of gene expression plays a central role in embryonic development. (biomedcentral.com)
  • The prognostic significance of the major redox regulator nuclear factor erythroid-2-related factor (NRF2) is recognized in many cancers, but the role of NRF1 is not generally well understood in cancer. (hindawi.com)
  • Taking the density of regulatory sites in promoters as a measure of the potential and complexity of gene regulation, we found it to be quantitatively the same in all three environments, despite their different physico-chemical conditions and species composition. (biomedcentral.com)
  • For a subset of five promoters, expression stability was further demonstrated in whole plant transgenics as well as in active nodules. (biomedcentral.com)
  • The coagulation system leans on a delicate balance between coagulant and anticoagulant factors. (csuohio.edu)
  • For this purpose we evaluated the gene expression profile of the two brain structures predominantly affected by brain damage, i.e. the cortex and the hippocampus, at four different stages of the disease in an infant rat model. (biomedcentral.com)
  • These results highlight the potential impact of gene regulation in the adaptation of bacteria to the different habitats through the distribution of their regulatory potential among specific functions, and point to critical environmental factors that challenge the growth of any microbial community. (biomedcentral.com)
  • This has been partly attributed to changing environmental factors such as exposure to traffic-related air pollution (TRAP) and nutrient deficiencies, including vitamin D. Furthermore, population-based studies have suggested that air pollution may contribute to vitamin D deficiency [ 1 ], while vitamin D levels may modify pollution-driven asthma symptoms in paediatric obesity [ 2 ]. (ersjournals.com)
  • To our knowledge, no study has assessed the proteomic response to more than one environmental factor, and their interactions, in the context of asthma and allergy. (ersjournals.com)
  • Root expression patterns are independent of infection with rhizobial bacteria, providing a stable read-out in the root section responsive to symbiotic bacteria. (biomedcentral.com)
  • Studies showed that these mutations result in a loss of CD59 complement inhibitory functions. (lu.se)
  • The aim of this study was to examine the correlation between VDR expression and inflammation and disease activity in patients with SLE. (vitamindwiki.com)
  • CONCLUSION: PBMC VDR expression is inversely associated with disease activity and inflammation in SLE patients, and VDR downregulation is likely driven by inflammation. (vitamindwiki.com)
  • Then we conducted behavioral tests, including tests with von Frey filaments and a laser heat test, to verify sensory pain, measured the expression of L-type calcium channels using western blotting and immunofluorescence of dorsal root ganglia (an important neural target for peripheral nociception), and examined the activity of L-type calcium channels and neuron excitability using electrophysiological measurements. (biomedcentral.com)
  • We found that short-term sleep deprivation before and after surgery increased expression and activity of L-type calcium channels in the lumbar dorsal root ganglia, and delayed recovery from postsurgical pain. (biomedcentral.com)
  • We conclude that the increased expression and activity of L-type calcium channels is associated with the sleep deprivation-mediated prolongation of postoperative pain. (biomedcentral.com)
  • Erasure of arterial gene expression was at least in part due to loss of canonical Notch activity and HEY2 expression. (refine.bio)
  • Among the functions with highest regulatory potential in each niche, we found significant enrichment of processes related to sensing and buffering external variable factors specific to each environment, like for example, the availability of co-factors in deep sea, of oligosaccharides in soil and the regulation of pH in the acid mine. (biomedcentral.com)
  • For instance, an expression time-series performed on microbial communities living in surface oceanic showed that processes of energy production were active in hours with light, while anabolic housekeeping processes were predominant during the night [ 4 ]. (biomedcentral.com)
  • Early ontogeny is associated with dramatic gene expression changes that underlie and determine the developmental processes. (biomedcentral.com)
  • This female specific dosage compensation mechanism depends on expression of Xist long ncRNA, which coats and transcriptionally silences future inactive X (Xi) balancing X-linked gene expression between XX females and XY males (Fig 1). (duke.edu)
  • Accumulating evidence suggests that it acts as an etiological factor in the initiation and progression of many of these conditions. (wjgnet.com)
  • Together, this data sheds new light about NFE2L family factors in pigment tumors and suggests that these factors are worth for further explorations. (hindawi.com)
  • In this study, we identify that the late stage of infection with C. hepatica-especially the egg-derived antigens-modulates the host immune responses to promote alternatively activated macrophage (M2) polarization and programmed death ligand 2 (PD-L2) expression. (bvsalud.org)
  • Although the field of OMICS is ever expanding (eg, see http://omics.org ), currently five different OMICS fields are well established: genotyping, gene expression profiling, epigenomics, proteomics, and metabolomics. (bmj.com)
  • Beyond this time, no differences in global gene expression in infected and control animals were detectable by microarray analysis. (biomedcentral.com)
  • Multiple stepwise regression analysis indicated that PBMC VDR downregulation was an independent risk factor for SLEDAI-2 K. VDR levels were also negatively correlated with NF-κB p65 (r = - 0.339, P = 0.001), TNF-α (r = - 0.268, P = 0.009), and IL-6 (r = - 0.313, P = 0.002) levels. (vitamindwiki.com)
  • Notably, nCounter analysis revealed that restoring HEY2 expression or Delta-like 4 (Dll4)-induced Notch signaling in cultured HUVEC or HUAEC only partially reinstated the arterial EC gene signature while combined overexpression of the 8 transcription factors restored this fingerprint much more robustly. (refine.bio)