Expression rats fetal proteins. Medical search. Frequent questions

IGF2 is the less characterized member of this family, and in mice and rats its expression in the brain occurs during embryonic development and adulthood but declines during aging [ 2 ]. (scientificarchives.com)
The differences of relative BMP expression after different time periods of exposure indicate the importance of timing for GSM-like RFR effects on embryonic development. (greenmedinfo.com)
Embryonic mouse models have demonstrated that ROCK protein inhibitor decreases the number of terminal lung buds. (medscape.com)
In this study we show that contactin coimmunoprecipitates with Na v 1.3 from postnatal day 0 rat brain where this channel is abundant, and from human embryonic kidney (HEK) 293 cells stably transfected with Na v 1.3 (HEK-Na v 1.3). (jneurosci.org)

Kinetically down-regulated genes involved in the lipid metabolism are: hydroxyacid oxidase 3, fatty acid CoA ligase long chain 2, and steroyl CoA desaturase 1.The regulation of protein expression of the cell cycle genes CDC42 and cyclin D1 was studied by Western Blot technique, in the oval cell liver regeneration. (uni-goettingen.de)
Desk I Genes involved with beta cell proliferation Up to now five REG protein have already been reported in human beings that participate in gene family. (immune-source.com)
The etiology of HCM is extremely heterogeneous, including malformation syndromes, inborn errors of metabolism, neuromuscular disorders, and in the majority of the cases mutations in cardiac sarcomere protein genes [ 5 ]. (biomedcentral.com)
This entailed mining available transcriptomic and/or genomic sequence datasets for the presence of homologues of known TIMPs, predicting secondary structures of defined protein sequences, systematic phylogenetic analyses and assessment of differential expression of genes encoding putative TIMPs in the developmental stages of A. suum , N. americanus and Schistosoma haematobium which infect the mammalian hosts. (biomedcentral.com)
These effects of choline are correlated with modifications in histone and DNA methylation in brain, and with alterations in the expression of genes that encode proteins important for learning and memory processing, suggesting a possible epigenomic mechanism of action. (mdpi.com)
qPCR was carried out to determine the changes in mRNA expression of genes of interest. (hindawi.com)
In the sperm of rats injected with THC and those nicotine-exposed, significant differential methylation at five of seven neurodevelopmentally active genes that were initially identified as significantly altered by oral gavage was identified. (duke.edu)
We also collected placenta and cord blood samples at delivery to examine fetal tissue DNA methylation of the genes that modify fetal growth and stress response such as insulin-like growth factor 2 ( IGF2 ) and corticotropin-releasing hormone ( CRH ). (biomedcentral.com)

Maternal low protein models result in fetal programming of obesity. (usda.gov)

Since obesity is also associated with increased inflammatory immune cell numbers in fat tissue, they tested whether numbers of particular subsets of immune cells called M1 and M2 macrophages are different in the fat tissues of offspring whose mothers were fed a low protein diet. (usda.gov)
It is currently unknown whether maternal LP diet-induced offspring obesity is associated with changes in M1, M1b, or M2 cell numbers and expression of inflammatory factors in fat tissue. (usda.gov)
Using rat offspring whose mothers were fed a low protein diet during pregnancy and who were fed a high-fat diet post-weaning, the investigators tested whether increased fat tissue was correlated with changes in numbers of adipose tissue M1, M1b and M2 macrophages. (usda.gov)
Fat tissue growth rate was highest in maternal low protein and post-weaning high fat diet group. (usda.gov)
In summary, these results indicate that a maternal low-protein diet combined with a post-weaning high fat diet contributes to changes in M1, M1b and M2 cell numbers to increase fat tissue inflammation. (usda.gov)
Alterations in its expression have an impact both in tissue overgrowth as well as reduce growth observed in the Beckwith-Wiedemann syndrome and the Silver-Russell syndrome, respectively [ 3 ]. (scientificarchives.com)
Electron transport chain (ETC), oxidative phosphorylation, and UCP1 proteins were measured in the interscapular BAT (iBAT) and thoracic perivascular adipose tissue (tPVAT) as well as inflammatory and oxidative parameters. (met-vasc.com)
Using probes modeled after species conserved domains of heparan sulfate proteoglycans, we cloned a novel gene called novocan, raised monoclonal antibodies against a segment of the predicted amino acid sequence of the expressed protein (NOVOcan) and used the antibodies to establish the cell and tissue localization of NOVOcan in postnatal rat brains by immunohistochemistry. (ox.ac.uk)
Tissue inhibitors of metalloproteases (TIMPs) are a multifunctional family of proteins that orchestrate extracellular matrix turnover, tissue remodelling and other cellular processes. (biomedcentral.com)
Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases. (oregonstate.edu)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)

