• Transcription factors are rapidly and transiently induced in brain by excitatory stimuli and may be important in coordinating changes in gene expression underlying neuronal plasticity. (johnshopkins.edu)
  • In particular, AMPA-type glutamate receptor (AMPA-R) plays central roles in not only main excitatory neurotransmission, but also expression of synaptic plasticity. (nii.ac.jp)
  • In this project, we will focus on N-glycosylation of AMPA-R, and we aim to elucidate their functions in synaptic transmission and plasticity. (nii.ac.jp)
  • We also revealed that there are raft-positive and -negative synapses in the same neuron, proposing the hypothesis that glycosylation of AMPA―R decides the synaptic localization, resulting in the regulation of synaptic strength in synaptic plasticity. (nii.ac.jp)
  • GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity. (rochester.edu)
  • MicroRNAs are noncoding RNAs that have been proposed to regulate gene expression and degradation at the posttranscriptional level, including the MOR, as well as synaptic plasticity and neuroplasticity, in both the peripheral and central nervous systems. (hindawi.com)
  • It is currently believed that miRNAs, as important regulatory factors of epigenetics, may be widely involved in the regulation of various cellular activities including neurobiological responses, such as neuronal growth, metabolism, apoptosis, and synaptic plasticity [ 6 , 7 ]. (hindawi.com)
  • Downregulation of MORs includes decreased MOR expression and increased degradation, and neuroadaptation includes synaptic plasticity and neuroplasticity [ 11 ]. (hindawi.com)
  • It is generally believed that rapid and reversible DNA methylation in the brain is essential for the stability of long-term memory , but very little is known about how synaptic signals can control DNA methylation to induce permanent changes in plasticity-related gene expression. (bionity.com)
  • Here we begin with studies of the balance between excitation and inhibition, synaptic plasticity, neurogenesis and neuromodulators. (sfari.org)
  • Genes that regulate activity-dependent synaptic plasticity, including ARC, have been implicated in autism. (sfari.org)
  • Variants of the UBE3A gene are associated with reduced activity-dependent synaptic plasticity. (sfari.org)
  • Synaptic plasticity in the hippocampus is altered in mice that lack SHANK2. (sfari.org)
  • Short-term synaptic plasticity (facilitation and depression) is altered in mice bearing 22q11.2 deletions and other mouse models. (sfari.org)
  • What molecular pathways are involved in changes in synaptic plasticity and their reversal? (sfari.org)
  • Can the relative influence of short-term synaptic plasticity (facilitation, depression) be distinguished from long-term synaptic plasticity in maintaining local circuit function and relevant behaviors? (sfari.org)
  • Xu YKT, Graves AR , Coste GI, Huganir RL , Bergles DE, Charles AS, Sulam J. Cross-modality supervised image restoration enables nanoscale tracking of synaptic plasticity in living mice. (neurotree.org)
  • Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors. (neurotree.org)
  • We study how synaptic transmission contributes to the timing of information processing: from vesicular release and transmitter clearance to the plasticity between cerebellar elements. (uab.edu)
  • By recording and imaging Purkinje cells and Bergmann glia, we study how transporters can influence the strength of synaptic signals and regulate the signal transduction pathways underlying cerebellar long-lasting plasticity. (uab.edu)
  • Indeed, problems at the synapse - in their formation and in the mechanisms through which the strength, or plasticity, of their connections are regulated - are thought to contribute to numerous mental and neurological disorders. (scienceblog.com)
  • They showed that neuronal activity, which triggers the activation of post-synaptic cellular receptors, called NMDA receptors, is needed for the function of OPHN1 at the synapse, and that in turn, OPHN1 regulates the plasticity, or strength of the connection. (scienceblog.com)
  • In this project we will test the role of early growth response 1 (Egr1), which regulates synaptic function, synaptic plasticity and epigenetic modification of receptors for stress-hormones, and preliminary data from the University of Amsterdam (UvA) group indicates the Egr1 expression is affected by ELS. (fapesp.br)
