• Increased levels of laminin-111 triggered an increase in the expression of α7-integrin receptor and this prevented onset of the disease. (wikipedia.org)
  • Integrin α7β1 plays an important role in maintaining adult skeletal muscle integrity and like dystrophin, provides anchorage and bidirectional signaling as a laminin receptor. (uea.ac.uk)
  • The expression of α7β1 integrin was upregulated upon dystrophin deficiency arguing for the molecular compensation and thus considered as potential candidate for treatment of Duchenne Muscular Dystrophy (DMD). (uea.ac.uk)
  • In this study we show that increased levels of the adult extracellular variant X2 interfere with muscle integrity, while the presence of embryonic integrin α7 extracellular variant X1 results in normal skeletal muscle architecture. (uea.ac.uk)
  • Adult Dorsal Root Ganglion (DRG) neurons plated on surfaces coated with a thin film of laminin exhibited increased neurite outgrowth, this growth was correlated with increased expression of laminin binding integrin subunits. (mun.ca)
  • Laminin-induced neurite growth was integrin-dependent as it was attenuated by treatment with either a cyclic Arg-Gly-Asp (RGD) peptide or a β1 integrin-blocking antibody (β1i). (mun.ca)
  • The addition of NGF to cells plated on laminin resulted in a significant and synergistic increase in the integrin-dependent outgrowth. (mun.ca)
  • Indeed, though only 30% of untreated cells moved about the endothelial surface, from the presence of TGF B the amount of motile cells multiply 3 fold and moved by emitting filopodia, indicative of integrin mediated displacement. (interleukin-receptor.com)
  • Integrin mRNA expression is elevated in TGF B taken care of cells To get a metastases linked mRNA signature distinct to TGF B handled H157 NSCLC cells, we utilized the SABiosciences RT2 Profiler PCR Array that measures the expression of 94 genes relevant to adhesion molecules, proteases and extracellular matrix elements. (interleukin-receptor.com)
  • Interestingly sufficient, TGF B induced increases while in the expression of various integrins, such as 2, v, B1 integrins and most prominently, B3 integrin as it has become described in other methods. (interleukin-receptor.com)
  • B3 integrin is required to mediate the TGF B driven increases in cell transmigration across LECs Based to the considerable induction of integrin expression observed in our experimental ailments, we investigated the part of integrins in NSCLC adhesion to LECs. (interleukin-receptor.com)
  • AAV2 for example can attach to heparan sulfate proteoglycan (HSPG) cell surface receptors, fibroblast growth factor receptor-1 (FGFR1), hepatocyte growth factor (HGF) receptor, and laminin receptor, whereas ανβ5 integrin and α5β1 integrin can act as co-receptors. (progen.com)
  • At the end of the behavioral tests, the levels of tumor necrosis factor- (TNF-), interleukin (IL)-1, nitric oxide (NO), inducible nitric oxide synthase (iNOS), CD11b/c integrin expression, and synaptophysin immunoreactivity were determined in the brain tissues. (health-e-nc.org)
  • NO levels, CD11b/c integrin expression, and synaptophysin Rabbit polyclonal to Vang-like protein 1 immunoreactivity were also reduced as compared with those in the LPS-challenged group. (health-e-nc.org)
  • Globular domains (G-Domain) of the α chain are the regions on laminin-111 that allow the binding of integrins, glycoproteins, sulfated glycolipids and dystroglycan. (wikipedia.org)
  • When α chains of laminin-111 bind to cell surface receptors integrins α1β1, α3β1, α4β1, α6β1 and Cdc42 GTPase are activated. (wikipedia.org)
  • Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI. (lookformedical.com)
  • Accordingly, the differential expression of 18 chosen genes was confirmed by Serious MEK162 MEK inhibitor Time PCR, including the many integrins detected. (interleukin-receptor.com)
  • Thus, Dab2 mediates the simultaneous attachment of clathrin-coated cargos containing transmembrane proteins with one or more NPXY motifs, such as the low density lipoprotein (LDL) receptor, megalin, and integrins, to the myosin motor, enabling endocytosis and directional trafficking. (biomedcentral.com)
  • In contrast, the intestinal SALSA was more enriched with the scavenger receptor cysteine-rich domains. (researchgate.net)
  • Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of oncogenic alterations, including the constitutively active epidermal growth factor receptor (EGFRvIII). (cancer-genetics.org)
