• Predictions achieve correlations of 0.68 with true values, and maintain accurate differentially expressed genes (AUC 0.81). (nih.gov)
  • Because of the recent development of new methods (especially microarrays) for identifying differentially expressed genes, a burst of research on caste differentiation is predicted. (europa.eu)
  • Using a treatment and sex interaction model, 13 and 4 differentially expressed genes were identified in liver and muscle respectively. (biomedcentral.com)
  • Sex-specific differentially expressed (DE) genes were identified in both sexes. (biomedcentral.com)
  • Differentially expressed genes (DEGs) may be responsible for phenotypic differences between various biological conditions. (mdpi.com)
  • Identifying caste-specific patterns of gene expression thus offers a special opportunity to study the generation of adaptive morphological variation by a fundamental biological process, and is the key to profound understanding of the evolution of sociality. (europa.eu)
  • Instances of recent, parallel phenotypic evolution provide an opportunity to assess whether parallel patterns are seen at the level of gene expression, and to assess the relative contribution of cis - and trans -changes to gene regulation in the early stages of divergence. (biorxiv.org)
  • These results demonstrate that parallel patterns of gene expression in mice that have independently adapted to cold environments are driven largely by tissue-specific and cis -regulatory changes, providing insight into the mechanisms of adaptive gene regulatory evolution at the earliest stages of divergence. (biorxiv.org)
  • Together, our work describes the gene regulatory dynamics of rapid environmental adaptation, and the repeatability of these patterns over multiple instances of adaptation. (biorxiv.org)
  • In conclusion, our results indicate that DNA methylation regulates neurodevelopmental gene expression dynamics through steering transcription factor activity, but does not explain sexually dimorphic gene expression patterns in zebra finch telencephalon. (ugent.be)
  • The results showed that nine ZmCAMTA genes showed highly diversified gene structures and tissue-specific expression patterns. (frontiersin.org)
  • For genes encoding the disrupted interactions, we evaluate their expression patterns across developing brains and within specific cell types, using both bulk and inferred cell-type-specific brain transcriptomes. (springer.com)
  • Using the newly released and larger ASC dataset, we confirm these observations and take them in several new directions: (1) By defining a set of genes encoding these disrupted protein interactors in ASD subjects and another for their siblings, we evaluate their expression patterns in developing brain from fetal to early postnatal development and within general cell types of brain tissue. (springer.com)
  • Based on these results and prior studies, increased AQP9 expression may lead to increased arsenic transport in the female fetal placenta, which in turn may alter the expression patterns of key developmental genes that we have previously shown to be associated with arsenic exposure. (biomedcentral.com)
  • Improved access to bioinformatics tools enables scientists to process, manage, and store raw data, annotate sequences to define genes, and quantitate RNA sequence data to get insight into gene expression patterns. (genengnews.com)
  • An alternative approach is gene coexpression analysis, which detects groups of genes with similar expression patterns across unrelated sets of transcriptomic data from the same organism. (mdpi.com)
  • Previous data has reported similarity between human brain and testis gene expression patterns. (karger.com)
  • Hence, it means that human testis could also play a crucial role in human speciation if these two tissues exhibit similar gene expression patterns. (karger.com)
  • Determining the large scale anatomy of gene expression patterns of various human tissues could draw a more convincing conclusion, and better our understanding of the correlation/inter-correlation among different tissues. (karger.com)
  • Among the 17 tissues, the highest similarity in gene expression patterns was between human brain and testis, based on DDD and clustering analysis. (karger.com)
  • Present results provide evidence to support the proposal that human testis and brain share the highest similarity of gene expression patterns. (karger.com)
  • Although we were unable to confirm a genetic or epigenetic cause for this allele specific expression, the expression patterns of the two genes match those predicted for imprinted genes. (le.ac.uk)
  • flanking region indicated the presence of a consensus motif that occurs in all milk-protein-encoding genes, except the kappa-casein-encoding gene. (eurekamag.com)
  • Furthermore, the loss of DNA-binding activity correlates with increased expression of MMTV and other mammary-specific genes, including β-casein, whey acidic protein and α-lactalbumin, indicating that CDP150 is a developmentally controlled, naturally occurring dominant-negative protein. (utexas.edu)