In isolated rat islets mRNA amounts were significantly elevated by glucose proteins foetal serum or particular growth factors such as for example insulin GSK1838705A growth hormones and platelet-derived development elements (PDGF)19. (immune-source.com)
This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. (researchgate.net)
This Rat Matrix Metalloproteinease-8 (Neutrophil Collagenase) ELISA Kit from Innovative Research is intended for quantitative detection of rat MMP-8 in cell culture supernates, serum and plasma (heparin). (innov-research.com)
Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medium to examine the expression of IPO13 and K17. (molvis.org)
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
Cells were grown in RPMI1640 medium supplemented with 10% foetal bovine serum. (viamedica.pl)

In a perfused, fluid-filled, adult rat lung model, ASL glucose was estimated to be 0.5 mM when perfusate glucose was 10 mM [ 4 ]. (ersjournals.com)
The programming of blood pressure, insulin responses to glucose, cholesterol metabolism, blood coagulation, and hormonal settings are all areas of active research.The BMJ's recent editorial on the fetal origins hypothesis stated that it rests only on the "very general" proposition that fetal undernutrition causes coronary heart disease. (bmj.com)
Myocardial gene expression of glucose transporter 1 and glucose transporter 4 in response to uteroplacental insufficiency in the rat. (childrensmercy.org)
Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats. (childrensmercy.org)
Placental expression of glucose transporter proteins 1 and 3 in growth-restricted fetal rats. (childrensmercy.org)
Exposing fetal rats to high levels of glucocorticoids reduces birth weight and results in adults with high blood levels of insulin and glucose. (cdc.gov)
Male offspring of female rats with a history of fetal exposure to glucocorticoids also exhibit low birth weight and glucose intolerance - a multigenerational effect ( 6 ). (cdc.gov)
hypertension and vascular defects ( 8 , 9 ), altered fetal pancreatic development and structure ( 10 ), altered glucose tolerance ( 11 ), altered liver structure and function ( 12 ), altered gene expression ( 13 ), and possibly type 2 diabetes mellitus ( 10 ). (cdc.gov)
Our data show that treatment with FIN improves kidney and vascular damage in a new rat model of DKD with T1D associated with a reduction in inflammation, fibrosis and osteogenic factors independently from changes in glucose homeostasis. (met-vasc.com)
The conclusion is that prescription of stevia in the doses of 250 and 500 mg/kg/d decreases the omentin level indirectly via activating insulin sensitivity and lowering blood glucose in STZ-induced diabetic rats. (researchgate.net)
The alteration of ClC-2 expression in various developmental stages of cerebral white matter with/without being exposed to high glucose was analyzed using RT-PCR, active oxygen detection, TUNEL staining, Western Blot as well as immuno-histochemical staining. (ijbs.com)
In neonates with congenital hyperinsulinism, fetal hyperinsulinemia increases the storage of glucose and lipids with a consequent hyperplasia and hypertrophy of myocardial cells. (biomedcentral.com)

Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia. (genscript.com)
Adaptive responses to maternal hypoxia include activation of placental PLP-Falpha/E gene expression, which may then participate in maternal hematological adjustments required for maintaining maternal and fetal oxygen delivery. (genscript.com)
Meiri H, Osol G, Cetin I, Gizurarson S, Huppertz B. Personalized Therapy Against Preeclampsia by Replenishing Placental Protein 13 (PP13) Targeted to Patients with Impaired PP13 Molecule or Function. (hi.is)
Huppertz B, Meiri H, Gizurarson S, Osol G, Sammar M. Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia. (hi.is)
Factors that cause a low incidence of tumours in offspring after birth, compared contribute to fetal susceptibility to near the end of gestation, in offspring with the incidence and multiplicity of these agents include maternal, pla that were exposed trans placental y. the same types of tumours in their cental, and fetal metabolism, the im This pattern can be seen in the directly exposed mothers. (who.int)

