• It has a special configuration that gives particular elastic properties to protein: collagen fibers are located in the extracellular matrix and have the capacity to increase or reduce their volume according to the degree of compression to which they are subjected. (springer.com)
  • Osteocytes compose lacunar-canalicular network by their cytoplasmic dendrites that connect them to each other and to cells on the bone surface, important for intracellular and extracellular communication (Figure 1 ) [ 11 , 12 ]. (biomedcentral.com)
  • uNK cells isolated from obese women had altered expression of genes and pathways associated with extracellular matrix remodeling and growth factor signaling. (jci.org)
  • Among the extracellular matrix compounds used in this study, two (collagen I and fibronectin) allowed only a weak attachment of cortical neurons to the substratum, while the others (collagen IV, laminin, and basal lamina from Engelbreth-Holm-Swarm sarcoma) allowed both firm attachment and moderate to extensive neurite outgrowth from neuronal cell bodies. (curehunter.com)
  • In DNA microarray results, compared to control, CaG treated mouse group showed upregulation of 192 genes including collagen,typeI,alpha1 (Col1a1), consistent with the highly increased in vitro extracellular matrix (ECM) adhesion on collagen 1 and up-regulation of heparanase (Hpse). (biomedcentral.com)
  • GO and KEGG analyses showed that the upregulated DEGs were mainly enriched in the extracellular matrix (ECM) organization of the biological process (BP), the collagen-containing ECM of cellular component (CC), and the ECM structural constituent of molecular function (MF). (hindawi.com)
  • Efficient and stable expression of foreign genes in cells and transgenic animals is important for gain-of-function studies and the establishment of bioreactors. (chinaagrisci.com)
  • 2.2e-16) with that of the wild type cells, indicating that the GFP knock-in did not alter the global expression of endogenous genes. (chinaagrisci.com)
  • Genes mainly involved in coding adhesion molecules and growth factors have also been found to be upregulated in other types of CAFs, including colon ( 12 ) and pancreatic ( 13 ). (spandidos-publications.com)
  • Then, the relationship between the expression level of the core genes and the prognosis of gastric cancer patients was analyzed using the Gene Expression Profiling Interactive Analysis (GEPIA) database. (hindawi.com)
  • Results: ADGRG1 is the most abundant GPCR mRNA in both human and mouse islets, and its expression inhumanislets strongly correlates with genes important for β-cell function and T2 Drisk. (lu.se)
  • Objective -To evaluate expression of the α6 chain of type IV collagen in the glomerular basement membranes (GBM) of healthy dogs. (avma.org)
  • Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. (wikipedia.org)
  • Type VII collagen is the major component of structures in the skin called anchoring fibrils. (medlineplus.gov)
  • When type VII collagen is abnormal or missing, anchoring fibrils cannot form properly. (medlineplus.gov)
  • As a result, little type VII collagen is available to make anchoring fibrils. (medlineplus.gov)
  • When the abnormally shaped collagen molecules are incorporated into anchoring fibrils, they interfere with the fibrils' normal function and prevent them from effectively connecting the epidermis and the dermis. (medlineplus.gov)
  • The qPCR results showed that the GFP knock-in had no effect ( P =0.29, P =0.66 and P =0.20 for PK15, PEF and IPI-2I cells, respectively) on the mRNA expression of COL1A1 gene. (chinaagrisci.com)
  • Using mRNA microarray gene expression analysis of 15 ACP patient samples, we have found several pharmaceutical targets that are significantly and consistently overexpressed in our panel of ACP relative to other pediatric brain tumors, pituitary tumors, normal pituitary and normal brain tissue. (biomedcentral.com)
  • Expression of mouse zonadhesin mRNA is evident only within the testis, and the protein is found exclusively on the apical region of the sperm head. (embl.de)
  • Fibroblasts from lesional tissue of patients with eosinophilic fasciitis produce excess collagen in vitro and display elevated TGF-beta and type 1 collagen mRNA levels when examined via in situ hybridization with specific cDNA. (medscape.com)