  • In this BEPE-Project, we intend to assess the immediate ELS impacts on synaptic plasticity and its relation with Egr1 gene expression. (fapesp.br)
  • To do so, we will use an animal model of early life stress (ELS), in which there is an abnormal and fragmented maternal care, and evaluate synaptic plasticity by electrophysiological assessment. (fapesp.br)
  • After that, we will modulate the Egr1 expression in ELS animals using molecular tools, aiming to revert the possible ELS impacts on synaptic function and plasticity. (fapesp.br)
  • Experimental part: Glial cell line-derived neurotrophic factor (GDNF) plays important role in the survival and function of dopaminergic neurons, learning, memory and synaptic plasticity. (helsinki.fi)
  • Since Akt1 is part of the PTEN/Akt1/CREB signaling pathway, which participates in synaptic plasticity and long-term memory, we investigated whether NCX1 expression/activity might also be involved in some hippocampal-dependent learning and memory processes. (unina.it)
  • While this compensatory plasticity in the auditory system relies on robust dendritic sprouting and novel synapse formation, the compensatory plasticity in the cercal escape circuitry shows little obvious dendritic sprouting and instead may rely on shifts in excitatory and inhibitory synaptic strength. (biomedcentral.com)
  • We performed differential expression analysis using EdgeR and DESeq2 and examined Gene Ontologies to identify candidates potentially involved in this plasticity. (biomedcentral.com)
  • Crickets also show compensatory plasticity in escape responses after unilateral removal of one of the wind-sensitive appendages known as a cercus, though this compensation relies on synaptic strength alterations [ 9 ] instead of obvious anatomical reorganization. (biomedcentral.com)
  • Publications] Hiroyuki Nawa 他2名: 'Neurotrophic Factors in Brain Synaptic Plasticity' Critical Rev.Neurobiology. (nii.ac.jp)
  • Neurotrophic Factors in Brain Synaptic Plasticity' Critical Rev.Neurobiol. (nii.ac.jp)
  • We use several preparations including primary cultures of dissociated neurons to understand the role of Ng in events of synaptic plasticity, such as those associated with hebbian plasticity (Long Term Potentiation -LTP- and Long Term Depression -LTD) and homeostatic plasticity (synaptic scaling). (uam.es)
  • ATAD1 plays a critical role in regulating the surface expression of AMPA receptors thereby regulating synaptic plasticity, learning, and memory. (antibodiesinc.com)
  • By studying the visual system of mammals, the Shatz Lab discovered that adult wiring emerges from dynamic interactions between neurons involving neural function and synaptic plasticity. (stanford.edu)
  • By studying and/or generating knockout mice, the lab is exploring a role for these molecules in synaptic plasticity, learning, memory and neurological disorders. (stanford.edu)
  • These include genes involved in regulating transcription, neuron structure, and synaptic plasticity. (cdc.gov)
  • The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. (lu.se)
  • AMPA and NMDA receptors mediate most excitatory synaptic transmission in the CNS. (jneurosci.org)
  • Using a quantitative cell ELISA, a dramatic increase was observed in the surface expression of AMPA receptors, but not NMDA receptors, between 3 and 10 d in culture. (jneurosci.org)
  • Morphine tolerance is an adaptive process induced by chronic morphine that has been shown to result from complex alterations at the molecular level with μ opioid receptors (MORs), as well as at the synaptic, cellular, and circuit levels. (hindawi.com)
  • Morphine tolerance is an adaptive process that has been proposed to result from complex alterations at the molecular level with μ opioid receptors (MORs), as well as at the synaptic, cellular, and circuit levels, in both the peripheral and central nervous systems. (hindawi.com)
  • low Mn, less soluble) resulted in deposition of Mn in the olfactory bulb and striatum, altered the expression of divalent metal transporter 1 (Dmt1), dopamine D1 (Drd1) and D2 (Drd2) receptors, and induced a subtle neuroinflammatory response in the striatum and midbrain. (cdc.gov)