Similarly, in maternal diabetes, hyperglycemia can produce fetal hyperinsulinemia that can persist until the neonatal period. (biomedcentral.com)

Tosh DN, Fu Q, Callaway CW, McKnight RA, McMillen IC, Ross MG, Lane RH, Desai M. Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth. (childrensmercy.org)
Obesity is linked to in utero exposure to glucocorticoids, protein restrictions, and maternal diet and obesity. (cdc.gov)
In humans, low protein intake by women in late pregnancy has been associated with low birth weight, a marker of risk for obesity and other metabolic disorders later in life ( 14 ). (cdc.gov)
Gestational diabetes mellitus (GDM), characterized by hyperglycemia that develops during pregnancy, increases the risk of fetal macrosomia, childhood obesity and cardiometabolic disorders later in life. (biomedcentral.com)

Immunohistochemistry and in situ hybridization (ISH) showed aberrant expression and localization of these molecules at the histological level. (greenmedinfo.com)
Gene and protein expressions were analyzed by real-time RT-PCR and Western blotting, respectively, protein distribution by immunohistochemistry, and steroid hormone concentrations by radioimmunoassay. (biomedcentral.com)
Osteonectin expression was evaluated using immunohistochemistry with anti-secreted protein acidic and rich in cystein (anti-SPARC) antibody. (bvsalud.org)

However, it is not known whether maternal undernutrition increases ATM phenotypic expression in F1 offspring. (usda.gov)
P-glycoprotein expression in mouse brain increases with maturation. (childrensmercy.org)
Elovl activity is low in fetal liver but increases significantly after birth. (oregonstate.edu)
The expression of contactin and Na v 1.3 in the HEK-Na v 1.3 stable cell line significantly increases the current density. (jneurosci.org)
Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)

7. Lindvall, O., Björklund, A.: Organization of catecholamine neurons in the rat central nervous system. (lu.se)

Use of human fetal brain tissues demonstrated that there is a significant, sex-specific, inverse relationship between DNA methylation and gene expression at this locus. (duke.edu)
Bisulfite pyrosequencing identified significant changes in rat sperm DNA methylation at Dlgap2, as well as significant losses of methylation at the same locus in F1 nucleus accumbens (NAc) tissues. (duke.edu)
ENU during the final week of gestat the rapidly changing patterns of gene In both the fetus and the pregnant ion is approximately 50 times that of expression in fetal target tissues, female rat, the target organ for single the mother. (who.int)

Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. (childrensmercy.org)
The epigenome, such as methylation of DNA, controls gene expression without altering the DNA sequence [ 1 ]. (biomedcentral.com)

The activation of this pathway modulates gene transcription and activates multiple downstream Kinasesphosphatases branches, affecting key cellular processes such as protein synthesis, autophagy, apoptosis, and resistance to oxidative stress [ 9 ]. (scientificarchives.com)
Sparstolonin B was showed to alleviate joint swelling in RA rats, inhibited inflammatory cell infiltration and the release of ROS, reduced damage caused by oxidative stress, and suppressed the rate of apoptosis in synovial cells. (hindawi.com)

involved in the control of maternal and fetal adaptations to pregnancy [RGD, Feb 2006]. (genscript.com)
Intrahepatic cholestasis of pregnancy (ICP) is a condition specific to pregnancy, leading to increased fetal morbidity and mortality. (medscimonit.com)

Univariate analysis showed that S100A16 expression was significantly associated with age, pT stage, recurrence, and cancer-specific death. (bvsalud.org)
The protein levels of AMPKα, p-CREB and antioxidant systems (heme oxygenase-1 (HO-1) and catalase) were significantly reduced in HF but normalized in HF-Chow mice. (met-vasc.com)
Our results showed that ClC-2 mRNA and protein expressions in GDM group were significantly increased in white matter of fetal rats after E18 stage, and elevated the level of TNF-α and iNOS in white matter at P0 and P3 stage of newborn rats. (ijbs.com)
However, PDGFα positive cell number at P0 stage and CNPase expression at P3 stage were significantly decreased. (ijbs.com)
In a pilot study, our group recently demonstrated that cannabis use in humans, and exposure to delta-9-tetrahydrocannabinol (THC, the main psychoactive component of cannabis) in rats, is associated with significantly altered levels of DNA methylation in sperm. (duke.edu)
One gene identified as being significantly differentially methylated was an autism candidate gene, Discs-Large Associated Protein 2 (DLGAP2). (duke.edu)

