Expression of stat3. Medical search. Frequent questions

In conclusion, the novel agent VP79s inhibits the JAK/STAT3 signalling pathway resulting in rapid downregulation of MCL-1 expression and inducing potent anti-MM activity. (confex.com)
Niclosamide seems to inhibit the STAT3 signalling pathway. (wikipedia.org)

Examination of upstream mediators of STAT3 signalling suggested a mechanism for VP79s inhibition of STAT3 activation via inhibition of JAK2 phosphorylation and downregulation of the IL-6 receptors, CD126 and CD130. (confex.com)
Wogonin stimulated the activation of NF\B and Erk but down\controlled STAT3 phosphorylation in the Avosentan (SPP301) CD4+ T cells. (findadig.com)
Wogonin down\controlled Erk and STAT3\Y705 phosphorylation in the regulatory T cells but advertised NF\B and STAT3\S727 activation. (findadig.com)
A significant reduction in STAT3 phosphorylation and a decrease in the number of Th17 cells were observed with RGE treatment. (hindawi.com)
Our findings provide the first evidence that RGE can regulate Th17 and reciprocally promote Treg cells by inhibiting the phosphorylation of STAT3. (hindawi.com)
As signal transducer and activator of transcription (STAT) 3 phosphorylation directly regulates retinoic acid receptor-related orphan receptor (ROR) γ t, which is the master molecule of Th17, the Janus kinase (JAK)2-STAT3 pathway initiated by IL-6 is essential in the Th17 development. (hindawi.com)
Specifically, STAT3 becomes activated after phosphorylation of tyrosine 705 in response to such ligands as interferons, epidermal growth factor (EGF), Interleukin (IL-)5 and IL-6. (wikipedia.org)
Additionally, activation of STAT3 may occur via phosphorylation of serine 727 by Mitogen-activated protein kinases (MAPK) and through c-src non-receptor tyrosine kinase. (wikipedia.org)
Tissue samples will be obtained at the end of clamp studies to measure in vivo activities of the following insulin/inflammatory signaling proteins: 1) tyrosine/serine phosphorylation of IRS, 2) PI-3 kinase, 3) Akt/PKB, 4) PKC isoforms, 5) STAT3 and 6) IKK. (umassmed.edu)
STAT3 protein expression and tyrosine phosphorylation will be measured using phospho-specific STAT3 (Tyr705) polyclonal antibody. (umassmed.edu)
Walnut polyphenol extracts inhibit Helicobacter pylori -induced STAT3 Tyr705 phosphorylation through activation of PPAR-γ and SOCS1 induction. (nuthealth.org)
Fresh walnut polyphenol extracts (WPE) were found to suppress the phosphorylation and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) induced by H. pylori infection in RGM-1 gastric mucosal cells. (nuthealth.org)
Notably, H. pylori infection significantly decreased suppressor of cytokine signaling 1 (SOCS1), but WPE induced expression of SOCS1, by which the suppressive effect of walnut extracts on STAT3 Tyr705 phosphorylation was not seen in SOCS1 KO cells. (nuthealth.org)
Conclusively, WPE inhibits H. pylori -induced STAT3 phosphorylation in a PPAR-γ and SOCS1-dependent manner. (nuthealth.org)

The mRNA and protein expression levels of FOXA2 were determined by reverse transcription‑quantitative PCR and western blotting, respectively. (spandidos-publications.com)
Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)

STAT3 is upregulated in MM and increases the expression of genes involved proliferation, angiogenesis and evasion of apoptosis. (confex.com)
STAT3 target genes include prosurvival BCL2 family members, such as MCL-1 which is overexpressed in MM, leading to apoptosis resistance and is associated with shorter patient survival. (confex.com)
STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. (wikipedia.org)
In conclusion, SCARA5 inhibited the proliferation and EMT and induced the apoptosis of OSCC cells through the inhibition of STAT3 and PI3K/AKT signaling pathways, thereby exerting a tumor suppressor effect. (degruyter.com)

Our results indicate that the spinal IL-33/ST2 signaling pathway contributes to chronic itch via astrocytic JAK2-STAT3 cascade activation, promoting TNF-α release to regulate the GRP/GRPR signaling-related itch response. (nih.gov)
This expression was dependent on activation of either NF-κB, JAK1/JAK2 or BTK pathways since these pathways were activated in tumor B-cells and ex vivo treatment with the inhibitory molecules PHA-408, ruxolitinib and ibrutinib led to decrease of its expression. (springer.com)