  • The overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is usually associated with aggressive and infiltrating breast cancer (BC) phenotype, and metastases. (dovepress.com)
  • P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
  • Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
  • Description: The APB5 monoclonal antibody reacts with the mouse CD140b molecule, the beta chain of the platelet derived growth factor receptor (PDGF receptor). (thermofisher.com)
  • The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. (thermofisher.com)
  • The O-linked 2,3-sialic acid serves as a binding receptor for AAV4, whereas the N-linked sialic acid represents the binding receptors for AAV1, AAV5 & AAV6 with, for example, the platelet-derived growth factor receptor acting as a co-receptor for AAV5 internalization. (progen.com)
  • Laminin-111 (also "laminin-1") is a protein of the type known as laminin isoforms. (wikipedia.org)
  • It was among the first of the laminin isoforms to be discovered. (wikipedia.org)
  • The distribution of the different laminin isoforms is tissue-specific. (wikipedia.org)
  • In cell adhesion laminin-111 and other isoforms are important proteins that anchor cells to the extracellular matrix (ECM). (wikipedia.org)
  • We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
  • This suggests that while a combination of Piezo2 and other Na V isoforms is sufficient to elicit activity in response to transient stimuli, Na V 1.1 is required for transmission of receptor potentials generated during sustained muscle stretch. (elifesciences.org)
  • Activation of c-Jun kinases leads to high levels of c-Jun expression which results in neurite outgrowth. (wikipedia.org)
  • Nonetheless, Nitric Oxide synthesis is shown to be an important element in laminin-mediated neurite outgrowth. (wikipedia.org)
  • The injection of laminin-111, however, helps with Duchenne muscular dystrophy, a neuromuscular disease in which the connection between the extracellular matrix and cell cytoskeleton is lost. (wikipedia.org)
  • By a yeast two-hybrid approach, we identified an interaction between the AChE and an 898 bp fragment of laminin-beta1 chain, an extracellular matrix protein involved in neuronal differentiation and adhesion processes. (tu-darmstadt.de)
  • Correction of chemistry hypercholesterol Chemistry and training Regression emissions foam was reached early somatic gene transfer making use of an adenovirus apoE vector.five but short apoE gene expression threshold a Restrict Restriction which prevents regression scientific studies sophisticated, additional clinically appropriate alterations Ver Ver. (alksignaling.com)
  • Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancer-genetics.org)
  • In addition, we performed genome-wide stratified and interaction analyses by gender, smoking and airway obstruction status, and assessed associations between gene expression and methylation for genome-wide significant CpGs (n=2802). (bmj.com)
  • Seven out of 31 CpGs were associated with gene expression levels. (bmj.com)
  • The co-infection with one of the AAV helper viruses leads to the initiation of AAV gene expression, replication and the production of AAV virions. (progen.com)
  • He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)
  • This study evaluates the effect of A. montana leaves hexane extract on several signaling cascades and gene expression in metastatic breast cancer cells upon insulin-like growth factor-1 (IGF-1) stimulation. (techscience.com)
  • Using a recombinant endonuclease-deficient Cas9-based gene promoter pulldown approach coupled with mass spectrometry, we found that MCUb is upregulated in the T2D heart due to loss of glucose homeostasis regulator nuclear receptor corepressor 2 repression, and chromatin immunoprecipitation assays identified peroxisome proliferator-activated receptor α as a mediator of MCUb gene expression in T2D cardiomyocytes. (diabetesjournals.org)
  • HomB protein contributes to the colonization and persistence of H. pylori , and the presence of homB genes affects the number of bacteria adhering to the host cells. (nature.com)
  • In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
  • Laminin 411 markedly induced the expression of the genes Foxa2 and Sox17 , markers for pancreatic precursor cells, efficiently induced IPC differentiation from MSCs, and up-regulated insulin expression at both mRNA and protein levels. (biomedcentral.com)