These EV contain a lipid bilayer associated to membrane proteins. (frontiersin.org)

Relative expression and localization of bone morphogenetic proteins (BMP) and their receptors (BMPR), members of a molecular family currently considered as major endocrine and autocrine morphogens and known to be involved in renal development, were investigated in newborn kidneys from RFR exposed and sham irradiated (control) rats. (greenmedinfo.com)
Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)

This study aims to investigate the effect and mechanism of type 2 voltage-gated chloride channel (ClC-2) on myelin development of newborn rats' cerebral white matter with gestational diabetes mellitus (GDM). (ijbs.com)

Nucleocytoplasmic transport is an essential phenomenon in eukaryotic cells controlled by the family of proteins called importins and exportins. (molvis.org)

We explored the effect of FIN in a novel model of type 1 diabetic Munich Wistar Frömter (MWF) rat (D) induced by injection of streptozotocin (15 mg/kg) and additional exposure to a high-fat/high-sucrose diet. (met-vasc.com)
Bone morphogenetic protein expression in newborn rat kidneys after prenatal exposure to radiofrequency radiation. (greenmedinfo.com)
In this study, a simulation model was designed for the exposure of pregnant rats to pulsed GSM-like RFR (9.4 GHz), based on the different resonant frequencies of man and rat. (greenmedinfo.com)
Present study was designed to establish a causal connection between changes in the cell-cell junction protein expression at the blood-testis barrier and alterations in the adult rat testis histology following an anti-androgen flutamide exposure. (biomedcentral.com)
A paternal rat model of THC exposure was used to determine whether these effects at Dlgap2 were heritable. (duke.edu)
Studies in experimental incidence and multiplicity of tumours to Wilms tumour in humans - in the animals increase and the latency period de adult rat after perinatal exposure to a creases with increasing dose. (who.int)
Most experimental studies of the predominant results of earlylife do not develop in rats exposed to the carcinogenesis during prenatal life exposure are what would be expect same carcinogen during adult life and infancy have been conducted ed from a higher effective dose to the (Diwan and Rice, 1995 ). (who.int)
The critical effects of acute duration iodomethane exposure are: (1) fetal losses in rabbits, (2) lesions in rat nasal epithelium, and (3) transient neurotoxicity in rats. (cdc.gov)
Chronic exposure of rats resulted in increased thyroid follicular cell tumors from sustained perturbation of thyroid hormone homeostasis. (cdc.gov)

Human fetal enterocytes in vitro: modulation of the phenotype by extracellular matrix. (qmul.ac.uk)

Uteroplacental insufficiency induces site-specific changes in histone H3 covalent modifications and affects DNA-histone H3 positioning in day 0 IUGR rat liver. (childrensmercy.org)
A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. (childrensmercy.org)
Gametic epigenetic changes - the collection of molecular modifications made to DNA and histone proteins that play a role in regulating gene activity - provide one potential explanation. (duke.edu)

In order to examine whether there are classes of progenitor cells with distinct developmental properties contributing to this developmental progression, we examined antigen expression in progenitor cells during rat retinal development. (nih.gov)
In conclusion, changes in Elovl-5 expression may account for much of the nutritional and developmental control of fatty acid elongation activity in the rat liver. (oregonstate.edu)

The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease. (bmj.com)
The hypothesis states that coronary heart disease is associated with specific patterns of disproportionate fetal growth that result from fetal undernutrition in middle to late gestation. (bmj.com)
These findings suggest that GSM-like radiofrequency radiation interferes with gene expression during early gestation and results in aberrations of bone morphogenetic protein expression in the newborn. (greenmedinfo.com)
High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and protects the brain from the neuropathological changes associated with Alzheimer's disease (AD), and neurological damage associated with epilepsy, fetal alcohol syndrome, and inherited conditions such as Down and Rett syndromes. (mdpi.com)

Therefore, this study aimed to determine whether maternal OCM nutrient intakes and levels modified fetal DNA methylation and in turn altered fetal growth patterns in pregnancies with and without GDM. (biomedcentral.com)