In particular, we found that CD28-activated RelA/NF-κB induces the expression of IL-6 that, in a positive feedback loop, mediates the activation and nuclear translocation of tyrosine phosphorylated STAT3 (pSTAT3). (pasteur.fr)
These results highlight the interest of therapies targeting the PD-1/PD-L1 axis in activated lymphomas with PD-L1 expression, with possible synergies with tyrosine kinase inhibitors. (springer.com)

We defined the transcription inhibition of STAT3 in miR200c expression and the negative correlation between miR200c and c-Myb expression. (bvsalud.org)

The Janus kinase (JAK)/Signal transducer and activator of transcription 3 (STAT3) pathway in MM can be both constitutively active due to autonomous mutations or activated by growth and survival factors, such as interleukin-6 (IL-6), secreted by bone marrow stromal cells and other cells within the bone marrow microenvironment. (confex.com)
Loss-of-function mutations in the STAT3 gene result in Hyperimmunoglobulin E syndrome, associated with recurrent infections as well as disordered bone and tooth development. (wikipedia.org)
Mutations in the STAT3 gene cause most cases of AD-HIES. (medlineplus.gov)
The STAT3 protein is also involved in the formation of cells that build and break down bone tissue, which could help explain why STAT3 gene mutations lead to the skeletal and dental abnormalities characteristic of this condition. (medlineplus.gov)
It is unclear how STAT3 gene mutations lead to increased IgE levels. (medlineplus.gov)
ZNF341 gene mutations, which prevent production of functional ZNF341 protein, result in a shortage of STAT3 protein, leading to immune system problems similar to those caused by STAT3 gene mutations. (medlineplus.gov)
This disorder is caused by dominant-negative mutations in the STAT3 gene ( 9 ). (cdc.gov)

Nicotinamide (a type of Vitamin B3) naturally inhibits STAT3. (wikipedia.org)
However NAC (Acetylcysteine) inhibits STAT3 inhibitors. (wikipedia.org)

WPE induced significantly increased nuclear translocation nuclear translocation of PPAR-γ in RGM1 cells, by which PPAR-γ KO inhibited transcription of SOCS1 and suppressive effect of WPE on p-STAT3 Tyr705 was not seen. (nuthealth.org)

In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered by cells overexpressing DEFB1 , suggesting that this may be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)
LINC00926 is involved in hypoxia-induced vascular endothelial cell dysfunction via miR-3194-5p regulating JAK1/STAT3 signaling pathway. (nih.gov)

Here we show that CD28-mediated up-regulation of IL-17A gene expression depends on RelA/NF-κB and IL-6-associated STAT3 transcriptions factors. (pasteur.fr)
Common markers were analyzed in gene expression profiles of two studies (GSE31023 and GSE72577). (researchsquare.com)
Long non-coding RNA LINC00926 regulates WNT10B signaling pathway thereby altering inflammatory gene expression in PTSD. (nih.gov)
Organic dust induces inflammatory gene expression in lung epithelial cells via ROS-dependent STAT-3 activation. (cdc.gov)
STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. (thermofisher.com)
Professor Håkan Axelsson and his team have identified a series of gene expression programs that are characteristic for specific cell types of the nephron. (lu.se)

BACKGROUND Immune cell profiling of primary and metastatic CNS tumors has been focused on the tumor, not the tumor microenvironment (TME), or has been analyzed via biopsies.METHODS En bloc resections of gliomas (n = 10) and lung metastases (n = 10) were analyzed via tissue segmentation and high-dimension Opal 7-color multiplex imaging. (jci.org)
Correction: Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment. (medscape.com)

Western blotting was performed to examine the protein expression levels of endoplasmic reticulum stress (ERS)‑associated factors. (spandidos-publications.com)

STAT3 caused upregulation in E-selectin, a factor in metastasis of cancers. (wikipedia.org)
Increased activity of STAT3 in cancer cells, leads to changes in the function of protein complexes that control expression of inflammatory genes, with result profound change in the secretome and the cell phenotypes, their activity in the tumor, and their capacity for metastasis. (wikipedia.org)
The expression levels of EMT, metastasis and MEK / ERK pathway -related proteins were checked by western blot . (bvsalud.org)
In summary, the silence of STAT3 suppressed metastasis and progression of CCA cells by regulating miR200c through the c-Myb mediated MEK / ERK pathway , suggesting STAT3 is the effective target for CCA arising from CC. (bvsalud.org)