  • The gene structure and expression of the non-specific cytotoxic cell receptor protein (NCCRP-1) in Atlantic cod (Gadus morhua L. (nofima.no)
  • Streamlining Regulon Identification in Bacteria Regulons are a group of genes that can be turned on or off by the same regulatory protein. (doe.gov)
  • Type II collagen expression is therefore temporally regulated by tissue-specific transcription and splicing factors directing the synthesis of distinct molecular forms of the precursor protein in the developing Xenopus embryo. (rupress.org)
  • We investigate the functional relevance of de novo missense variants, specifically whether they are likely to disrupt protein interactions, and nominate novel genes in risk for ASD through integrated genomic, transcriptomic, and proteomic analyses. (springer.com)
  • Finally, we integrate protein interactions and cell-type-specific co-expression networks together with published association data to implicate novel genes in ASD risk in a cell-type-specific manner. (springer.com)
  • Consistent with other studies, genes identified by disrupted protein interactions are expressed early in development and in excitatory and inhibitory neuronal lineages. (springer.com)
  • Disrupted protein interactions identify gene sets involved in risk for ASD. (springer.com)
  • We found that HD-MM displays specific gene and miRNA expression profiles, involving the Signal Transducer and Activator of Transcription (STAT)3 pathway as well as the Transforming Growth Factor-beta (TGFβ) and the transcription regulator Nuclear Protein-1 (NUPR1). (oncotarget.com)
  • Mapping genetic variation to genes improves power and allows the effects of both protein-coding variation as well as variation in expression to be combined into "gene level" effects. (biomedcentral.com)
  • Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
  • Gimap5 is a member of at least seven related GTPase Immune Associated Protein ( Gimap ) genes located within 150 Kilobases (Kb) on rat chromosome (RNO) 4 [ 2 , 3 ]. (hindawi.com)
  • Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)
  • Expression of the heat shock protein IpbA in species of Pseudomonas is controlled by a ROSE-type RNA thermometer. (wikipedia.org)
  • The expression level from luc 25.7k is 1000-times higher than that with luc 1.7k, indicating that the protein yield per target gene is increased by 1000-times of magnitude for a longer template, luc 25.7k (Fig. 1 d). (nature.com)
  • A second group of methods, which includes DNA microarrays and proteomics, have advantages that overcome the limitations implicit in signature-tagged mutagenesis and in vivo expression technology, namely, the ability to directly measure expression (gene or protein) levels on a true genome-wide scale, but their application to analysis of bacterial pathogens during real infections is still in its infancy. (cdc.gov)
  • the tadpoles showed reduced expression of cα(E)-catenin , small muscle protein, dystrophin , and myosin light chain genes. (biomedcentral.com)
  • Genes contributing to the similarity include ribosomal protein (RP) genes as well as genes involved in transcription, translation and cell division. (karger.com)
  • By means of oligonucleotide microarray and RNA interference, we reveal that the sensitizing effect of IFN-β was possibly due to attenuation of MGMT expression via induction of the protein p53. (aacrjournals.org)
  • The AFF2 gene provides instructions for making a protein that is found in the nucleus of cells but whose function is not well understood. (medlineplus.gov)
  • Other studies show that the protein can attach to specific regions of messenger RNA (mRNA), which is a chemical cousin of DNA that serves as the genetic blueprint for protein production. (medlineplus.gov)
  • As a result, the AFF2 gene is turned off (silenced), and no protein is produced from it. (medlineplus.gov)
  • Rarely, small deletions of genetic material from the AFF2 gene are associated with fragile XE syndrome, although how these deletions affect the protein and lead to intellectual disability is unknown. (medlineplus.gov)
  • Under developmental conditions, the Tubulin beta-1 chain (β-Tubulin) was the most stable reference gene, followed by translation elongation factor (eEF2) and ribosomal protein S3 (RPS3). (lu.se)
  • We hypothesized that blood cell gene expression and serum protein analysis will provide insight into the relationship between CNT-induced lung and cardiovascular effects. (cdc.gov)
  • C-reactive protein, serum amyloid P) and accompanying liver gene expression were increased. (cdc.gov)
  • In 2001, mutations were discovered in the IKB kinase-complex-associated protein ( IKBKAP ) gene, with a major haplotype mutation located in the donor splice site of intron 20. (medscape.com)
  • Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)
  • Overview of Genetics A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
  • [ 12 ] This mutation alters the polyadenylation site of the gene and results in increased mRNA synthesis, with a subsequent increase in protein expression. (medscape.com)