  • There is an emerging literature that the distribution of the α9 and α10 subunits in peripheral tissues is widespread and non-synaptic, regulated in disease states, and may not always be assembled as heteromeric receptors. (frontiersin.org)
  • When NMDA receptors are activated in the synapse, the team found that OPHN1 is recruited to dendritic spines, where it locally regulates the actin cytoskeleton - as it turns out, in proximity to another receptor type in the synapse called AMPA receptors. (scienceblog.com)
  • α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly. (antibodiesinc.com)
  • The importance of their phenotypic regulation has been argumented since abnormal expression of neurotransmitters or their receptors are often associated with various neurological diseases. (nii.ac.jp)
  • brain-derived neurotrophic factor (BDNF), Fyn, CREB,alpha-CAMK2 and NOS.Molecular, biochemical and histochemical analyzes revealed that the neurotrophin mutant exhibited lower expression of various neurotransmitters, their receptors and the synaptic enzymes, and, in turn, the enzyme mutants contrained abnormal levels of neurotrophins. (nii.ac.jp)
  • These observations suggest that neurotrophins and these synaptic receptors/enzymes interact with each other during brain development and regulate synergistic synaptic development. (nii.ac.jp)
  • This work supports the hypothesis that the relative expression of 5-HT1A and 5-HT2B receptors tunes the neuronal excitability of serotonergic neurons through potassium channel regulation. (bvsalud.org)
  • The efficacy of GABAergic synapses relies on the number of postsynaptic GABAA receptors (GABAARs), which is regulated by a diffusion capture mechanism. (bvsalud.org)
  • We propose that following their activation or desensitization, synaptic receptors rapidly diffuse at the periphery of the synapse where they remain confined until they switch back to a resting state or are internalized. (bvsalud.org)
  • We speculate that this allows a renewal of activatable receptors at the synapse, contributing to maintain the efficacy of the synaptic transmission, in particular on sustained GABA transmission. (bvsalud.org)
  • We prepared neocortical slices from juvenile mice that were receiving eNRG1 subchronically and recorded inhibitory synaptic activity from layer V pyramidal neurons. (nih.gov)
  • Cortical GABAergic neurons cultured with eNRG1 exhibited a significant increase in surface GluA1 immunoreactivity at putative synaptic sites on their dendrites. (nih.gov)
  • The authors of the study discovered a mechanism that allows synaptic control of DNMT3A1 levels in neurons, thereby creating a time window for reduced DNA do novo methylation at a group of target genes. (bionity.com)
  • HuD has been implicated in various aspects of neuronal function, such as the commitment and differentiation of neuronal precursors as well as synaptic remodeling in mature neurons. (nih.gov)
  • HuD also functions as an important regulator of mRNA expression in neurons by interacting with AU-rich RNA element (ARE) and stabilizing multiple transcripts. (nih.gov)
  • This balance is determined in part by the number and function of excitatory and inhibitory synapses, the excitability of input and output neurons and the ability of microcircuits to compensate for synaptic alterations, known as synaptic homeostasis. (sfari.org)
  • We show that this pathway regulates the activity of pain-related neurons in PB, and that, in chronic pain, this inhibitory pathway is suppressed, and that this suppression is causally related to pain perception. (iasp-pain.org)
  • We have previously shown that diffusible intercellular factors such as nerve growth factor can regulate such neuronal phenotypes in cultured neurons. (nii.ac.jp)
  • Na-K-2Cl cotransporter 1 (NKCC1) regulates chloride influx in neurons and thereby GABAA receptor activity in normal and pathological conditions. (bvsalud.org)
  • Here, we characterized in hippocampal neurons the membrane expression, distribution and dynamics of exogenous NKCC1a and NKCC1b isoforms and compared them to those of the chloride extruder K-Cl cotransporter 2 (KCC2). (bvsalud.org)
  • Here, we describe the developmental effects of excessive peripheral NRG1 signals on synaptic activity and AMPA receptor expression of GABAergic interneurons in postnatal rodent neocortex. (nih.gov)
  • Similar effects on mEPSCs were observed in mice treated with a soluble, full-length form of NRG1 type I. Consistent with the electrophysiologic data, expression of the AMPA receptor GluA1 (i.e. (nih.gov)