We have recently reported that CD28 autonomous signaling induces the expression of IL-17A in peripheral CD4 T lymphocytes from healthy donors, multiple sclerosis, and type 1 diabetes patients. (pasteur.fr)
Sav1 Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis. (nih.gov)

Significant downregulation of β-defensin1 gene ( DEFB1 ) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)
We observed a downregulation in the expression of genes involved in host response, such as TNF signaling, IL-1β production, and phagosome formation in Mφ, and phosphatidylinositol signaling and TNF signaling in PMNs, being in line with the ability of the pathogen to survive within phagocytes. (frontiersin.org)

During viral infection, mice lacking STAT3 in T-cells display impairment in the ability to generate T-follicular helper (Tfh) cells and fail to maintain antibody based immunity. (wikipedia.org)
Treatment of LMP1/CD40-expressing lymphomatous mice with an anti-PD-L1 monoclonal antibody induced tumor regression with decreased spleen content, activation and proliferation rate of B-cells as well as a marked increase in T-cell activation, as assessed by CD62L and CD44 expression. (springer.com)

The effect of STAT3 on KLK5 expression in keratinocytes was not only substantiated by the increase in KLK5 expression following treatment with STAT3 siRNA but also by its decreased expression following STAT3 overexpression. (korea.ac.kr)
Overexpression and IL-17A-mediated stimulation of STAT3 increased the expression of SPINK5, which was blocked by STAT3 siRNA. (korea.ac.kr)
In a Polymerase Chain Reaction (PCR) array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of STAT3. (cdc.gov)
WPE inhibited the expression of c-Myc and IL-6/IL-6R signaling, which was attenuated in the RGM1 cells harboring SOCS1 specific siRNA. (nuthealth.org)

VP79s was more potent in inducing cell death in a panel of drug sensitive and drug resistant MM cell lines compared to standard and emerging therapeutic agents for MM. VP79s rapidly inhibited both constitutively active and IL-6-induced STAT3 signalling in MM cells. (confex.com)
STAT3 can promote oncogenesis by being constitutively active through various pathways as mentioned elsewhere. (wikipedia.org)

Immunofluorescence, RT-PCR, and western blotting were used to measure expression changes of stem-related genes and activation of related signaling pathways. (biomedcentral.com)
Finally, we found that MDLS promoted Oct4 expression by activating JAK/STAT3 and classic Wnt signaling pathways, and these effects were reversed by treatment with inhibitors of corresponding signaling pathways. (biomedcentral.com)
Therefore, SCARA5 was related to STAT3 and PI3K/AKT signaling pathways in OSCC. (degruyter.com)

The overexpression of transcription factors P-ATF2 and STAT3 also may play a role in tumorigenesis. (medscape.com)

pSTAT3 in turn cooperates with RelA/NF-κB by binding specific sequences within the proximal promoter of human IL-17A gene, thus inducing its expression. (pasteur.fr)
Finally, by using specific inhibitory drugs, we also identified class 1A phosphatidylinositol 3-kinase (PI3K) as a critical upstream regulator of CD28-mediated RelA/NF-κB and STAT3 recruitments and trans-activation of IL-17A promoter. (pasteur.fr)
Lastly, IL-21 also promotes activation of the STAT3 promoter and other transcriptional factors. (intechopen.com)
Their research confirmed that IL-21 activates STAT3, a protein that then connects with the promoter region of the gene encoding the T cell stimulatory protein CD28, firing up CD28. (newswise.com)

Overexpression of DEFB1 in IAV infected HBEpCs led to increased NF-kB expression. (cdc.gov)

Keratinocyte-specific loss of STAT3 induced a cutaneous inflammatory phenotype with pruritus and intense scratching behaviour in mice. (korea.ac.kr)

Curcumin and Epigallocatechin Gallate Inhibit the Cancer Stem Cell Phenotype via Down-regulation of STAT3-NFκB Signaling. (greenmedinfo.com)

In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), forms homo- or heterodimers, and translocates to the cell nucleus where it acts as a transcription activator. (wikipedia.org)
Furthermore, IL-21 promotes differential expression of many cytokines including interleukins and chemokines. (intechopen.com)