In the 2nd, 3rd, and 4th weeks after surgery, metabolic cages were used to detect the 12 h urine volume of rats in the sham and model groups. (bvsalud.org)

Outcomes of khat extract and cathinone on reproductive parameters of male rats. (edu.et)
Overnight starvation and fish oil-enriched diets repressed hepatic elongase activity in livers of adult male rats. (oregonstate.edu)
Flutamide (50 mg/kg body weight) was administered to male rats daily from 82 to 88 postnatal day. (biomedcentral.com)

Adult rats fed the peroxisome proliferator-activated receptor alpha (PPARalpha) agonist WY14,643 have increased hepatic elongase activity, Elovl-1, Elovl-5, Elovl-6, Delta5, Delta6, and Delta9 desaturase mRNA abundance, and mead acid (20:3,n-9) content. (oregonstate.edu)
Short-term treatment with flutamide applied to adult rats exerts its primary effect on the basal ES, coexisting junctional complexes and their constituent proteins Cx43 and ZO-1, without any apparent morphological alterations in the seminiferous epithelium. (biomedcentral.com)
The susceptibility of but a few known transplacental car and reach the fetus, a carcinogenic the fetus relative to that of adult rats cinogens are organic compounds chemical may have no transplacen is measured as the incidence and that act principal y or entirely by a ge tal carcinogenic activity or may only multiplicity of tumours that develop notoxic mode of action. (who.int)

Investigators at the Grand Forks Human Nutrition Research Center had shown in a previous study that maternal undernutrition such as a low protein diet causes the offspring to become obese. (usda.gov)

are laminin-like diffusible chemotactic protein involved with pancreatic morphogenesis and are likely involved in the legislation of duct-cell and foetal GSK1838705A islet cell migration. (immune-source.com)
These observations claim that is important in pancreatic morphogenesis both prenatally and in the regenerating adult rat pancreas. (immune-source.com)

Moreover, in aged mice and rats, the hippocampal expression of IGF2 is decreased, and adenoassociated viral vector (AAV)-mediated overexpression of IGF2 or recombinant administration of this peptide in the hippocampus restored hippocampal-dependent memory and dendritic spine density impairments [ 16 , 17 ]. (scientificarchives.com)
Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)
Expression of the L1 protein using recombinant DNA technology produces noninfectious virus-like particles (VLPs). (cdc.gov)

To test this hypothesis, we employed a reductionist model: isolated adult rat ventricular myocytes (ARVM) overexpressing wild-type (WT) or mutant SERCA, in which C674 is substituted with a redox-insensitive serine (C674S). (dissertation.com)

In adult rat pancreas mRNA was undetectable practically. (immune-source.com)
After duct ligation its appearance was suprisingly low in the top area of the pancreas whereas it had been highly upregulated in the tail component at 3rd 5 and 7th time GSK1838705A of post-ligation with the utmost expression on time 536. (immune-source.com)

In conclusion, we observed a complex interrelationship between maternal OCM nutrients and fetal DNA methylation levels regardless of GDM status, which may, epigenetically, program molecular pathways related to fetal growth and stress response. (biomedcentral.com)

Particular emphasis was placed on the basal ectoplasmic specialization (ES) in the seminiferous epithelium and expression of gap junction protein, connexin 43 (Cx43). (biomedcentral.com)
Seminiferous epithelium of both groups of rats displayed normal histology without any loss of germ cells. (biomedcentral.com)
IPO13 was colocalized with K17 in the epithelium of the pterygium, and overexpression or knockdown of the IPO13 gene induced upregulation or downregulation of K17 expression in PECs, respectively. (molvis.org)