  • However, if phagocytosis of the cell does not occur at the final stage of apoptosis or autophagic process, the cells are removed through secondary necrosis [ 12 ]. (biomedcentral.com)
  • In addition, the later expression of t-TGase, an indicator of apoptosis, on the inner wall of angiogenic capillaries in the SACCHACHITIN group may indicate a longer period of blood supply to the wound area, thus facilitating wound healing. (tmu.edu.tw)
  • Anti-FAP-treated myofibroblasts were analyzed for TIMP-1 expression by immunoblotting, for migratory potential by wound healing assay, and for apoptosis by Annexin V staining. (unimi.it)
  • Collagens are a big family of proteins, the main one forming connective tissue in all higher animals. (springer.com)
  • Collagens are a family of proteins that strengthen and support connective tissues, such as skin, bone, tendons, and ligaments, throughout the body. (medlineplus.gov)
  • 3%). The organic phase is mainly formed by collagen type I fibers, which provide elasticity and flexibility to bone, but also non-collagenous proteins as well, such as cytokines, growth factors, and proteoglycans. (biomedcentral.com)
  • The literature shows that in urinary incontinence occurrence, the gene expression of proteins was altered as well as increased activity of MMPs. (fapesp.br)
  • UV rays destroy our collagen and elastin proteins as well as dehydrates the skin, leaving it weathered, brittle and more susceptible to damage. (beautyandgroomingtips.com)
  • Some research has suggested that abnormal forms of type VII collagen that retain a procollagen fragment called the NC1 domain may increase the risk of tumor formation. (medlineplus.gov)
  • The tumor microenvironment or tumor stroma comprises various cell types, including cancer-associated fibroblasts (CAFs), immune cells, endothelial cells, and mesenchymal cells. (biomedcentral.com)
  • Experimental drugs targeting each of these gene products are currently being tested clinically and pre-clinically for the treatment of other tumor types. (biomedcentral.com)
  • Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
  • In vivo anti-cancer effect of dung beetle GAG on solid tumor size, survival time and gene-expression profiles was also assayed using B10F10 melanoma mice model. (biomedcentral.com)
  • Glycosaminoglycan, CaG can strengthen ECM by increasing activity of TIMP-2 and adhesion activity on collagen known to inhibit changes of ECM, leading to tumor cell invasion and progression. (biomedcentral.com)
  • Hence, altering expression of CS and heparan sulfate (HS) on surface of tumor cells is a potential molecular strategy to prevent malignant transformation and tumor metastasis [ 2 ]. (biomedcentral.com)
  • Cancer-associated fibroblasts (CAFs) are one major type of component identified in the tumor microenvironment. (spandidos-publications.com)
  • This is important because collagen, which is the most abundant protein in the human body, is necessary for skin elasticity. (drpingel.com)
  • This is important because type I collagen is the most abundant type of collagen in the body and helps to minimize wrinkles and fine lines as well as improve the elasticity and hydration in your skin. (drpingel.com)
  • Stabilize collagen aldimine reducible cross-links to reinforce the strength and elasticity of connective tissues such as cartilage, synovium, ligaments, tendons, fascia, bone, blood vessel walls and the dermis of the skin. (life-enthusiast.com)
  • the wrinkles are caused by age, as we age the skin loses the agent that gives it elasticity called collagen. (beautyandgroomingtips.com)
  • The purpose of the present study was to determine relationship between disease activity, systemic markers of cartilage degradation, urinary C-terminal cross-linking telopeptides of type II collagen (uCTX-II), and bone degradation, urinary C-terminal cross-linking telopeptides of type I collagen (uCTX-I), structural progression of osteoarthritis (OA) and potential therapeutic efficacy of type II collagen (COLLII) in combination with glucosamine and chondroitin sulfate (GC). (springer.com)
  • Articular cartilage is divided into four zones-superficial, intermediate, deep and calcified-according to morphology, the orientation of collagen fiber, and the proteoglycan content. (springer.com)