  • Changes in gene regulation have long been appreciated as a driving force of adaptive evolution, however the relative contributions of cis- and trans- acting changes to gene regulation over short evolutionary timescales remain unclear. (biorxiv.org)
  • Negative regulation has been shown to play a significant role in mediating tissue-specific MMTV expression. (utexas.edu)
  • Notably, a large number of stress-related elements present in the promoter regions of some ZmCAMTA genes, indicating a genetic basis of stress expression regulation of these genes. (frontiersin.org)
  • CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)
  • Gene regulation can occur at any point in gene expression, from the start of the transcription phase to the translation phase. (nature.com)
  • Due to the complexity of gene regulation, unveiling the complete mechanism of gene regulation has been a long-standing quest. (nature.com)
  • To elucidate the complex mechanism of gene regulation in living cellular systems, it is necessary to closely investigate each phase of gene expression and also to shed light on the cooperative effects between transcription and translation. (nature.com)
  • The aforementioned complex factors have made it difficult to investigate the impact of the DNA length on gene regulation, which has been an unexplored topic. (nature.com)
  • The higher expression of gremlin 1 and HIF1a genes after exposure to dragonfly larvae indicated an in vivo hypoxic reaction, while down-regulation of syndecan-2 may indicate impairment of angiogenesis. (biomedcentral.com)
  • The pattern of type II collagen expression during Xenopus laevis embryogenesis has been established after isolating specific cDNA and genomic clones. (rupress.org)
  • Two of these methods, signature-tagged mutagenesis and in vivo expression technology, do not directly measure gene expression and do not allow true genomic-scale analysis, but they have been devised to identify genes necessary for pathogens during real infections. (cdc.gov)
  • Genomic insights into the host specific adaptation of the Pneumocystis genus. (broadinstitute.org)
  • Nevertheless, the present study delivers a catalog of reference genes under varied experimental conditions for the coleopteran forest pest I. sexdentatus and paves the way for future gene expression and functional genomic studies on this species. (lu.se)
  • At later times and coincident with the appearance of chondrogenic tissues in the developing embryo, expression of the procollagen genes is characterized by the production of an additional, alternatively spliced transcript. (rupress.org)
  • Our study reveals a sex-dependent effect of EO diet in both tissues, and an influence on the expression of genes mainly involved in immune, inflammatory and stress pathway. (biomedcentral.com)
  • Our analysis suggests a sex-dependent effect of the EO dietary supplementation on the expression profile of both liver and muscle tissues. (biomedcentral.com)
  • The expression of truncated 1.7-kb CR-1 transcript (SF-CR-1) was significantly higher than the full-length 2.0-kb CR-1 transcript (FL-CR-1) in a majority of HCC tissues and cell lines. (aging-us.com)
  • Scientists have mapped which genes are turned on and off in the different tissues and organs in a sheep's body. (ed.ac.uk)
  • RNA serves as a functional read-out of exactly which genes are expressed in which tissues at any one time. (ed.ac.uk)
  • and (2) we impute genes only in tissues where expression quantitative loci (eQTLs) are associated with these genes. (biomedcentral.com)
  • We impute gene expression in specific tissues for each individual using the GTEx compendium [ 11 ] (Fig. 1 ) and learn a signature that is predictive of warfarin dose comprising gene-tissue pairs on a training cohort. (biomedcentral.com)
  • Amy Radunz, a nutritionist from the department of animal sciences at the University of Wisconsin in River Falls, has partnered with molecular biologist Hasan Khatib, an associate professor at University of Wisconsin-Madison, to ask how differences in maternal diet during pregnancy induce gene expression and DNA methylation changes in fetal tissues in sheep. (genengnews.com)
  • The study also looked at the impact of paternally expressed genes: IGF2, PEG1, PEG3, DLK1, and DIO3 for transcriptomic and epigenomic alterations of the imprinted genes in fetal tissues. (genengnews.com)
  • Central to this investigation is an understanding of what gene products are required and expressed during a natural infection and how this expression changes over time (from initial colonization to causation of disease and spread of the pathogen to new hosts) and space (in different cells or tissues within the host). (cdc.gov)
  • The differences in gene expression profiles induced by the two predators suggest that there are functional differences between the altered tail tissues of the two groups of tadpoles. (biomedcentral.com)