The insulin-like peptides family is composed of insulin, insulin-like growth factor 1 (IGF1), and insulin-like growth factor (IGF2), together with IGF binding proteins (IGFBP1- IGFBP6) [ 1 ]. (scientificarchives.com)
IGF2 is a single-chain secreted protein of 67 amino acids with important functions in fetal growth and development. (scientificarchives.com)
Despite this, IGF2 is the most abundantly expressed IGF in the central nervous system, where it is highly synthesized in the choroid plexus and meninges in adult rat brains [ 4 ]. (scientificarchives.com)
Unlike IGF1 receptor (IGF1R) and insulin receptor (IR), IGF2R does not have intrinsic tyrosine kinase activity but can recruit G proteins, and even though these G-protein-activated pathways are not well characterized in the brain, PKC and phospholipase C are involved in IGF2 actions in the brain [ 6 ] and other cell types [ 7 ], respectively. (scientificarchives.com)
As mentioned before, IGF2 levels are high in the hippocampus, and several groups have demonstrated the importance of IGF2 expression in shaping memory. (scientificarchives.com)
In rats, it has been demonstrated that the expression of IGF2 is physiologically upregulated during hippocampal-mediated learning, and it is important for memory formation and consolidation [ 11 , 12 ]. (scientificarchives.com)

Intrauterine growth restriction alters T-lymphocyte cell number and dual specificity phosphatase 1 levels in the thymus of newborn and juvenile rats. (childrensmercy.org)
He F, Peng Y, Yang Z, Ge Z, Tian Y, Ma T, Li H. Activated ClC-2 Inhibits p-Akt to Repress Myelination in GDM Newborn Rats. (ijbs.com)
Semi-quantitative duplex RT-PCR for BMP-4, -7, BMPR-IA, -IB, and -II showed increased BMP-4 and BMPR-IA, and decreased BMPR-II relative expression in newborn kidneys. (greenmedinfo.com)

In the fetal period, from nine weeks after conception onwards, there begins the phase of rapid growth that continues until after birth. (bmj.com)
The main feature of fetal growth is cell division. (bmj.com)
Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi. (childrensmercy.org)
Hemodynamic overload activates Gαq-mediated signaling responsible for transcriptional reactivation of fetal growth programs, activation of the mitogen-activated protein kinase (MAPK) cascade, and oxidative stress. (dissertation.com)
Using alpha-adrenergic receptor (αAR) stimulation as a model of Gq-mediated hypertrophy, we found that C674S expression decreased both CM growth and MAPK activation. (dissertation.com)
Intestinal inflammation-induced growth retardation acts through IL-6 in rats and depends on the -174 IL-6 G/C polymorphism in children. (qmul.ac.uk)
[ 5 ] Cohen and colleagues have found that in-utero overexpression of the cystic fibrosis transmembrane conductance regulator (CFTR) increased liquid secretion into the lung, accelerating lung growth in a rat model. (medscape.com)
Transforming growth factor family proteins like TGFß1 can oppose these effects. (medscape.com)

In this study, GDM model was induced in late pregnant rat model. (ijbs.com)
Pregnant rats were exposed to RFR during days 1-3 postcoitum (p.c.) (embryogenesis, pre-implantation) and days 4-7 p.c. (early organogenesis, peri-implantation). (greenmedinfo.com)

Splenocytes from C57BL/6 mice were stained either with a PE-Cy™7 Rat IgG2b, κ isotype control (left panel) or with the PE-Cy™7 Rat Anti-Mouse CD24 antibody (right panel) in conjunction with an APC Hamster Anti-Mouse CD3e antibody (Cat.No. 553066). (bdbiosciences.com)

Oval cells proliferate and differentiate in hepatocytes expressing albumin, and they differentiate in biliary cells expressing cytokeratin 7 (CK 7).Serial Analysis of Gene Expression (SAGE) was applied to the hepatic stem cell model of rat liver regeneration for studying gene expression pattern of liver regeneration during early stage of oval cell proliferation and differentiation. (uni-goettingen.de)
In contrast, Elovl-6, Delta9 desaturase, and FAS mRNA abundance paralleled changes in hepatic sterol regulatory element binding protein 1c (SREBP-1c) nuclear content. (oregonstate.edu)

Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. (thermofisher.com)
Uteroplacental insufficiency decreases p53 serine-15 phosphorylation in term IUGR rat lungs. (childrensmercy.org)
Levels of phosphorylation and protein expression were determined using western blotting. (hindawi.com)

Erythropoietin improved cognitive function and decreased hippocampal caspase activity in rat pups after traumatic brain injury. (childrensmercy.org)