  • This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. (nih.gov)
  • This bone turnover comprises the temporal and spatial coordination of two processes performed in bone remodeling units at discrete sites throughout the skeleton: removal of old and damaged bone by osteoclasts, called resorption, which can last 4-6 weeks, followed by new bone formation by osteoblasts, which produce collagen and mineralized bone matrix in a process lasting 4-5 months [ 3 ]. (biomedcentral.com)
  • Well, interestingly, vitamin C has been shown to be a very important factor in the synthesis of collagen (the body's natural ability to produce collagen). (drpingel.com)
  • We report a strategy for efficient transgene knock-in in the endogenous collagen type I alpha 1 chain ( COL1A1 ) gene using the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system. (chinaagrisci.com)
  • Materials and Methods Coll-GFP Mice Coll-GFP transgenic mice were generated around the C57BL6 background as described previously.2 In brief, 3.2 kb of CAL-101 (GS-1101, Idelalisib) the collagen I(1) (Col1a1) promoter and enhancer with the open reading frame of enhanced GFP yielded the highest levels of GFP expression when gene transcripts were generated. (holyexperiment.org)
  • The dominant collagen of this tissue is type II collagen (COLLII), together with smaller quantities of other collagens (IX, XII). (springer.com)
  • paper_name=The Effect of SACCHACHITIN on keratinocyte proliferation and theexpressions of type I collagen and tissue-transglutaminase during skin wound healing ------>confirm_date=20060426 ------>tch_id=082002 ------>pmid=15199592 ------>page1=122 ------>fullAbstract=SACCHACHITIN is a skin wound-healing membrane made of residual fruiting body of Ganoderma tsugae. (tmu.edu.tw)
  • Its effect on proliferating cell nuclear antigen (PCNA) expression in actively proliferating cells, type I collagen expression and tissue remodeling in the healing tissue, and the association of tissue-transglutaminase (t-TGase) with wound healing were investigated by immunohistochemical staining. (tmu.edu.tw)
  • At scar tissue, type I collagen was positively stained in the SACCHACHITIN group since day 7 but not in the control group till day 12. (tmu.edu.tw)
  • SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Effect of SACCHACHITIN on keratinocyte proliferation and the expressions of type I collagen and tissue-transglutaminase during skin wound healing. (tmu.edu.tw)
  • Bowel tissue cultures were treated with anti-FAP antibody, and soluble collagen, TIMP-1, and MMPs were measured in tissue culture supernatants by immunoblotting. (unimi.it)
  • Treatment of stenotic tissues with anti-FAP antibody induced a dose-dependent decrease in collagen production, particularly affecting type I collagen. (unimi.it)
  • An observational retrospective study, 1-year follow-up, on 104 patients with OA (nodular osteoarthritis of the hand, erosive osteoarthritis of the hand, EOA, osteoarthritis of the knee or hip) who were treated with GC or glucosamine, chondroitin sulfate and collagen type II (GCC). (springer.com)
  • A total of 7 possible genetic alterations and epigenetic changes in CAFs are discussed, including gene differential expression, karyotype analysis, gene copy number variation, loss of heterozygosis, allelic imbalance, microsatellite instability, post‑transcriptional control and DNA methylation. (spandidos-publications.com)
  • LAD type 2 is a metabolic defect of fucose metabolism that affects all fucosylated molecules, including sialyl-Lewis X, which is deficient in LAD type 2. (medscape.com)
  • Bioinformatics data mining of gene expression profiles using the Gene Expression Omnibus (GEO) database has led to identifying promising biomarkers associated with disease development [ 12 ]. (hindawi.com)
  • This clinically proven* serum, formulated with 12 specialized algae and ULTRA SMART Drone Peptide Technology, targets multiple signs of aging. (elemis.com)
  • ELEMIS formulated this powerful serum with 12 unique varieties of micro algae and seaweeds for visibly transformative results. (elemis.com)
  • The treatment also reduced TIMP-1 production in CD strictures, without altering MMP-3 and MMP-12 secretion. (unimi.it)