  • Bortoluzzi S, Alessi FD, Romualdi C, Danieli GA: Differential expression of genes coding for ribosomal proteins in different human tissues. (karger.com)
  • Furthermore, the CNT effects on lung and cardiovascular tissues were characterized by a coordinated gene expression analysis. (cdc.gov)
  • In recent years, our understanding of genetic predisposition to PD has advanced vastly, including causative mutations in the genes encoding α-synuclein, LRRK2, parkin, PINK1, and DJ-1 just to name a few 5 . (nature.com)
  • Nigrostriatal neuron-specific expression may be useful for specific gene therapy approaches to Parkinson's disease or for genetic analyses of nigrostriatal neuron physiology. (harvard.edu)
  • Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)
  • Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility. (nih.gov)
  • In 1993, using genetic linkage, the gene for familial dysautonomia was localized to the distal long arm of chromosome 9(q31) with sufficient DNA markers to permit prenatal diagnosis and carrier identification for families in which an individual had been affected. (medscape.com)
  • The Online Mendelian Inheritance in Man ( OMIM ) database is a searchable catalog of human genes and genetic disorders. (msdmanuals.com)
  • Mutations affecting the expression of genes are known to underlie much of adaptive evolution. (biorxiv.org)
  • Such mutations can arise in cis -(near the gene of interest) or in trans -(at a distant locus), but the relative contribution of these different kinds of changes to adaptation is poorly understood, especially during very recent divergence. (biorxiv.org)
  • Using crosses between warm-adapted and cold-adapted mice, we found that mutations acting in a context specific manner ( cis -regulatory and tissue-specific changes) predominate expression divergence and are more likely to be involved in parallel evolution. (biorxiv.org)
  • Mutations in the AFF2 gene cause fragile XE syndrome, a condition characterized by mild intellectual disability and learning difficulties. (medlineplus.gov)
  • [ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
  • Examples include inherited mutations in BRCA1/2 in breast and ovarian cancer, and mutations in mismatch repair genes (Lynch syndrome) in colorectal and endometrial cancer. (cdc.gov)
  • Cell specific quantitative iron mapping on brain slices by immuno-μPIXE in healthy elderly and Parkinson's disease. (mpg.de)
  • Quantitative real-time PCR was used to test the expression of ZmCAMTA genes under several abiotic stresses (drought, salt, and cold), various stress-related hormones [abscisic acid, auxin, salicylic acid (SA), and jasmonic acid] and biotic stress [rice black-streaked dwarf virus (RBSDV) infection]. (frontiersin.org)
  • Here, we used quantitative real-time PCR, profiling the expression of 93 genes in single-cells from three different cell lines. (frontiersin.org)
  • In particular, we use drug pathways and expression quantitative trait loci knowledge to impute gene expression-on the assumption that differential expression of key pathway genes may impact dose requirement. (biomedcentral.com)
  • A suitable reference gene selection is fundamental for quantitative gene expression analysis and functional genomics studies in I. sexdentatus. (lu.se)
  • The findings were validated further using real-time quantitative reverse transcription PCR (RT-qPCR)-based target gene expression analysis. (lu.se)
  • Therefore, caste differentiation must involve the differential expression of genes that are shared by all castes. (europa.eu)
  • Only a small fraction of the massive differential expression in the developing zebra finch telencephalon could be explained by differential CpG and CpH DNA methylation. (ugent.be)
  • a , Differential expression of potassium channel genes, depicted as a heatmap of z -score normalized RPKM gene expression values. (jneurosci.org)
  • Twelve commonly used reference genes in Coleopterans were screened under different experimental conditions to obtain accurate and reliable normalization of gene expression data. (lu.se)
  • In sex-specific conditions, RPS3, β-Tubulin, and eEF2 were the most stable reference genes. (lu.se)
  • Both genes are activated at the beginning of neurula stage and steady-state mRNA levels progressively increase thereafter. (rupress.org)
  • At later stages of development and parallel to increased mRNA accumulation, collagen expression becomes progressively more confined to chondrogenic regions of the tadpole. (rupress.org)
  • During the early period of mRNA accumulation, there is also a transient pattern of expression in localized sites that will later not undergo chondrogenesis, such as the floor plate in the ventral neural tube. (rupress.org)
  • By annotated MM patient mRNA/microRNA (miRNA) datasets, we investigated mRNAs and miRNAs profiles with relation to changes in transcriptional regulators expression. (oncotarget.com)
  • We also employed DTS to detect the differences in mRNA expression of salt-treated Arabidopsis seedlings to illustrate further the efficiency of the subtraction method. (nih.gov)
