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  • regulators
  • Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2. (semanticscholar.org)
  • miR-125b is expressed family members as key regulators of the neurogenic-to- throughout zebrafish embryos and is enriched in the gliogenic switch in developing neural stem/progenitor brain, while loss of miR-125b elevates p53 expression cells (NSCs) by controlling the "competence" necessary and triggers p53-dependent apoptosis in these embryos for NSCs to respond to gliogenic cell-extrinsic signals . (deepdyve.com)
  • inhibition
  • In line with this notion, our previous studies in the PD mouse model demonstrate that overexpression of LRRK2 accelerated α-synuclein-mediated neurodegeneration, while inhibition of LRRK2 expression ameliorated α-synuclein-induced neuropathology ( 11 ). (pubmedcentralcanada.ca)
  • Let-7c over-expression enhanced apoptosis in ECs whereas inhibition of let-7c could partly alleviate apoptotic cell death mediated by ox-LDL. (mysciencework.com)
  • Examination of miRNA function by overexpression and inhibition showed that increased miRNA-146a expression negatively regulated the release of the proinflammatory chemokines IL-8 and RANTES. (westminster.ac.uk)
  • suppresses
  • Microrna-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. (springer.com)
  • miR-133 enhances myoblast proliferation by repressing serum response factor (SRF) mIR-133 suppresses SP1 expression In rats, miR-133b is expressed in retinal dopaminergicamacrine cell, and this expression is significantly increased during early stage during retinal degeneration. (wikipedia.org)
  • miR-133 suppresses Prdm16 expression in skeletal muscle stem cells (satellite cells), which controls myogenic vs. brown adipogenic lineage determination in these cells. (wikipedia.org)
  • mechanism
  • Therefore, our results demonstrate a novel molecular mechanism for the dysregulated expression of SRC-3 in hepatocellular carcinoma. (springer.com)
  • Therefore, the present study was undertaken to investigate the influence of miR-494 on HIF-1α expression and its relative mechanism in human hepatic cell line L02. (biomedcentral.com)
  • A cellular mechanism that degrades unwanted RNAs in the cytoplasm but not in the nucleus. (slideserve.com)
  • embryonic
  • Non-coding RNAs play roles in embryonic development of animals and these functions might be expected to evolve rapidly. (pubmedcentralcanada.ca)
  • Recent studies in zebrafish have identified the role of microRNAs during the maternal-to-embryonic transition (MET). (biomedcentral.com)
  • We recently reported the cloning and expression of bovine NOBOX during early embryonic development and our gene knockdown studies indicate that NOBOX is a maternal effect gene essential for early embryonic development. (biomedcentral.com)
  • Expression analysis of miR-196a in bovine oocytes and during early embryonic development indicated that it is expressed both in oocytes and embryos and tends to increase at the four-cell and eight-cell stages. (biomedcentral.com)
  • antisense
  • Supplementary Fig. 1 (a-b) Western blot analysis of SRC-3 expression in HepG2 cells with or without transfection of miR-195 mimics (a), antisense (b) or negative control (NC). (springer.com)
  • LNCaP and PC3 human prostate cancer cells (American Type Culture Collection) were grown to 50% confluency and transfected with either microRNA precursor or antisense microRNA inhibitor (Ambion) at 100 nmol/L final concentration using Lipofectamine 2000 reagent (Invitrogen). (aacrjournals.org)
  • inflammatory
  • Over-expression of miR-124 could effectively attenuate the LPS-induced expression of pro-inflammatory cytokines and promote the secretion of neuroprotective factors. (biomedcentral.com)
  • Here, we review microRNAs, inflammatory factors, referred to as the senescence- which are commonly downregulated with age and in- associated secretory phenotype (SASP) . (deepdyve.com)
  • hypoxia
  • How hypoxia regulates gene expression in the human carotid body (CB) remains poorly understood. (springer.com)
  • In mammals, the hypoxia-dependent changes, on a gene expression level, are primarily mediated by the α-subunits of hypoxia-inducible transcription factors (HIFs). (spandidos-publications.com)
  • Quantitative RT-PCR showed that miR-494 was up-regulated to peak after 4 hours of hypoxia in human liver cell line L02. (biomedcentral.com)
  • Hypoxia inducible factor-1 (HIF-1) is recognized as the master transcription factor consisting of a constitutively expressed HIF-1β subunit and an oxygen-regulated HIF-1α subunit in response to hypoxia [ 7 ]. (biomedcentral.com)
  • We hypothesize that miR-494 may have a role in influencing HIF-1α expression and contribute to the cellular response to hypoxia. (biomedcentral.com)