  • Furthermore, the expression of the genes known to govern insulin expression including Pdx1 and Ngn3 was markedly induced by laminin 411, which suggests that Pdx 1 and Ngn 3 signaling pathways are involved in laminin 411 induced-insulin expression machinery. (biomedcentral.com)
  • We observed that EGFRvIII expression alters the expression of EV-regulating genes (vesiculome) and EV properties, including their protein composition. (cancer-genetics.org)
  • Enriched expression of genes in LRECb was associated with stem cell attributes and identified WNT, TGF-β, and MAPK pathways of self renewal and proliferation. (frontiersin.org)
  • We also observed enhanced expression of MMPs, ADAMTS, TIMP and CTGF, amongst other genes. (interleukin-receptor.com)
  • Furthermore, AAV enables long-term transgene expression due to its latent state and thus in theory genes only need to be delivered once. (progen.com)
  • Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)
  • We show that the absence of Yap and Taz causes a severe peripheral neuropathy due to a developmental impairment in axonal sorting, and that Yap/Taz-Tead1 are required for the transcriptional regulation of laminin receptors in Schwann cell. (holyexperiment.org)
  • The synthesized laminin-111 formed in an embryo contributes to the formation of Reichert's membrane, a thick extra-embryonic basement membrane. (wikipedia.org)
  • When the laminin α1 chain is deficient in an organism, an embryo dies, likely as a result of a defective Reichert's membrane due to a lack of laminin-111 being produced. (wikipedia.org)
  • If the β1 or γ1 chains of laminin-111 are absent the basement membrane fails to form. (wikipedia.org)
  • The self-assembly and tight network formation by laminin-111 are essential for holding the basement membrane together. (wikipedia.org)
  • Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)
  • Depending on the serotype, different receptors and co-receptors located in the host membrane mediate the entry process. (progen.com)
  • Mutations in GPR56 , an orphan G-protein-coupled receptor (GPCR), cause bilateral frontoparietal polymicrogyria (BFPP), a disorder characterized by mental retardation, seizures, motor developmental delay, and ataxia. (jneurosci.org)
  • Scope includes mutations and abnormal protein expression. (cancer-genetics.org)
  • The outcomes secure the indisputable fact that immunogenic poly-tope necessary protein inside the presence of chitin and also chitosan microparticles as mucosal adjuvants has the capacity to cause humoral along with cell-mediated responses parenteral immunization within BALB/c rodents. (sirna-library.com)
  • A fragment of the Dab2 human cDNA was also isolated based on its frequent loss of expression in ovarian cancer, and was termed DOC-2 (Differentially expressed in ovarian carcinoma gene 2) [ 2 ]. (biomedcentral.com)
  • Different levels of expression of α chains have a large influence on the differential expression of laminin, thereby determining the isoform produced. (wikipedia.org)
  • Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. (cancer-genetics.org)
  • The anti- laminin degrading activity of a peptide which binds to the receptor, but has no active site, will be tested in specific aim #3. (grantome.com)
  • These variances might be as a consequence of their diverse targeting molecules though P144 binds to TGF B, SB431542 especially inhibits the phosphorylation of one among its receptors namely TGF BRI. (interleukin-receptor.com)
  • Although the cellular controls of urokinase and its receptor are poorly understood, they represent ideal therapeutic targets and may ultimately yield anti-metastatic agents. (grantome.com)
  • For example, the PI3K/AKT pathway is used by laminin-111 (promotes cell-survival), 511 (prevents apoptosis with laminin 521), and 521 (stabilizes pluripotency of human embryonic stem cells). (wikipedia.org)
  • From studying a mouse model, it was found that transcription factors present in the parietal endoderm regulate the expression of the α1 and large amounts of laminin-111 are produced. (wikipedia.org)
  • Conversely, atRA or TTNPB promoted β-cell differentiation accompanied by enhanced expression of vascular basement component, laminin. (bath.ac.uk)