  • cis -regulated genes under selection influenced phenotypes such as body size, fat content, immune functioning, and skeletal morphology. (biorxiv.org)
  • For example, PrediXcan [ 10 ] imputes the expected baseline expression of a gene based on the allele composition of SNPs in proximity to that gene ( cis -SNPs) and uses these predicted baseline expression values to identify gene associations to disease phenotypes. (biomedcentral.com)
  • Their findings shed new light on the animal's complex biology, including insight into the function of genes linked to immunity and meat quality. (ed.ac.uk)
  • Although analyses that give information on the expression of a few genes provide insight and have been responsible for a large proportion of the bacterial pathogenesis literature currently available, our ultimate goal is to understand expression changes across the whole genome. (cdc.gov)
  • Few nutrigenomics studies have used a high-throughput RNA-Sequencing (RNA-Seq) approach, despite great potential of RNA-Seq data in gene expression quantification and in co-expression network analyses. (biomedcentral.com)
  • Functional analyses indicated that some of the genes induced by dragonfly larvae caused an increase in laminins necessary for cell adhesion in the extracellular matrix. (biomedcentral.com)
  • These findings demonstrate that liver-specific CR-1 overexpression in transgenic mice deregulates signaling pathways and genes associated with HCC. (aging-us.com)
  • We focus on 116 genes from the pharmacokinetic and pharmacodynamic pathways of warfarin within training and validation sets comprising both European and African-descent individuals. (biomedcentral.com)
  • While butyrate is a known histone deacetylase inhibitor that activates expression of many genes involved in immune system pathways, its effects on virus infections and on the antiviral type I interferon (IFN) response have not been adequately investigated. (bvsalud.org)
  • We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
  • Therefore, MMTV has adopted a normal cellular process to control viral expression during mammary differentiation. (utexas.edu)
  • Gene expression must be appropriately maintained to regulate development, differentiation, and proliferation of cells. (intechopen.com)
  • Intracellular amastigote protocols need further refinement, but we describe a first generation tool for high-throughput comparative molecular characterization of patients' isolates, based on the changing expression profiles of promastigotes during in vitro differentiation. (cambridge.org)
  • Detailed analysis of cell cycle predictive genes allowed us to define subpopulations with distinct gene expression profiles and to calculate a cell cycle index that illustrates the transition of cells between cell cycle phases. (frontiersin.org)
  • Using network based analysis, different clusters of co-expressed genes that were highly correlated to the diet were detected in males vs. females, in agreement with DE analysis. (biomedcentral.com)
  • Multivariable linear regression analysis was used to examine their relationship with arsenic exposure and with key developmental genes, after stratification by fetal sex. (biomedcentral.com)
  • Ongoing comparative analysis will provide insights to help us understand gene function across all large animal species, including humans. (ed.ac.uk)
  • c , Principal components analysis of the 24 samples, based on overall gene expression, demonstrating clear separation of clusters by neuron subtype. (jneurosci.org)
  • c , Heatmap of z -score normalized RPKM expression levels of the same genes which contain the splice events in a , preserving the ordering of rows as in a . d , Principal components analysis of the 24 samples, based on the overall splice events quantification, demonstrating clear separation of clusters by neuron subtype. (jneurosci.org)
  • DAVID was used to perform the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis for the different expression genes (DEGs). (medscimonit.com)
  • Ten DEGs, including 7 hub genes from PPI analysis, were confirmed by real-time PCR. (medscimonit.com)
  • The additional information generated by whole genome studies goes far beyond that derived by characterizing in isolation more genes and gene products, because analysis of the whole genome allows complete regulatory networks to be identified and characterized. (cdc.gov)
  • The most common approach in transcriptomics (RNA-seq and microarrays) is differential gene expression analysis (DGEA). (mdpi.com)
  • Familial dysautonomia is an autosomal recessive disorder with complete penetrance but variable expression. (medscape.com)
  • Holt-Oram syndrome (HOS) (OMIM 142900) is a heart-upper limb malformation complex with an autosomal dominant inheritance and near-complete penetrance but variable expression. (medscape.com)
  • Characterization of the gene expression signature specific to the TB interface in our model revealed signaling mechanisms operative in human breast cancer metastases and predicted a therapeutic inhibitor of cancer-mediated osteolysis. (biomedcentral.com)