Iron and BIM (Bcl-2-interacting mediator of cell death) proteins were involved in the cytotoxic sensitization process. (jneurosci.org)

lcn2 expression and secretion increased after inflammatory stimulation in cultured astrocytes. (jneurosci.org)
The administration of Sparstolonin B inhibited the secretion of IL-17 from Th17 cells and triggered the secretion of TGF- β from Treg cells, thus leading to the reduced expression of TLR4, MyD88, and NF- κ B, and the suppression of TNF- α secretion. (hindawi.com)

In the maternal low protein diet group, M1 cell numbers did not change while M2 cell numbers increased when the offspring were fed a high-fat diet. (usda.gov)
In the maternal normal protein group, both M1 and M2 cell numbers increased when fed a post-weaning high-fat diet. (usda.gov)
The ratio of M1 and M2 did not change with maternal and post weaning diets while M1b cell numbers increased in maternal normal protein and post-weaning high-fat diet group. (usda.gov)
Interestingly, cyclin D1 and CDC42 proteins are coexpressed temporally with the oval cell protein marker AFP. (uni-goettingen.de)
for example, in the rat, several cell types are born during the prenatal period, while others are born postnatally. (nih.gov)
In GDM group, ClC-2 expression in the corpus callosum (CC) and cingulate gyrus (CG) regains, and TUNEL positive cell number were increased at P0 and P3 stage. (ijbs.com)
LCN2 protein induced upregulation of glial fibrillary acidic protein (GFAP), cell migration, and morphological changes similar to characteristic phenotypic changes termed reactive astrocytosis. (jneurosci.org)
9. Björklund, A., Skagerberg, G.: Evidence for a major spinal cord projection from the diencephalic A11 dopamine cell group in the rat. (lu.se)
As shown by examination of semi-thin and ultrathin sections, cell surface occupied by the basal ES connecting neighboring Sertoli cells and the number of gap and tight junctions coexisting with the basal ES were apparently reduced in flutamide-treated rats. (biomedcentral.com)
To introduce altered Drosophila Gap1 transgenes into flies, the sevenless ( sev ) enhancer/promoter cassette, an eye-specific promoter, was used to drive expression in cone cell precursors at appropriate levels. (sdbonline.org)
We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. (molvis.org)
Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)
The data showed that adenine activated AMP-activated protein kinase (AMPK) signaling contributing to autophagic cell death through mTOR in both colon cancer cell lines. (hindawi.com)
Contactin/F3, a cell adhesion molecule, has been shown to interact with and enhance surface expression of sodium channels Na v 1.2 and Na v 1.9. (jneurosci.org)
Retinoic acid is a regulator of gene expression which, by binding to its nuclear receptor, determines the degree of differentiation in multiple cancer cell types. (viamedica.pl)
This substance acts in a similar way on a rat pheochromocytoma cell line PC12. (viamedica.pl)
Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)

The human neutrophil collagenase(HNC) cDNA clone has been sequenced and shown to encode a 467-residue protein. (innov-research.com)

Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
Hence, it was proposed that oval cells could represent a second compartment involved in the liver regeneration when the insult of the organ is too massive and proliferation of hepatocytes is suppressed.We performed the model of rat liver regeneration via oval cells using the protocol of 70% partial hepatectomy (PH) plus 2-Acetoamidofluorene (2-AAF) treatment. (uni-goettingen.de)
Oval cells are induced between 1 and 3 days after PH inside the portal field and they express the typical onco-foetal marker alpha foeto-protein (AFP), at mRNA and protein levels. (uni-goettingen.de)
Cases with >5% expression and more than moderate staining intensity on cancer cells were considered positive. (bvsalud.org)
The severity of the phenotypes correlates with the expression levels of the hEGFR KI allele, which is not efficiently expressed in epithelial and bone cells, but is expressed at similar and even higher levels as the endogenous Egfr in brain and heart. (silverchair.com)
These findings demonstrate that expression of these two markers by progenitors is highly correlated with a bias towards the production of amacrine and horizontal cells. (nih.gov)
In zebrafishes, forced expression of rat lcn2 gene increased the number and thickness of cellular processes in GFAP-expressing radial glia cells, suggesting that lcn2 expression in glia cells plays an important role in vivo . (jneurosci.org)
Macrophage inflammatory protein-2: chromosomal regulation in rat intestinal epithelial cells. (qmul.ac.uk)
MMP8, an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells. (innov-research.com)
Importin 13 (IPO13), a member of the importin-β superfamily, was originally identified in the fetal rat lung and differentially expressed in cells of epithelial and mesenchymal origin. (molvis.org)
Adenine improves the survival of rat Purkinje cells and enhances the storage of erythrocyte in whole blood [ 6 - 8 ]. (hindawi.com)
Purified GST fusion proteins of the N and C termini of Na v 1.3 pull down contactin from lysates of transfected HEK 293 cells. (jneurosci.org)
which may render the genetic mate doses of NDMA is the kidney, but a Transplacental carcinogenesis rial of fetal cells highly accessible to much lower incidence of tumours is stu dies with ENU in nonhuman pri carcinogens. (who.int)