  • The autoimmune attack occurs when autoantibodies form against the nicotinic acetylcholine postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)
  • [ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)
  • Even though there is not a general mechanism that applies to all laminins in signalling, there are some common pathways that can be seen in more than one isoform of laminin. (wikipedia.org)
  • Our results demonstrate that laminin 411 acts as a potent differentiation inducer of IPCs from UC-MSCs via the Pdx1 and Ngn3 signaling pathways. (biomedcentral.com)
  • Dab2 also modulates cellular signaling pathways by mediating the endocytosis and recycling of surface receptors and associated signaling components. (biomedcentral.com)
  • After the attachment of AAV to the cell surface receptor of the target cell, the virus gets internalized by endocytosis. (progen.com)
  • Modulation of LDL receptor endocytosis by Dab2 has also been studied in cultured cells [ 36 ], though a role in vivo has not yet been established. (biomedcentral.com)
  • As neurons in the adult rat DRG can be classified into at least three separate subpopulations based on morphologic and phenotypic differences, a cell selection approach was utilized to show that laminin-induced neurite growth occurs in the absence of added trophic factors only in heavy chain neurofilament positive and calcitonin gene related peptide positive DRG neurons (NGF-responsive population). (mun.ca)
  • Additionally, the presence of laminin-111 increased muscle strength and protected it from injury. (wikipedia.org)
  • Laminin-111 is predominantly expressed in the embryonic epithelium, but can also be found in some adult epithelium such as the kidney, liver, testis, ovaries, and brain blood vessels. (wikipedia.org)
  • Although it is expressed abundantly during the early embryonic stage, laminin-111 is mostly absent in adults. (wikipedia.org)
  • Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)
  • Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)
  • Taken together, these features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues. (jci.org)
  • The single-molecule resolution of dSTORM allows quantifying molecules at the nanoscale, giving a detailed insight into the distributions of individual NP ligands and cell receptors. (ibecbarcelona.eu)
  • Studies will be undertaken to determine what part of the urokinase molecule is responsible for receptor modulation. (grantome.com)
  • The existence of multiple molecular forms, the homology with other neuronal cell adhesion molecules, and the early expression pattern, suggest that AChE may function in cell adhesion, and thus in neurite growth, guidance and even synaptogenesis. (tu-darmstadt.de)
  • These factors include neurotrophins, such as Nerve Growth Factor (NGF), and adhesion molecules, such as laminin. (mun.ca)
  • Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)
  • This last point is crucial, since it explains how upregulation of this receptor can contribute to an ascending spiral of RAGE-dependent cellular perturbation. (jci.org)
  • Preliminary studies show that urokinase is a negative regulator of its receptor in well differentiated cells. (grantome.com)
  • In contrast, laminin alone is not sufficient to stimulate significant neurite growth from lectin Griffonia simplicifolia 1B4 positive neurons (IB4+ve), although it is still required to elicit a growth response from these cells in the presence of Glial Cell Line Derived Neurotrophic Factor (GDNF) (e.g., neurite growth occurred only when cells were plated on laminin in the presence of GDNF). (mun.ca)
  • Flow cytometry, Quantitative realtime PCR, immunofluorescence staining, ELISA, Western blotting and other techniques were applied to determine IPC generation, insulin expression and related mechanisms. (biomedcentral.com)
  • Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) can reduce hypertension and may also contribute to reducing proteinuria. (medscape.com)
  • The linkage between cells and the ECM is formed by binding cell surface receptors to one end of the laminin α chain and binding ECM components to another region of the laminin. (wikipedia.org)
  • Besides anchoring cells to the ECM, laminins are also involved in the signalling of cells and other components of the ECM. (wikipedia.org)
  • Poorly differentiated cells display 10X more urokinase receptors than well differentiated cell types. (grantome.com)