  • Stochastic models of gene transcription with upstream drives: exact solution and sample path characterization. (crossref.org)
  • Gene expression profiling is increasingly used in the field of infectious diseases for characterization of host, pathogen and the nature of their interaction. (cambridge.org)
  • The purpose of this study was to develop a robust, standardized method for comparative expression profiling and molecular characterization of Leishmania donovani clinical isolates. (cambridge.org)
  • These Unigenes represent a wide range of genes classified according to their characterization and function. (karger.com)
  • Gene expression profiling of in vitro drug perturbations is useful for many biomedical discovery applications including drug repurposing and elucidation of drug mechanisms. (nih.gov)
  • Here, we employed single-cell gene expression profiling to describe the dynamic transition between cell proliferative states in three different cell lines using a panel consisting of 93 marker genes. (frontiersin.org)
  • Gene expression profiling of Leishmania (Leishmania). (cambridge.org)
  • The limitations and possibilities associated with expression profiling in intracellular amastigotes and promastigotes were assessed through a series of comparative experiments in which technical and biological parameters were scrutinized. (cambridge.org)
  • Gleason score and prostate specific antigen) others such as gene expression profiling for breast cancer are used to predict response to therapy and guide treatment decisions. (cdc.gov)
  • However, there are many new biomarkers that have been incorporated into the AJCC 8th Edition as a component of prognostic stage and will be collected starting in January 2018, if they are not already part of routine surveillance (such as breast cancer gene expression profiling and human papilloma virus). (cdc.gov)
  • Other tumor-related genome markers are rapidly maturing providing prognostic indicators for survival and response to therapy (e.g. gene expression profiling in prostate cancer ). (cdc.gov)
  • This method, duplex-specific nuclease (DSN)-mediated transcriptome subtraction (DTS), is based on the normalization strategy of the crab duplex-specific nuclease and the subtraction method of suppression subtractive hybridization. (nih.gov)
  • CR-1 over-expression significantly increased in vivo xenograft tumor growth of HCC cells in nude mice and in vitro HCC cell proliferation, migration, and invasion. (aging-us.com)
  • In vivo models that mimic the breast cancer-specific osteolytic bone microenvironment are limited. (biomedcentral.com)
  • In a previous report using the resources of the New Hampshire Birth Cohort Study (NHBCS), we found that low-to-moderate i n utero exposure to arsenic, a highly toxic and widespread pollutant, was associated with altered expression of several key developmental genes in the fetal portion of the placenta. (biomedcentral.com)
  • Using NanoString technology, we further analyzed the fetal placenta samples from the NHBCS for the expression of genes encoding arsenic transporters and metabolic enzymes. (biomedcentral.com)
  • We found that maternal arsenic exposure was strongly associated with expression of the AQP9 gene, encoding an aquaglyceroporin transporter, in female but not male fetal placenta. (biomedcentral.com)
  • This gene encodes an arginine-specific ADP-ribosyltransferase. (nih.gov)
  • The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
  • The others are the site-specific TFs or the DNA sequence-specific binding proteins. (intechopen.com)
  • Genes encoding disrupted complementary interactors tend to be risk genes, and an interaction network built from these proteins is enriched for ASD proteins. (springer.com)
  • The fact that the Gimap genes are located together in a tight cluster on RNO4 (and in conserved synteny with many other species), combined with their sequence similarities, suggests the possibility that the proteins carry out similar function. (hindawi.com)
  • Gene expression in living cells is strictly self-regulated to ensure that the correct amounts of proteins are made at the most appropriate timing and location for maintaining cellular homeostasis. (nature.com)
  • We evaluated serum proteins and blood cell gene expression of biomarkers related to potential cardiovascular effects. (cdc.gov)
  • At 24hr, inflammatory serum proteins and blood cell gene expression had returned to baseline and the systemic tissue response had diminished. (cdc.gov)
  • To investigate gene regulatory evolution, we studied expression in parents and allele-specific expression in F1 hybrids of crosses between warm-adapted and cold-adapted strains. (biorxiv.org)
  • Methylation has previously been associated with allele specific expression in ants. (le.ac.uk)
  • Here we searched for allele specific expression in twelve genes associated with worker reproduction in bees. (le.ac.uk)
  • We found allele specific expression in Ecdysone 20 monooxygenase and IMP-L2-like. (le.ac.uk)