  • Prevention of Pancreatic β-Cell Failure in Type 2 Diabetes. (lu.se)
  • This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. (wikipedia.org)
  • These #Streptococcus species, specifically #Streptococcus (St.) pneumoniae and St. infantis, can secrete substances that up-regulate #Collagen synthesis. (metabiom.org)
  • Not only is vitamin C a powerful antioxidant, but it's also responsible for helping to maintain activity in the enzymes that are part of collagen synthesis. (drpingel.com)
  • The authors of the review state that stress affects collagen synthesis through glucocorticoid-mediated processes. (drpingel.com)
  • And when it comes to collagen, according to a study published in 2015, vitamin C significantly induced collagen synthesis in women of all ages, but especially in those under age 50. (drpingel.com)
  • Well, that's exactly what we're going to focus on next-the top vegan collagen sources that are rich in vitamin C and promote collagen synthesis. (drpingel.com)
  • In fact, a 2018 study showed that the vitamin C abundant in strawberries actually increases type I collagen synthesis. (drpingel.com)
  • Methods: Human chondrocytes were harvested from 12 osteoarthritic knee joints and seeded into a type I collagen (col-I) hydrogel at low density (2×105 cells/ml gel). (iospress.com)
  • The prostaglandin-endoperoxide synthase 2 gene (PTGS2), which encodes cyclooxygenase-2, was found to upregulate the expression of TGF-β2 ( 14 ). (spandidos-publications.com)
  • In mice with ureteral obstruction that were treated with the pan antiCTGF- antibody (1D11) or TGF- receptor type I inhibitor (SB431542), kidney pericyte-myofibroblast transition was blunted. (holyexperiment.org)
  • Composition and structural organization of type IV collagen in the GBM of healthy adult dogs is different from that described for other species. (avma.org)
  • For purposes of simplicity, collagen is the structural protein that keeps your skin plump and wrinkle-free . (drpingel.com)
  • La información más reciente sobre el nuevo Coronavirus de 2019, incluidas las clínicas de vacunación para niños de 6 meses en adelante. (stanfordchildrens.org)
  • Noncoding RNA sequences can regulate gene expression via interactions with epigenetic and other control mechanisms. (stanford.edu)
  • Various mechanical, hormonal, and biochemical factors affect the expression and function of GJC. (biomedcentral.com)
  • The biochemical activity of GDP-D-mannose-4,6 dehydratase (GMD) that converts mannose to fucose is decreased in patients with LAD type 2. (medscape.com)
  • The vitreous, ILM, and retinal ECM all contain glycosaminoglycans (GAGs), while the vitreous and ILM contain collagens. (molvis.org)
  • Results: Myofibroblasts from stenotic CD mucosa showed upregulation of FAP expression when compared with nonstenotic mucosa. (unimi.it)
  • Within one year, tests have shown that the continuous use of retinol is beneficial in the reduction of expression lines and deep wrinkles. (cosmeticnews.com)
  • Twelve weeks down the line, the deep wrinkles of the skin are not visible. (cosmeticnews.com)
  • Glycation is basically a physiological process that begins with the consumption of sugar, and ends up with the destruction of healthy collagen and elastin fibres (which contribute to the firmness of your skin) that eventually results in wrinkles and saggy skin. (beautyandgroomingtips.com)
  • Without proper collagen, you'll begin to experience joint discomfort, signs of aging, stiff muscles and tendons, and more. (drpingel.com)
  • In the severe phenotype of leukocyte adhesion deficiency (LAD) type 1, the prognosis for long-term survival is poor. (medscape.com)
  • Keratin 12 expression was not altered in Tgfb2(-/-) mice, implicating normal corneal type epithelial differentiation. (nih.gov)
  • This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
  • Beneficial effects of collagen type III on β-cell function via activation of the cAMP/protein kinase A pathway, suppression of RhoA and caspase-3 activity, increased β-cell viability, and proliferation were abolished when ADGRG1 was downregulated in β-cells. (lu.se)
  • Integrin alpha 2 is one of twelve integrin family alpha subunits that share the beta 1 subunit (1‑3). (novusbio.com)