  • These results indicate that NRG1 circulating in the periphery influences postnatal development of synaptic AMPA receptor expression in cortical GABAergic interneurons and may play a role in conditions characterized by GABA-associated neuropathologic processes. (nih.gov)
  • Regulating synaptic membrane exocytosis 3 is a protein that in humans is encoded by the RIMS3 gene. (wikipedia.org)
  • MicroRNAs (miRNAs) are noncoding RNAs of approximately 20 nucleotides in length that block gene expression at the posttranscriptional level by partial complementary binding to the 3′-untranslated region (3′-UTR) of mRNA of target genes in animals, resulting in mRNA degradation or translation inhibition [ 3 ]. (hindawi.com)
  • As ChIP-seq cannot establish physical co-occurrence of two marks on the same allele, admixture of cells that either express (green) or do not express (red) the gene in focus could explain the occurrence of both marks as well as the low expression level in the overall population. (researchgate.net)
  • In contrast, in the case of ''true'' bivalency, virtually all cells in the population carry both marks simultaneously at the promoter in question, leading to low, if any, expression for that gene in all cells. (researchgate.net)
  • Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. (researchgate.net)
  • The epigenetic regulation of spatiotemporal gene expression is crucial for human development. (researchgate.net)
  • Research has shown that DNA methylation affects the fine-tuning of gene expression in response to neuronal activity in the brain. (bionity.com)
  • Synaptic vesicle membrane protein VAT-1 homolog is a protein that in humans is encoded by the VAT1 gene . (wn.com)
  • The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. (wn.com)
  • In melanocytic cells VAT1 gene expression may be regulated by MITF . (wn.com)
  • That has been a major objective of studies in Van Aelst's lab, where previous experiments have shown that "knocking-down" expression of the gene that encodes the production of the OPHN1 protein (the gene is designated by the italic OPHN1) causes a potentially important change in neuronal structure. (scienceblog.com)
  • Those spines were found to be abnormally short and misshapen when expression of the OPHN1 gene was acutely reduced. (scienceblog.com)
  • By manipulating OPHN1 gene expression on the postsynaptic side of the gap, the team was able to unravel a key link between OPHN1 function and synaptic activity. (scienceblog.com)
  • Is our mode of sexuality governed by the same shared neural gene expression patterns? (sciencealert.com)
  • We don't know that," senior researcher and integrative biologist Hans Hofmann admitted to Science , but "we certainly would speculate that the kind of gene expression patterns … might [show up] in humans as well. (sciencealert.com)
  • In the species that became monogamous, genes involved with various kinds of cognitive functions - including neural development, synaptic activity, and memory - exhibited heightened expression, while other genes related to gene transcription were down-regulated. (sciencealert.com)
  • To test the hypothesis that neural gene expression differences underlie differential capacities to bond, we performed RNA-sequencing on tissue from three brain regions important for bonding and other social behaviors across bond-forming prairie voles and non-bonding meadow voles. (cdc.gov)
  • We examined gene expression in the amygdala, hypothalamus, and combined ventral pallidum/nucleus accumbens in virgins and at three time points after mating to understand species differences in gene expression at baseline, in response to mating, and during bond formation. (cdc.gov)
  • RESULTS: We first identified species and brain region as the factors most strongly associated with gene expression in our samples. (cdc.gov)
  • Next, we found gene categories related to cell structure, translation, and metabolism that differed in expression across species in virgins, as well as categories associated with cell structure, synaptic and neuroendocrine signaling, and transcription and translation that varied among the focal regions in our study. (cdc.gov)
  • Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)