  • RePub, Erasmus University Repository: Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice. (eur.nl)
  • In this study, we investigated the role of embryonic gene Cripto-1 (CR-1) in hepatocellular carcinoma (HCC) using hepatocyte-specific CR-1-overexpressing transgenic mice. (aging-us.com)
  • Hepatocyte-specific over-expression of CR-1 in transgenic mice enhanced hepatocyte proliferation after 2/3 partial hepatectomy (2/3 PHx). (aging-us.com)
  • However, histological signs of precancerous lesions, hepatocyte dysplasia or HCC formation were not observed in the livers of 3-, 6- or 8-month-old hepatocyte-specific CR-1-overexpressing transgenic mice. (aging-us.com)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • Here, we compared evolved gene expression differences between a warm-adapted house mouse strain and two different cold-adapted strains that have independently evolved similar phenotypic traits, such as increased body size and decreased extremity length during the last few hundred years. (biorxiv.org)
  • species-specific differences predominate before and after this stage. (news-medical.net)
  • A further 80 genes showed greater than 5 fold differences in expression after exposure to dragonfly larvae and 81 genes showed altered expression after exposure to larval salamanders. (biomedcentral.com)
  • d , Heatmap of z -score normalized RPKM expression levels of genes significantly enriched in each neuron subtype. (jneurosci.org)
  • f , Specific examples of druggable genes enriched in each neuron subtype, visualized as boxplots of RPKM expression levels. (jneurosci.org)
  • Incomplete dosage compensation, independent of DNA methylation, was found to be largely responsible for sexually dimorphic gene expression, with dosage compensation increasing throughout life. (ugent.be)
  • Hence, we asked whether it is possible to fill these gaps by predicting cell-specific drug perturbation profiles using available expression data from related conditions--i.e. from other drugs and cell types. (nih.gov)
  • Finally, we integrated the expression data with scans for selection in natural populations and found substantial parallelism in the two northern populations for genes under selection. (biorxiv.org)
  • We used population level selection scans in wild animals to identify regions of the genome under selection and combined these findings with the gene expression data to identify candidate genes underlying adaptation to novel environments. (biorxiv.org)
  • Our aim is to use the potential of RNA-Sequencing data in order to evaluate the effect of an EO supplementary diet on gene expression in both lamb liver and muscle. (biomedcentral.com)
  • Our data define specific molecular features of HD-MM that may translate in the identification of novel relevant druggable targets. (oncotarget.com)
  • Our data substantiates the Gimap5 frameshift mutation as the primary defect with only limited contributions to lymphopenia from the remaining Gimap genes. (hindawi.com)
  • However, we now have a number of methods that allow identification of genes critical for survival in a host as well as methods that allow direct measurement of gene expression during interaction with a host. (cdc.gov)
  • Methods of studying differential GENE EXPRESSION of especially low-abundance, tissue-specific gene transcripts. (bvsalud.org)
  • assigns single-cell RNA-seq expression to cancer clones by probabilistically mapping RNA-seq to clone-specific copy number profiles using reparametrization gradient variational inference . (github.com)
  • By comparing the TB signature with gene expression profiles from human breast metastases and an in vitro osteoclast model, we demonstrate that our model mimics both the human breast cancer bone microenvironment and osteoclastogenesis. (biomedcentral.com)
  • High SETD4 expression is associated with Breast Cancer. (nih.gov)
  • For example, the 2015 annual report showed breast cancer incidence by molecular subtypes using tumor biomarkers for hormone receptor (HR) and human growth factor-neu receptor (HER2) expression. (cdc.gov)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • On the biological level, we demonstrate that gene expression levels fluctuate during in vitro development of both intracellular amastigotes and promastigotes. (cambridge.org)
  • These in vitro, and their expression in these human tumour virus. (who.int)
  • Expression of two nonallelic type II procollagen genes during Xenopus laevis embryogenesis is characterized by stage-specific production of alternatively spliced transcripts. (rupress.org)
  • Our results demonstrate that imputed expression can improve dose prediction and bridge population-specific compositions. (biomedcentral.com)
  • Here, we studied gene expression in liver and brown adipose tissue in two wild-derived strains of house mice that independently adapted to cold, northern environments, and we compared them to a strain of house mice from a warm, southern environment. (biorxiv.org)
  • One approach is to target gene transfer to a specific type of neuron. (harvard.edu)