  • Integrin alpha 2 beta 1 is the non-covalent heterodimer of 160 kDa alpha 2 (CD49b) and 130 kDa beta 1 (CD29) type I transmembrane glycoprotein subunits and is one of six very late antigens on activated T cells, designated VLA2 (3). (novusbio.com)
  • Compared to NFs, CAFs possess numerous types of potential genetic alterations and epigenetic changes. (spandidos-publications.com)
  • Expression of the α6(IV) chain was not observed in GBM of the human subjects, regardless of the age of the subject. (avma.org)
  • Characteristics of a Three-Generation Family with Stickler Syndrome Type I Carrying Two Different COL2A1 Mutations. (nih.gov)
  • These mutations alter the structure or disrupt the production of the pro-α1(VII) chain protein, which affects the production of type VII collagen. (medlineplus.gov)
  • The recessive types of dystrophic epidermolysis bullosa (RDEB) result from mutations in both copies of the COL7A1 gene in each cell. (medlineplus.gov)
  • Most of the COL7A1 gene mutations responsible for RDEB-sev gen result in production of abnormally short pro-α1(VII) chains that cannot form type VII collagen. (medlineplus.gov)
  • Somewhat less severe forms of RDEB, grouped as the generalized and localized types (RDEB-gen and -loc), are caused by other types of mutations. (medlineplus.gov)
  • In many cases, these mutations alter a part of type VII collagen known as the triple helical domain. (medlineplus.gov)
  • Mutations that substitute other amino acids for glycine in this region can disrupt the triple-stranded structure of type VII collagen. (medlineplus.gov)
  • DDEB can also be caused by other types of mutations, particularly changes that affect the folding of type VII collagen. (medlineplus.gov)
  • Mutations in the COL7A1 gene can also cause a rare condition called epidermolysis bullosa with congenital localized absence of skin (also known as Bart syndrome or aplasia cutis congenita type VI). (medlineplus.gov)
  • Mouse Models of Kidney Fibrosis Unilateral ureteral obstruction (UUO) CAL-101 (GS-1101, Idelalisib) was performed in adult (8 to 12 weeks) C57BL6 wild-type or Coll-GFP mice as described previously.2 Briefly, the left ureter was ligated twice using 4-0 nylon surgical sutures at the level of the lower pole of kidney. (holyexperiment.org)
  • Outflow facility in mice with a targeted type I collagen mutation. (ucsd.edu)
  • To date, adeno-associated virus (AAV) has been the most effective vector for retinal gene delivery because it elicits minimal immune response and can mediate long-term transgene expression in a variety of non-dividing retinal cell types. (molvis.org)
  • [ 4 ] Ishida et al found 11 of 12 lesions (92%) in the tibia, with one lesion in the ulna. (medscape.com)
  • Similarly, no significant differences ( P =0.64, P =0.48 and P =0.80 for PK15, PEF and IPI-2I cells, respectively) were found between the GFP knock-in and wild type cells by Western blotting. (chinaagrisci.com)
  • While collagen is typically found in abundance in animal-based products, such as bone broth made from beef or chicken, and fish, I recommend choosing vegan collagen sources to avoid the inflammatory effects of animal-based foods. (drpingel.com)
  • Fortunately, there are some great vegan collagen sources, largely thanks to the high amounts of vitamin C found in many plant-based foods. (drpingel.com)
  • Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
  • [12] In all cultures vegetables are spiced less than meat, presumably because they are more resistant to spoilage. (wikidoc.org)
  • Blue cells = expressed in wild-type. (jax.org)
  • IL-17F is expressed in activated CD4 + T cells, basophils, and mast cells, three important cell types involved in allergic airway inflammation [ 3 ]. (hindawi.com)
  • Conclusions and Clinical Relevance -Results indicate that the α6(IV) chain is expressed in GBM of healthy dogs, but the expression is age-dependent. (avma.org)
  • Conclusions: FAP inhibition reduced type I collagen and TIMP-1 production by CD strictures ex vivo without compromising uninvolved bowel areas. (unimi.it)
  • Conclusions:Wedemonstrate a mechanistic link between ADGRG1 expression andβ-cell function. (lu.se)
  • [ 12 ] Elevated neutrophil cell counts returned to the reference range, and clinical improvement was achieved with reduction of infections. (medscape.com)