Using a rat model of prenatal low protein (LP, 8% protein) diet followed by a postnatal high fat energy diet (HE, 45% fat) or low fat normal energy diet (NE, 10% fat) for 12 weeks, we investigated the effect of these diets on adiposity, programming of the offspring ATM phenotype, and the associated inflammatory response. (usda.gov)

S100A16 expression may be a biomarker of a biologically aggressive phenotype and poor prognosis in patients with BC who underwent RC. (bvsalud.org)
Model rats underwent bladder outlet obstruction surgery. (bvsalud.org)
Sperm DNA from rats exposed to THC or vehicle control via oral gavage underwent RRBS. (duke.edu)
Sperm DNA from rats exposed to nicotine or vehicle control underwent pyrosequencing at the same regions. (duke.edu)

Ras signaling can be thought of in simple terms as occuring downstream of receptor tyrosine kinases, triggered by association of adaptor proteins with the phosphorylated cytoplasmic tails of these receptors. (sdbonline.org)

Dihydropyrimidinase-related protein 3 is an enzyme that in humans is encoded by the DPYSL3 gene. (wikipedia.org)

Bisulfite pyrosequencing of sperm DNA from rats exposed to injected THC or vehicle control was performed to examine methylation at regions identified by RRBS. (duke.edu)
We analyzed the association between maternal OCM nutrients and fetal DNA methylation using a generalized linear mixed model. (biomedcentral.com)

Protein Expression in Down Syndrome Brain. (wikipedia.org)

Important cytoprotective mechanisms activated by oxidative inflammatory conditions are mediated by nitrated fatty acids that covalently modify proteins to limit inflammation and oxidant stress. (aspetjournals.org)
Sparstolonin B improved inflammatory responses and oxidative stress by inhibiting the NLRP3 inflammasome, inhibiting the expression of FucT-V and downregulating the TLR4/MYD88/NF-𝜅B signaling pathway in order to rescue RA. (hindawi.com)

In this process, astrocytes proliferate to fill gaps and undergo a typical morphological change: a large cytoplasmic mass, long and branched processes, and increased expression of intermediate filaments such as glial fibrillary acidic protein (GFAP). (jneurosci.org)

We determined the arthritis index for each group of rats, and pathological changes were evaluated by hematoxylin-eosin staining. (hindawi.com)
Lewy bodies which are intraneuronal aggregates composed mainly of misfolded alpha synuclein (a-syn) protein is a pathological hallmark seen in both sporadic and genetic forms of PD. (lu.se)

Anatomy4

Organisms1

Chemicals and Drugs4

Information Science1

Embryonic4

Genes8

Result in fetal1

Tissue12

Serum6

Glucose12

Placental5

Neonatal1

Obesity4

Immunohistochemistry3

Increases5

Neurons1

Tissues3

Epigenome2

Apoptosis2

Pregnancy2

Significantly6

Lipid1

Bone morphoge2

Gestational diabetes1

Family of proteins1

Exposure9

Extracellular matrix1

Histone3

Developmental2

Gestation4

Patterns1

Sham1

Male rats3

Adult rats3

Undernutrition1

Pancreatic2

Recombinant3

Hypothesis1

Pancreas2

Molecular1

Epithelium3

IGF26

Newborn3

Growth8

Pregnant2

Mice1

Hepatic2

Phosphorylation3

Hippocampal1

Mediator1

Secretion2

Cell17

Encode1

Cells13

Prenatal1

Underwent4

Receptors1

Humans1

Methylation2

Syndrome1

Inflammatory2

Morphological1

Pathological2