  • HSV-1 vector particles containing either gC - GDNF or gC - BDNF target gene transfer to nigrostriatal neurons, which contain specific receptors for GDNF or BDNF. (harvard.edu)
  • To identify the most predictive genes we used a variable selection strategy. (frontiersin.org)
  • In conclusion, we provide useful experimental approaches and bioinformatics to identify informative and predictive genes at the single-cell level, which opens up new means to describe and understand cell proliferation and subpopulation dynamics. (frontiersin.org)
  • We build gene-tissue signatures associated with warfarin dose in a cohort-specific manner and identify a signature of 11 gene-tissue pairs that significantly augments the International Warfarin Pharmacogenetics Consortium dosage-prediction algorithm in both populations. (biomedcentral.com)
  • Multiple transcript variants encoding different isoforms have been found for this gene. (nih.gov)
  • For example, steroid and thyroid hormones directly bind to nuclear receptors, which induce expression of specific genes. (intechopen.com)
  • Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)
  • Two groups of scientists, including researchers at the Max Planck Institute of Molecular Genetics in Dresden and the Max Planck Institute for Evolutionary Biology in Plön, have now succeeded in demonstrating, for the first time, that parallels exist between individual development and phylogeny on the level of gene expression. (news-medical.net)
  • Conclusion: Targeted gene transfer can be used in combination with neuronal-specific promoters to achieve a high level of nigrostriatal neuron-specific expression. (harvard.edu)
  • Together, our work revealed how PARIS drives adverse effects on modulation of PPAR-γ associated gene clusters in DA neurons. (nature.com)
  • Background: Direct gene transfer into neurons has potential for developing gene therapy treatments for specific neurological conditions, and for elucidating neuronal physiology. (harvard.edu)
  • A second approach to achieve neuronal type-specific expression is to use a cell type-specific promoter, and we have used the tyrosine hydroxylase (TH) promoter to restrict expression to catecholaminergic neurons or a modified neurofilament heavy gene promoter to restrict expression to neurons, and both of these promoters support long-term expression from HSV-1 vectors. (harvard.edu)
  • Immunofluorescent costaining was performed to detect both recombinant gene products and nigrostriatal neurons. (harvard.edu)
  • Moreover, we identified that PARIS actively modulates expression of PPARγ target genes by physically binding to the promoter regions. (nature.com)
  • Results: Helper virus-free HSV-1 vector packaging was performed using either gC - GDNF or gC - BDNF and vectors that contain either the TH promoter or the modified neurofilament heavy gene promoter. (harvard.edu)
  • We then surveyed the distribution of stress-related cis -regulatory elements in the −1.5 kb promoter regions of ZmCAMTA genes. (frontiersin.org)
  • Due to the complex cellular composition of specific brain areas, neuronal type-specific recombinant gene expression is required for many potential applications of neuronal gene transfer. (harvard.edu)
  • To both improve nigrostriatal-neuron specific expression, and to establish that targeted gene transfer can be followed by long-term expression, we performed targeted gene transfer with vectors that support long-term, neuronal-specific expression. (harvard.edu)
  • The combination of targeted gene transfer with neuronal-specific promoters improved nigrostriatal neuron-specific expression (83 to 93%) compared to either approach alone, and supported long-term (1 month) expression at levels similar to those observed using untargeted gene transfer. (harvard.edu)
  • Using inferred gene co-expression for three neuronal cell types-excitatory, inhibitory, and neural progenitor-we implicate several hundred genes in risk (FDR \(\le \hspace{0.17em}\) 0.05), ~ 60% novel, with characteristics of genuine ASD genes. (springer.com)
  • Across cell types, these genes affect neuronal morphogenesis and neuronal communication, while neural progenitor cells show strong enrichment for development of the limbic system. (springer.com)
  • This study demonstrated that reduction of full-length CDP levels in two independent strains of CDP knockout mice increased endogenous MMTV and other mammary-specific cellular genes in undifferentiated mammary glands, suggesting a critical role for CDP in the MMTV life cycle. (utexas.edu)
  • Accordingly, we discovered that although butyrate globally increases baseline expression of more than 800 cellular genes , it strongly represses IFN-induced expression of 60% of ISGs and upregulates 3% of ISGs. (bvsalud.org)
  • It is expected that the enhancement of gene expression efficiency with a shrunken DNA conformation would also be a rather general mechanism in living cellular environments. (nature.com)
  • Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate. (broadinstitute.org)