Due to the relevance of IL-17A in the pathophysiology of several inflammatory and autoimmune diseases, we characterized the mechanisms and signaling mediators responsible for CD28-induced IL-17A expression. (pasteur.fr)
A direct connection between the PTEN-Akt-FOXO axis (suppressive) and the leukemia inhibitory factor receptor beta (LIFRbeta)-STAT3 signaling pathway (oncogenic) was shown. (wikipedia.org)
For a rescue assay, a p38 MAPK activator, U46619, was used to investigate the regulatory mechanism of FOXA2 involving p38/STAT3 signaling. (spandidos-publications.com)
In conclusion, FOXA2 served a protective role against LPS‑induced pneumonia by regulating p38/STAT3 signaling, providing a novel idea for the development of targeted therapeutic strategies for pneumonia. (spandidos-publications.com)
STAT3 promotes migration and invasion of cholangiocarcinoma arising from choledochal cyst by transcriptionally inhibiting miR200c through the c-myb/MEK/ERK signaling pathway. (bvsalud.org)

Previous research showed that scavenger receptor class A member 5 (SCARA5) was one of the potential biomarkers of OSCC, and its expression is significantly low in OSCC. (degruyter.com)

Expression of spinal IL-33 and ST2 significantly increased in ACD mice, as evidenced by increased mRNA and protein levels. (nih.gov)

A tumor suppressor role of STAT3 has also been reported. (wikipedia.org)
In the report on human glioblastoma tumor, or brain cancer, STAT3 was shown to have an oncogenic or a tumor suppressor role depending upon the mutational background of the tumor. (wikipedia.org)

In this study, we elucidated the potential role of STAT3 in the skin barrier and its effect on kallikrein-related peptidase 5 (KLK5) and serine protease inhibitor Kazal-type 5 (SPINK5) expression using a mouse model with keratinocyte-specific ablation of STAT3. (korea.ac.kr)
MiR200c inhibitor reversed the changes induced by STAT3 silence, which was restored by si-c-Myb. (bvsalud.org)
MEK activator significantly reversed the inactivation of the MEK / ERK pathway induced by si-STAT3+miR200c inhibitor+si-c-Myb. (bvsalud.org)

It appears that at these early stages of development, STAT3 activation is required for self-renewal of embryonic stem cells (ESCs). (wikipedia.org)
such as thyroid disease, diabetes, intestinal inflammation, and low blood counts, while constitutive STAT3 activation is associated with various human cancers and commonly suggests poor prognosis. (wikipedia.org)

We screened 480 commercially available small-molecule compounds and discovered that MDLS greatly promoted the expression of Oct4 at both mRNA and protein levels. (biomedcentral.com)
In addition, we found that in the presence of LIF, MDLS could replace feeder cells to maintain the undifferentiated state of OG2-mES cells (Oct4-GFP reporter gene mouse embryonic stem cell line), and the MDLS-expanded OG2-mES cells showed an elevated expression levels of pluripotency markers in vitro. (biomedcentral.com)
DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation. (nih.gov)

In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that β-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)
Based on the consistent expression patterns associated with patient survival outcomes and in tumors vs. normal lung tissues, 10 miRNAs were considered to be putatively tumor suppressive and 4 miRNAs were deemed as oncogenic in lung cancer. (cdc.gov)

To further confirm the central memory properties of treated cells, the team assessed expression of genes involved in differentiating T cells and found expression of central-memory differentiating genes to be highly expressed on the identified central memory cells generated by the combination. (newswise.com)

[ 2 ] Endothelial nitric oxide synthases (eNOS), CD34, and CD105/endoglin expression are markers of angiogenesis in pyogenic granulomas. (medscape.com)