  • New mutations have been found in the synaptic nuclear envelope protein 1 (SYNE1) gene and in the synaptic nuclear envelope protein 2 (SYNE2) gene in a few families, also termed Nesprin-1 and Nesprin-2, respectively. (medscape.com)
  • The first suggests that disruption of the inner nuclear membrane and the nuclear lamina causes disorganization of nuclear chromatin and gene expression, while the second proposes that the mechanical strength of the cell nucleus is disrupted when the nuclear lamina is weakened leading to structural and signaling defects in mechanically stressed tissue such as muscle and heart. (medscape.com)
  • Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. (lu.se)
  • Impact of PAP on the CREB, BNDF and synaptic proteins reminiscent of SAP-97, synaptophysin, synapsin-I, and PSD-95 expression was analysed by Western blot. (aabioetica.org)
  • In abstract, these information point out that PDE10A is concerned in QUIN-mediated synaptotoxicity and its inhibition elicit neuroprotection by decreasing the oxidative stress and defending synaptic proteins through up-regulation of cAMP signalling cascade. (aabioetica.org)
  • By 1d post-exposure, both fumes caused loss of tyrosine hydroxylase (TH) protein and altered the expression of various synaptic proteins in the striatum and midbrain. (cdc.gov)
  • DIP and Dpr proteins are expressed in a synaptic layer-specific fashion in the visual system. (nih.gov)
  • How interactions between these proteins regulate layer-specific synaptic circuitry is not known. (nih.gov)
  • Knockin mutants disrupting the DIP/Dpr binding interface reveal a role for these proteins during normal development, while ectopic expression studies support an instructive role for interactions between DIPs and Dprs in circuit development. (nih.gov)
  • Its availability and activity are locally regulated by proteins such as neurogranin (Ng), very abundant in the post-synaptic environment, which sequesters CaM in a Ca+2 and phosphorylation dependent manner. (uam.es)
  • In the crayfish and lobster opener neuromuscular preparations of the walking legs and claws, there are regional differences in synaptic transmission even though the entire muscle is innervated by a single excitatory tonic motor neuron. (biologists.com)
  • The claw and leg opener muscles in the crayfish and lobster provide preparations in which regional differences in synaptic strength and muscle fibre phenotype can be compared, since the postsynaptic responses differ among regions of the muscle even though it is innervated by a single excitatory tonic motor neuron. (biologists.com)
  • This activity is dependent on the rules that each neuron uses to integrate synaptic inputs. (uab.edu)
  • Remarkably, these effects are not associated with changes in the expression of GABAergic and glutamatergic synaptic components, but with a reduction of parvalbumin (PV) neuron density and PV mRNA levels. (biorxiv.org)
  • Synaptojanin 1 is a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. (thermofisher.com)
  • As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. (thermofisher.com)
  • VGF and other neuropeptides such as secretogranin II and neuropeptide Y (NPY) are regulated in the hippocampus when voluntary exercise was employed as a mood stimulator. (frontiersin.org)
  • The Na+/Ca2+ exchanger 1 (NCX1), which is highly expressed in the hippocampus, cortex, and amygdala, regulates Akt1 phosphorylation. (unina.it)
  • In a new series of experiments, Van Aelst and colleagues set out to discover what would happen on the receiving, or post-synaptic side of the gap, when the function of the oligophrenin protein was disturbed under carefully controlled conditions. (scienceblog.com)
  • Evidence for increased excitatory drive is based largely on the frequency and amplitude of spontaneous and action-potential-evoked excitatory synaptic potentials. (sfari.org)
  • Increased frequencies and amplitudes of excitatory synaptic potentials have been observed in mouse models bearing human mutations in genes such as NLGN3, SHANK3, TSC1 and TSC2. (sfari.org)
  • PAP up-regulated CREB and BDNF, and synaptic protein expression. (aabioetica.org)
  • Its function is regulated by several kinases, phosphatase and protein-protein interactions. (helsinki.fi)
  • These studies support an important role for the DIP/Dpr protein interaction network in regulating cell-type-specific connectivity patterns. (nih.gov)
