• 1 The World Health Organization (WHO) in 2005 defined AOT as a tumor composed of odontogenic epithelium, presenting a variety of histo-architectural patterns, embedded in mature connective tissue stroma, and characterized by slow and progressive growth. (ac.ir)
  • specifically, enamel is deposited by ameloblasts derived from the epithelium, while dentin is deposited by odontoblasts derived from mesenchymal cells. (ispub.com)
  • The immunostaining pattern of HSP27 revealed that the differentiation level of ameloblastoma corresponds to the differentiation level of odontogenic cells in tooth germ and that HSP27 might play a role in this. (ijofr.org)
  • The purpose of this study was to investigate the expression pattern of Mage-D1 in rat tooth germ development and its differential mineralization ability to ectomesenchymal stem cells (EMSCs), and to explore its potential mechanism. (researchsquare.com)
  • Results showed that the expression of Mage-D1 during rat tooth germ development was temporally and spatially specific. (researchsquare.com)
  • The purpose of the study was to demonstrate the presence of heat-shock protein (HSP) 27 in developing tooth germs and ameloblastoma and compare their expressions. (ijofr.org)
  • All slides and records proliferating odontogenic epithelial cells of which were diagnosed as ameloblastoma were palisading peripheral tall columnar to cuboidal included and analyzed. (bvsalud.org)
  • Adenomatoid odontogenic tumor (AOT) is an uncommon benign odontogenic lesion, with debatable histogenesis and variable histopathology. (ac.ir)
  • Further, HSP27 can be taken up as a marker of differentiation of ameloblasts along with markers such as cytokeratin 19. (ijofr.org)
  • In this study, we assayed the effect of exogenous mouse recombinant GDF-5 on cell proliferation of dental pulp cells and determined the expression levels of odontoblast differentiation marker genes in the cells of isolated mouse dental pulp tissues in the presence of GDF-5. (ispub.com)
  • Here, we investigated the effect of GDF-5 on the proliferation of dental pulp cells and their differentiation into odontoblasts by assaying the expression levels of odontoblast marker genes. (ispub.com)
  • showed that knocking out Mage-D1 can induce the expression of autophagy-related genes by enhancing the activity and differentiation of osteoclasts, thereby accelerating the process of periodontitis 23 . (researchsquare.com)
  • Coordinated patterns of gene expression differ among Malawi species and prefigure the future-ordered distribution of functional teeth of specific size and spacing. (biomedcentral.com)
  • This variation in gene expression among species occurs early in the developmental programme for dental patterning. (biomedcentral.com)
  • GDF-5 also increased the gene expression and enzyme activity of alkaline phosphatase. (ispub.com)
  • Identification of gene expression profiles, RNA interactions, gene regulation patterns, and single nucleotide polymorphisms (SNPs) is important for determining the molecular mechanisms underlying the normal odontogenesis and the pathology of oral and dental disorders. (ac.ir)
  • Moreover, the hsa-miR-134-5p regulated the SHH and TFAP2A gene expression. (ac.ir)
  • Along with other BMPs, including BMP-2, -4 and -7, which are well known as potent osteoinductive growth factors, GDF-5 plays important roles in the development of bones, cartilage and tendons, as evidenced by the tendency for the gene and protein expression levels of GDF-5 to increase over time in these tissues. (ispub.com)
  • PurposePrevious studies indicate that breast cancer molecular subtypes differ with respect to their dependency on autophagy, but our knowledge of the differential expression and prognostic significance of autophagy-related biomarkers in breast cancer is limited.Methods Immunohistochemistry (IHC) was performed on tissue microarrays from a large popu. (researchgate.net)
  • We investigate the expression of conserved gene networks (involving bmp2 , bmp4 , eda , edar , fgf8 , pax9 , pitx2 , runx2 , shh and wnt7b ) known to pattern iterative structures and teeth in other vertebrates. (biomedcentral.com)
  • MSX2 in ameloblast cell fate and activity. (ac.ir)
  • 15. Twist and Snail expression in tumor and stromal cells of epithelial odontogenic tumors. (nih.gov)
  • 18. Cell proliferation proteins and aggressiveness of histological variants of ameloblastoma and keratocystic odontogenic tumor. (nih.gov)
  • 19. Detection of cytokeratins in ghost cells of calcifying cystic odontogenic tumor indicates an altered keratinization and hair follicle differentiation for their development. (nih.gov)
  • 20. Co-expression of Ki-67 and p53 protein in ameloblastoma and keratocystic odontogenic tumor. (nih.gov)
  • Ameloblastoma is the most frequent odontogenic tumor. (nih.gov)
  • By applying Weighted Gene Co-expression Network Analysis on expression data of odontoblast, ameloblast, and Ameloblastoma, we found a proliferation-associated gene module that was significantly disrupted in tumor tissues. (nih.gov)
  • Cells inside the proliferating epithelial cell public had been positive for Notch I and acquired an appearance similar to calcifying epithelial odontogenic tumor with amyloid-like debris. (cancer8.info)
  • The association between EBV gene expression and inhibition of MHC class I HLA expression implies that antigen display is either directly inhibited by EBV, facilitating immune evasion by tumor cells, and/or that tumor cells with inhibited presentation are selected for their ability to sustain higher levels of EBV to take maximum advantage of EBV oncogene-mediated tumor-promoting actions. (gsea-msigdb.org)