  • The ability of urokinase to reduce receptor number in poorly differentiated cells will be determined in specific aim #2. (grantome.com)
  • At the age of defect onset, GPR56 expression is restricted specifically to developing granule cells in the rostral cerebellum, suggesting that GPR56 regulates properties of these cells. (jneurosci.org)
  • After seven days in the presence of ascorbic acid, which causes proliferation, basal lamina deposition and myelination, Yap and Taz were found in the nuclei of many Schwann cells. (holyexperiment.org)
  • Here, we developed a labeling approach to quantify the number of functional cetuximabs conjugated to NPs and the expression of epidermal growth factor receptors (EGFRs) in breast cancer cells using direct stochastic optical reconstruction microscopy (dSTORM). (ibecbarcelona.eu)
  • Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)
  • Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)
  • In concordance with this observation, augmented surface expression of the C-C chemokine receptor 2 (CCR2) of mDC suggest an increased migration activity to inflamed peripheral tissues, such as the skin. (uni-marburg.de)
  • We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues. (techscience.com)
  • The regulation of expression of urokinase and its receptor in colon cancer will be investigated. (grantome.com)
  • however, little is known about a role of laminin 411 in the regulation of IPC differentiation from human MSCs. (biomedcentral.com)
  • According to the American Society of Clinical Oncology (ANCO) guidelines on breast cancer follow-up and management, symptoms of breast cancer recurrence include presence of new breast lumps, pain in the bone, chest or abdomen, dyspnea and constant headaches ( 5 ). (iiarjournals.org)
  • More importantly, administration of laminin 411-induced IPCs rapidly and significantly down-regulated fasting blood glucose levels, significantly reduced the HbA1c concentration and markedly improved the symptoms and survival of T1DM rats. (biomedcentral.com)
  • Patients with DH and CD may have the same association with histocompatibility antigens (HLA), the presence of circulating IgA against transglutaminase autoantigens and clinical remission on gluten-free diet. (scielo.br)
  • These novel finding highlights a potential clinical application of laminin 411 induced-IPCs in the treatment of T1DM, which calls for further studies. (biomedcentral.com)
  • When injected with myoblast transplants, laminin-111 decreased degeneration and inflammatory reactions and increased the success of the transplantation. (wikipedia.org)
  • The tissue tropism of the different AAV serotypes is determined by the different cell surface receptors used for the attachment to the target cell. (progen.com)
  • Their expression profiles are consistent with the hypothesis that the neurexins and AChE have a function in early neuronal differentiation and axonogenesis. (tu-darmstadt.de)
  • At a molecular level, the number of functional antibodies on the NP surface and the density of receptors on the target cell determine the targeting interaction. (ibecbarcelona.eu)
  • Finally, we correlated the NP functionality, cell receptor density, and NP uptake to identify the highest cell uptake selectivity regimes. (ibecbarcelona.eu)
  • Further analysis indicated that Src was potentially a key point of collaboration between NGF and laminin induced neurite growth in NGF-responsive adult DRG neurons. (mun.ca)
  • UC-MSCs were then cultured in the IPC induction and differentiation medium in the presence of laminin 411. (biomedcentral.com)
  • Indeed, all of the cultured colon cancer cell lines degrade laminin, in the presence of plasminogen. (grantome.com)
  • DH is characterized by the presence of IgA deposits on top of the dermal papillae and manifests itself mainly on the extensor surface of the limbs, buttocks and scapular area. (scielo.br)
  • PDGFRb is a receptor tyrosine kinase that forms dimers on the surface upon ligand binding and phosphorylates substrates. (thermofisher.com)
  • PDGFRb is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. (thermofisher.com)
  • In its presence, growth factors either adsorb or moisten the surface of the bone substitutes, promoting an adequate integration with the host bone 13 . (bvsalud.org)
  • The specific expression and distribution of the different BM components in the islets were yet to be fully characterized. (nature.com)