STAT3 is essential for the differentiation of the TH17 helper T cells, which have been implicated in a variety of autoimmune diseases. (wikipedia.org)
In this study, we found that the SCARA5 expression was lower in CAL-27 and SCC-9 cells than that in human normal oral epithelial keratinocytes. (degruyter.com)
Curcumin sensitized breast cancer cells to chemotherapeutic drugs by reducing the BCSC population mainly through a reduction in the expression of ABCG2. (greenmedinfo.com)
To further confirm, the expression of candidate genes was investigated in exosomes derived from the parental HT-29 colorectal cancer cell line (HT-29-EXOs), and cancer stem cells (CSCs) -enriched spheroids (CSC-EXOs) derived thereof. (researchsquare.com)
With vorinostat relaxing the chromatin, IL-21-generated STAT3 activated CD28, resulting in expansion of T cells bearing the markers for central memory T cells. (newswise.com)
Silence of STAT3 increased miR200c expression and retarded the migration and invasion of CCA cells , accompanied by decreased levels of Vimentin , N-cadherin , MMP2 and MMP9, and elevated expression of E-cadherin , resulting in inactivating MEK / ERK pathway . (bvsalud.org)
In the immune system, the STAT3 protein regulates genes that are involved in the maturation of immune system cells, especially certain types of T cells . (medlineplus.gov)
A shortage of functional STAT3 blocks the maturation of T cells (specifically a subset known as Th17 cells) and other immune cells. (medlineplus.gov)

Also, we observed that the expression of pluripotency markers and alkaline phosphatase (AP) increased significantly in MDLS-treated colonies. (biomedcentral.com)
According to real-time PCR, expression of PDGFA (P=0.0086) and RAF1 (P=0.048) were upregulated in TDEs but significantly decreased (P=0.0001) in MVs. (researchsquare.com)

The researchers also analyzed patient databases and found that glioblastoma patients with low expression of galectin1 and HOXA5 proteins had the best prognosis. (news-medical.net)
Together, these proteins along with another called STAT3 activate mechanisms that promote a particularly aggressive type of glioblastoma. (news-medical.net)

Analysis of downstream STAT3 targets demonstrated that treatment with VP79s resulted in a rapid time-dependent decrease in expression of MCL-1. (confex.com)

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. (wikipedia.org)
Signal transducer and activator of transcription 3 (STAT3) have been highlighted in cancer regulation . (bvsalud.org)

Here, we attempted to elucidate the roles of STAT3 in CCA-CC and explore its mechanism. (bvsalud.org)
To carry out its roles, the STAT3 protein attaches to DNA and helps control the activity of particular genes. (medlineplus.gov)

In addition, SCARA5 repressed OSCC cell epithelial-mesenchymal transformation (EMT), evidenced by increased E-cadherin expression and reduced N-cadherin expression. (degruyter.com)
Mali showed that p-STAT3 was positively expressed in OSCC cell lines [ 15 ]. (degruyter.com)
NF-κB, one of the most cited transcription factor in B-cell lymphomas, is able to increase tumor cell expression of PD-L1 either directly or indirectly [ 3 ]. (springer.com)

Our findings reveal a novel mechanism by which human CD28 may amplify IL-17A expression in human T lymphocytes and provide biological bases for immunotherapeutic approaches targeting CD28-associated class 1A PI3K to dampen IL-17A-mediated inflammatory response in autoimmune/inflammatory disorders. (pasteur.fr)

Hyperactivation of STAT3 occurs in COVID-19 infection and other viral infections. (wikipedia.org)

In the study, we used weighted gene co-expression network analysis to construct a co-expression network to screen out highly prognostic immune-related genes. (techscience.com)

These results suggest that the expression of SPINK5 and KLK5 in keratinocytes could be dependent on STAT3 and that STAT3 might play an essential role in the maintenance of skin barrier homeostasis. (korea.ac.kr)

STAT3-deficient mouse embryos cannot develop beyond embryonic day 7, when gastrulation begins. (wikipedia.org)

Anatomy23

Organisms7

Diseases5

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes36

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Signalling pathway2

Phosphorylation14

MRNA and protein expression2

Apoptosis4

JAK22

Tyrosine2

Inhibition1

Mutations7

Inhibits2

Tyr7051

JAK12

Gene expression6

Microenvironment2

Protein expression1

Metastasis4

Induces2

Downregulation2

Antibody2

SiRNA4

Constitutively active2

Pathways3

Transcription Factors1

Promoter4

Overexpression1

Pruritus1

Phenotype1

Cytokines2

Signaling5

Biomarkers1

Mice1

Tumor suppressor2

Inhibitor3

Activation2

Oct43

Survival2

Genes involved1

Angiogenesis1

Cells8

Significantly2

Glioblastoma2

Targets1

Activator2

Roles2

Cell3

Mechanism1

Occurs1

Immune1

Dependent1

Embryonic1