  • To gain insights into the impact of hypomyelination on excitatory and inhibitory neuronal network function in A1, we took advantage of mice in which ErbB receptor signaling in oligodendrocytes has been eliminated by expression of a dominant-negative ErbB4 in cells of the oligodendrocyte lineage under the control of the CNPase promoter (CNP-DN-ErbB4, 15 ). (biorxiv.org)
  • The correlation between slow fibre phenotype and strength of innervation suggests a relationship between synaptic structure and expression of troponin isoforms. (biologists.com)
  • At different transcriptional, posttranscriptional, and epigenetic levels, MOR levels may be regulated, and miRNAs mainly regulate MOR levels at the posttranscriptional level [ 13 ]. (hindawi.com)
  • How is this enzyme regulated by synaptic activity in order to set precisely fitting epigenetic signatures in the DNA? (bionity.com)
  • By combining these methods, we aim to better understand how glutamate transporters shape synaptic signals and their physiological roles in normal and pathological states. (uab.edu)
  • Furthermore, ectopically expressed NPAS3 in PC12 cells produced parallel responses for nuclear factor kappa-light-chain-enhancer of activated B cells [NF-κB (P65)] expression, which specifies that NPAS3 regulates VGF through the NF-κB signaling pathway. (frontiersin.org)
  • ICA69 regulates activity-dependent synaptic strengthening and learning and memory. (neurotree.org)
  • Another hypothesis, not entirely independent of the first, suggests that autism-related changes in synaptic transmission depend on neuronal activity, or experience. (sfari.org)
  • Loss of the metabolism and sleep regulating neuronal populations expressing orexin and oxytocin in the hypothalamus in amyotrophic lateral sclerosis. (lu.se)
  • What is the influence of neuronal activity on the expression of autism-risk genes? (sfari.org)
  • Analysis of myofibrillar isoforms showed that levels of troponin-T 1 (TnT 1 ), a 55 kDa isoform expressed in slow-tonic (S 2 ) fibres, were correlated with synaptic properties. (biologists.com)
  • characterise the morphological and synaptic defects associated with the mis-expression of Dscam2 isoforms. (genetics-gsa.org)
  • Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina. (neurotree.org)
  • In addition, this glutamate release exerts an influence on synaptic transmission and regulates neuronal circuits. (neurosciencenews.com)
  • Next, neuroscientists tried to find out if these hybrid cells were functional, that is, able to actually release glutamate with a speed comparable to that of synaptic transmission. (neurosciencenews.com)
  • In addition, glutamate released into the synaptic cleft is cleared via transporters found on the postsynaptic Purkinje cells. (uab.edu)
  • Therefore, the morphology of the spine neck and the expression and regulation of calcium pumps and buffers control the duration of calcium transients in spines. (jneurosci.org)
  • Their expression levels may be prognostic in cancer and osteoporosis, and recent evidence suggests they may be involved in immune regulation. (frontiersin.org)
  • We aim to study how the mechanisms of synaptic transmission and the regulation of vesicular fusion affect Purkinje cell integration and firing properties. (uab.edu)
  • The regulation of synaptic timing by vesiclular release may be a generalized mechanism for refining temporal signaling throughout the nervous system. (uab.edu)
  • An in-depth knowledge of the molecular basis of synaptic regulation is fundamental to decipher the mechanisms involved in the formation of memories. (uam.es)
  • These hormones regulate the body's growth, and are involved in cell to cell communication, control metabolic activity, sleep-wake homeostasis, and altered regulation or dysregulation of adaptive response in various physiologic and pathophysiologic states. (medscape.com)
  • 2010 ), but the underlying mechanism of dysfunctions of neurogenesis and synaptic activity in relation to the pathology of psychiatric disorder is currently unknown. (frontiersin.org)
  • This network collectively detailed how NPAS3 connects with VGF and intersected neural cell proliferation, synaptic activity and psychiatric disorders. (frontiersin.org)
  • In turn, neural activity regulates the expression of genes involved in the process of circuit tuning. (stanford.edu)