  • Our data clearly reflect such tumor promotion, showing that deregulation of key proteins involved in apoptosis (BCL2-related protein A1 and Fas apoptotic inhibitory molecule), cell cycle checkpoints (AKIP, SCYL1, and NIN), and metastasis (matrix metalloproteinase 1) is closely correlated with the levels of EBV gene expression in NPC. (gsea-msigdb.org)
  • Background: Keratocystic odontogenic tumour and ameloblastoma are classified under tumours by WHO. (journalcra.com)
  • Aims and Objectives: To investigate the involvement of apoptosis inhibition in these lesions, expression of Bcl-2 was examined in 10 cases of KCOT (keratocystic odontogenic tumour) and ameloblastoma each. (journalcra.com)
  • 17. Neoplastic odontogenic epithelial cells express bone sialoprotein. (nih.gov)
  • Odontogenic ameloblast-associated protein is a protein that in humans is encoded by the ODAM gene. (wikipedia.org)
  • 1. [Expression of p-p38MARK, uPA and Ki-67 in epithelial odontogenic tumour]. (nih.gov)
  • 8. Methylation frequencies of cell-cycle associated genes in epithelial odontogenic tumours. (nih.gov)
  • Treatment of HDPCs with 1α,25(OH) 2 D 3 at a concentration of 10 nM or 100 nM significantly upregulated the expression of dentin sialophosphoprotein (DSPP) and dentin matrix protein1 (DMP1), the odontogenesis-related genes. (molcells.org)
  • To identify the molecular mechanisms by which EBV-associated epithelial cancers are maintained, we measured the expression of essentially all human genes and all latent EBV genes in a collection of 31 laser-captured, microdissected nasopharyngeal carcinoma (NPC) tissue samples and 10 normal nasopharyngeal tissues. (gsea-msigdb.org)
  • Expression levels of six viral genes (EBNA1, EBNA2, EBNA3A, EBNA3B, LMP1, and LMP2A) were correlated among themselves and strongly inversely correlated with the expression of a large subset of host genes. (gsea-msigdb.org)
  • Among the human genes whose inhibition was most strongly correlated with increased EBV gene expression were multiple MHC class I HLA genes involved in regulating immune response via antigen presentation. (gsea-msigdb.org)
  • 9. Immunohistochemical demonstration of an enamel sheath protein, sheathlin, in odontogenic tumors. (nih.gov)
  • The purpose of our research was to judge Notch 1 in the ameloblast/stratum intermedium cell levels during enamel advancement in KO mice and in TgP70TKO proliferating epithelial public and developing molars to recognize the potential function of Notch in the forming of these abnormal buildings. (cancer8.info)
  • History Amelogenins are highly conserved protein secreted by ameloblasts in the teeth body organ of developing tooth. (cancer8.info)
  • The histologic results had been much like that observed in individual calcifying epithelial odontogenic tumors (CEOT) that are uncommon harmless epithelial odontogenic tumors that are usually produced from stratum intermedium Sclareol which may be the cell level next to the ameloblasts (11 12 The introduction of a tooth depends upon sequential and reciprocal connections between epithelial and mesenchymal levels (13). (cancer8.info)
  • Quantitatively the basal layer/ peripheral ameloblast- like cells of both tumours had similar over expression while parabasal and central/superficial cells showed considerable differences. (journalcra.com)
  • Our study indicates similar over-expression of bcl-2 in both the odontogenic lesions specifically basal layer / peripheral ameloblast- like cells which may represent tumorigenesis by escaping apoptosis. (journalcra.com)
  • However, little is known about the potential of vitamin D as an odontogenic inducer in human dental pulp cells (HDPCs) in vitro . (molcells.org)
  • This study was designed to determine and compare the stimulatory effect of different concentrations of MgO on expression of bone morphogenic protein (BMP-2) and SMADs 1/5/9 in signal transduction pathway of normal human dental pulp cells (HDPCs). (madridge.org)
  • 13. Expression of bone morphogenetic proteins and their associated molecules in ameloblastomas and adenomatoid odontogenic tumors. (nih.gov)
  • Nevertheless TgP70T expression on the KO background didn't result in phenotypic recovery but to unusual proliferation from the stratum intermedium level and some locations within the causing cellular public had been amelogenin proteins positive by immunohistochemistry (7). (cancer8.info)
  • In previous work, magnesium oxide (MgO) has been considered for its potential ability to enhance cell attachment, proliferation rate and expression of dentin matrix proteins. (madridge.org)
  • Previous studies showed that MgO upregulated attachment, proliferation rate, alkaline phosphatase (ALP) activity, and expression of dentin sialoprotein (DSP), dentin matrix protein (DMP-1), dentin sialophosphoprotein (DSPP) and type I collagen (COL-I) in HDPCs in vitro [9 , 10] . (madridge.org)
  • 7. [Expression of nuclear factor-kappaB, Ki-67 and matrix metalloproteinase-9 in calcifying odontogenic cyst]. (nih.gov)
  • 5. TGF-β1, Smad-2/-3, Smad-1/-5/-8, and Smad-4 signaling factors are expressed in ameloblastomas, adenomatoid odontogenic tumors, and calcifying cystic odontogenic tumors: an immunohistochemical study. (nih.gov)
  • Our study revealed over-expression of Bcl-2 in all the cases in both tumours. (journalcra.com)