  • To discover cell and molecular underpinnings of circuit tuning, her lab has conducted functional screens for genes regulated by neural activity. (stanford.edu)
  • Second, Mutated enhancer box (E-box) of VGF promoter showed a significant response to this basic helix-loop-helix (bHLH) transcription factor, which suggested an indirect regulatory mechanism for controlling VGF expression by NPAS3. (frontiersin.org)
  • Additionally, there is no such thing as a accessible information on the connection between the appliance of tPBM and hippocampal brain-derived neurotrophic issue (BDNF) expression in animal fashions of stress. (aabioetica.org)
  • In contrast to their transient induction after stimulation, certain transcription factors display stable, relatively high basal levels of expression in brain. (johnshopkins.edu)
  • Here we demonstrate that this "constitutive" expression of the transcription factor zif268 in cortex is driven by natural synaptic activity. (johnshopkins.edu)
  • Moreover, HuD regulates the nuclear processing/stability of N-myc pre-mRNA in neuroblastoma cells and also regulates the neurite elongation and morphological differentiation. (nih.gov)
  • Using laminar current-source density (CSD) analysis, we found layer-specific changes of the spatiotemporal synaptic patterns with increased cross-columnar integration and simultaneous weakening of early local sensory input processing within infragranular layers Vb. (nature.com)
  • These changes in the spatiotemporal synaptic pattern were accompanied by an increase of lateral corticocortical input revealed by CSD residual analysis 22 . (nature.com)
  • The non-specific lethal complex regulates genes and pathways genetically linked to Parkinson's disease. (medscape.com)
  • Do reported variants in genes that regulate autophagy, or cellular self-ingestion, play a role in synapse elimination? (sfari.org)
  • Here we establish that DIP-α and its interacting partners Dpr6 and Dpr10 regulate multiple processes, including arborization within layers, synapse number, layer specificity, and cell survival. (nih.gov)
  • Memories are encoded by long-term changes in synaptic efficiency and connectivity. (uam.es)
  • And second, targeting Ng expression to improve cognition is very likely devoid of side-effects, since Ng expression is tightly regulated in space and time (only expressed in the postnatal forebrain) and specifically associated to cognitive performance. (uam.es)
  • Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy. (neurotree.org)
  • How do compensatory changes in synaptic function alter the initial perturbation in E/I balance? (sfari.org)
  • We are using computer models and heterologous expression systems to study the biophysical properties of these molecules. (uab.edu)
  • This is why neuroscientists have long suggested that astrocytes may have an active role in synaptic transmission and participate in information processing. (neurosciencenews.com)
  • By identifying a new cell type with the characteristics of an astrocyte and expressing the molecular machinery necessary for synaptic transmission, neuroscientists from the Department of Basic Neurosciences of the Faculty of Biology and Medicine of the University of Lausanne (UNIL) and the Wyss Center for Bio and Neuroengineering in Geneva put an end to years of controversy. (neurosciencenews.com)
  • Our research focuses on the details of fast synaptic transmission. (uab.edu)
  • Knowledge of the temporal properties of synaptic transmission is required to understand synaptic integration. (uab.edu)
  • The altered expression of DAT may be related to several neurological diseases such as Parkinson's disease, addiction and ADHD. (helsinki.fi)
  • Morphine administration can lead not only to changes in the expression levels of multiple miRNAs in neuronal tissues or cells but also to differences in the types and degrees of expression of miRNAs induced by different opioids [ 5 , 8 - 10 ]. (hindawi.com)
  • Synaptic activity triggers intracellular calcium (Ca+2) oscillations that locally modulate several signaling pathways. (uam.es)
  • Evidence for reduced synaptic inhibition is based on assays of function mediated by gamma-aminobutyric acid (GABA). (sfari.org)
  • Btbd11 supports cell-type-specific synaptic function. (neurotree.org)